Microarray analysis of the infrapatellar fat pad in knee osteoarthritis: Relationship with joint inflammation

Journal of Rheumatology

Volumn 38, Issue 9, 2011, Pages 1966-1972

  Gandhi, Rajiv ^a   Takahashi, Mark ^a,b   Virtanen, Carl ^a,b   Syed, Khalid ^a   Davey, J Roderick ^a   Mahomed, Nizar N ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY HEALTH NETWORK   (Canada)

Author keywords

Genetics; Infrapatellar fat pad; Knee; Osteoarthritis

Indexed keywords

ADIPONECTIN; HORMONE RECEPTOR; LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; RNA; UNCLASSIFIED DRUG;

ADIPOGENESIS; ADULT; AGED; ARTICLE; CD36 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DGAT2 GENE; DISEASE COURSE; ENERGY METABOLISM; FEMALE; GENE; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INFLAMMATION; INFRAPATELLAR FAT PAD; KNEE; KNEE OSTEOARTHRITIS; LIPID METABOLISM; MALE; MICROARRAY ANALYSIS; PPAR GAMMA GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THRSP GENE;

ADIPOGENESIS; ADIPOSE TISSUE; ADULT; AGED; AGED, 80 AND OVER; COHORT STUDIES; ENERGY METABOLISM; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; KNEE JOINT; MALE; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOARTHRITIS, KNEE;

EID: 80052328640     PISSN: 0315162X     EISSN: 14992752     Source Type: Journal    
DOI: 10.3899/jrheum.101302     Document Type: Article

References (38)

