Examining the effects of age, sex, and body mass index on normative median motor nerve excitability measurements

Clinical Neurophysiology

Volumn 122, Issue 10, 2011, Pages 2081-2088

  McHugh, John C ^a   Reilly, Richard B ^b   Connolly, Sean ^a  

^a ST VINCENT S UNIVERSITY HOSPITAL   (Ireland)

^b TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

Ageing; BMI; KCNQ; Nerve excitability; Peripheral nerve; QTRAC; Sex

Indexed keywords

POTASSIUM CHANNEL KCNQ;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; BODY MASS; BODY TEMPERATURE; COMPUTER PROGRAM; FEMALE; HUMAN; HUMAN EXPERIMENT; HYPERPOLARIZATION; MALE; MEDIAN NERVE; MOTOR NERVE; MUSCLE ACTION POTENTIAL; MUSCLE TONE; NERVE EXCITABILITY; NERVE STIMULATION; NORMAL HUMAN; PERCEPTIVE THRESHOLD; PRIORITY JOURNAL; REST; SEX DIFFERENCE; STIMULUS RESPONSE; WRIST;

ADULT; AGED; AGED, 80 AND OVER; AGING; BODY MASS INDEX; EVOKED POTENTIALS, MOTOR; FEMALE; HUMANS; MALE; MEDIAN NERVE; MIDDLE AGED; POTASSIUM CHANNELS, VOLTAGE-GATED; SEX CHARACTERISTICS;

EID: 80052415751     PISSN: 13882457     EISSN: 18728952     Source Type: Journal    
DOI: 10.1016/j.clinph.2011.03.020     Document Type: Article

References (23)

1. Bae J.S., Sawai S., Misawa S., Kanai K., Isose S., Shibuya K., et al. Effects of age on excitability properties in human motor axons. Clin Neurophysiol 2008, 119:2282-2286.
2. Baker M., Bostock H. Depolarization changes the mechanism of accommodation in rat and human motor axons. J Physiol 1989, 411:545-561.
3. Baker M., Bostock H., Grafe P., Martius P. Function and distribution of three types of rectifying channel in rat spinal root myelinated axons. J Physiol 1987, 383:45-67.
4. Barrett E.F., Barrett J.N. Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 1982, 323:117-144.
5. Bostock H., Cikurel K., Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 1998, 21:137-158.
6. Bostock H., Rothwell J.C. Latent addition in motor and sensory fibres of human peripheral nerve. J Physiol 1997, 498:277-294.
7. Efroymson M.A. Multiple regression analysis. Mathematical Methods for Digital Computers 1960, John Wiley and Sons, New York. A. Ralston, H.S. Wilf (Eds.).
8. Franssen H., Gebbink T.A., Wokke J.H., van den Berg L.H., van Schelven L.J. Is cold paresis related to axonal depolarization?. J Peripher Nerv Syst 2010, 15:227-237.
9. Jankelowitz S.K., McNulty P.A., Burke D. Changes in measures of motor axon excitability with age. Clin Neurophysiol 2007, 118:1397-1404.
10. Kawamura Y., O'Brien P., Okazaki H., Dyck P.J. Lumbar motoneurons of man II: the number and diameter distribution of large- and intermediate-diameter cytons in "motoneuron columns" of spinal cord of man. J Neuropathol Exp Neurol 1977, 36:861-870.
11. Kiernan M.C., Burke D., Andersen K.V., Bostock H. Multiple measures of axonal excitability: a new approach in clinical testing. Muscle Nerve 2000, 23:399-409.
12. Kiernan M.C., Lin C.S., Andersen K.V., Murray N.M., Bostock H. Clinical evaluation of excitability measures in sensory nerve. Muscle Nerve 2001, 24:883-892.
13. Kiernan M.C., Cikurel K., Bostock H. Effects of temperature on the excitability properties of human motor axons. Brain 2001, 124:816-825.
14. Kuwabara S., Kanai K., Sung J.Y., Ogawara K., Hattori T., Burke D., et al. Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons. Muscle Nerve 2002, 26:283-287.
15. Kuwabara S., Misawa S., Kanai K., Tamura N., Nakata M., Sawai S., et al. The effects of physiological fluctuation of serum potassium levels on excitability properties in healthy human motor axons. Clin Neurophysiol 2007, 118:278-282.
16. Nodera H., Kaji R. Nerve excitability testing and its clinical application to neuromuscular diseases. Clin Neurophysiol 2006, 117:1902-1916.
17. Puksa L., Stalberg E., Falck B. Reference values of F wave parameters in healthy subjects. Clin Neurophysiol 2003, 114:1079-1090.
18. Roos M.R., Rice C.L., Vandervoort A.A. Age-related changes in motor unit function. Muscle Nerve 1997, 20:679-690.
19. Schwarz J.R., Glassmeier G., Cooper E.C., Kao T.C., Nodera H., Tabuena D., et al. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol 2006, 573:17-34.
20. Swallow M. Fibre size and content of the anterior tibial nerve of the foot. J Neurol Neurosurg Psychiatry 1966, 29:205-213.
21. Tabachnik B.G., Fidell L.S. Multiple Regression. Using multivariate statistics 2001, Allyn and Bacon. 4th ed.
22. Wysowski D.K., Kornegay C., Nourjah P., Trontell A. Sex and age differences in serum potassium in the United States. Clin Chem 2003, 49:190-192.
23. Yerdelen D., Uysal H., Koc F., Sarica Y. Effects of sex and age on strength-duration properties. Clin Neurophysiol 2006, 117:2069-2072.