Profiles of SUMO and ubiquitin conjugation in an Alzheimer's disease model

Neuroscience Letters

Volumn 502, Issue 3, 2011, Pages 201-208

  McMillan, Laura E ^a   Brown, Jon T ^a   Henley, Jeremy M ^a   Cimarosti, Helena ^a,b  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

Alzheimer's disease; GluA1; GluK2 3; Glutamate receptors; Posttranslational modification; SENP 1; SUMO; Tg2576 mice; UBC9; Ubiquitin

Indexed keywords

AMPA RECEPTOR; AMYLOID PRECURSOR PROTEIN; KAINIC ACID RECEPTOR; PEPTIDASE; PROTEIN UBC9; SENP 1 ENZYME; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CONJUGATION; CONTROLLED STUDY; GENE MUTATION; GENE OVEREXPRESSION; HIPPOCAMPUS; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SUMOYLATION; UBIQUITINATION;

ALZHEIMER DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; MALE; MICE; MICE, TRANSGENIC; SMALL UBIQUITIN-RELATED MODIFIER PROTEINS; SUMO-1 PROTEIN; SUMOYLATION; UBIQUITIN-CONJUGATING ENZYMES; UBIQUITINATION; UBIQUITINS;

EID: 80052378498     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2011.07.045     Document Type: Article

References (32)