1. Buckwalter JA, Martin JA. Osteoarthritis. Adv Drug Deliv Rev 2006;58:150-67.
2. Saxne T, Lindell M, Mansson B, Petersson IF, Heinegard D. Inflammation is a feature of the disease process in early knee joint osteoarthritis. Rheumatology 2003;42:903-4.
3. Pelletier JP, Martel-Pelletier J, Abramson SB. Osteoarthritis, an inflammatory disease: potential implication for the selection of new therapeutic targets. Arthritis Rheum 2001;44:1237-47.
4. Felson DT, Lawrence RC, Dieppe PA, Hirsch R, Helmich CG, Jordan JM, et al. Osteoarthritis: new insights. Part 1: the disease and its risk factors. Ann Intern Med 2000;133:635-46.
5. Valdes AM, Spector TD. The contribution of genes to osteoarthritis. Rheum Dis Clin North Am 2008;34:581-603.
6. Hochberg MC, Lethbridge-Cejku M, Scott WW Jr, Reichie R, Plato CC, Tobin JD. The association of body weight, body fatness and body fat distribution with osteoarthritis of the knee: data from the Baltimore Longitudinal Study of Aging. J Rheumatol 1995;22:488-93.
7. Hart DJ, Doyle DV, Spector TD. Association between metabolic factors and knee osteoarthritis in women: the Chingford Study. J Rheumatol 1995;22:1118-23.
8. Kershaw EE, Flier JS. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 2004;89:2548-56.
9. Toussirot E, Streit G, Wendling D. The contribution of adipose tissue and adipokines to inflammation in joint diseases. Curr Med Chem 2007;14:1095-100.
10. Margetic S, Gazzola C, Pegg GG, Hill RA. Leptin: a review of its peripheral actions and interactions. Int J Obes Relat Metab Disord 2002;26:1407-33.
11. Fantuzzi G. Adipose tissue, adipokines, and inflammation. J Allergy Clin Immunol 2005;115:911-9.
12. Turhan E, Doral MN, Atay AO, Demirel M. A giant extrasynovial osteochondroma in the infrapatellar fat pad: end stage Hoffa's disease. Arch Orthop Trauma Surg 2008;128:515-9.
13. Ushiyama T, Chano T, Inoue K, Matsusue Y. Cytokine production in the infrapatellar fat pad: another source of cytokines in knee synovial fluids. Ann Rheum Dis 2003;62:108-12.
14. Presle N, Pottie P, Dumond H, Guillaume C, Lapicque F, Pallu S, et al. Differential distribution of adipokines between serum and synovial fluid in patients with osteoarthritis. Contribution of joint tissues to their articular production. Osteoarthritis Cartilage 2006;14:690-5.
15. Distel E, Cadoudal T, Durant S, Poignard A, Chevalier X, Benelli C. The infrapatellar fat pad in knee osteoarthritis: an important source of interleukin-6 and its soluble receptor. Arthritis Rheum 2009;60:3374-7.
16. Cameron M, Briggs K, Steadman J. Reproducibility and reliability of the Outerbridge classification for grading chondral lesions of the knee arthroscopically. Am J Sports Med 2003;31:83-6.
17. Rocha PM, Barata JT, Teixeira PJ, Ross R, Sardinha LB. Independent and opposite associations of hip and waist circumference with metabolic syndrome components and with inflammatory and atherothrombotic risk factors in overweight and obese women. Metabolism 2008;57:1315-22.
18. Tontonoz P, Nagy L, Alvarez JG, Thomazy VA, Evans RM. PPAR-gamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998;93:241-52.
19. Gandhi R, Takahashi M, Syed KA, Davey JR, Mahomed NN. Relationship between body habitus and joint leptin levels in a knee osteoarthritis population. J Orthop Res 2010;28:329-33.
20. Murphy G, Knäuper V, Atkinson S, Butler G, English W, Hutton M, et al. Matrix metalloproteinase in arthritic disease. Arthritis Research 2002;4:39-49.
21. Clockaerts S, Basteaansen-Jenniskens YM, Runhaar J, Van Osch GJVM, Van Offel JF, Verhaar JAN, et al. The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review. Osteoarthritis Cartilage 2010;18:876-82.
22. Goldring SR, Goldring MB. The role of cytokines in cartilage matrix degeneration in osteoarthritis. Clin Orthop Relat Res 2004;427:S27-36.
23. Bohnsack M, Klages P, Hurschler C, Halcour A, Wilharm A, Ostermeier S, et al. Influence of an infrapatellar fat pad edema on patellofemoral biomechanics and knee kinematics: a possible relation to the anterior knee pain syndrome. Arch Orthop Trauma Surg 2009;129:1025-30.
24. Gualillo O, Gonzalez-Juanatey JR, Lago F. The emerging role of adipokines as mediators of cardiovascular diseases: physiological and clinical perspectives. Trends Cardiovasc Med 2007;17:277-85.
25. Chen TH, Chen L, Hsieh MS, Chang CP, Chou DT, Tsai TH. Evidence for a protective role for adiponectin in osteoarthritis. Biochim Biophys Acta 2006;1762:711-8.
26. Lago R, Gomez R, Otero M, Lago F, Gallego R, Dieguez C, et al. A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes. Osteoarthritis Cartilage 2008;16:1101-9.
27. Ehling A, Schaffler A, Herfarth H, Tarner IH, Anders S, Distler O, et al. The potential of adiponectin in driving arthritis. J Immunol 2006;176:4468-78.
28. Lago F, Dieguez C, Gomez-Reino J, Gualillo O. Adipokines as emerging mediators of immune response and inflammation. Nat Clin Pract Rheumatol 2007;3:716-24.
29. Omoto S, Nishida K, Yamaii Y, Shibahara M, Nishida T, Doi T, et al. Expression and localization of connective tissue growth factor (CTGF/Hcs24/CCN2) in osteoarthritic cartilage. Osteoarthritis Cartilage 2004;12:771-8.
30. Schett G, Kiechl S, Bonora E, Zwerina J, Mayr A, Axmann R, et al. Vascular cell adhesion molecule 1 as a predictor of severe osteoarthritis of the hip and knee joints. Arthritis Rheum 2009;60:2381-9.
31. Berger JP. Role of PPAR, transcriptional cofactors, and adiponectin in the regulation of nutrient metabolism, adipogenesis and insulin action: view from the chair. Int J Obes 2005;29:S3-4.
32. Tsuchida A, Yamauchi T, Takekawa S, Hada Y, Ito Y, Maki T, et al. Peroxisome proliferator-activated receptor (PPAR)-alpha activation increases adiponectin receptors and reduces obesity-related inflammation in adipose tissue: comparison of activation of PPAR-alpha, PPAR-gamma, and their combination. Diabetes 2005;54:3358-70.
33. Giaginis C, Giagini A, Theocharis S. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands as potential therapeutic agents to treat arthritis. Pharmacol Res 2009;60:160-9.
34. Boileau C, Martel-Pelletier J, Fahmi H, Mineau F, Boily M, Pelletier JP. The peroxisome proliferator-activated receptor gamma agonist pioglitazone reduces the development of cartilage lesions in an experimental dog model of osteoarthritis: in vivo protective effects mediated through the inhibition of key signaling and catabolic pathways. Arthritis Rheum 2007;56:2288-98.
35. Ji JD, Cheon H, Jun JB, Choi SJ, Kim YR, Lee YH, et al. Effects of peroxisome proliferator-activated receptor-gamma (PPAR-gamma) on the expression of inflammatory cytokines and apoptosis induction in rheumatoid synovial fibroblasts and monocytes. J Autoimmun 2001;17:215-21.
36. Afif H, Benderdour M, Mfuna-Endam L, Martel-Pelletier J, Pelletier JP, Duval N, et al. Peroxisome proliferator-activated receptor gamma-1 expression is diminished in human osteoarthritic cartilage and is downregulated by interleukin-1-beta in articular chondrocytes. Arthritis Res Ther 2007;9:R31.
37. Combs TP, Wagner JA, Berger J, Doebber T, Wang WJ, Zhang BB, et al. Induction of adipocyte complement-related protein of 30 kilodaltons by PPAR-gamma agonists: a potential mechanism of insulin sensitization. Endocrinology 2002;143:998-1007.
38. Rojas-Rodriguez J, Escobar-Linares LE, Garcia-Carrasco M, Escarcega RO, Fuentes-Alexandro S, Zamora-Ustaran A. The relationship between the metabolic syndrome and energy-utilization deficit in the pathogenesis of obesity-induced osteoarthritis. Med Hypothesis 2007;69:860-8.