Nerve excitability testing and its clinical application to neuromuscular diseases

Clinical Neurophysiology

Volumn 117, Issue 9, 2006, Pages 1902-1916

  Nodera, Hiroyuki ^a   Kaji, Ryuji ^a  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

Author keywords

Axon; Ion channels; Membrane potential; Nerve excitability; Threshold tracking

Indexed keywords

POTASSIUM CHANNEL; SODIUM CHANNEL;

DEMYELINATION; DIAGNOSTIC APPROACH ROUTE; DIAGNOSTIC TEST; HUMAN; HYPERPOLARIZATION; MOTOR NERVE CONDUCTION; MOTOR NEUROPATHY; MYELINATION; NERVE CELL EXCITABILITY; NERVE CELL MEMBRANE POTENTIAL; NERVE EXCITABILITY; NEUROMUSCULAR DISEASE; NON INVASIVE MEASUREMENT; NON INVASIVE PROCEDURE; PRIMARY AFFERENT DEPOLARIZATION; PRIORITY JOURNAL; RANVIER NODE; REVIEW;

ACTION POTENTIALS; ANIMALS; ELECTRIC STIMULATION; ELECTROMYOGRAPHY; HUMANS; ION CHANNELS; MUSCLE, SKELETAL; NEURAL CONDUCTION; NEUROMUSCULAR DISEASES; PERIPHERAL NERVES; RANVIER'S NODES; REACTION TIME;

EID: 33747347898     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.clinph.2006.01.018     Document Type: Review

References (81)

