Decoding functional metabolomics with docosahexaenoyl ethanolamide (DHEA) identifies novel bioactive signals

Journal of Biological Chemistry

Volumn 286, Issue 36, 2011, Pages 31532-31541

  Yang, Rong ^a   Fredman, Gabrielle ^a   Krishnamoorthy, Sriram ^a   Agrawal, Nitin ^b   Irimia, Daniel ^b   Piomelli, Daniele ^c,d   Serhan, Charles N ^a  

^a HARVARD INSTITUTES OF MEDICINE   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-INFLAMMATORIES; DERIVED PRODUCTS; FUNCTIONAL SCREENING; IN-VIVO; INFLAMMATORY CELLS; LIPIDOMICS; METABOLOMICS; MICROFLUIDIC CHAMBERS; NEUROINFLAMMATION; NOVEL MOLECULES; ORGAN INJURIES; OXIDATIVE METABOLISM; REPERFUSION; SINGLE-CELL LEVEL; TISSUE DAMAGE; TRAUMATIC BRAIN INJURIES; WHOLE BLOOD;

BRAIN; MAMMALS; TISSUE;

PLATELETS;

10,17 DIHYDROXYDOCOSAHEXAENOYLETHANOLAMIDE; 15 HYDROXY 16(17) EPOXYDOCOSAHEXAENOYLETHANOLAMIDE; CANNABINOID 2 RECEPTOR; DOCOSAHEXAENOIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONCENTRATION RESPONSE; DRUG MECHANISM; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKOCYTE AGGREGATION; LEUKOCYTE MOTILITY; LIPIDOMICS; LUNG INJURY; MALE; MICROFLUIDICS; MONOCYTE; MOUSE; NONHUMAN; OXYGENATION; POLYMORPHONUCLEAR CELL; PRIORITY JOURNAL; REPERFUSION INJURY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; TANDEM MASS SPECTROMETRY; THROMBOCYTE AGGREGATION;

AMIDES; ANIMALS; ANTI-INFLAMMATORY AGENTS; BLOOD CELLS; CELL MOVEMENT; DOCOSAHEXAENOIC ACIDS; HUMANS; LEUKOCYTES; METABOLOMICS; MICE; MICROFLUIDICS; OXIDANTS; PLATELET ADHESIVENESS; PROTECTIVE AGENTS; RECEPTOR, CANNABINOID, CB2; TANDEM MASS SPECTROMETRY;

EID: 80052407513     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.237990     Document Type: Article

References (42)

