Chronic renal failure alters endothelial function in cerebral circulation in mice

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 301, Issue 3, 2011, Pages

  Bugnicourt, Jean Marc ^a,c   da Silveira, Charlène ^a,b   Bengrine, Abderrahmane ^a,b   Godefroy, Olivier ^b,c   Baumbach, Gary ^d   Sevestre, Henri ^b,c   Bode Boeger, Stefanie M ^e   Kielstein, Jan T ^f   Massy, Ziad A ^a,b,c   Chillon, Jean Marc ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ DE PICARDIE JULES VERNE   (France)

^c AMIENS UNIVERSITY HOSPITAL   (France)

^d UNIVERSITY OF IOWA   (United States)

^e OTTO VON GUERICKE UNIVERSITY   (Germany)

^f HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ApoE mice; Endogenous endothelial nitric oxide synthase inhibitors; Endothelium dependent relaxation; Inflammatory markers; Pial vessels

Indexed keywords

APOLIPOPROTEIN E; ARGININE; CAVEOLIN 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN; ROCK 1 PROTEIN; ROCK 2 PROTEIN; SERINE; THREONINE; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOLE; ARTICLE; ATHEROSCLEROSIS; BLOOD SAMPLING; BRAIN CIRCULATION; CELL FUNCTION; CHRONIC KIDNEY FAILURE; CONTROLLED STUDY; DISEASE SEVERITY; ENDOTHELIUM CELL; ENZYME REGULATION; FEMALE; INFLAMMATION; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; VASOCONSTRICTION;

ANALYSIS OF VARIANCE; ANIMALS; APOLIPOPROTEINS E; ARGININE; ARTERIOLES; BLOTTING, WESTERN; CAVEOLIN 1; CEREBROVASCULAR CIRCULATION; CEREBROVASCULAR DISORDERS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; FEMALE; INFLAMMATION MEDIATORS; KIDNEY FAILURE, CHRONIC; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEPHRECTOMY; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; PIA MATER; PPAR GAMMA; RHO-ASSOCIATED KINASES; VASCULAR CELL ADHESION MOLECULE-1; VASODILATION; VASODILATOR AGENTS;

EID: 80052316768     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.01237.2010     Document Type: Article

References (40)

