ERK pathway mediates P2X7 expression and cell death in renal interstitial fibroblasts exposed to necrotic renal epithelial cells

American Journal of Physiology - Renal Physiology

Volumn 301, Issue 3, 2011, Pages

  Ponnusamy, Murugavel ^a   Liu, Na ^a,b   Gong, Rujun ^a   Yan, Haidong ^b   Zhuang, Shougang ^a,b,c  

^a BROWN UNIVERSITY   (United States)

^b TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^c RHODE ISLAND HOSPITAL   (United States)

Author keywords

Elk1; ERK1 2; Renal fibroblast

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PURINERGIC P2X7 RECEPTOR; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR ELK 1;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; EPITHELIUM CELL; FIBROBLAST; KIDNEY EPITHELIUM; KIDNEY INTERSTITIUM; KIDNEY TUBULE NECROSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; SUPERNATANT;

EID: 80052404286     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00215.2011     Document Type: Article

References (24)

1. Cagnol S, Chambard JC. ERK and cell death: mechanisms of ERKinduced cell death-apoptosis, autophagy and senescence. FEBS J 277: 2-21, 2010.
2. Chang CH, Huang Y, Anderson R. Activation of vascular endothelial cells by IL-1alpha released by epithelial cells infected with respiratory syncytial virus. Cell Immunol 221: 37-41, 2003.
3. De Borst MH, Wassef L, Kelly DJ, Van Goor H, Navis GJ. Mitogenactivated protein kinase signaling in the kidney: target for intervention? Signal Transduction 6: 32-53, 2006.
4. Donnahoo KK, Meng X, Ao L, Ayala A, Shames BD, Cain MP, Harken AH, Meldrum DR. Differential cellular immunolocalization of renal tumour necrosis factor-alpha production during ischaemia versus endotoxaemia. Immunology 102: 53-58, 2001.
5. Ernest S, Bello-Reuss E. Expression and function of P-glycoprotein in a mouse kidney cell line. Am J Physiol Cell Physiol 269: C323-C333, 1995.
6. Harada H, Chan CM, Loesch A, Unwin R, Burnstock G. Induction of proliferation and apoptotic cell death via P2Y and P2X receptors, respectively, in rat glomerular mesangial cells. Kidney Int 57: 949-958, 2000.
7. Mehta A, Sekhon CP, Giri S, Orak JK, Singh AK. Attenuation of ischemia/reperfusion induced MAP kinases by N-acetyl cysteine, sodium nitroprusside and phosphoramidon. Mol Cell Biochem 240: 19-29, 2002.
8. Meldrum KK, Meldrum DR, Hile KL, Yerkes EB, Ayala A, Cain MP, Rink RC, Casale AJ, Kaefer MA. P38 MAPK mediates renal tubular cell TNF-alpha; production and TNF-alpha;-dependent apoptosis during simulated ischemia. Am J Physiol Cell Physiol 281: C563-C570, 2001.
9. Pavlovic D, Andersen NA, Mandrup-Poulsen T, Eizirik DL. Activation of extracellular signal-regulated kinase (ERK)1/2 contributes to cytokineinduced apoptosis in purified rat pancreatic beta-cells. Eur Cytokine Netw 11: 267-274, 2000.
10. Ponnusamy M, Ma L, Gong R, Pang M, Chin YE, Zhuang S. P2X7 receptors mediate deleterious renal epithelial-fibroblast cross talk. Am J Physiol Renal Physiol 300: F62-F70, 2011.
11. Sharma A, Callahan LM, Sul JY, Kim TK, Barrett L, Kim M, Powers JM, Federoff H, Eberwine J. A neurotoxic phosphoform of Elk-1 associates with inclusions from multiple neurodegenerative diseases. PLos One 5: e9002, 2010.
12. Stefanelli C, Tantini B, Fattori M, Stanic I, Pignatti C, Clo C, Guarnieri C, Caldarera CM, Mackintosh CA, Pegg AE, Flamigni F. Caspase activation in etoposide-treated fibroblasts is correlated to ERK phosphorylation and both events are blocked by polyamine depletion. FEBS Lett 527: 223-228, 2002.
13. Subramaniam S, Unsicker K. ERK and cell death: ERK1/2 in neuronal death. FEBS J 277: 22-29, 2010.
14. Taylor SR, Turner CM, Elliott JI, McDaid J, Hewitt R, Smith J, Pickering MC, Whitehouse DL, Cook HT, Burnstock G, Pusey CD, Unwin RJ, Tam FW. P2X7 deficiency attenuates renal injury in experimental glomerulonephritis. J Am Soc Nephrol 20: 1275-1281, 2009.
15. Turner CM, Elliott JI, Tam FW. P2 receptors in renal pathophysiology. Purinergic Signal 5: 513-520, 2009.
16. Turner CM, Tam FW, Lai PC, Tarzi RM, Burnstock G, Pusey CD, Cook HT, Unwin RJ. Increased expression of the pro-apoptotic ATPsensitive P2X7 receptor in experimental and human glomerulonephritis. Nephrol Dial Transplant 22: 386-395, 2007.
17. Turner CM, Vonend O, Chan C, Burnstock G, Unwin RJ. The pattern of distribution of selected ATP-sensitive P2 receptor subtypes in normal rat kidney: an immunohistological study. Cells Tissues Organs 175: 105-117, 2003.
18. Vonend O, Turner CM, Chan CM, Loesch A, Dell'Anna GC, Srai KS, Burnstock G, Unwin RJ. Glomerular expression of the ATP-sensitive P2X receptor in diabetic and hypertensive rat models. Kidney Int 66: 157-166, 2004.
19. Wang X, Martindale JL, Holbrook NJ. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 275: 39435-39443, 2000.
20. Wang X, Wang H, Xu L, Rozanski DJ, Sugawara T, Chan PH, Trzaskos JM, Feuerstein GZ. Significant neuroprotection against ischemic brain injury by inhibition of the MEK1 protein kinase in mice: exploration of potential mechanism associated with apoptosis. J Pharmacol Exp Ther 304: 172-178, 2003.
21. Wasylyk B, Hagman J, Gutierrez-Hartmann A. Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway. Trends Biochem Sci 23: 213-216, 1998.
22. Zhou L, Luo L, Qi X, Li X, Gorodeski GI. Regulation of P2X7 gene transcription. Purinergic Signal 5: 409-426, 2009.
23. Zhuang S, Kinsey GR, Yan Y, Han J, Schnellmann RG. Extracellular signal-regulated kinase activation mediates mitochondrial dysfunction and necrosis induced by hydrogen peroxide in renal proximal tubular cells. J Pharmacol Exp Ther 325: 732-740, 2008.
24. Zhuang S, Yan Y, Daubert RA, Han J, Schnellmann RG. ERK promotes hydrogen peroxide-induced apoptosis through caspase-3 activation and inhibition of Akt in renal epithelial cells. Am J Physiol Renal Physiol 292: F440-F447, 2007.