Hypoxic exercise training promotes antitumour cytotoxicity of natural killer cells in young men

Clinical Science

Volumn 121, Issue 8, 2011, Pages 343-353

  Wang, Jong Shyan ^a   Weng, Tzu Pin ^a  

^a CHANG GUNG UNIVERSITY   (Taiwan)

Author keywords

Antitumour cytotoxicity; Exercise; Hypoxia; Natural killer cell; Senescence.

Indexed keywords

CD45RO ANTIGEN; CD57 ANTIGEN; GRANZYME B; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1; PHOSPHATIDYLSERINE;

AEROBIC CAPACITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CONTROLLED STUDY; CYTOTOXICITY; EXERCISE; EXERCISE TEST; HEART RATE; HUMAN; HUMAN CELL; HYPOXIC EXERCISE TRAINING; MALE; NASOPHARYNX CARCINOMA; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION;

ADULT; ANOXIA; ANTINEOPLASTIC AGENTS; BODY MASS INDEX; CELL AGING; CELL DEATH; GLYCOPROTEINS; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; MALE; NEOPLASMS; PERFORIN; PHENOTYPE; RANDOMIZED CONTROLLED TRIALS AS TOPIC; TREATMENT OUTCOME;

EID: 80052313587     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20110032     Document Type: Article

References (31)

