Stathmin expression and megakaryocyte differentiation: A potential role in polyploidy

Experimental Hematology

Volumn 31, Issue 5, 2003, Pages 389-397

  Rubin, Camelia Iancu ^a   French, Deborah L ^a   Atweh, George F ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

STATHMIN;

ARTICLE; CELL DIFFERENTIATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CORRELATION ANALYSIS; DNA CONTENT; DNA DETERMINATION; EMBRYO; FLOW CYTOMETRY; HUMAN; HUMAN CELL; LEUKEMIA CELL; MEGAKARYOCYTE; MEGAKARYOPOIESIS; MICROSCOPY; MITOSIS INHIBITION; NORTHERN BLOTTING; PHENOTYPE; POLYPLOIDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

MURINAE;

EID: 0038577270     PISSN: 0301472X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0301-472X(03)00043-2     Document Type: Article

References (39)

1. Long M., Hoffman R. Trombocytopoiesis. Hoffman R., Benz E.J., Shanttil S.J., et al. Hematology. Basic Principles and Practice. 3rd ed:2000;245-260 Churchill Livingstone, Philadelphia.
2. Ravid K., Lu J., Zimmet J.M., Jones M.R. Roads to polyploidy: the megakaryocyte example. J Cell Physiol. 190:2002;7-20.
3. Odell T.T., Murphy J.R., Jackson C.W. Stimulation of megakaryocytopoiesis by acute thrombocytopenia in rats. Blood. 48:1976;765-775.
4. + cells are correlated with different levels of platelet release. Blood. 99:2002;888-897.
5. Jacobsson S., Carneskog J., Ridell B., Wadenvik H., Swolin B., Kutti J. Flow cytometric analysis of megakaryocyte ploidy in chronic myeloproliferative disorders and reactive thrombocytosis. Eur J Haematol. 56:1996;287-292.
6. Rabellino E.M., Levene R.B., Nachman R.L., Leung L.L. Human megakaryocytes III. Characterization in myeloproliferative disorders . Blood. 63:1984;615-622.
7. Kobayashi Y., Ozawa M., Maruo N., Kondo M. Megakaryocytic ploidy in myelodysplastic syndromes. Leuk Lymphoma. 9:1993;55-61.
8. Hofmann W.K., Kalina U., Koschmieder S., Seipelt G., Hoelzer D., Ottmann O.G. Defective megakaryocytic development in myelodysplastic syndromes. Leuk Lymphoma. 38:2000;13-19.
9. Nagata Y., Muro Y., Todokoro K. Thrombopoietin-induced polyploidization of bone marrow megakaryocytes is due to a unique regulatory mechanism in late mitosis. J Cell Biol. 139:1997;449-457.
10. Vitrat N., Cohen-Solal K., Pique C., et al. Endomitosis of human megakaryocytes are due to abortive mitosis. Blood. 91:1998;3711-3723.
11. Hyman A.A., Karsenti E. Morphogenetic properties of microtubules and mitotic spindle assembly. Cell. 84:1996;401-410.
12. Desai A., Mitchison T.J. Microtubule polymerization dynamics. Annu Rev Cell Dev Biol. 13:1997;83-117.
13. Belmont L.D., Mitchison T.J. Identification of a protein that interacts with tubulin dimers and increases the catastrophe rate of microtubules. Cell. 84:1996;623-631.
14. Marklund U., Larsson N., Gradin H.M., Brattsand G., Gullberg M. Oncoprotein 18 is a phosphorylation-responsive regulator of microtubule dynamics. EMBO J. 15:1996;5290-5298.
15. Larsson N., Marklund U., Gradin H.M., Brattsand G., Gullberg M. Control of microtubule dynamics by oncoprotein 18: dissection of the regulatory role of multisite phosphorylation during mitosis. Mol Cell Biol. 17:1997;5530-5539.
16. Horwitz S.B., Shen H.J., He L., et al. The microtubule-destabilizing activity of metablastin (p19) is controlled by phosphorylation. J Biol Chem. 272:1997;8129-8132.
17. Howell B., Deacon H., Cassimeris L. Decreasing oncoprotein 18/stathmin levels reduces microtubule catastrophes and increases microtubule polymer in vivo. J Cell Sci. 112:1999;3713-3722.
18. Gavet O., Ozon S., Manceau V., Lawler S., Curmi P., Sobel A. The stathmin phosphoprotein family: intracellular localization and effects on the microtubule network. J Cell Sci. 111:1998;3333-3346.
