07H239-A, a new cytotoxic eremophilane sesquiterpene from the marine-derived xylariaceous fungus LL-07H239

Journal of Natural Products

Volumn 67, Issue 9, 2004, Pages 1565-1567

  McDonald, Leonard A ^a   Barbieri, Laurel R ^a   Bernan, Valerie S ^a   Janso, Jeffrey ^a   Lassota, Peter ^a,b   Carter, Guy T ^a  

^a WYETH RESEARCH   (United States)

^b NOVARTIS PHARMA AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

07H239 A; EREMOPHILANE SESQUITERPENE; O7H239 A; SESQUITERPENE; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CYTOTOXICITY; FERMENTATION; FUNGUS; HUMAN; HUMAN CELL; LEUKEMIA CELL; MYCELIUM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; XYLARIACEOUS FUNGUS LL 07H239;

ANTINEOPLASTIC AGENTS; ASCOMYCOTA; DRUG SCREENING ASSAYS, ANTITUMOR; FATTY ACIDS, UNSATURATED; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; NAPHTHALENES; SESQUITERPENES; TUMOR CELLS, CULTURED;

FUNGI;

EID: 4644311703     PISSN: 01633864     EISSN: None     Source Type: Journal    
DOI: 10.1021/np049924g     Document Type: Article

References (10)

1. The microorganism, isolated from a Nypa (mangrove palm) frond in Kuala Selangor, Malaysia, was supplied by Dr. Gareth Jones. Subsequent comparison of the ITS region with GenBank sequences revealed that LL-07H239 is a member of the Xylariaceae. Both the xylarenals (ref 3) and integric acid (ref 6) were reported from Xylaria sp. fungi.
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