Atorvastatin protects against ischemia-reperfusion injury in fructose-induced insulin resistant rats

Cardiovascular Drugs and Therapy

Volumn 25, Issue 4, 2011, Pages 285-297

  Prakash, Prem ^a   Khanna, Vivek ^a   Singh, Vishal ^a   Jyoti, Anupam ^a   Jain, Manish ^a   Keshari, Ravi Shankar ^a   Barthwal, Manoj Kumar ^a   Dikshit, Madhu ^a  

^a CENTRAL DRUG RESEARCH INSTITUTE   (India)

Author keywords

Akt Nitric Oxide Synthase (NOS); Atorvastatin; Endothelial Dysfunction; High fructose diet; Insulin Resistance Syndrome; Myocardial Ischemia Reperfusion Injury

Indexed keywords

ATORVASTATIN; C REACTIVE PROTEIN; CREATINE KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FRUCTOSE; GAMMA INTERFERON; GLUCOSE; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; LACTATE DEHYDROGENASE; MALONALDEHYDE; MYELOPEROXIDASE; NITRITE; PROTEIN KINASE B; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR;

ACUTE CORONARY SYNDROME; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE DIET; CARBOHYDRATE INTAKE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HEART INFARCTION SIZE; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; INSULIN RESISTANCE; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY; TREATMENT DURATION; WISTAR RAT;

ANIMALS; ENDOTHELIUM, VASCULAR; FRUCTOSE; HEPTANOIC ACIDS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INSULIN RESISTANCE; MALE; NITRIC OXIDE SYNTHASE; NITRITES; OXIDATIVE STRESS; PROTO-ONCOGENE PROTEINS C-AKT; PYRROLES; RATS; RATS, WISTAR; REPERFUSION INJURY;

EID: 80052287778     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6312-x     Document Type: Article

References (64)

