Neural stem cell-based cell carriers enhance therapeutic efficacy of an oncolytic adenovirus in an orthotopic mouse model of human glioblastoma

Molecular Therapy

Volumn 19, Issue 9, 2011, Pages 1714-1726

  Ahmed, Atique U ^a   Thaci, Bart ^a   Alexiades, Nikita G ^a   Han, Yu ^a   Qian, Shuo ^a   Liu, Feifei ^a   Balyasnikova, Irina V ^a   Ulasov, Ilya Y ^a   Aboody, Karen S ^b   Lesniak, MacIej S ^a  

^a UNIVERSITY OF CHICAGO   (United States)

^b CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; DRUG CARRIER; ONCOLYTIC ADENOVIRUS; RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL MIGRATION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG EFFICACY; GLIOBLASTOMA; HOST; HUMAN; HUMAN CELL; IMMUNE SYSTEM; IN VIVO STUDY; MALE; MOUSE; NEURAL STEM CELL; NONHUMAN; ONCOLYTIC VIROTHERAPY; RECEPTOR UPREGULATION; SURVIVAL TIME; TUMOR VOLUME; TUMOR XENOGRAFT; VIRUS INFECTION;

ADENOVIRIDAE; ANIMALIA;

EID: 80052406372     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2011.100     Document Type: Article

References (32)

