Yeast-based protein delivery to mammalian phagocytic cells is increased by coexpression of bacterial listeriolysin

Microbes and Infection

Volumn 13, Issue 11, 2011, Pages 908-913

  Walch, Barbara ^a   Breinig, Tanja ^a,b   Geginat, Gernot ^c   Schmitt, Manfred J ^a   Breinig, Frank ^a  

^a SAARLAND UNIVERSITY   (Germany)

^b SAARLAND UNIVERSITY   (Germany)

^c UNIVERSITY OF MANNHEIM   (Germany)

Author keywords

Listeriolysin O; Saccharomyces cerevisiae; T cell

Indexed keywords

ANTIGEN; LISTERIOLYSIN O;

ANIMAL CELL; ANTIGEN PRESENTATION; ARTICLE; CONTROLLED STUDY; IMMUNOSTIMULATION; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PHAGOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION; YEAST;

ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; ANTIGENS; BACTERIAL TOXINS; HEAT-SHOCK PROTEINS; HEMOLYSIN PROTEINS; HUMANS; MEMBRANE PROTEINS; PHAGOCYTES; YEASTS;

BACTERIA (MICROORGANISMS); LISTERIA MONOCYTOGENES; MAMMALIA; SACCHAROMYCES CEREVISIAE;

EID: 80052369564     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2011.05.006     Document Type: Article

References (27)

