Synthesis and cytotoxic evaluation of eremophilane sesquiterpene 07H239-A derivatives

Chemical and Pharmaceutical Bulletin

Volumn 59, Issue 9, 2011, Pages 1186-1189

  Song, Yong Xiang ^a   Cheng, Bin ^a   Zhu, Xun ^a   Qiao, Li Tao ^a   Wang, Jia Jian ^a   Gu, Yu Cheng ^b   Li, Meng Feng ^a   Liu, Lan ^a   Lin, Yong Cheng ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

Author keywords

Amidation; Cytotoxicity; Sesquiterpene; Structure activity relationship

Indexed keywords

4 (6,8 DIMETHYLDECA 2,4 DIENOYLOXY) 8A METHYL 6 OXO 7 (3 OXOPROP 1 EN 2 YL) 1,2,3,4,6,7,8,8A OCTAHYDRONAPHTHALENE 1 CARBOXYLIC ACID; [4 (1 METHOXY 1 OXOPROPAN 2 YLCARBAMOYL) 4A METHYL 7 OXO 6 (3 OXOPROP 1 EN 2 YL) 1,2,3,4,4A,5,6,7 OCTAHYDRONAPHTHALEN 1 YL] 6,8 DIMETHYLDECA 2,4 DIENOATE; [4 (1 METHOXY 3 METHYL 1 OXOBUTAN 2 YLCARBAMOYL) 4A METHYL 7 OXO 6 (3 OXOPROP 1 EN 2 YL) 1,2,3,4,4A,5,6,7 OCTAHYDRONAPHTHALEN 1 YL] 6,8 DIMETHYLDECA 2,4 DIENOATE; [4 (1 METHOXY 4 METHYL 1 OXOPENTAN 2 YLCARBAMOYL) 4A METHYL 7 OXO 6 (3 OXOPROP 1 EN 2 YL) 1,2,3,4,4A,5,6,7 OCTAHYDRONAPHTHALEN 1 YL] 6,8 DIMETHYLDECA 2,4 DIENOATE; [4 (2 METHOXY 2 OXOETHYLCARBAMOYL) 4A METHYL 7 OXO 6 (3 OXOPROP 1 EN 2 YL) 1,2,3,4,4A,5,6,7 OCTAHYDRONAPHTHALEN 1 YL] 6,8 DIMETHYLDECA 2,4 DIENOATE; EPIRUBICIN; EREMOPHILANE DERIVATIVE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

AMIDATION; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAPHTHALENES; SESQUITERPENES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 80052301094     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.59.1186     Document Type: Article

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