1. Baker M., Bostock H., Grafe P., and Martius P. Function and distribution of three types of rectifying channel in rat spinal root myelinated axons. J Physiol 383 (1987) 45-67
2. Barrett E.F., and Barrett J.N. Intracellular recording from vertebrate myelinated axons: mechanism of the depolarizing afterpotential. J Physiol 323 (1982) 117-144
3. Bean J.W. An attempt to use chronaxie as a measure of excitability. Am J Physiol 107 (1934) 275-283
4. Beckstein O., Biggin P.C., Bond P., Bright J.N., Domene C., Grottesi A., Holyoake J., and Sansom M.S. Ion channel gating: insights via molecular simulations. Fed Eur Biochem Soc Lett 555 (2003) 85-90
5. Bergmans J. The Physiology of Single Human Nerve Fibres (1970), University of Louvain, Vander, Belgium
6. Bostock H. The strength-duration relationship for excitation of myelinated nerve: computed dependence on membrane parameters. J Physiol 341 (1983) 59-74
7. Bostock H., Cikurel K., and Burke D. Threshold tracking techniques in the study of human peripheral nerve. Muscle Nerve 21 (1998) 137-158
8. Bostock H., Lin C.S., Howells J., Trevillion L., Jankelowitz S., and Burke D. After-effects of near-threshold stimulation in single human motor axons. J Physiol 564 (2005) 931-940
9. Bostock H., and Rothwell J.C. Latent addition in motor and sensory fibres of human peripheral nerve. J Physiol 498 Pt 1 (1997) 277-294
10. Bostock H., Sharief M.K., Reid G., and Murray N.M. Axonal ion channel dysfunction in amyotrophic lateral sclerosis. Brain 118 Pt 1 (1995) 217-225
11. Brismar T. Abnormal Na-currents in diabetic rat nerve nodal membrane. Diabet Med 1993; 10 Suppl 2: 110S-2S.
12. Brismar T., and Schwarz J.R. Potassium permeability in rat myelinated nerve fibres. Acta Physiol Scand 124 (1985) 141-148
13. Burke D., Kiernan M.C., and Bostock H. Excitability of human axons. Clin Neurophysiol 112 (2001) 1575-1585
14. Campbell E.D., Hickey R.P., Nixon K.H., and Richardson A.T. Value of nerve-excitability measurements in prognosis of facial palsy. Br Med J 5296 (1962) 7-10
15. Cappelen-Smith C., Kuwabara S., Lin C.S., Mogyoros I., and Burke D. Membrane properties in chronic inflammatory demyelinating polyneuropathy. Brain 124 (2001) 2439-2447
16. Cappelen-Smith C., Lin C.S., and Burke D. Activity-dependent hyperpolarization and impulse conduction in motor axons in patients with carpal tunnel syndrome. Brain 126 (2003) 1001-1008
17. Clay J.R. On the persistent sodium current in squid giant axons. J Neurophysiol 89 (2003) 640-644
18. Corfas G., Velardez M.O., Ko C.P., Ratner N., and Peles E. Mechanisms and roles of axon-Schwann cell interactions. J Neurosci 24 (2004) 9250-9260
19. Dawson G.D. The relative excitability and conduction velocity of sensory and motor nerve fibres in man. J Physiol 131 (1956) 436-451
20. Dedek K., Kunath B., Kananura C., Reuner U., Jentsch T.J., and Steinlein O.K. Myokymia and neonatal epilepsy caused by a mutation in the voltage sensor of the KCNQ2 K + channel. Proc Natl Acad Sci USA 98 (2001) 12272-12277
21. Devaux J.J., Kleopa K.A., Cooper E.C., and Scherer S.S. KCNQ2 is a nodal K + channel. J Neurosci 24 (2004) 1236-1244
22. Geddes L.A. Accuracy limitations of chronaxie values. IEEE Trans Biomed Eng 51 (2004) 176-181
23. Grafe P., Bostock H., and Schneider U. The effects of hyperglycaemic hypoxia on rectification in rat dorsal root axons. J Physiol 480 Pt 2 (1994) 297-307
24. Greene D.A., Lattimer S.A., and Sima A.A. Sorbitol, phosphoinositides, and sodium-potassium-ATPase in the pathogenesis of diabetic complications. N Engl J Med 316 (1987) 599-606
25. Guo D., Ramu Y., Klem A.M., and Lu Z. Mechanism of rectification in inward-rectifier K + channels. J Gen Physiol 121 (2003) 261-275
26. Gutman G.A., Chandy K.G., Adelman J.P., Aiyar J., Bayliss D.A., Clapham D.E., Covarriubias M., Desir G.V., Furuichi K., Ganetzky B., Garcia M.L., Grissmer S., Jan L.Y., Karschin A., Kim D., Kuperschmidt S., Kurachi Y., Lazdunski M., Lesage F., Lester H.A., McKinnon D., Nichols C.G., O'Kelly I., Robbins J., Robertson G.A., Rudy B., Sanguinetti M., Seino S., Stuehmer W., Tamkun M.M., Vandenberg C.A., Wei A., Wulff H., and Wymore R.S. International Union of Pharmacology. XLI. Compendium of voltage-gated ion channels: potassium channels. Pharmacol Rev 55 (2003) 583-586
27. Hirota N., Kaji R., Bostock H., Shindo K., Kawasaki T., Mizutani K., Oka N., Kohara N., Saida T., and Kimura J. The physiological effect of anti-GM1 antibodies on saltatory conduction and transmembrane currents in single motor axons. Brain 120 Pt 12 (1997) 2159-2169
28. Hodgkin A.L., and Katz B. The effect of sodium ions on the electrical activity of the giant axon of the squid. J Physiol 108 (1949) 37-77
