Staurosporine induces megakaryocytic differentiation through the upregulation of JAK/Stat3 signaling pathway

Annals of Hematology

Volumn 90, Issue 9, 2011, Pages 1017-1029

  Peng, Hsuan Yu ^a   Liao, Hui Fen ^a,b  

^a NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Janus kinase (JAK); Megakaryocyte differentiation; Protein kinase C (PKC); Signal transducers and activators of transcription 3 (Stat3); Staurosporine

Indexed keywords

CD61 ANTIGEN; CELL MARKER; FIBRINOGEN RECEPTOR; JANUS KINASE; JANUS KINASE INHIBITOR; PROTEIN INHIBITOR; PROTEIN KINASE C; SMALL INTERFERING RNA; STAT3 PROTEIN; STAUROSPORINE; THROMBOCYTE FACTOR 4;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL LINEAGE; CELL NUCLEUS MEMBRANE; CELL STRAIN K 562; CELL VIABILITY; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; ERYTHROLEUKEMIA CELL; EX VIVO STUDY; GENETIC TRANSFECTION; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; MALE; MEGAKARYOCYTE; MOUSE; NONHUMAN; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; CELLS, CULTURED; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; JANUS KINASES; K562 CELLS; MEGAKARYOCYTES; MICE; PHOSPHORYLATION; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; STAUROSPORINE; UP-REGULATION;

EID: 80052390408     PISSN: 09395555     EISSN: 14320584     Source Type: Journal    
DOI: 10.1007/s00277-011-1186-3     Document Type: Article

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