1. Moretta, L., Bottino, C., Pende, D., Vitale, M., Mingari, M. C. and Moretta, A. (2005) Human natural killer cells: molecular mechanisms controlling NK cell activation and tumor cell lysis. Immunol. Lett. 100, 7-13
2. Westerlind, K. C. (2003) Physical activity and cancer prevention - mechanisms. Med. Sci. Sports Exercise 35, 1834-1840
3. Fairey, A. S., Courneya, K. S., Field, C. J. and Mackey, J. R. (2002) Physical exercise and immune system function in cancer survivors: a comprehensive review and future directions. Cancer 94, 539-551
4. bright cell distributions during and after intensive training. J. Appl. Physiol. 96, 2167-2173
5. Timmons, B.W. and Cieslak, T. (2008) Human natural killer cell subsets and acute exercise: a brief review. Exercise Immunol. Rev. 14, 8-23
6. Wang, J. S., Wu,M.H., Mao, T. Y., Fu, T. C. andHsu, C. C. (2010) Effects of normoxic and hypoxic exercise trainings on cardiac hemodynamics and perfusion and oxygenation in skeletal muscle and cerebral tissue in men. J. Appl. Physiol. 109, 219-229
7. Wang, J. S. and Wu, C. K. (2009) Systemic hypoxia affects exercise-mediated antitumor cytotoxicity of natural killer cells. J. Appl. Physiol. 107, 1817-1824
8. Lanier, L. L. (2003) Natural killer cell receptor signaling. Curr. Opin. Immunol. 15, 308-314
9. Smyth, M. J., Cretney, E., Kelly, J. M., Westwood, J. A., Street, S. E., Yagita, H., Takeda, K., van Dommelen, S. L., Degli-Esposti, M. A. and Hayakawa, Y. (2005) Activation of NK cell cytotoxicity. Mol. Immunol. 42, 501-510
10. Trapani, J. A. and Smyth, M. J. (2002) Functional significance of the perforin/granzyme cell death pathway. Nat. Rev. Immunol. 2, 735-747
11. Wang, J. S., Lin, H. Y., Cheng, M. L. and Wong, M. K. (2007) Chronic intermittent hypoxia modulates eosinophil- and neutrophil-platelet aggregation and inflammatory cytokine secretion caused by strenuous exercise in men. J. Appl. Physiol. 103, 305-314
12. Thompson, W. R., Gordon, N. F. and Pescatello, L. S. (2009) General principle of exercise prescription. In ACSM's Guidelines for Exercise Testing and Prescription. 8th edn, pp. 152-182, Lippincott Williams & Wilkins, Philadelphia, PA
13. Wang, J. S., Chung, Y. and Chow, S. E. (2009) Exercise paradoxically modulates platelet-impeded apoptosis of nasopharyngeal carcinoma by natural killer cell. Med. Sci. Sports Exercise 41, 115-122
14. Nausch, N. and Cerwenka, A. (2008) NKG2D ligands in tumor immunity. Oncogene 27, 5944-5958
15. Ito, M., Maruyama, T., Saito, N., Koganei, S., Yamamoto, K. and Matsumoto, N. (2006) Killer cell lectin-like receptor G1 binds three members of the classical cadherin family to inhibit NK cell cytotoxicity. J. Exp. Med. 203, 289-295
16. Huntington, N. D., Tabarias, H., Fairfax, K., Brady, J., Hayakawa, Y., Degli-Esposti, M. A., Smyth, M. J., Tarlinton, D. M. and Nutt, S. L. (2007) NK cell maturation and peripheral homeostasis is associated with KLRG1 up-regulation. J. Immunol. 178, 4764-4770
17. + NK-cell subset. Blood 116, 3865-3874
18. Sun, J. C., Beilke, J. N. and Lanier, L. L. (2010) Immune memory redefined: characterizing the longevity of natural killer cells. Immunol. Rev. 236, 83-94
19. Voehringer, D., Koschella, M. and Pircher, H. (2002) Lack of proliferative capacity of human effector and memory T cells expressing killer cell lectin like receptor G1 (KLRG1). Blood 100, 3698-3702
20. Simpson, R. J., Florida-James, G. D., Cosgrove, C., Whyte, G. P., Macrae, S., Pircher, H. and Guy, K. (2007) High-intensity exercise elicits the mobilization of senescent T lymphocytes into the peripheral blood compartment in human subjects. J. Appl. Physiol. 103, 396-401
21. Timmons, B.W., Tarnopolsky, M. A. and Bar-Or, O. (2006) Sex-based effects on the distribution of NK cell subsets in response to exercise and carbohydrate intake in adolescents. J. Appl. Physiol. 100, 1513-1519
22. Timmons, B.W. and Bar-Or, O. (2007) Evidence of sex-based differences in natural killer cell responses to exercise and carbohydrate intake in children. Eur. J. Appl. Physiol. 101, 233-240
23. Senju, M., Makiyama, K., Hara, K., Hulstaert, F., Lowder, J. N. and Jewell, D. P. (1991) Two-color immunofluorescence and flow cytometric analysis of peripheral blood lymphocyte subsets in Caucasian and Japanese healthy subjects. Jpn. J. Med. 30, 509-515
24. Farag, S. S. and Caligiuri, M. A. (2006) Human natural killer cell development and biology. Blood Rev. 20, 123-137
25. Nieman, D. C., Buckley, K. S., Henson, D. A., Warren, B. J., Suttles, J., Ahle, J. C., Simandle, S., Fagoaga, O. R. and Nehlsen-Cannarella, S. L. (1995) Immune function in marathon runners versus sedentary controls. Med. Sci. Sports Exercise 27, 986-992
26. Woods, J. A., Davis, J. M., Smith, J. A. and Nieman, D. C. (1999) Exercise and cellular innate immune function. Med. Sci. Sports Exercise 31, 57-66
27. Pedersen, B. K. and Hoffman-Goetz, L. (2000) Exercise and the immune system: regulation, integration, and adaptation. Physiol. Rev. 80, 1055-1081
28. Campbell, P. T.,Wener, M. H., Sorensen, B., Wood, B., Chen-Levy, Z., Potter, J. D., McTiernan, A. and Ulrich, C. M. (2008) Effect of exercise on in vitro immune function: a 12-month randomized, controlled trial among postmenopausal women. J. Appl. Physiol. 104, 1648-1655
29. Facco, M., Zilli, C., Siviero, M., Ermolao, A., Travain, G., Baesso, I., Bonamico, S., Cabrelle, A., Zaccaria, M. and Agostini, C. (2005) Modulation of immune response by the acute and chronic exposure to high altitude. Med. Sci. Sports Exercise 37, 768-774
30. Campbell, J. P., Guy, K., Cosgrove, C., Florida-James, G. D. and Simpson, R. J. (2008) Total lymphocyte CD8 expression is not a reliable marker of cytotoxic T-cell populations in human peripheral blood following an acute bout of high-intensity exercise. Brain Behav. Immun. 22, 375-380
31. Metelitsa, L. S., Naidenko, O. V., Kant, A., Wu, H. W., Loza, M. J., Perussia, B., Kronenberg, M. and Seeger, R. C. (2001) Human NKT cells mediate antitumor cytotoxicity directly by recognizing target cell CD1d with bound ligand or indirectly by producing IL-2 to activate NK cells. J. Immunol. 167, 3114-3122