19. Mistry S.J., Li H.C., Atweh G.F. Role for protein phosphatases in the cell-cycle-regulated phosphorylation of stathmin. Biochem J. 334:1998;23-29.
20. Iancu C., Mistry S.J., Arkin S., Wallenstein S., Atweh G.F. Effects of stathmin inhibition on the mitotic spindle. J Cell Sci. 114:2001;909-916.
21. Brattsand G., Roos G., Marklund U., et al. Quantitative analysis of the expression and regulation of an activation-regulated phosphoprotein (oncoprotein 18) in normal and neoplastic cells. Leukemia. 7:1993;569-579.
22. Rowlands D.C., Williams A., Jones N.A., et al. Stathmin expression is a feature of proliferating cells of most, if not all, cell lineages. Lab Invest. 72:1995;100-113.
23. Luo X.N., Mookerjee B., Ferrari A., Mistry S., Atweh G.F. Regulation of phosphoprotein p18 in leukemic cells. Cell cycle regulated phosphorylation by p34cdc2 kinase. J Biol Chem. 269:1994;10312-10318.
24. Drachman J.G., Sabath D.F., Fox N.E., Kaushansky K. Thrombopoietin signal transduction in purified murine megakaryocytes. Blood. 89:1997;483-492.
25. Jackson C.W. Cholinesterase as a possible marker for early cells of the megakaryocytic series. Blood. 42:1973;413-421.
26. Zhu X.X., Kozarsky K., Strahler J.R., et al. Molecular cloning of a novel human leukemia-associated gene. Evidence of conservation in animal species. J Biol Chem. 264:1989;14556-14560.
27. Okazaki T., Yoshida B.N., Avraham K.B., et al. Molecular diversity of the SCG10/stathmin gene family in the mouse. Genomics. 18:1993;360-373.
28. Alitalo R. Induced differentiation of K562 leukemia cells: a model for studies of gene expression in early megakaryoblasts. Leuk Res. 14:1990;501-514.
29. Long M.W., Heffner C.H., Williams J.L., Peters C., Prochownik E.V. Regulation of megakaryocyte phenotype in human erythroleukemia cells. J Clin Invest. 85:1990;1072-1084.
30. Yen A., Varvayanis S., Platko J.D. 12-O-tetradecanoylphorbol-13-acetate and staurosporine induce increased retinoblastoma tumor suppressor gene expression with megakaryocytic differentiation of leukemic cells. Cancer Res. 53:1993;3085-3091.
31. ++ dependent protein kinase. Biochem Biophys Res Commun. 135:1986;397-402.
32. Tabilio A., Rosa J.P., Testa U., et al. Expression of platelet membrane glycoproteins and α-granule proteins by a human erythroleukemia cell line (HEL). EMBO J. 3:1984;453-459.
33. Wittmann T., Hyman A., Desai A. The spindle: a dynamic assembly of microtubules and motors. Nat Cell Biol. 3:2001;E28-E34.
34. Glotzer M. Animal cell cytokinesis. Annu Rev Cell Dev Biol. 17:2001;351-386.
35. Cassimeris L. Accessory protein regulation of microtubule dynamics throughout the cell cycle. Curr Opin Cell Biol. 11:1999;134-141.
36. Marklund U., Osterman O., Melander H., Bergh A., Gullberg M. The phenotype of a "Cdc2 kinase target site-deficient" mutant of oncoprotein 18 reveals a role of this protein in cell cycle control. J Biol Chem. 269:1994;30626-30635.
37. Chang C., Hora N., Huberman N., Hinderer R., KuKuruga M., Hanash S. Oncoprotein 18 levels and phosphorylation mediate megakaryocyte polyploidization in human erythroleukemia cells. Proteomics. 1:2001;1415-1423.
38. Di Paolo G., Pellier V., Catsicas M., Antonsson B., Catsicas S., Grenningloh G. The phosphoprotein stathmin is essential for nerve growth factor-stimulated differentiation. J Cell Biol. 133:1996;1383-1390.
39. Kikuchi J., Furukawa Y., Iwase S., et al. Polyploidization and functional maturation are two distinct processes during megakaryocytic differentiation: involvement of cyclin-dependent kinase inhibitor p21 in polyploidization. Blood. 89:1997;3980-3990.