1. Ahn K., Hee Song J., Kim D.K., Park M.H., Jo S.A., Koh Y.H. Ubc9 gene polymorphisms and late-onset Alzheimer's disease in the Korean population: a genetic association study. Neurosci. Lett. 2009, 465:272-275.
2. Almeida C.G., Takahashi R.H., Gouras G.K. Beta-amyloid accumulation impairs multivesicular body sorting by inhibiting the ubiquitin-proteasome system. J. Neurosci. 2006, 26:4277-4288.
3. Almeida C.G., Tampellini D., Takahashi R.H., Greengard P., Lin M.T., Snyder E.M., Gouras G.K. Beta-amyloid accumulation in APP mutant neurons reduces PSD-95 and GluR1 in synapses. Neurobiol. Dis. 2005, 20:187-198.
4. Anderson D.B., Wilkinson K.A., Henley J.M. Protein SUMOylation in neuropathological conditions. Drug News Perspect. 2009, 22:255-265.
5. Barghorn S., Nimmrich V., Striebinger A., Krantz C., Keller P., Janson B., Bahr M., Schmidt M., Bitner R.S., Harlan J., Barlow E., Ebert U., Hillen H. Globular amyloid beta-peptide oligomer - a homogenous and stable neuropathological protein in Alzheimer's disease. J. Neurochem. 2005, 95:834-847.
6. Chang E.H., Savage M.J., Flood D.G., Thomas J.M., Levy R.B., Mahadomrongkul V., Shirao T., Aoki C., Huerta P.T. AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:3410-3415.
7. Choi J., Levey A.I., Weintraub S.T., Rees H.D., Gearing M., Chin L.S., Li L. Oxidative modifications and down-regulation of ubiquitin carboxyl-terminal hydrolase L1 associated with idiopathic Parkinson's and Alzheimer's diseases. J. Biol. Chem. 2004, 279:13256-13264.
8. Cimarosti H., Lindberg C., Bomholt S.F., Ronn L.C., Henley J.M. Increased protein SUMOylation following focal cerebral ischemia. Neuropharmacology 2008, 54:280-289.
9. Dorval V., Fraser P.E. Small ubiquitin-like modifier (SUMO) modification of natively unfolded proteins tau and alpha-synuclein. J. Biol. Chem. 2006, 281:9919-9924.
10. Dorval V., Mazzella M.J., Mathews P.M., Hay R.T., Fraser P.E. Modulation of Abeta generation by small ubiquitin-like modifiers does not require conjugation to target proteins. Biochem. J. 2007, 404:309-316.
11. Gocke C.B., Yu H., Kang J. Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates. J. Biol. Chem. 2005, 280:5004-5012.
12. Hardy J. A hundred years of Alzheimer's disease research. Neuron 2006, 52:3-13.
13. Hermann D., Both M., Ebert U., Gross G., Schoemaker H., Draguhn A., Wicke K., Nimmrich V. Synaptic transmission is impaired prior to plaque formation in amyloid precursor protein-overexpressing mice without altering behaviorally-correlated sharp wave-ripple complexes. Neuroscience 2009, 162:1081-1090.
14. Howlett D.R., Richardson J.C. The pathology of APP transgenic mice: a model of Alzheimer's disease or simply overexpression of APP?. Histol. Histopathol. 2009, 24:83-100.
15. Hsieh H., Boehm J., Sato C., Iwatsubo T., Tomita T., Sisodia S., Malinow R. AMPAR removal underlies Abeta-induced synaptic depression and dendritic spine loss. Neuron 2006, 52:831-843.
16. Jacobsen J.S., Wu C.C., Redwine J.M., Comery T.A., Arias R., Bowlby M., Martone R., Morrison J.H., Pangalos M.N., Reinhart P.H., Bloom F.E. Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:5161-5166.
17. Keck S., Nitsch R., Grune T., Ullrich O. Proteasome inhibition by paired helical filament-tau in brains of patients with Alzheimer's disease. J. Neurochem. 2003, 85:115-122.
18. Lam Y.A., Pickart C.M., Alban A., Landon M., Jamieson C., Ramage R., Mayer R.J., Layfield R. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:9902-9906.
19. Li Y., Wang H., Wang S., Quon D., Liu Y.W., Cordell B. Positive and negative regulation of APP amyloidogenesis by sumoylation. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:259-264.
20. Martin S., Nishimune A., Mellor J.R., Henley J.M. SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 2007, 447:321-325.
21. Martin S., Wilkinson K.A., Nishimune A., Henley J.M. Emerging extranuclear roles of protein SUMOylation in neuronal function and dysfunction. Nat. Rev. Neurosci. 2007, 8:948-959.
22. Oh S., Hong H.S., Hwang E., Sim H.J., Lee W., Shin S.J., Mook-Jung I. Amyloid peptide attenuates the proteasome activity in neuronal cells. Mech. Ageing Dev. 2005, 126:1292-1299.
23. Parihar M.S., Brewer G.J. Amyloid-beta as a modulator of synaptic plasticity. J. Alzheimers Dis. 2010, (e-pub ahead of print, 30 August).
24. Pickart C.M. Ubiquitin enters the new millennium. Mol. Cell 2001, 8:499-504.
25. Szegedi V., Juhasz G., Budai D., Penke B. Divergent effects of Abeta1-42 on ionotropic glutamate receptor-mediated responses in CA1 neurons in vivo. Brain Res. 2005, 1062:120-126.
26. Terry R.D., Masliah E., Salmon D.P., Butters N., DeTeresa R., Hill R., Hansen L.A., Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann. Neurol. 1991, 30:572-580.
27. Tiraboschi P., Hansen L.A., Thal L.J., Corey-Bloom J. The importance of neuritic plaques and tangles to the development and evolution of AD. Neurology 2004, 62:1984-1989.
28. Wilkinson K.A., Henley J.M. Mechanisms, regulation and consequences of protein SUMOylation. Biochem. J. 2010, 428:133-145.
29. Wilkinson K.A., Nakamura Y., Henley J.M. Targets and consequences of protein SUMOylation in neurons. Brain Res. Rev. 2010, 64:195-212.
30. Yang W., Sheng H., Warner D.S., Paschen W. Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J. Cereb. Blood Flow Metab. 2008, 28:892-896.
31. Yi J.J., Ehlers M.D. Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol. Rev. 2007, 59:14-39.
32. Zhang Y.Q., Sarge K.D. Sumoylation of amyloid precursor protein negatively regulates Abeta aggregate levels. Biochem. Biophys. Res. Commun. 2008, 374:673-678.