The role of the dorsal hippocampus on the Ginkgo biloba facilitation effect of fear extinction as assessed with fear-potentiated startle

Psychopharmacology

Volumn 215, Issue 3, 2011, Pages 403-411

  Shen, Yu Fang ^a   Chou, Yu Hsuan ^b,d   Yang, Yi Ling ^c   Lu, Kwok Tung ^e  

^a HSIN SHENG COLLEGE OF MEDICAL CARE AND MANAGEMENT   (Taiwan)

^b CHIA YI CHRISTIAN HOSPITAL   (Taiwan)

^c NATIONAL CHIAYI UNIVERSITY   (Taiwan)

^d Ching Ho Hospital   (Taiwan)

^e NONE

Author keywords

Dorsal hippocampus; EGb761; Fear potentiated startle; Ginkgo biloba

Indexed keywords

GINKGO BILOBA EXTRACT; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; FLAVONOID; GINKGO BILOBA EXTRACT 761; PLANT EXTRACT;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN FUNCTION; CONDITIONING; CONTROLLED STUDY; DRUG EFFECT; FACILITATION; FEAR; HIPPOCAMPUS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REINFORCEMENT; SIGNAL TRANSDUCTION; STARTLE REFLEX; ANIMAL; ANIMAL BEHAVIOR; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALS; BEHAVIOR, ANIMAL; EXTINCTION, PSYCHOLOGICAL; FEAR; FLAVONOIDS; HIPPOCAMPUS; MALE; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; PLANT EXTRACTS; RATS; RATS, SPRAGUE-DAWLEY; STARTLE REACTION;

EID: 80052334709     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-011-2244-1     Document Type: Article

References (64)

