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Volumn 2, Issue 8, 2011, Pages

PPARγ population shift produces disease-related changes in molecular networks associated with metabolic syndrome

Author keywords

Bi stable switches; Disease related networks; Metabolic syndrome; PPARg; Protein population shift

Indexed keywords

PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RETINOID X RECEPTOR ALPHA;

EID: 80052323083     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2011.74     Document Type: Article
Times cited : (7)

References (40)
  • 1
    • 70349330663 scopus 로고    scopus 로고
    • Cancer attractors: A systems view of tumors from a gene network dynamics and developmental perspective
    • Huang S, Ernberg I, Kauffman S. Cancer attractors: a systems view of tumors from a gene network dynamics and developmental perspective. Semin Cell Dev Biol 2009; 20: 869-876.
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 869-876
    • Huang, S.1    Ernberg, I.2    Kauffman, S.3
  • 2
    • 70350340728 scopus 로고    scopus 로고
    • The role of dynamic conformational ensembles in biomolecular recognition
    • Boehr DD, Nussinov R, Wright PE. The role of dynamic conformational ensembles in biomolecular recognition. Nat Chem Biol 2009; 5: 789-796.
    • (2009) Nat Chem Biol , vol.5 , pp. 789-796
    • Boehr, D.D.1    Nussinov, R.2    Wright, P.E.3
  • 3
    • 70349705654 scopus 로고    scopus 로고
    • Influence of sequence changes and environment on intrinsically disordered proteins
    • Mohan A, Uversky VN, Radivojac P. Influence of sequence changes and environment on intrinsically disordered proteins. PLoS Comput Biol 2009; 5: e1000497.
    • (2009) PLoS Comput Biol , vol.5
    • Mohan, A.1    Uversky, V.N.2    Radivojac, P.3
  • 4
    • 0020490156 scopus 로고
    • Identification of a protein that purifies with the scrapie prion
    • Bolton DC, McKinley MP, Prusiner SB. Identification of a protein that purifies with the scrapie prion. Science 1982; 218: 1309-1311.
    • (1982) Science , vol.218 , pp. 1309-1311
    • Bolton, D.C.1    McKinley, M.P.2    Prusiner, S.B.3
  • 6
    • 77949848854 scopus 로고    scopus 로고
    • Prion-like transmission of protein aggregates in neurodegenerative diseases
    • Brundin P, Melki R, Kopito R. Prion-like transmission of protein aggregates in neurodegenerative diseases. Nat Rev Mol Cell Biol 2010; 11: 301-307.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 301-307
    • Brundin, P.1    Melki, R.2    Kopito, R.3
  • 7
    • 33750142707 scopus 로고    scopus 로고
    • Age-related changes in human crystalline determined from comparative analysis of post-translational modifications in young and aged lens: Does deamidation contribute to crystallin insolubility?
    • DOI 10.1021/pr050473a
    • Wilmarth PA, Tanner S, Dasari S, Nagalla SR, Riviere MA, Bafna V et al. Age-related changes in human crystallins determined from comparative analysis of post-translational modifications in young and aged lens: does deamidation contribute to crystallin insolubility? J Proteome Res 2006; 5: 2554-2566. (Pubitemid 44595158)
    • (2006) Journal of Proteome Research , vol.5 , Issue.10 , pp. 2554-2566
    • Wilmarth, P.A.1    Tanner, S.2    Dasari, S.3    Nagalla, S.R.4    Riviere, M.A.5    Bafha, V.6    Pevzner, P.A.7    David, L.L.8
  • 8
    • 78049277867 scopus 로고    scopus 로고
    • Natural and amyloid self-assembly of S100 proteins: Structural basis of functional diversity
    • Fritz G, Botelho HM, Morozova-Roche LA, Gomes CM. Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity. FEBS J 2010; 277: 4578-4590.
    • (2010) FEBS J , vol.277 , pp. 4578-4590
    • Fritz, G.1    Botelho, H.M.2    Morozova-Roche, L.A.3    Gomes, C.M.4
  • 9
    • 33645978121 scopus 로고    scopus 로고
    • Metabolic syndrome - A new world-wide definition. A Consensus Statement from the International Diabetes Federation
    • Alberti KG, Zimmet P, Shaw J. Metabolic syndrome - a new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabetes Med 2006; 23: 469-480.
    • (2006) Diabetes Med , vol.23 , pp. 469-480
    • Alberti, K.G.1    Zimmet, P.2    Shaw, J.3
  • 10
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the Third National Health and Nutrition Examination Survey
    • Ford ES, Giles WH, Dietz WH. Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey. JAMA 2002; 287: 356-359. (Pubitemid 34251969)
    • (2002) Journal of the American Medical Association , vol.287 , Issue.3 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3
