NANOG has a role in mesenchymal stem cells' immunomodulatory effect

Stem Cells and Development

Volumn 20, Issue 9, 2011, Pages 1521-1528

  Sun, Zhao ^a   Han, Qin ^a   Zhu, Yashu ^a   Li, Zhenya ^a   Chen, Bin ^a   Liao, Lianming ^a   Bian, Chunjing ^a   Li, Jing ^a   Shao, Changshun ^b   Zhao, Robert Chunhua ^a  

^a INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

^b RUTGERS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DICKKOPF 1 PROTEIN; GROWTH FACTOR; INTERLEUKIN 10; TRANSCRIPTION FACTOR NANOG; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2; TRANSFORMING GROWTH FACTOR BETA3;

ARTICLE; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; FEMALE; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE ACTIVATION; MESENCHYMAL STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SECRETION; RNA INTERFERENCE;

ADULT; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BASE SEQUENCE; CELL PROLIFERATION; CELLS, CULTURED; COCULTURE TECHNIQUES; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; HOMEODOMAIN PROTEINS; HUMANS; IMMUNOMODULATION; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LECTINS, C-TYPE; LYMPHOCYTES; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RNA INTERFERENCE; TRANSFORMING GROWTH FACTOR BETA;

EID: 80052334901     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2010.0366     Document Type: Article

References (47)