29. Horn S., Quasthoff S., Grafe P., Bostock H., Renner R., and Schrank B. Abnormal axonal inward rectification in diabetic neuropathy. Muscle Nerve 19 (1996) 1268-1275
30. Kaji R. Physiology of conduction block in multifocal motor neuropathy and other demyelinating neuropathies. Muscle Nerve 27 (2003) 285-296
31. Kaji R., Bostock H., Kohara N., Murase N., Kimura J., and Shibasaki H. Activity-dependent conduction block in multifocal motor neuropathy. Brain 123 Pt 8 (2000) 1602-1611
32. Kaji R., and Nodera H. Puffer fish poisoning. Guillain-Barre syndrome and persistent sodium channels. Ann Neurol 57 (2005) 309
33. Kaji R., Oka N., Tsuji T., Mezaki T., Nishio T., Akiguchi I., and Kimura J. Pathological findings at the site of conduction block in multifocal motor neuropathy. Ann Neurol 33 (1993) 152-158
34. Kanai K., Kuwabara S., Arai K., Sung J.Y., Ogawara K., and Hattori T. Muscle cramp in Machado-Joseph disease: altered motor axonal excitability properties and mexiletine treatment. Brain 126 (2003) 965-973
35. Kiernan M.C., and Bostock H. Effects of membrane polarization and ischaemia on the excitability properties of human motor axons. Brain 123 Pt 12 (2000) 2542-2551
36. Kiernan M.C., Burke D., Andersen K.V., and Bostock H. Multiple measures of axonal excitability: a new approach in clinical testing. Muscle Nerve 23 (2000) 399-409
37. Kiernan M.C., Guglielmi J.M., Kaji R., Murray N.M., and Bostock H. Evidence for axonal membrane hyperpolarization in multifocal motor neuropathy with conduction block. Brain 125 (2002) 664-675
38. Kiernan M.C., Hales J.P., Gracies J.M., Mogyoros I., and Burke D. Paraesthesiae induced by prolonged high frequency stimulation of human cutaneous afferents. J Physiol 501 Pt 2 (1997) 461-471
39. Kiernan M.C., Krishnan A.V., Lin C.S., Burke D., and Berkovic S.F. Mutation in the Na + channel subunit SCN1B produces paradoxical changes in peripheral nerve excitability. Brain 128 (2005) 1841-1846
40. Kiernan M.C., Lin C.S., Andersen K.V., Murray N.M., and Bostock H. Clinical evaluation of excitability measures in sensory nerve. Muscle Nerve 24 (2001) 883-892
41. Kiernan M.C., Lin C.S., and Burke D. Differences in activity-dependent hyperpolarization in human sensory and motor axons. J Physiol 558 (2004) 341-349
42. Kiernan M.C., Mogyoros I., and Burke D. Conduction block in carpal tunnel syndrome. Brain 122 Pt 5 (1999) 933-941
43. Kiernan M.C., Walters R.J., Andersen K.V., Taube D., Murray N.M., and Bostock H. Nerve excitability changes in chronic renal failure indicate membrane depolarization due to hyperkalaemia. Brain 125 (2002) 1366-1378
44. Kitano Y., Kuwabara S., Misawa S., Ogawara K., Kanai K., Kikkawa Y., Yagui K., and Hattori T. The acute effects of glycemic control on axonal excitability in human diabetics. Ann Neurol 56 (2004) 462-467
45. Kubo Y., Adelman J.P., Clapham D.E., Jan L.Y., Karschin A., Kurachi Y., Lazdunski M., Nichols C.G., Seino S., and Vandenberg C.A. International Union of Pharmacology. LIV. Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels. Pharmacol Rev 57 (2005) 509-526
46. Kugelberg E. Facial reflexes. Brain 75 (1952) 385-396
47. Kuwabara S., Kanai K., Sung J.Y., Ogawara K., Hattori T., Burke D., and Bostock H. Axonal hyperpolarization associated with acute hypokalemia: multiple excitability measurements as indicators of the membrane potential of human axons. Muscle Nerve 26 (2002) 283-287
48. Kuwabara S., Mori M., Ogawara K., Hattori T., and Yuki N. Indicators of rapid clinical recovery in Guillain-Barre syndrome. J Neurol Neurosurg Psychiatry 70 (2001) 560-562
49. Kuwabara S., Ogawara K., Sung J.Y., Mori M., Kanai K., Hattori T., Yuki N., Lin C.S., Burke D., and Bostock H. Differences in membrane properties of axonal and demyelinating Guillain-Barre syndromes. Ann Neurol 52 (2002) 180-187
50. Lagrange A. Retigabine: bending potassium channels to our will. Epilepsy Curr 5 (2005) 166-168
51. Lambert E.F., Skinner B.F., and Forbes A. Some conditions affecting intensity and duration thersholds in motor nerve, with reference to chronaxie of subordination. Am J Physiol 106 (1933) 721-737
52. Li J., Bai Y., Ghandour K., Qin P., Grandis M., Trostinskaia A., Ianakova E., Wu X., Schenone A., Vallat J.M., Kupsky W.J., Hatfield J., and Shy M.E. Skin biopsies in myelin-related neuropathies: bringing molecular pathology to the bedside. Brain 128 (2005) 1168-1177
53. Lin C.S., Kuwabara S., Cappelen-Smith C., and Burke D. Responses of human sensory and motor axons to the release of ischaemia and to hyperpolarizing currents. J Physiol 541 (2002) 1025-1039
54. Lin C.S., Mogyoros I., Kuwabara S., Cappelen-Smith C., and Burke D. Accommodation to depolarizing and hyperpolarizing currents in cutaneous afferents of the human median and sural nerves. J Physiol 529 Pt 2 (2000) 483-492