1. Atkins CM, Selcher JC, Petraitis JJ, Trzaskos JM, Sweatt D (1998) The MAPK cascade is required for mammalian associative learning. Nat Neurosci 1: 602-609
2. Bading H, Greenberg ME (1991) Stimulation of protein tyrosine phosphorylation by NMDAreceptor activation. Science 253: 912-914 (Pubitemid 21917237)
3. Blum S, Moore AN, Adams F, Dash PK (1999) A mitogen-activated protein kinase cascade in the CA1/CA2 subfield of the dorsal hippocampus is essential for long-term spatial memory. J Neurosci 19: 3535-3544 (Pubitemid 29203133)
4. Cammarota M, Bevilaqua RM, Rossato JI, Ramirezz M, Medina JH (2005) Relationship between short- and long-term memory and short- and long-term extinction. Neurobiol Learn Mem 84: 25-32 (Pubitemid 40776093)
5. Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998) A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM kinase II. Neuron 20: 895-904 (Pubitemid 28247395)
6. Chetkovich DM, Gray R, Jonhston D, Sweatt JD (1991) N-methyl-Daspartate receptor activation increases cAMP levels and voltagegated Ca2+ channel activity in area CA1 of hippocampus. Proc Natl Acad Sci USA 88: 6467-6471 (Pubitemid 21914967)
7. Clostre F (2000) Ginkgo biloba extract (EGb761). State of knowledge in the dawn of the year 2000. Ann Pharm Fr 57: 1S8-1S88
8. Curtis-Prior P, Vere D, Fray P (1999) Therapeutic value of Ginkgo biloba in reducing symptoms of decline in mental function. J Pharm Pharmacol 51: 535-541 (Pubitemid 29319778)
9. Davis M (1986) Pharmacological and anatomical analysis of fear conditioning using the fear-potentiated startle paradigm. Behav Neurosci 100: 814-824 (Pubitemid 17002689)
10. Davis M, Myers KM (2002) The role of glutamate and gammaaminobutyric acid in fear extinction: clinical implications for exposure therapy. Biol Psychiatry 52: 998-1007 (Pubitemid 35356357)
11. Davis M, Falls WA, Gewirtz J (2000a) Neural systems involved in fear inhibition: extinction and conditioned inhibition. In: Myslobodsky M, Weiner I (eds) Contemporary issues in modeling psychopathology. Kluwer, Boston, pp 113-142
12. Davis S, Vanhoutte P, Pages C, Caboche J, Laroche S (2000b) The MAPK/ERK cascade targets both Elk-1 and cAMP response element binding protein to control long-term potentiationdependent gene expression in the dentate gyrus in vivo. J Neurosci 20: 4563-4572 (Pubitemid 30396622)
13. DeFeudis FV (1991) Ginkgo biloba extract (EGb 761): pharmacological activities and clinical applications. Elsevier, Amsterdam
14. DeFeudis FV, Drieu K (2000) Ginkgo biloba extract (EGb 761) and CNS functions: basic studies and clinical applications. Curr Drug Targets 1: 25-58
15. Diamond BJ, Shifflett C, Feiwel N (2000) Ginkgo biloba extract: mechanisms and clinical indications. Arch Phys Med Rehabil 81: 668-678 (Pubitemid 30257692)
16. Dillon GM, Qu XL, Marcus JN, Dodart JC (2008) Excitotoxic lesions restricted to the dorsal CA1 field of the hippocampus impair spatial memory and extinction learning in C57BL/6 mice. Neurobiol Learn Mem 90: 426-433
17. Drieu K (1986) Preparation et definition de l'extrait de Ginkgo biloba. Presse Méd 15: 1455-1457 (Pubitemid 16018103)
18. English JD, Sweatt JD (1996) Activation of p42 mitogen-activated protein kinase in hippocampal long-term potentiation. J Biol Chem 271: 24329-24332 (Pubitemid 26333160)
19. Gong OH, Wu Q, Huang XN, Sun AS, Shi JS (2005) Protective effects of Ginkgo biloba leaf extract on aluminum-induced brain dysfunction in rats. Life Sci 77: 140-148 (Pubitemid 40603499)
20. Grewal SS, York RD, Stork PJ (1998) Extracellular-signal-regulated kinase signalling in neurons. Curr Opin Neurobiol 9: 544-553 (Pubitemid 29484377)
21. Hasenöhrl RU, Nichau CH, Frisch CH, De Souza Silva MA, Huston JP, Mattern CM, Häcker R (1996) Anxiolytic-like effect of combined extracts of Zingiber officinale and Ginkgo biloba in the elevated plus-maze. Pharmacol Biochem Behav 53: 271-275 (Pubitemid 26060766)
22. Hasenöhrl RU, Topic B, Frisch C, Häcker R, Mattern CM, Huston JP (1998) Dissociation between anxiolytic and hypomnestic effects for combined extracts of Zingiber officinale and Ginkgo biloba to healthy young volunteers. Pharmacol Biochem Behav 59: 527-535 (Pubitemid 28072751)
23. Herry C, Garcia R (2002) Prefrontal cortex long-term potentiation, but not long-term depression, is associated with the maintenance of extinction of learned fear in mice. J Neurosci 22: 577-583 (Pubitemid 34049098)