1. Schoen C., Kolb-Maurer A., Geginat G., Loffler D., Bergmann B., Stritzker J., Szalay A.A., Pilgrim S., Goebel W. Bacterial delivery of functional messenger RNA to mammalian cells. Cell. Microbiol. 2005, 7:709-724.
2. Loeffler D.I., Schoen C.U., Goebel W., Pilgrim S. Comparison of different live vaccine strategies in vivo for delivery of protein antigen or antigen-encoding DNA and mRNA by virulence-attenuated Listeria monocytogenes. Infect. Immun. 2006, 74:3946-3957.
3. Darji A., zur Lage S., Garbe A.I., Chakraborty T., Weiss S. Oral delivery of DNA vaccines using attenuated Salmonella typhimurium as carrier. FEMS Immunol. Med. Microbiol. 2000, 27:341-349.
4. Weiss S., Krusch S. Bacteria-mediated transfer of eukaryotic expression plasmids into mammalian host cells. Biol. Chem. 2001, 382:533-541.
5. Lewis G.K. Live-attenuated Salmonella as a prototype vaccine vector for passenger immunogens in humans: are we there yet?. Exp. Rev. Vaccines 2007, 6:431-440.
6. Schoen C., Loeffler D.I., Frentzen A., Pilgrim S., Goebel W., Stritzker J. Listeria monocytogenes as novel carrier system for the development of live vaccines. Int. J. Med. Microbiol. 2008, 298:45-58.
7. Kayal S., Charbit A. Listeriolysin O: a key protein of Listeria monocytogenes with multiple functions. FEMS Microbiol. Rev. 2006, 30:514-529.
8. Hybiske K., Stephens R.S. Exit strategies of intracellular pathogens. Nat. Rev. Microbiol. 2008, 6:99-110.
9. Hess J., Miko D., Catic A., Lehmensiek V., Russell D.G., Kaufmann S.H. Mycobacterium bovis Bacille-Calmette-Guerin strains secreting listeriolysin of Listeria monocytogenes. Proc. Natl. Acad. Sci. USA 1998, 95:5299-5304.
10. Stubbs A.C., Martin K.S., Coeshott C., Skaates S.V., Kuritzkes D.R., Bellgrau D., Franzusoff A., Duke R.C., Wilson C.C. Whole recombinant yeast vaccine activates dendritic cells and elicits protective cell-mediated immunity. Nat. Med. 2001, 7:625-629.
11. Haller A.A., Lauer G.M., King T.H., Kemmler C., Fiolkoski V., Lu Y., Bellgrau D., Rodell T.C., Apelian D., Franzusoff A., Duke R.C. Whole recombinant yeast-based immunotherapy induces potent T cell responses targeting HCV NS3 and core proteins. Vaccine 2007, 25:1452-1463.
12. Bernstein M.B., Chakraborty M., Wansley E.K., Guo Z., Franzusoff A., Mostbock S., Sabzevari H., Schlom J., Hodge J.W. Recombinant Saccharomyces cerevisiae (yeast-CEA) as a potent activator of murine dendritic cells. Vaccine 2008, 26:509-521.
13. Wansley E.K., Chakraborty M., Hance K.W., Bernstein M.B., Boehm A.L., Guo Z., Quick D., Franzusoff A., Greiner J.W., Schlom J., Hodge J.W. Vaccination with a recombinant Saccharomyces cerevisiae expressing a tumor antigen breaks immune tolerance and elicits therapeutic antitumor responses. Clin. Cancer Res. 2008, 14:4316-4325.
14. Boehm A.L., Higgins J., Franzusoff A., Schlom J., Hodge J.W. Concurrent vaccination with two distinct vaccine platforms targeting the same antigen generates phenotypically and functionally distinct T-cell populations. Cancer Immunol. Immunother. 2010, 59:397-408.
15. Heintel T., Breinig F., Schmitt M.J., Meyerhans A. Extensive MHC class I-restricted CD8 T lymphocyte responses against various yeast genera in humans. FEMS Immunol. Med. Microbiol. 2003, 39:279-286.
16. Breinig F., Heintel T., Schumacher A., Meyerhans A., Schmitt M.J. Specific activation of CMV-primed human T lymphocytes by cytomegalovirus pp65 expressed in fission yeast. FEMS Immunol. Med. Microbiol. 2003, 38:231-239.
17. Heiligenstein S., Eisfeld K., Sendzik T., Jimenez-Becker N., Breinig F., Schmitt M.J. Retrotranslocation of a viral A/B toxin from the yeast endoplasmic reticulum is independent of ubiquitination and ERAD. EMBO J. 2006, 25:4717-4727.
18. Ito H., Fukuda Y., Murata K., Kimura A. Transformation of intact yeast cells treated with alkali cations. J. Bacteriol. 1983, 153:163-168.
19. Skoberne M., Schenk S., Hof H., Geginat G. Cross-presentation of Listeria monocytogenes-derived CD4 T cell epitopes. J. Immunol. 2002, 169:1410-1418.
20. Watanabe I., Nomura T., Tominaga T., Yamamoto K., Kohda C., Kawamura I., Mitsuyama M. Dependence of the lethal effect of pore-forming haemolysins of Gram-positive bacteria on cytolytic activity. J. Med. Microbiol. 2006, 55:505-510.
21. Lorenz M.C., Fink G.R. The glyoxylate cycle is required for fungal virulence. Nature 2001, 412:83-86.
22. Guzman C.A., Domann E., Rohde M., Bruder D., Darji A., Weiss S., Wehland J., Chakraborty T., Timmis K.N. Apoptosis of mouse dendritic cells is triggered by listeriolysin, the major virulence determinant of Listeria monocytogenes. Mol. Microbiol. 1996, 20:119-126.
23. Carrero J.A., Calderon B., Unanue E.R. Listeriolysin O from Listeria monocytogenes is a lymphocyte apoptogenic molecule. J. Immunol. 2004, 172:4866-4874.
24. Remondo C., Cereda V., Mostbock S., Sabzevari H., Franzusoff A., Schlom J., Tsang K.Y. Human dendritic cell maturation and activation by a heat-killed recombinant yeast (Saccharomyces cerevisiae) vector encoding carcinoembryonic antigen. Vaccine 2009, 27:987-994.
25. Glomski I.J., Gedde M.M., Tsang A.W., Swanson J.A., Portnoy D.A. The Listeria monocytogenes hemolysin has an acidic pH optimum to compartmentalize activity and prevent damage to infected host cells. J. Cell. Biol. 2002, 156:1029-1038.
26. Tweten R.K. Cholesterol-dependent cytolysins, a family of versatile pore-forming toxins. Infect. Immun. 2005, 73:6199-6209.
27. Bavdek A., Gekara N.O., Priselac D., Gutierrez Aguirre I., Darji A., Chakraborty T., Macek P., Lakey J.H., Weiss S., Anderluh G. Sterol and pH interdependence in the binding, oligomerization, and pore formation of Listeriolysin O. Biochemistry 2007, 46:4425-4437.