55. Lu Z. Mechanism of rectification in inward-rectifier K + channels. Annu Rev Physiol 66 (2004) 103-129
56. Mackel R., and Brink E. Conduction of neural impulses in diabetic neuropathy. Clin Neurophysiol 114 (2003) 248-255
57. McIntyre C.C., Richardson A.G., and Grill W.M. Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle. J Neurophysiol 87 (2002) 995-1006
58. Meisler M.H., and Kearney J.A. Sodium channel mutations in epilepsy and other neurological disorders. J Clin Invest 115 (2005) 2010-2017
59. Mogyoros I., Kiernan M.C., and Burke D. Strength-duration properties of human peripheral nerve. Brain 119 Pt 2 (1996) 439-447
60. Mogyoros I., Kiernan M.C., and Burke D. Strength-duration properties of sensory and motor axons in carpal tunnel syndrome. Muscle Nerve 20 (1997) 508-510
61. Mogyoros I., Kiernan M.C., Burke D., and Bostock H. Strength-duration properties of sensory and motor axons in amyotrophic lateral sclerosis. Brain 121 Pt 5 (1998) 851-859
62. Moldovan M., and Krarup C. Mechanisms of hyperpolarization in regenerated mature motor axons in cat. J Physiol 560 (2004) 807-819
63. Moldovan M., and Krarup C. Persistent abnormalities of membrane excitability in regenerated mature motor axons in cat. J Physiol 560 (2004) 795-806
64. Nodera H., Bostock H., Kuwabara S., Sakamoto T., Asanuma K., Jia-Ying S., Ogawara K., Hattori N., Hirayama M., Sobue G., and Kaji R. Nerve excitability properties in Charcot-Marie-Tooth disease type 1A. Brain 127 (2004) 203-211
65. Ocana M., Cendan C.M., Cobos E.J., Entrena J.M., and Baeyens J.M. Potassium channels and pain: present realities and future opportunities. Eur J Pharmacol 500 (2004) 203-219
66. Panizza M., Nilsson J., Roth B.J., Grill S.E., Demirci M., and Hallett M. Differences between the time constant of sensory and motor peripheral nerve fibers: further studies and considerations. Muscle Nerve 21 (1998) 48-54
67. Panizza M., Nilsson J., Roth B.J., Rothwell J., and Hallett M. The time constants of motor and sensory peripheral nerve fibers measured with the method of latent addition. Electroencephalogr Clin Neurophysiol 93 (1994) 147-154
68. Priori A., Bossi B., Ardolino G., Bertolasi L., Carpo M., Nobile-Orazio E., and Barbieri S. Pathophysiological heterogeneity of conduction blocks in multifocal motor neuropathy. Brain 128 (2005) 1642-1648
69. Priori A., Cinnante C., Pesenti A., Carpo M., Cappellari A., Nobile-Orazio E., Scarlato G., and Barbieri S. Distinctive abnormalities of motor axonal strength-duration properties in multifocal motor neuropathy and in motor neurone disease. Brain 125 (2002) 2481-2490
70. Rasband M.N. It's "juxta" potassium channel! J Neurosci Res 76 (2004) 749-757
71. Sahenk Z., Chen L., and Mendell J.R. Effects of PMP22 duplication and deletions on the axonal cytoskeleton. Ann Neurol 45 (1999) 16-24
72. Sahenk Z., and Mendell J.R. Alterations in nodes of Ranvier and Schmidt-Lanterman incisures in Charcot-Marie-Tooth neuropathies. Ann NY Acad Sci 883 (1999) 508-512
73. Seneviratne K.N., and Peiris O.A. The effect of ischaemia on the excitability of human sensory nerve. J Neurol Neurosurg Psychiatry 31 (1968) 338-347
74. Stephanova D.I., and Daskalova M. Excitability properties of normal and demyelinated human motor nerve axons. Electromyogr Clin Neurophysiol 44 (2004) 147-152
75. Sung J.Y., Kuwabara S., Kaji R., Ogawara K., Mori M., Kanai K., Nodera H., Hattori T., and Bostock H. Threshold electrotonus in chronic inflammatory demyelinating polyneuropathy: correlation with clinical profiles. Muscle Nerve 29 (2004) 28-37
76. Taddese A., and Bean B.P. Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron 33 (2002) 587-600
77. Waxman S.G., Cummins T.R., Dib-Hajj S., Fjell J., and Black J.A. Sodium channels, excitability of primary sensory neurons, and the molecular basis of pain. Muscle Nerve 22 (1999) 1177-1187
78. Weiss G. Sur la possibilite de rendre comparables entre eux les appareils servant a l'excitation electrique. Arch Ital Biol 35 (1901) 413-446
79. Wickenden A.D., Yu W., Zou A., Jegla T., and Wagoner P.K. Retigabine, a novel anti-convulsant, enhances activation of KCNQ2/Q3 potassium channels. Mol Pharmacol 58 (2000) 591-600
80. Yang Q., Kaji R., Hirota N., Kojima Y., Takagi T., Kohara N., Kimura J., Shibasaki H., and Bostock H. Effect of maturation on nerve excitability in an experimental model of threshold electrotonus. Muscle Nerve 23 (2000) 498-506
81. Yang Q., Kaji R., Takagi T., Kohara N., Murase N., Yamada Y., Seino Y., and Bostock H. Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathy. Brain 124 (2001) 1149-1155