1. Arnason, B. G. (ed). (2010) The Brain and Host Defense, Elsevier, San Diego, CA
2. Bailes, J. E., and Mills, J. D. (2010) J. Neurotrauma 27, 1617-1624
3. Marcheselli, V. L., Hong, S., Lukiw, W. J., Tian, X. H., Gronert, K., Musto, A., Hardy, M., Gimenez, J. M., Chiang, N., Serhan, C. N., and Bazan, N. G. (2003) J. Biol. Chem. 278, 43807-43817
4. Yanes, O., Clark, J., Wong, D. M., Patti, G. J., Sánchez-Ruiz, A., Benton, H. P., Trauger, S. A., Desponts, C., Ding, S., and Siuzdak, G. (2010) Nat. Chem. Biol. 6, 411-417
5. Hassan, I. R., and Gronert, K. (2009) J. Immunol. 182, 3223-3232
6. Bazan, N. G., Calandria, J. M., and Serhan, C. N. (2010) J. Lipid Res. 51, 2018-2031
7. Serhan, C. N., Chiang, N., and Van Dyke, T. E. (2008) Nat. Rev. Immunol. 8, 349-361
8. Serhan, C. N., Hong, S., Gronert, K., Colgan, S. P., Devchand, P. R., Mirick, G., and Moussignac, R. L. (2002) J. Exp. Med. 196, 1025-1037
9. Kasuga, K., Yang, R., Porter, T. F., Agrawal, N., Petasis, N. A., Irimia, D., Toner, M., and Serhan, C. N. (2008) J. Immunol. 181, 8677-8687
10. Xu, Z. Z., Zhang, L., Liu, T., Park, J. Y., Berta, T., Yang, R., Serhan, C. N., and Ji, R. R. (2010) Nat. Med. 16, 592-597
11. Spite, M., Norling, L. V., Summers, L., Yang, R., Cooper, D., Petasis, N. A., Flower, R. J., Perretti, M., and Serhan, C. N. (2009) Nature 461, 1287-1291
12. De Petrocellis, L., Melck, D., Bisogno, T., and Di Marzo, V. (2000) Chem. Phys. Lipids 108, 191-209
13. Berger, A., Crozier, G., Bisogno, T., Cavaliere, P., Innis, S., and Di Marzo, V. (2001) Proc. Natl. Acad. Sci. U.S.A. 98, 6402-6406
14. Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A., and Mechoulam, R. (1992) Science 258, 1946-1949
15. Di Marzo, V., Melck, D., Bisogno, T., and De Petrocellis, L. (1998) Trends Neurosci. 21, 521-528
16. Kozak, K. R., and Marnett, L. J. (2002) Prostaglandins Leukot. Essent. Fatty Acids 66, 211-220
17. Pavlopoulos, S., Thakur, G. A., Nikas, S. P., and Makriyannis, A. (2006) Curr. Pharm. Des. 12, 1751-1769
18. Ueda, N., Yamamoto, K., Yamamoto, S., Tokunaga, T., Shirakawa, E., Shinkai, H., Ogawa, M., Sato, T., Kudo, I., Inoue, K., Takizawa, H., Nagano, T., Hirobe, M., Matsuki, N., and Saito, H. (1995) Biochim. Biophys. Acta 1254, 127-134
19. Yang, R., Chiang, N., Oh, S. F., and Serhan, C. N. (2011) Curr. Protoc. Immunol., Suppl. 94, in press
20. Olson, K. R., and Eglen, R. M. (2007) Assay Drug Dev. Technol. 5, 137-144
21. Krishnamoorthy, S., Recchiuti, A., Chiang, N., Yacoubian, S., Lee, C. H., Yang, R., Petasis, N. A., and Serhan, C. N. (2010) Proc. Natl. Acad. Sci. U.S.A. 107, 1660-1665
22. Irimia, D., Liu, S. Y., Tharp, W. G., Samadani, A., Toner, M., and Poznansky, M. C. (2006) Lab Chip 6, 191-198
23. Dona, M., Fredman, G., Schwab, J. M., Chiang, N., Arita, M., Goodarzi, A., Cheng, G., Von Andrian, U. H., and Serhan, C. N. (2008) Blood 112, 848-855
24. Qiu, F. H., Wada, K., Stahl, G. L., and Serhan, C. N. (2000) Proc. Natl. Acad. Sci. U.S.A. 97, 4267-4272
25. Kumar, V., Fausto, N., and Abbas, A. (2004) Robbins and Cotran Pathologic Basis of Disease, 7th Ed., Saunders Elsevier, Philadelphia
26. Tjonahen, E., Oh, S. F., Siegelman, J., Elangovan, S., Percarpio, K. B., Hong, S., Arita, M., and Serhan, C. N. (2006) Chem. Biol. 13, 1193-1202
27. Felder, C. C., Briley, E. M., Axelrod, J., Simpson, J. T., Mackie, K., and Devane, W. A. (1993) Proc. Natl. Acad. Sci. U.S.A. 90, 7656-7660
28. Van Gils, J. M., Zwaginga, J. J., and Hordijk, P. L. (2009) J. Leukoc. Biol. 85, 195-204
29. Pace-Asciak, C. R., Reynaud, D., Demin, P., and Nigam, S. (1999) Adv. Exp. Med. Biol. 447, 123-132
30. Rowley, F. A., Kuhn, H., and Schewe, T. (eds). (1998) Eicosanoids and Related Compounds in Plants and Animals, Portland Press, London
31. Sheskin, T., Hanus, L., Slager, J., Vogel, Z., and Mechoulam, R. (1997) J. Med. Chem. 40, 659-667
32. Zygmunt, P. M., Petersson, J., Andersson, D. A., Chuang, H., Sørgård, M., Di Marzo, V., Julius, D., and Högestätt, E. D. (1999) Nature 400, 452-457
33. Franklin, A., Parmentier-Batteur, S., Walter, L., Greenberg, D. A., and Stella, N. (2003) J. Neurosci. 23, 7767-7775
34. Furman, M. I., Barnard, M. R., Krueger, L. A., Fox, M. L., Shilale, E. A., Lessard, D. M., Marchese, P., Frelinger, A. L., 3rd, Goldberg, R. J., and Michelson, A. D. (2001) J. Am. Coll. Cardiol. 38, 1002-1006
35. Sarma, J., Laan, C. A., Alam, S., Jha, A., Fox, K. A., and Dransfield, I. (2002) Circulation 105, 2166-2171
36. Weyrich, A. S., and Zimmerman, G. A. (2004) Trends Immunol. 25, 489-495
37. Rinder, H. M., Bonan, J. L., Rinder, C. S., Ault, K. A., and Smith, B. R. (1991) Blood 78, 1730-1737
38. Kilgore, K. S., Todd, R. F., and Lucchesi, B. R. (1999) Reperfusion Injury, Lippincott, Williams and Wilkins, Philadelphia
39. Preissner, W. C., Schröder, J. M., and Christophers, E. (1983) Br. J. Dermatol. 109, 1-8
40. Nishiura, H., Shibuya, Y., Matsubara, S., Tanase, S., Kambara, T., and Yamamoto, T. (1996) J. Biol. Chem. 271, 878-882
41. Kim, H. Y., Moon, H. S., Cao, D., Lee, J., Kevala, K., Jun, S. B., Lovinger, D. M., Akbar, M., and Huang, B. X. (2011) Biochem. J. 435, 327-336
42. Calder, P. C. (2010) Proc. Nutr. Soc. 69, 565-573