Gastric cytoprotective activity of ilicic aldehyde: Structure-activity relationships

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 15, 2005, Pages 3547-3550

  Donadel, Osvaldo J ^a   Guerreiro, Eduardo ^a   María, Alejandra O ^a   Wendel, Graciela ^a   Enriz, Ricardo D ^a   Giordano, Oscar S ^a   Tonn, Carlos E ^a  

^a UNIVERSIDAD NACIONAL DE SAN LUIS   (Argentina)

Author keywords

Eremophilane; Eudesmane; Gastric cytoprotection; Ilicic aldehyde; Sesquiterpenes

Indexed keywords

ALDEHYDE; ANTIULCER AGENT; ILICIC ALDEHYDE; SESQUITERPENE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CELL PROTECTION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; GASTROINTESTINAL TRACT; MALE; MOLECULAR DYNAMICS; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-ULCER AGENTS; GASTROINTESTINAL TRACT; MALE; RATS; RATS, WISTAR; SESQUITERPENES; STOMACH ULCER; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS NORVEGICUS;

EID: 21744457229     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.05.053     Document Type: Article

References (22)

1. A.K. Picman Biochem. Syst. Ecol. 14 1986 256
2. O.S. Giordano, M.J. Pestchanker, E. Guerreiro, J.R. Saad, R.D. Enriz, A.M. Rodríguez, E.A. Jauregui, J. Guzmán, A.O. María, and G. Wendel J. Med. Chem. 35 1992 2452
3. S. Szabó, J.S. Trier, and P.W. Frankel Science 214 1981 200
4. A.M. Rodríguez, R.D. Enriz, L.N. Santágata, E.A. Jáuregui, M.J. Pestchanker, and O.S. Giordano J. Med. Chem. 40 1997 1827
5. E. Guerreiro, J. Kavka, O.S. Giordano, and E. Gros Phytochemistry 18 1979 1235
6. M.B. Kurina Sanz, O.J. Donadel, P.C. Rossomando, C.E. Tonn, and E. Guerreiro Phytochemistry 44 1997 897
7. M.H. Abu Zarga, E.M. Hamed, S.S. Sabri, W. Voelter, and K.P. Zeller J. Nat. Prod. 61 1998 798
8. +, 28] 238, 223, 220, 205, 202, 187, 162, 147, 135
9. 3), 125.75, 149.13, 42.04, 35.84, 40.29, 39.43, 32.39, 29.26, 28.86, 173.59, 143.81, 171.64, 125.30, 19.08, 15.35
10. O.J. Donadel, E.E. García, E. Guerreiro, and C.E. Tonn An. Asoc. Quim. Argent. 86 1998 90
11. O.J. Donadel, E. Guerreiro, and C.E. Ardanáz Rapid Commun. Mass Spectrom. 15 2001 164
12. Denny, R. W.; Nickon, A. In Organic Reactions, Wiley: New York, 1973; Vol. 20, pp 133-336.
13. C. Zdero, F. Bohlmann, A. Anderberg, and R.M. King Phytochemistry 30 1991 2643
14. Fieser, L. F.; Fieser, M. In Reagents for Organic Synthesis, Wiley: New York, 1967; Vol. 1, pp 142-144.
15. A.G. González, J. Bermejo Barrera, J.T. Méndez, M. López Sánchez, and J.L. Eiroa Martínez Phytochemistry 31 1992 1816
16. F. Bohlmann, N. Ates (Gören), and J. Jakupovic Phytochemistry 22 1983 1159
17. S. Öküz, and G.A. Topçu Phytochemistry 31 1992 195
18. J.G. Urones, I.S. Marcos, P. Basabe, A. Giménez, A. González, and A.M. Lithgow Phytochemistry 38 1995 443
19. O.S. Giordano, E. Guerreiro, J. Romo, and M.I. Jiménez Rev. Latinoamer. Quim. 6 1979 131
20. A. Robert, J.E. Nezamis, C. Lancaster, and A. Hencher J. Gastroenterol. 77 1979 433
21. C. Blandazzi, G. Gherardi, C. Marveggio, G. Natale, D. Carignani, and M. Del Tacca Digestion 56 1995 220
22. 2O. The organic layers were dried, evaporated at low temperature, and subjected to analysis by GC-MS. The results showed that the quantitative hydrolysis of compound 12 to 8 was completed after 2 h