Structure-activity relationships in tripodal transmembrane anion transporters: The effect of fluorination

Journal of the American Chemical Society

Volumn 133, Issue 35, 2011, Pages 14136-14148

  Busschaert, Nathalie ^a   Wenzel, Marco ^a   Light, Mark E ^a   Iglesias Hernández, Paulina ^b   Pérez Tomás, Ricardo ^b   Gale, Philip A ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANION TRANSPORT; ANTIPORTS; CONTRIBUTING FACTOR; FLUORESCENCE ASSAY; FLUORINATED COMPOUND; HUMAN CANCER CELLS; IN-VITRO; LIPOPHILICITY; MAXIMUM TRANSPORT; PHENYL GROUP; PROTON NMR; SINGLE CRYSTAL X-RAY DIFFRACTION; STRUCTURE ACTIVITY RELATIONSHIPS; TRANSMEMBRANES; TRANSPORT ACTIVITY; TRIFLUOROMETHYL;

CELL DEATH; CHLORINE COMPOUNDS; FLUORINATION; FLUORINE; HALOGENATION; ION SELECTIVE ELECTRODES; LIPID BILAYERS; METABOLISM; SINGLE CRYSTALS; STOICHIOMETRY; THIOUREAS; TRANSPORT PROPERTIES; UREA; X RAY DIFFRACTION;

NEGATIVE IONS;

BICARBONATE; CHLORIDE; NITRATE; ORGANIC ANION TRANSPORTER; SULFATE; THIOUREA; TRIPODAL TRANSMEMBRANE ANION TRANSPORTER; UNCLASSIFIED DRUG; UREA;

APOPTOSIS; ARTICLE; CALCULATION; CATION TRANSPORT; CELL ASSAY; CELL VACUOLE; CELL VIABILITY; CONTROLLED STUDY; FLUORESCENCE ANALYSIS; FLUORINATION; HUMAN; HUMAN CELL; IN VITRO STUDY; ION SELECTIVE ELECTRODE; LIPID BILAYER; LIPOPHILICITY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLID STATE; STOICHIOMETRY; STRUCTURE ACTIVITY RELATION; X RAY DIFFRACTION;

ANIONS; BINDING SITES; CELL LINE, TUMOR; CELL SURVIVAL; CRYSTALLOGRAPHY, X-RAY; HALOGENATION; HUMANS; ION TRANSPORT; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 80052323743     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja205884y     Document Type: Article

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