1. Amann K, Neususs R, Ritz E, Irzyniec T, Wiest G, Mall G. Changes of vascular architecture independent of blood pressure in experimental uremia. Am J Hypertens 8: 409-417, 1995.
2. Baumbach GL, Dobrin PB, Hart MN, Heistad DD. Mechanics of cerebral arterioles in hypertensive rats. Circ Res 62: 56-64, 1988.
3. Baumbach GL, Sigmund CD, Faraci FM. Structure of cerebral arterioles in mice deficient in expression of the gene for endothelial nitric oxide synthase. Circ Res 95: 822-829, 2004.
4. Baumbach GL, Walmsley JG, Hart MN. Composition and mechanics of cerebral arterioles in hypertensive rats. Am J Pathol 133: 464-471, 1988.
5. Baylis C. Arginine, arginine analogs and nitric oxide production in chronic kidney disease. Nat Clin Pract Nephrol 2: 209-220, 2006.
6. -/- mice. Front Biosci 17: 2367-2371, 2011.
7. Beyer AM, Baumbach GL, Halabi CM, Modrick ML, Lynch CM, Gerhold TD, Ghoneim SM, de Lange WJ, Keen HL, Tsai YS, Maeda N, Sigmund CD, Faraci FM. Interference with PPARgamma signaling causes cerebral vascular dysfunction, hypertrophy, and remodeling. Hypertension 51: 867-871, 2008.
8. Brian JE Jr, Faraci FM, Moore SA. COX-2-dependent delayed dilatation of cerebral arterioles in response to bradykinin. Am J Physiol Heart Circ Physiol 280: H2023-H2029, 2001.
9. Dayoub H, Rodionov RN, Lynch C, Cooke JP, Arning E, Bottiglieri T, Lentz SR, Faraci FM. Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation. Stroke 39: 180-184, 2008.
10. Faraci FM, Lynch C, Lamping KG. Responses of cerebral arterioles to ADP: eNOS-dependent and eNOS-independent mechanisms. Am J Physiol Heart Circ Physiol 287: H2871-H2876, 2004.
11. Furchgott RF. Role of endothelium in responses of vascular smooth muscle. Circ Res 53: 557-573, 1983.
12. Hand MF, Haynes WG, Webb DJ. Hemodialysis and L-arginine, but not D-arginine, correct renal failure-associated endothelial dysfunction. Kidney Int 53: 1068-1077, 1998.
13. Iseki K, Fukiyama K. Clinical demographics and long-term prognosis after stroke in patients on chronic haemodialysis. The Okinawa Dialysis Study (OKIDS). Group Nephrol Dial Transplant 15: 1808-1813, 2000.
14. Jankowski V, Vanholder R, van der Giet M, Tolle M, Karadogan S, Gobom J, Furkert J, Oksche A, Krause E, Tran TN, Tepel M, Schuchardt M, Schluter H, Wiedon A, Beyermann M, Bader M, Todiras M, Zidek W, Jankowski J. Mass-spectrometric identification of a novel angiotensin peptide in human plasma. Arterioscler Thromb Vasc Biol 27: 297-302, 2007.
15. Ju H, Zou R, Venema VJ, Venema RC. Direct interaction of endothelial nitric-oxide synthase and caveolin-1 inhibits synthase activity. J Biol Chem 272: 18522-18525, 1997.
16. Kielstein JT, Donnerstag F, Gasper S, Menne J, Kielstein A, Martens-Lobenhoffer J, Scalera F, Cooke JP, Fliser D, Bode-Boger SM. ADMA increases arterial stiffness and decreases cerebral blood flow in humans. Stroke 37: 2024-2029, 2006.
17. Kielstein JT, Zoccali C. Asymmetric dimethylarginine: a novel marker of risk and a potential target for therapy in chronic kidney disease. Curr Opin Nephrol Hypertens 17: 609-615, 2008.
18. Kitayama J, Faraci FM, Lentz SR, Heistad DD. Cerebral vascular dysfunction during hypercholesterolemia. Stroke 38: 2136-2141, 2007.
19. Kontos HA, Wei EP, Kukreja RC, Ellis EF, Hess ML. Differences in endothelium-dependent cerebral dilation by bradykinin and acetylcholine. Am J Physiol Heart Circ Physiol 258: H1261-H1266, 1990.
20. Lass P, Buscombe JR, Harber M, Davenport A, Hilson AJ. Cognitive impairment in patients with renal failure is associated with multiple-infarct dementia. Clin Nucl Med 24: 561-565, 1999.
21. London GM. Cardiovascular calcifications in uremic patients: clinical impact on cardiovascular function. J Am Soc Nephrol 14: S305-S309, 2003.
22. London GM, Drueke TB. Atherosclerosis and arteriosclerosis in chronic renal failure. Kidney Int 51: 1678-1695, 1997.
23. London GM, Marchais SJ, Guerin AP, Metivier F, Adda H. Arterial structure and function in end-stage renal disease. Nephrol Dial Transplant 17: 1713-1724, 2002.
24. Maizel J, Six I, Slama M, Tribouilloy C, Sevestre H, Poirot S, Giummelly P, Atkinson J, Choukroun G, Andrejak M, Kamel S, Maziere JC, Massy ZA. Mechanisms of aortic and cardiac dysfunction in uremic mice with aortic calcification. Circulation 119: 306-313, 2009.
25. Martens-Lobenhoffer J, Bode-Boger SM. Fast and efficient determination of arginine, symmetric dimethylarginine, and asymmetric dimethylarginine in biological fluids by hydrophilic-interaction liquid chromatography-electrospray tandem mass spectrometry. Clin Chem 52: 488-493, 2006.
26. Massy ZA, Ivanovski O, Nguyen-Khoa T, Angulo J, Szumilak D, Mothu N, Phan O, Daudon M, Lacour B, Drueke TB, Muntzel MS. Uremia accelerates both atherosclerosis and arterial calcification in apolipoprotein E knockout mice. J Am Soc Nephrol 16: 109-116, 2005.
27. Muntner P, He J, Hamm L, Loria C, Whelton PK. Renal insufficiency and subsequent death resulting from cardiovascular disease in the United States. J Am Soc Nephrol 13: 745-753, 2002.
28. Murray AM. Cognitive impairment in the aging dialysis and chronic kidney disease populations: an occult burden. Adv Chronic Kidney Dis 15: 123-132, 2008.
29. Nakatani T, Naganuma T, Uchida J, Masuda C, Wada S, Sugimura T, Sugimura K. Silent cerebral infarction in hemodialysis patients. Am J Nephrol 23: 86-90, 2003.
30. New DI, Chesser AM, Thuraisingham RC, Yaqoob MM. Structural remodeling of resistance arteries in uremic hypertension. Kidney Int 65: 1818-1825, 2004.
31. Pannier B, Guerin AP, Marchais SJ, Metivier F, Safar ME, London GM. Postischemic vasodilation, endothelial activation, and cardiovascular remodeling in end-stage renal disease. Kidney Int 57: 1091-1099, 2000.
32. Rosenblum WI, McDonald M, Wormley B. Calcium ionophore and acetylcholine dilate arterioles on the mouse brain by different mechanisms. Stroke 20: 1391-1395, 1989.
33. Schiffrin EL, Amiri F, Benkirane K, Iglarz M, Diep QN. Peroxisome proliferator-activated receptors: vascular and cardiac effects in hypertension. Hypertension 42: 664-668, 2003.
34. Segarra G, Medina P, Ballester RM, Lluch P, Aldasoro M, Vila JM, Lluch S, Pelligrino DA. Effects of some guanidino compounds on human cerebral arteries. Stroke 30: 2206-2210, 1999.
35. Seliger SL, Gillen DL, Longstreth WT Jr, Kestenbaum B, Stehman-Breen CO. Elevated risk of stroke among patients with end-stage renal disease. Kidney Int 64: 603-609, 2003.
36. Seliger SL, Siscovick DS, Stehman-Breen CO, Gillen DL, Fitzpatrick A, Bleyer A, Kuller LH. Moderate renal impairment and risk of dementia among older adults: the Cardiovascular Health Cognition Study. J Am Soc Nephrol 15: 1904-1911, 2004.
37. van Guldener C, Janssen MJ, Lambert J, Steyn M, Donker AJ, Stehouwer CD. Endothelium-dependent vasodilatation is impaired in peritoneal dialysis patients. Nephrol Dial Transplant 13: 1782-1786, 1998.
38. Vanholder R, Baurmeister U, Brunet P, Cohen G, Glorieux G, Jankowski J. A bench to bedside view of uremic toxins. J Am Soc Nephrol 19: 863-870, 2008.
39. Vanholder R, Massy Z, Argiles A, Spasovski G, Verbeke F, Lameire N. Chronic kidney disease as cause of cardiovascular morbidity and mortality. Nephrol Dial Transplant 20: 1048-1056, 2005.
40. Wever R, Boer P, Hijmering M, Stroes E, Verhaar M, Kastelein J, Versluis K, Lagerwerf F, van Rijn H, Koomans H, Rabelink T. Nitric oxide production is reduced in patients with chronic renal failure. Arterioscler Thromb Vasc Biol 19: 1168-1172, 1999.