1. Jiang XX, Y Zhang, B Liu, SX Zhang, Y Wu, Yu XD and N Mao. (2005). Human mesenchymal stem cells inhibit differentiation and function of monocyte-derived dendritic cells. Blood 105:4120-4126.
2. Bartholomew A, C Sturgeon, M Siatskas, K Ferrer, K Mc- Intosh, S Patil, W Hardy, S Devine, D Ucker, R Deans, A Moseley and R Hoffman. (2002). Mesenchymal stem cells suppress lymphocyte proliferation in vitro and prolong skin graft survival in vivo. Exp Hematol 30:42-48.
3. Krampera M, S Glennie, J Dyson, D Scott, R Laylor, E Simpson and F Dazzi. (2003). Bone marrow mesenchymal stem cells inhibit the response of naive and memory antigenspecific T cells to their cognate peptide. Blood 101:3722-3729.
4. Le Blanc K, I Rasmusson, C Gotherstrom, C Seidel, B Sundberg, M Sundin, K Rosendahl, C Tammik and O Ringdén. (2004). Mesenchymal stem cells inhibit the expression of CD25 (interleukin-2 receptor) and CD38 on phytohaemagglutinin-activated lymphocytes. Scand J Immunol 60:307-315.
5. Spaggiari GM, A Capobianco, S Becchetti, MC Mingari and L Moretta. (2006). Mesenchymal stem cell-natural killer cell interactions: Evidence that activated NK cells are capable of killing MSCs, whereas MSCs can inhibit IL-2-induced NKcell proliferation. Blood 107:1484-1490.
6. Zhang W, W Ge, C Li, S You, L Liao, Q Han, W Deng and RC Zhao. (2004). Effects of mesenchymal stem cells on differentiation, maturation, and function of human monocytederived dendritic cells. Stem Cells Dev 13:263-271.
7. Le Blanc K, F Frassoni, L Ball, F Locatelli, H Roelofs, I Lewis, E Lanino, B Sundberg, ME Bernardo, M Remberger, G Dini, RM Egeler, A Bacigalupo, W Fibbe and O Ringdén; Developmental Committee of the European Group for Blood and Marrow Transplantation. (2008). Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 371:1579-1586.
8. Le Blanc K, I Rasmusson, B Sundberg, C Götherström, M Hassan, M Uzunel and O Ringdén. (2004). Treatment of severe acute graft-versus-host disease with third party haploidentical mesenchymal stem cells. Lancet 363:1439-1441.
9. Puissant B, C Barreau, P Bourin, C Clavel, J Corre, C Bousquet, C Taureau, B Cousin, M Abbal, P Laharrague, L Penicaud, L Casteilla and A Blancher. (2005). Immunomodulatory effect of human adipose tissue-derived adult stem cells: Comparison with bone marrow mesenchymal stem cells. Br J Haematol 129:118-129.
10. Wolbank S, A Peterbauer, M Fahrner, S Hennerbichler, M van Griensven, G Stadler, H Redl and C Gabriel. (2007). Dose-dependent immunomodulatory effect of human stem cells from amniotic membrane: A comparison with human mesenchymal stem cells from adipose tissue. Tissue Eng 13:1173-1183.
11. Anzalone R, M Lo Iacono, T Loria, A Di Stefano, P Giannuzzi, F Farina and G La Rocca. (2010). Wharton's jelly mesenchymal stem cells as candidates for beta cells regeneration: Extending the differentiative and immunomodulatory benefits of adult mesenchymal stem cells for the treatment of type 1 diabetes. Stem Cell Rev Oct 23 [Epub ahead of print]; DOI: 10.1007/s12015-010-9196-4.
12. Roelen DL, BJ van der Mast, PS In't Anker, C Kleijburg, M Eikmans, E van Beelen, GM de Groot-Swings, WE Fibbe, HH Kanhai, SA Scherjon and FH Claas. (2009). Differential immunomodulatory effects of fetal versus maternal multipotent stromal cells. Hum Immunol 70:16-23.
13. Di Nicola M, C Carlo-Stella, M Magni, M Milanesi, PD Longoni, P Matteucci, S Grisanti and AM Gianni. (2002). Human bone marrow stromal cells suppress T-lymphocyte proliferation induced by cellular or nonspecific mitogenic stimuli. Blood 99:3838-3843.
14. Groh ME, B Maitra, E Szekely and ON Koc. (2005). Human mesenchymal stem cells require monocyte-mediated activation to suppress alloreactive T cells. Exp Hematol 33:928-934.
15. Sato K, K Ozaki, I Oh, A Meguro, K Hatanaka, T Nagai, K Muroi and K Ozawa. (2007). Nitric oxide plays a critical role in suppression of T-cell proliferation by mesenchymal stem cells. Blood 109:228-234.
16. Ren G, L Zhang, X Zhao, G Xu, Y Zhang, AI Roberts, RC Zhao and Y Shi. (2008). Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell 2:141-150.
17. Meisel R, A Zibert, M Laryea, U Gobel, W Daubener and D Dilloo. (2004). Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenasemediated tryptophan degradation. Blood 103:4619-4621.
18. Aggarwal S and MF Pittenger. (2005). Human mesenchymal stem cells modulate allogeneic immune cell responses. Blood 105:1815-1822.
19. Najar M, R Rouas, G Raicevic, HI Boufker, P Lewalle, N Meuleman, D Bron, M Toungouz, P Martiat and L Lagneaux. (2009). Mesenchymal stromal cells promote or suppress the proliferation of T lymphocytes from cord blood and peripheral blood: The importance of low cell ratio and role of interleukin-6. Cytotherapy 11:570-583.
20. Fang B, M Shi, L Liao, S Yang, Y Liu and RC Zhao. (2003). Multiorgan engraftment and multilineage differentiation by human fetal bone marrow Flk1 + /CD31-/CD34- progenitors. J Hematother Stem Cell Res 12:603-613.
21. Guo H, B Fang, L Liao, Z Zhao, J Liu, H Chen, SH Hsu, Q Cui and RC Zhao. (2003). Hemangioblastic characteristics of fetal bone marrow-derived Flk1( + )CD31(-)CD34(-) cells. Exp Hematol 31:650-658.