1. Deorah, S, Lynch, CF, Sibenaller, ZA and Ryken, TC (2006). Trends in brain cancer incidence and survival in the United States: Surveillance, Epidemiology, and End Results Program, 1973 to 2001. Neurosurg Focus 20: E1
2. Dey, M, Ulasov, IV and Lesniak, MS (2010). Virotherapy against malignant glioma stem cells. Cancer Lett 289: 1-10
3. Fisher, K (2006). Striking out at disseminated metastases: the systemic delivery of oncolytic viruses. Curr Opin Mol Ther 8: 301-313 (Pubitemid 44256364)
4. Aboody, KS, Brown, A, Rainov, NG, Bower, KA, Liu, S, Yang, W et al. (2000). Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas. Proc Natl Acad Sci USA 97: 12846-12851
5. Benedetti, S, Pirola, B, Pollo, B, Magrassi, L, Bruzzone, MG, Rigamonti, D et al. (2000). Gene therapy of experimental brain tumors using neural progenitor cells. Nat Med 6: 447-450 (Pubitemid 30208163)
6. Danks, MK, Yoon, KJ, Bush, RA, Remack, JS, Wierdl, M, Tsurkan, L et al. (2007). Tumortargeted enzyme/prodrug therapy mediates long-term disease-free survival of mice bearing disseminated neuroblastoma. Cancer Res 67: 22-25 (Pubitemid 46142755)
7. Sims, TL Jr, Hamner, JB, Bush, RA, Fischer, PE, Kim, SU, Aboody, KS et al. (2009). Neural progenitor cell-mediated delivery of osteoprotegerin limits disease progression in a preclinical model of neuroblastoma bone metastasis. J Pediatr Surg 44: 204-210; discussion 210
8. Coukos, G, Makrigiannakis, A, Kang, EH, Caparelli, D, Benjamin, I, Kaiser, LR et al. (1999). Use of carrier cells to deliver a replication- selective herpes simplex virus-1 mutant for the intraperitoneal therapy of epithelial ovarian cancer. Clin Cancer Res 5: 1523-1537 (Pubitemid 29282962)
9. Tyler, MA, Ulasov, IV, Sonabend, AM, Nandi, S, Han, Y, Marler, S et al. (2009). Neural stem cells target intracranial glioma to deliver an oncolytic adenovirus in vivo. Gene Ther 16: 262-278
10. Willmon, C, Harrington, K, Kottke, T, Prestwich, R, Melcher, A and Vile, R (2009). Cell carriers for oncolytic viruses: Fed Ex for cancer therapy. Mol Ther 17: 1667-1676
11. Aboody, KS, Najbauer, J and Danks, MK (2008). Stem and progenitor cell-mediated tumor selective gene therapy. Gene Ther 15: 739-752 (Pubitemid 351627357)
12. Einstein, O and Ben-Hur, T (2008). The changing face of neural stem cell therapy in neurologic diseases. Arch Neurol 65: 452-456 (Pubitemid 351549952)
13. Pluchino, S, Quattrini, A, Brambilla, E, Gritti, A, Salani, G, Dina, G et al. (2003). Injection of adult neurospheres induces recovery in a chronic model of multiple sclerosis. Nature 422: 688-694 (Pubitemid 36514101)
14. Pluchino, S, Zanotti, L, Rossi, B, Brambilla, E, Ottoboni, L, Salani, G et al. (2005). Neurosphere-derived multipotent precursors promote neuroprotection by an immunomodulatory mechanism. Nature 436: 266-271 (Pubitemid 41021278)
15. Thomas, CE, Abordo-Adesida, E, Maleniak, TC, Stone, D, Gerdes, CA and Lowenstein, PR (2001). Gene transfer into rat brain using adenoviral vectors. Curr Protoc Neurosci Chapter 4: Unit 4.24
16. Muruve, DA (2004). The innate immune response to adenovirus vectors. Hum Gene Ther 15: 1157-1166 (Pubitemid 40052429)
17. Ulasov, IV, Zhu, ZB, Tyler, MA, Han, Y, Rivera, AA, Khramtsov, A et al. (2007). Survivindriven and fiber-modified oncolytic adenovirus exhibits potent antitumor activity in established intracranial glioma. Hum Gene Ther 18: 589-602 (Pubitemid 47187091)
18. Aghi, MK and Chiocca, EA (2009). Phase ib trial of oncolytic herpes virus G207 shows safety of multiple injections and documents viral replication. Mol Ther 17: 8-9
19. Haseley, A, Alvarez-Breckenridge, C, Chaudhury, AR and Kaur, B (2009). Advances in oncolytic virus therapy for glioma. Recent Pat CNS Drug Discov 4: 1-13
20. Ferguson, SD, Ahmed, AU, Thaci, B, Mercer, RW and Lesniak, MS (2010). Crossing the boundaries: stem cells and gene therapy. Discov Med 9: 192-196
21. Sun, L, Lee, J and Fine, HA (2004). Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. J Clin Invest 113: 1364-1374 (Pubitemid 39069935)
22. Carbajal, KS, Schaumburg, C, Strieter, R, Kane, J and Lane, TE (2010). Migration of engrafted neural stem cells is mediated by CXCL12 signaling through CXCR4 in a viral model of multiple sclerosis. Proc Natl Acad Sci USA 107: 11068-11073
23. Heese, O, Disko, A, Zirkel, D, Westphal, M and Lamszus, K (2005). Neural stem cell migration toward gliomas in vitro. Neuro-oncology 7: 476-484 (Pubitemid 41555619)
24. Schmidt, NO, Koeder, D, Messing, M, Mueller, FJ, Aboody, KS, Kim, SU et al. (2009). Vascular endothelial growth factor-stimulated cerebral microvascular endothelial cells mediate the recruitment of neural stem cells to the neurovascular niche. Brain Res 1268: 24-37
25. Magge, SN, Malik, SZ, Royo, NC, Chen, HI, Yu, L, Snyder, EY et al. (2009). Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J Neurosci Res 87: 1547-1555
26. Ramalingam, R, Worgall, S, Rafii, S and Crystal, RG (2000). Downregulation of CXCR4 gene expression in primary human endothelial cells following infection with E1-E4+ adenovirus gene transfer vectors. Mol Ther 2: 381-386
27. Ulasov, IV, Tyler, MA, Han, Y, Glasgow, JN and Lesniak, MS (2007). Novel recombinant adenoviral vector that targets the interleukin-13 receptor 2 chain permits effective gene transfer to malignant glioma. Hum Gene Ther 18: 118-129 (Pubitemid 46446049)
28. de la Monte SM, Ho DD, Schooley RT, Hirsch MS and Richardson EP Jr. (1987). Subacute encephalomyelitis of AIDS and its relation to HTLV-III infection. Neurology 37: 562-569 (Pubitemid 17057929)
29. Brodie, C, Weizman, N, Katzoff, A, Lustig, S and Kobiler, D (1997). Astrocyte activation by Sindbis virus: expression of GFAP, cytokines, and adhesion molecules. Glia 19: 275-285 (Pubitemid 27165235)
30. Montgomery, DL (1994). Astrocytes: form, functions, and roles in disease. Vet Pathol 31: 145-167
31. Woiciechowsky, C, Schöning, B, Stoltenburg-Didinger, G, Stockhammer, F and Volk, HD (2004). Brain-IL-1 beta triggers astrogliosis through induction of IL-6: inhibition by propranolol and IL-10. Med Sci Monit 10: BR325-BR330 (Pubitemid 39278553)
32. Ulasov, IV, Tyler, MA, Rivera, AA, Nettlebeck, DM, Douglas, JT and Lesniak, MS (2008). Evaluation of E1A double mutant oncolytic adenovectors in anti-glioma gene therapy. J Med Virol 80: 1595-1603