24. Hikind N, Maroun M (2008) Microinfusion of the D1 receptor antagonist, SCH23390 into the IL but not the BLA impairs consolidation of extinction of auditory fear conditioning. Neurobiol Learn Mem 90: 217-222
25. Hsu E, Packard MG (2008) Medial prefrontal cortex infusions of bupivavaine or AP-5 block extinction of amphetamine conditioned place preference. Neurobiol Learn Mem 89: 504-512 (Pubitemid 351484248)
26. Hugues S, Deschaux O, Garcia R (2004) Postextinction infusion of a mitogen-activated protein kinase inhibitor into the medial prefrontal cortex impairs memory of the extinction of conditioned fear. Learn Mem 11: 540-543 (Pubitemid 39299701)
27. Kornhauser JM, Greenberg ME (1997) A kinase to remember: dual roles for MAP kinase in long-term memory. Neuron 18: 839-842 (Pubitemid 27274601)
28. Krieglstein J, Beck T, Seibert A (1986) Influence of an extract of Ginkgo biloba on cerebral blood flow and metabolism. Life Sci 39: 2327-2334 (Pubitemid 17190202)
29. Krieglstein J, Ausmeier F, Ei-Abhar H, Lippert K, Welsch JM, Rupalla K (1995) Neuroprotective effects of Ginkgo biloba constituents. Eur J Pharm Sci 3: 9-48
30. Landes P (1997) Market report: whole food magazine's 2nd annual herb market survey for U.S. health food stores. Herbal Gram 40: 52
31. Le Bars PL, Katz MM, Berman N, Itil TM, Freedman AM, Schatzberg AF (1997) A placebo-controlled, double-blind, randomized trial of an extract of Ginkgo biloba for dementia. JAMA 278: 1327-1332 (Pubitemid 27449692)
32. Le Bars PL, Koeser M, Itil KZ (2000) A 26-week analysis of a double-blind, placebo-controlled trial of the Ginkgo Biloba extract EGb761 in dementia. Dement Geriatr Cogn Disord 11: 230-237 (Pubitemid 30416029)
33. Lebrón K, Milad MR, Quirk GJ (2004) Delayed recall of fear extinction in rats with lesions of ventral medial prefrontal cortex. Learn Mem 11(5): 544-548 (Pubitemid 39299702)
34. Ledgerwood L, Richardson R, Cranney J (2003) Effects of D-cycloserine on extinction of conditioned freezing. Behav Neurosci 117: 341-349 (Pubitemid 36384252)
35. Ledgerwood L, Richardson R, Cranney J (2004) D-cycloserine and the facilitation of extinction of conditioned fear. Consequences for reinstatement. Behav Neurosci 118: 505-513 (Pubitemid 38685318)
36. Lin CCK, Cheng WL, Hsu SH, Chang CMJ (2003a) The effects of Ginkgo biloba extracts on the memory and motor functions of rats with chronic cerebral insufficiency. Neuropsychobiology 47: 47-51
37. Lin CH, Yeh SH, Lu HY, Gean PW (2003b) The similarities and diversities of signal pathways leading to consolidation of conditioning and consolidation of extinction of fear memory. J Neurosci 23: 8310-8317
38. Lu KT, Walker DL, Davis M (2001) Mitogen-activated protein kinase cascade in the basolateral nucleus of amygdala is involved in extinction of fear potentiated startle. J Neurosci 21(RC162): 1-5
39. Milad MR, Quirk GJ (2002) Neurons in medial prefrontal cortex signal memory for fear extinction. Nature 420: 70-74 (Pubitemid 35291441)
40. Millan SJ, Gacia de la Asuncion J, Pallardo JG, O'Conner E, Martin J, Droy-Lefaiz MT, Vina J (1998) A Ginkgo biloba extract (EGb761) prevents mitochondrial aging by protecting against oxidative stress. Free Radical Biol Med 24: 298-304 (Pubitemid 28008808)
41. O'Hara M, Kiefer D, Farrell K, Kemper K (1998) A review of 12 commonly used medicinal herbs. Arch Fam Med 7: 523-536 (Pubitemid 128433264)
42. Porsolt RD, Martin P, Lenegre A, Fromage S, Drieu K (1990) Effects of an extract of Ginkgo biloba (EGb761) on 'learned helplessness' and other models of stress in rodents. Pharmacol Biochem Behav 36: 963-971 (Pubitemid 20272323)
43. Quirk GJ, Garcia R, Gonzalez-Lim F (2006) Prefrontal mechanisms in extinction of conditioned fear. Biol Psychiatry 60: 337-343 (Pubitemid 44215848)
44. Ressler KJ, Rothbaum BO, Tannebaum L, Anderson P, Graap K, Zimand E, Hodges L, Davis M (2004) Cognitive enhancers as adjuncts to psychotherapy: use of D-cycloserine in phobics to facilitate extinction of fear. Arch Gen Psychiatry 61: 1136-1144 (Pubitemid 39463415)
45. Roberson ED, English JD, Adams JP, Selcher JC, Kondratick C, Sweatt JD (1999) The mitogen-activated protein kinase cascade couples PKA and PKC to cAMP response element binding protein phosphorylation in area CA1 of hippocampus. J Neurosci 19: 4337-4348 (Pubitemid 29241087)
46. Roozendaal B (2003) Systems mediating acute glucocorticoid effects on memory consolidation and retrieval. Prog Neuropsychopharmacol Biol Psychiatry 27: 1213-1223 (Pubitemid 37501027)