  • 13
    • 7444269499 scopus 로고    scopus 로고
    • Does the metabolic-syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease?
    • DOI 10.2337/diacare.27.11.2676
    • Stern MP, Williams K, Gonzalez-Villalpando C, Hunt KJ, Haffner SM. Does the metabolic syndrome improve identification of individuals at risk of type 2 diabetes and/or cardiovascular disease? Diabetes Care 2004; 27: 2676-2681. (Pubitemid 39441469)
    • (2004) Diabetes Care , vol.27 , Issue.11 , pp. 2676-2681
    • Stern, M.P.1    Williams, K.2    Gonzalez-Villalpando, C.3    Hunt, K.J.4    Haffner, S.M.5
  • 14
    • 4444222221 scopus 로고    scopus 로고
    • Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults
    • DOI 10.1161/01.CIR.0000140677.20606.0E
    • Malik S, Wong ND, Franklin SS, Kamath TV, L'Italien GJ, Pio JR et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004; 110: 1245-1250. (Pubitemid 39202340)
    • (2004) Circulation , vol.110 , Issue.10 , pp. 1245-1250
    • Malik, S.1    Wong, N.D.2    Franklin, S.S.3    Kamath, T.V.4    L'Italien, G.J.5    Pio, J.R.6    Williams, G.R.7
  • 15
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • DOI 10.1016/S0140-6736(05)66378-7
    • Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet 2005; 365: 1415-1428. (Pubitemid 40523737)
    • (2005) Lancet , vol.365 , Issue.9468 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 16
    • 28944446431 scopus 로고    scopus 로고
    • The many faces of PPARgamma
    • Lehrke M, Lazar MA. The many faces of PPARgamma. Cell 2005; 123: 993-999.
    • (2005) Cell , vol.123 , pp. 993-999
    • Lehrke, M.1    Lazar, M.A.2
  • 17
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann JM, Moore LB, Smith-Oliver TA, Wilkison WO, Willson TM, Kliewer SA. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J Biol Chem 1995; 270: 12953-12956.
    • (1995) J Biol Chem , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 18
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • DOI 10.1056/NEJM199810013391403
    • Ristow M, Muller-Wieland D, Pfeiffer A, Krone W, Kahn CR. Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N Engl JMed 1998; 339: 953-959. (Pubitemid 28455097)
    • (1998) New England Journal of Medicine , vol.339 , Issue.14 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 19
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • DOI 10.1038/3099
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, Kuusisto J et al. A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 1998; 20: 284-287. (Pubitemid 28507675)
    • (1998) Nature Genetics , vol.20 , Issue.3 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 20
    • 77954941113 scopus 로고    scopus 로고
    • Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5
    • Choi JH, Banks AS, Estall JL, Kajimura S, Bostrom P, Laznik D et al. Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5. Nature 2010; 466: 451-456.
    • (2010) Nature , vol.466 , pp. 451-456
    • Choi, J.H.1    Banks, A.S.2    Estall, J.L.3    Kajimura, S.4    Bostrom, P.5    Laznik, D.6
  • 21
    • 56749130032 scopus 로고    scopus 로고
    • Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA
    • Chandra V, Huang P, Hamuro Y, Raghuram S, Wang Y, Burris TP et al. Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA. Nature 2008; 456: 350-356.
    • (2008) Nature , vol.456 , pp. 350-356
    • Chandra, V.1    Huang, P.2    Hamuro, Y.3    Raghuram, S.4    Wang, Y.5    Burris, T.P.6
  • 23
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • DOI 10.1016/S1534-5807(02)00131-4
    • Yun Z, Maecker HL, Johnson RS, Giaccia AJ. Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia. Dev Cell 2002; 2: 331-341. (Pubitemid 34266118)
    • (2002) Developmental Cell , vol.2 , Issue.3 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 26
    • 80052313993 scopus 로고    scopus 로고
    • CXCL12 (stromal cell derived factor-1) secretion by preadipocytes is enhanced by short-chain fatty acids acting through a G protein-coupled receptor (GPR41)
    • 2-5 September 2007, Christchurch, New Zealand, 2007
    • Kennedy RL, Thomas L, Garland S, Kazi M. CXCL12 (stromal cell derived factor-1) secretion by preadipocytes is enhanced by short-chain fatty acids acting through a G protein-coupled receptor (GPR41). ESA Annual Scientific Meeting 2007, 2-5 September 2007, Christchurch, New Zealand, 2007.
    • ESA Annual Scientific Meeting 2007
