Assessment of margin of exposure based on biomarkers in blood: An exploratory analysis

Regulatory Toxicology and Pharmacology

Volumn 61, Issue 1, 2011, Pages 44-52

  Aylward, Lesa L ^a   Becker, Richard A ^b   Kirman, Christopher R ^a   Hays, Sean M ^a  

^a LLP   (United States)

^b American Chemistry Council   (United States)

Author keywords

Biomarkers; Interspecies extrapolation; PBPK; Uncertainty factors

Indexed keywords

BIOLOGICAL MARKER; TOXIC SUBSTANCE; TOXIN;

ARTICLE; BASAL METABOLIC RATE; BIOLOGICAL MONITORING; BLOOD LEVEL; CONCENTRATION (PARAMETERS); EXPOSURE VARIABLE; HAZARD ASSESSMENT; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; MARGIN OF EXPOSURE; NONHUMAN; PARTITION COEFFICIENT; PRIORITY JOURNAL; SPECIES COMPARISON; TOXICOKINETICS; TOXICOLOGICAL PARAMETERS;

ANIMALS; BIOLOGICAL MARKERS; BODY WEIGHT; DRUG ADMINISTRATION ROUTES; HUMANS; LETHAL DOSE 50; LIVER; MICE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; RATS; RISK ASSESSMENT; TOXICITY TESTS; VOLATILE ORGANIC COMPOUNDS;

ANIMALIA;

EID: 80052422340     PISSN: 02732300     EISSN: 10960295     Source Type: Journal    
DOI: 10.1016/j.yrtph.2011.06.001     Document Type: Article

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