The effects of physiological fluctuation of serum potassium levels on excitability properties in healthy human motor axons

Clinical Neurophysiology

Volumn 118, Issue 2, 2007, Pages 278-282

  Kuwabara, Satoshi ^a   Misawa, Sonoko ^a   Kanai, Kazuaki ^a   Tamura, Noriko ^a   Nakata, Miho ^a   Sawai, Setsu ^a   Hattori, Takamichi ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Axonal excitability; Membrane potential; Potassium channel; Serum potassium level; Sodium channel; Threshold tracking

Indexed keywords

ADULT; ARTICLE; BLOOD LEVEL; CORRELATION ANALYSIS; FEMALE; HUMAN; HYPERPOLARIZATION; MALE; MEMBRANE STEADY POTENTIAL; MUSCLE ACTION POTENTIAL; NERVE EXCITABILITY; NERVE FIBER; NORMAL HUMAN; POTASSIUM BLOOD LEVEL; PRIORITY JOURNAL; REFRACTORY PERIOD; STATISTICAL ANALYSIS; STATISTICAL SIGNIFICANCE; VOLUNTEER;

ADULT; AXONS; FEMALE; HUMANS; MALE; MEMBRANE POTENTIALS; MOTOR NEURONS; MUSCLE, SKELETAL; NEURAL CONDUCTION; POTASSIUM; REFERENCE VALUES;

EID: 33845964411     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinph.2006.10.009     Document Type: Article

References (13)

1. Bostock H., Cikurel K., and Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 21 (1998) 137-158
2. Burke D., Kiernan M.C., and Bostock H. Excitability of human axons. Clin Neurophysiol 112 (2001) 1575-1585
3. Kiernan M.C., and Bostock H. Effects of membrane polarization and ischaemia on the excitability of human motor axons. Brain 123 (2000) 2542-2551
4. Kiernan M.C., Burke D., Andersen K.V., and Bostock H. Multiple measures of axonal excitability: a new approach in clinical testing. Muscle Nerve 23 (2000) 399-409
5. Kiernan M.C., Hart I.K., and Bostock H. Excitability properties of motor axons in patients with spontaneous motor unit activity. J Neurol Neurosurg Psychiatry 70 (2001) 56-64
6. Kiernan M.C., Walters R.J., Andersen K.V., Taube D., Murray N.M., and Bostock H. Nerve excitability changes in chronic renal failure indicate membrane depolarization due to hyperkalaemia. Brain 125 (2002) 1366-1378
7. Kuwabara S., Cappelen-Smith C., Lin S.-Y.C., Mogyoros I., Bostock H., and Burke D. Excitability properties of median and peroneal motor axons. Muscle Nerve 23 (2000) 1365-1373
8. Kuwabara S., Kanai K., Sung J.Y., Ogawara K., Hattori T., Burke D., et al. Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons. Muscle Nerve 26 (2002) 283-287
9. Kuwabara S., and Misawa S. Axonal ionic pathophysiology in human peripheral neuropathy and motor neuron disease. Curr Neurovasc Res 1 (2004) 373-379
10. Kuwabara S., Misawa S., Tamura N., Kanai K., Hiraga A., Ogawara K., et al. The effects of mexiletine on excitability properties of human median motor axons. Clin Neurophysiol 116 (2005) 284-289
11. Kanai K., Kuwabara S., Misawa S., Tamura N., Ogawara K., Nakata M., et al. Altered axonal excitability properties in amyotrophic lateral sclerosis: Impaired potassium channel function and relation with disease stage. Brain 129 (2006) 953-962
12. Misawa S., Kuwabara S., Ogawara K., Kitano Y., and Hattori T. Strength-duration properties and glycemic control in human diabetic motor nerves. Clin Neurophysiol 116 (2005) 254-258
13. Mogyoros I., Kiernan M., Burke D., and Bostock H. Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis. Brain 121 (1998) 851-859