    • Kennedy, R.L.1    Thomas, L.2    Garland, S.3    Kazi, M.4
  • 27
    • 7044263120 scopus 로고    scopus 로고
    • Molecular mechanisms of insulin resistance that impact cardiovascular biology
    • DOI 10.2337/diabetes.53.11.2735
    • Wang CC, Goalstone ML, Draznin B. Molecular mechanisms of insulin resistance that impact cardiovascular biology. Diabetes 2004; 53: 2735-2740. (Pubitemid 39425897)
    • (2004) Diabetes , vol.53 , Issue.11 , pp. 2735-2740
    • Wang, C.C.L.1    Goalstone, M.L.2    Draznin, B.3
  • 29
    • 0032588487 scopus 로고    scopus 로고
    • PPARgamma, the ultimate thrifty gene
    • Auwerx J. PPARgamma, the ultimate thrifty gene. Diabetologia 1999; 42: 1033-1049.
    • (1999) Diabetologia , vol.42 , pp. 1033-1049
    • Auwerx, J.1
  • 30
    • 34548580881 scopus 로고    scopus 로고
    • Long-term risk of cardiovascular events with rosiglitazone: A meta-analysis
    • DOI 10.1001/jama.298.10.1189
    • Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA 2007; 298: 1189-1195. (Pubitemid 47403105)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.10 , pp. 1189-1195
    • Singh, S.1    Loke, Y.K.2    Furberg, C.D.3
  • 31
    • 0034681773 scopus 로고    scopus 로고
    • Thiazolidinediones: An update
    • Schoonjans K, Auwerx J. Thiazolidinediones: an update. Lancet 2000; 355: 1008-1010. (Pubitemid 30148273)
    • (2000) Lancet , vol.355 , Issue.9208 , pp. 1008-1010
    • Schoonjans, K.1    Auwerx, J.2
  • 32
    • 17644404111 scopus 로고    scopus 로고
    • Phosphorylation of GATA2 by akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: A novel pathway linking obesity to atherosclerosis
    • DOI 10.1161/01.CIR.0000161814.02942.B2
    • Menghini R, Marchetti V, Cardellini M, Hribal ML, Mauriello A, Lauro D et al. Phosphorylation of GATA2 by Akt increases adipose tissue differentiation and reduces adipose tissue-related inflammation: a novel pathway linking obesity to atherosclerosis. Circulation 2005; 111: 1946-1953. (Pubitemid 40570214)
    • (2005) Circulation , vol.111 , Issue.15 , pp. 1946-1953
    • Menghini, R.1    Marchetti, V.2    Cardellini, M.3    Hribal, M.L.4    Mauriello, A.5    Lauro, D.6    Sbraccia, P.7    Lauro, R.8    Federici, M.9
  • 33
    • 58649105336 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice
    • e664
    • Menghini R, Menini S, Amoruso R, Fiorentino L, Casagrande V, Marzano V et al. Tissue inhibitor of metalloproteinase 3 deficiency causes hepatic steatosis and adipose tissue inflammation in mice. Gastroenterology 2009; 136: 663-672 e664.
    • (2009) Gastroenterology , vol.136 , pp. 663-672
    • Menghini, R.1    Menini, S.2    Amoruso, R.3    Fiorentino, L.4    Casagrande, V.5    Marzano, V.6
  • 34
    • 70349633646 scopus 로고    scopus 로고
    • TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1
    • Cardellini M, Menghini R, Martelli E, Casagrande V, Marino A, Rizza S et al. TIMP3 is reduced in atherosclerotic plaques from subjects with type 2 diabetes and increased by SirT1. Diabetes 2009; 58: 2396-2401.
    • (2009) Diabetes , vol.58 , pp. 2396-2401
    • Cardellini, M.1    Menghini, R.2    Martelli, E.3    Casagrande, V.4    Marino, A.5    Rizza, S.6
  • 35
    • 77949902266 scopus 로고    scopus 로고
    • Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation
    • Bernot D, Barruet E, Poggi M, Bonardo B, Alessi MC, Peiretti F. Down-regulation of tissue inhibitor of metalloproteinase-3 (TIMP-3) expression is necessary for adipocyte differentiation. J Biol Chem 2010; 285: 6508-6514.
    • (2010) J Biol Chem , vol.285 , pp. 6508-6514
    • Bernot, D.1    Barruet, E.2    Poggi, M.3    Bonardo, B.4    Alessi, M.C.5    Peiretti, F.6
  • 38
    • 46249092554 scopus 로고    scopus 로고
    • GROMACS 4: Algorithms for highly efficient, load-balanced, and scalable molecular simulation
    • Hess B, Kutzner C, van der Spoel D, Lindahl E. GROMACS 4: algorithms for highly efficient, load-balanced, and scalable molecular simulation. J Chem Theory Comput 2008; 4: 435-447.
    • (2008) J Chem Theory Comput , vol.4 , pp. 435-447
    • Hess, B.1    Kutzner, C.2    Van Der Spoel, D.3    Lindahl, E.4
  • 39
    • 33646153295 scopus 로고    scopus 로고
    • FANMOD: A tool for fast network motif detection
    • Wernicke S, Rasche F. FANMOD: a tool for fast network motif detection. Bioinformatics 2006; 22: 1152-1153.
    • (2006) Bioinformatics , vol.22 , pp. 1152-1153
    • Wernicke, S.1    Rasche, F.2


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