22. Cao Y, Z Sun, L Liao, Y Meng, Q Han and RC Zhao. (2005). Human adipose tissue-derived stem cells differentiate into endothelial cells in vitro and improve postnatal neovascularization in vivo. Biochem Biophys Res Commun 332:370-379.
23. Liu Y, X Yan, Z Sun, B Chen, Q Han, J Li and RC Zhao. (2007). Flk-1 + adipose-derived mesenchymal stem cells differentiate into skeletal muscle satellite cells and ameliorate muscular dystrophy in mdx mice. Stem Cells Dev 16:695-706.
24. Yan X, Y Liu, Q Han, M Jia, L Liao, M Qi and RC Zhao. (2007). Injured microenvironment directly guides the differentiation of engrafted Flk-1( + ) mesenchymal stem cell in lung. Exp Hematol 35:1466-1475.
25. Chen L, WZhang, H Yue, Q Han, B Chen, M Shi, J Li, B Li, S You, Y Shi and RC Zhao. (2007). Effects of human mesenchymal stem cells on the differentiation of dendritic cells from CD34 + cells. Stem Cells Dev 16:719-731.
26. Han Q, Z Sun, L Liu, B Chen, Y Cao, K Li and RC Zhao. (2007). Impairment in immuno-modulatory function of Flk1( + )CD31(-)CD34(-) MSCs from MDS-RA patients. Leuk Res 31:1469-1478.
27. Zhang B, R Liu, D Shi, X Liu, Y Chen, X Dou, X Zhu, C Lu, W Liang, L Liao, M Zenke and RC Zhao. (2009). Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2 dependent regulatory dendritic cell population. Blood 113:46-57.
28. Zhu Y, Z Sun, Q Han, L Liao, J Wang, C Bian, J Li, X Yan, Y Liu, C Shao and RC Zhao. (2009). Human mesenchymal stem cells inhibit cancer cell proliferation by secreting DKK- 1. Leukemia 23:925-933.
29. Greco SJ, K Liu and P Rameshwar. (2007). Functional similarities among genes regulated by OCT4 in human mesenchymal and embryonic stem cells. Stem Cells 25:3143-3154.
30. La Rocca G, R Anzalone, S Corrao, F Magno, T Loria, M Lo Iacono, A Di Stefano, P Giannuzzi, L Marasa, F Cappello, G Zummo and F Farina. (2009). Isolation and characterization of Oct-4 + /HLA-G + mesenchymal stem cells from human umbilical cord matrix: Differentiation potential and detection of new markers. Histochem Cell Biol 131:267-282.
31. Li J, M Shi, Y Cao, W Yuan, T Pang, B Li, Z Sun, L Chen and RC Zhao. (2006). Knockdown of hypoxia-inducible factor- 1alpha in breast carcinoma MCF-7 cells results in reduced tumor growth and increased sensitivity to methotrexate. Biochem Biophys Res Commun 342:1341-1351.
32. Maruyama M, T Ichisaka, M Nakagawa and S Yamanaka. (2005). Differential roles for Sox15 and Sox2 in transcriptional control in mouse embryonic stem cells. J Biol Chem 280:24371-24379.
33. Mitsui K, Y Tokuzawa, H Itoh, K Segawa, M Murakami, K Takahashi, M Maruyama, M Maeda and S Yamanaka. (2003). The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113:631-642.
34. Chambers I, D Colby, M Robertson, J Nichols, S Lee, S Tweedie and A Smith. (2003). Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113:643-655.
35. Chambers I, J Silva, D Colby, J Nichols, B Nijmeijer, M Robertson, J Vrana, K Jones, L Grotewold and A Smith. (2007). Nanog safeguards pluripotency and mediates germline development. Nature 450:1230-1234.
36. Zhao Y,HWang and TMazzone. (2006). Identification of stem cells from human umbilical cord blood with embryonic and hematopoietic characteristics. Exp Cell Res 312:2454-2464.
37. Suzuki A, A Raya, Y Kawakami, M Morita, T Matsui, K Nakashima, FH Gage, C Rodríguez-Esteban and JC Izpisúa Belmonte. (2006). Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103:10294-10299.
38. Xu RH, TL Sampsell-Barron, F Gu, S Root, RM Peck, G Pan, J Yu, J Antosiewicz-Bourget, S Tian, R Stewart and JA Thomson. (2008). NANOG is a direct target of TGFbeta/ activin-mediated SMAD signaling in human ESCs. Cell Stem Cell 3:196-206.
39. Roberts AB, MA Anzano, LM Wakefield, NS Roche, DF Stern and MB Sporn. (1985). Type beta transforming growth factor: A bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A 82:119-123.
40. ten Dijke P, P Hansen, KK Iwata, C Pieler and JG Foulkes. (1988). Identification of another member of the transforming growth factor type beta gene family. Proc Natl Acad Sci U S A 85:4715-4719.
41. Derynck R, PB Lindquist, A Lee, D Wen, J Tamm, JL Graycar, L Rhee, AJ Mason, DA Miller, RJ Coffey, et al. (1988). A new type of transforming growth factor-beta, TGFbeta 3. EMBO J 7:3737-3743.
42. Fedi P, A Bafico, A Nieto Soria, WH Burgess, T Miki, DP Bottaro, MH Kraus and SA Aaronson. (1999). Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling. J Biol Chem 274:19465-19472.
43. Glinka A, W Wu, H Delius, AP Monaghan, C Blumenstock and C Niehrs. (1998). Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction. Nature 391:357-362.
44. Etheridge SL, GJ Spencer, DJ Heath and PG Genever. (2004). Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells. Stem Cells 22: 849-860.
45. Aguilera O, MF Fraga, E Ballestar, MF Paz, M Herranz, J Espada, JM García, A Muñoz, M Esteller and JM González- Sancho. (2006). Epigenetic inactivation of the Wnt antagonist DICKKOPF-1 (DKK-1) gene in human colorectal cancer. Oncogene 25:4116-4121.
46. Kuphal S, S Lodermeyer, F Bataille, M Schuierer, BH Hoang and AK Bosserhoff. (2006). Expression of Dickkopf genes is strongly reduced in malignant melanoma. Oncogene 25:5027-5036.
47. Vibhakar R, G Foltz, JG Yoon, L Field, H Lee, GY Ryu, J Pierson, B Davidson and A Madan. (2007). Dickkopf-1 is an epigenetically silenced candidate tumor suppressor gene in medulloblastoma. Neuro Oncol 9:135-144.