47. Roozendaal B, Griffith QK, Buranday J, de Quervain DJF, McGaugh JL (2002) The hippocampus mediates glucocorticoid-induced impairment of spatial memory retrieval: dependence on the basolateral amygdala. Proc Natl Acad Sci 100: 1328-1333 (Pubitemid 36184001)
48. Santini E, Ge H, Ren K, Peña de Ortiz S, Quirk GJ (2004) Consolidation of fear extinction requires protein synthesis in the medial prefrontal cortex. J Neurosci 24: 5704-5710 (Pubitemid 38857224)
49. Schafe GE, Nadel NV, Sullivan GM, Harris A, LeDoux JE (1999) Memory consolidation for contextual and auditory fear conditioning is dependent on protein synthesis, PKA, and MAP kinase. Learn Mem 6: 97-110 (Pubitemid 29207259)
50. Stackman RW, Eckenstein F, Frei B, Kulhanek D, Nowlin J, Quinn JF (2003) Prevention of age-related spatial memory deficits in a transgenic mouse model of Alzheimer's disease by chronic Ginkgo biloba treatment. Exp Neurol 184: 510-520 (Pubitemid 37444058)
51. Tang F, Nag S, Shiu SYW, Pang SF (2002) The effects of melatonin and Ginkgo biloba extract on memory loss and choline acetyltransferase activities in the brain of rats infused intracerebroventricularly with β-amyloid 1-40. Life Sci 71: 2625-2631 (Pubitemid 35279305)
52. Taylor JE (1992) In vitro interactions of EGb 761 with biogenic amine uptake sites and NMDA receptors. In: Christen Y, Costintin J, Lacour M (eds) Effects of Ginkgo biloba extract (EGb 761) on the central nervous system. Elsevier, Paris
53. Van Dongen MC, Van Rossum E, Kessels AG, Sielhorst HJ, Knipschild PG (2000) The efficacy of ginkgo for elderly people with dementia and age-associated memory impairment: new results of a randomized clinical trial. J Am Geriatr Soc 48: 1183-1194
54. Vianna MR, Igaz LM, Coitinho AD, Medina JH, Izquierdo I (2003) Memory extinction requires gene expression in rat hippocampus. Neurobiol Learn Mem 79: 199-203 (Pubitemid 36379191)
55. Walker DL, Ressler KJ, Lu KT, Davis M (2002) Facilitation of conditioned fear extinction by systemic administration or intraamygdala infusions of D-cycloserine as assessed with fear potentiated startle in rats. J Neurosci 22(6): 2343-2351 (Pubitemid 35386533)
56. Walz R, Roesler R, Quevedo J, Rockenbach IC, Amaral OB, ViannaMR, Lenz G, Medina JH, Izquierdo I (1999a) Dose-dependent impairment of inhibitory avoidance retention in rats by immediate posttraining infusion of a mitogen-activated protein kinase kinase inhibitor into cortical structures. Behav Brain Res 105: 219-223 (Pubitemid 29469767)
57. Walz R, Roesler R, Barros DM, de Souza MM, Rodrigues C, Sant'Anna MK, Quevedo J, Choi HK, Neto WP, DeDavid e Silva TL, Medina JH, Izquierdo I (1999b) Effects of post-training infusions of a mitogen activated protein kinase kinase inhibitor into the hippocampus or entorhinal cortex on short- and long-term retention of inhibitory avoidance. Behav Pharmacol 10: 723-730 (Pubitemid 30028746)
58. Ward CP, Redd K, Williams BM, Caler JR, Luo Y, McCoy JG (2002) Ginkgo biloba extract: cognitive enhancer or antistress buffer. Pharmacol Biochem Behav 72: 913-922 (Pubitemid 34621318)
59. Yang YL, Lu KT (2005) Facilitation of conditioned fear extinction by D-cycloserine is mediated by mitogen activated protein kinase and PI-3 kinase cascades and requires de novo protein synthesis in basolateral nucleus of amygdala. Neuroscience 134: 247-260 (Pubitemid 40943651)
60. Yang YL, Su YW, Ng MC, Chang CL, Lu KT (2005) Extract of Ginkgo biloba EGb 761 facilitates fear conditioning measured by fear potentiated startle. Neurosci Lett 383: 145-150
61. Yang YL, Chao PK, Lu KT (2006) Systemic and intra-amygdala administration of glucocorticoid agonist and antagonist modulate extinction of conditioned fear. Neuropsychopharmacology 31: 912-924
62. Yang YL, Chao PK, Ro LS, Wo YYP, Lu KT (2007a) Glutamate NMDA receptors within the amygdala participate in the modulatory effect of glucocorticoids on extinction of conditioned fear in rats. Neuropsychopharmacology 32: 1042-1051
63. Yang YL, Su YW, Ng MC, Chao PK, Tung LC, Lu KT (2007b) Extract of Ginkgo biloba EGb761 facilitates extinction of conditioned fear measured by fear potentiated startle. Neuropsychopharmacology 32: 332-342
64. Yang YL, Hsieh CW, Wo YY, Yang YC, Lu KT (2009) Intra-amygdaloid infusion of Ginkgo biloba leaf extract (EGb761) facilitates fear potentiated startle in rats. Psychopharmacology 202: 187-196