1. GM Reaven 2003 Insulin resistance/compensatory hyperinsulinemia, essential hypertension, and cardiovascular disease J Clin Endocrinol Metab 88 2399 403 12788834 10.1210/jc.2003-030087 1:CAS:528:DC%2BD3sXkslCktbw%3D (Pubitemid 36724403)
2. L Cai W Li G Wang L Guo Y Jiang YJ Kang 2002 Hyperglycemia-induced apoptosis in mouse myocardium: mitochondrial cytochrome C-mediated caspase-3 activation pathway Diabetes 51 1938 48 12031984 10.2337/diabetes.51.6.1938 1:CAS:528:DC%2BD38XktlSktbc%3D (Pubitemid 34564309)
3. U Rajamani MF Essop 2010 Hyperglycemia-mediated activation of the hexosamine biosynthetic pathway results in myocardial apoptosis Am J Physiol Cell Physiol 299 C139 47 20410435 10.1152/ajpcell.00020.2010 1:CAS:528:DC%2BC3cXpslSgsLo%3D
4. A Miller K Adeli 2008 Dietary fructose and the metabolic syndrome Curr Opin Gastroenterol 24 204 9 18301272 10.1097/MOG.0b013e3282f3f4c4 1:CAS:528:DC%2BD1cXisVelur4%3D (Pubitemid 351322788)
5. SM Haffner S Lehto T Ronnemaa K Pyorala M Laakso 1998 Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction N Engl J Med 339 229 34 9673301 10.1056/NEJM199807233390404 1:STN:280:DyaK1czivVKgsg%3D%3D (Pubitemid 28350165)
6. P Bressler SR Bailey M Matsuda RA DeFronzo 1996 Insulin resistance and coronary artery disease Diabetologia 39 1345 50 8933003 10.1007/s001250050581 1:CAS:528:DyaK28XmvFCjtrk%3D (Pubitemid 26356065)
7. E Cho EB Rimm MJ Stampfer WC Willett FB Hu 2002 The impact of diabetes mellitus and prior myocardial infarction on mortality from all causes and from coronary heart disease in men J Am Coll Cardiol 40 954 60 12225722 10.1016/S0735-1097(02)02044-2 (Pubitemid 34994991)
8. R Marfella M D'Amico C Di Filippo E Piegari F Nappo K Esposito, et al. 2002 Myocardial infarction in diabetic rats: role of hyperglycaemia on infarct size and early expression of hypoxia-inducible factor 1 Diabetologia 45 1172 81 12189448 10.1007/s00125-002-0882-x 1:CAS:528:DC%2BD38Xmt1Shs7o%3D (Pubitemid 34985294)
9. JE Jordan SA Simandle CD Tulbert DW Busija AW Miller 2003 Fructose-fed rats are protected against ischemia/reperfusion injury J Pharmacol Exp Ther 307 1007 11 14534360 10.1124/jpet.103.055970 1:CAS:528:DC%2BD3sXpslShsb8%3D (Pubitemid 37494219)
10. PJ Hanley KV Gopalan RA Lareau DK Srivastava M von Meltzer J Daut 2003 Beta-oxidation of 5-hydroxydecanoate, a putative blocker of mitochondrial ATP-sensitive potassium channels J Physiol 547 387 93 12562916 10.1113/jphysiol.2002.037044 1:CAS:528:DC%2BD3sXivFSrt7g%3D (Pubitemid 36304972)
11. M Das JE Parker AP Halestrap 2003 Matrix volume measurements challenge the existence of diazoxide/glibencamide-sensitive KATP channels in rat mitochondria J Physiol 547 893 902 12562892 10.1113/jphysiol.2002.035006 1:CAS:528:DC%2BD3sXjt1Slt78%3D (Pubitemid 36367370)
12. S Morel C Berthonneche S Tanguy MC Toufektsian P Perret C Ghezzi, et al. 2005 Early pre-diabetic state alters adaptation of myocardial glucose metabolism during ischemia in rats Mol Cell Biochem 272 9 17 16010967 10.1007/s11010-005- 4778-1 1:CAS:528:DC%2BD2MXjvV2ktbw%3D (Pubitemid 40867360)
13. DJ Chess B Lei BD Hoit AM Azimzadeh WC Stanley 2007 Deleterious effects of sugar and protective effects of starch on cardiac remodeling, contractile dysfunction, and mortality in response to pressure overload Am J Physiol Heart Circ Physiol 293 H1853 60 17616744 10.1152/ajpheart.00544.2007 1:CAS:528:DC%2BD2sXhtVOqtrjK (Pubitemid 47367235)
14. CX Zhao X Xu Y Cui P Wang X Wei S Yang, et al. 2009 Increased endothelial nitric-oxide synthase expression reduces hypertension and hyperinsulinemia in fructose-treated rats J Pharmacol Exp Ther 328 610 20 19008412 10.1124/jpet.108.143396 1:CAS:528:DC%2BD1MXhs1Kgsrk%3D
15. Y Nagai S Yonemitsu DM Erion T Iwasaki R Stark D Weismann, et al. 2009 The role of peroxisome proliferator-activated receptor gamma coactivator-1 beta in the pathogenesis of fructose-induced insulin resistance Cell Metab 9 252 64 19254570 10.1016/j.cmet.2009.01.011 1:CAS:528:DC%2BD1MXntlSjsrk%3D
16. F Gao E Gao TL Yue EH Ohlstein BL Lopez TA Christopher, et al. 2002 Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation Circulation 105 1497 502 11914261 10.1161/01.CIR. 0000012529.00367.0F 1:CAS:528:DC%2BD38XjsVyrtbc%3D (Pubitemid 34263284)
17. DJ Hausenloy DM Yellon 2004 New directions for protecting the heart against ischaemia-reperfusion injury: targeting the Reperfusion Injury Salvage Kinase (RISK)-pathway Cardiovasc Res 61 448 60 14962476 10.1016/j.cardiores. 2003.09.024 1:CAS:528:DC%2BD2cXhtFWmsL8%3D (Pubitemid 38210151)
18. S Atar Y Ye Y Lin SY Freeberg SP Nishi S Rosanio, et al. 2006 Atorvastatin-induced cardioprotection is mediated by increasing inducible nitric oxide synthase and consequent S-nitrosylation of cyclooxygenase-2 Am J Physiol Heart Circ Physiol 290 H1960 8 16339820 10.1152/ajpheart.01137.2005 1:CAS:528:DC%2BD28XkvFSmsbc%3D
19. RM Bell DM Yellon 2003 Atorvastatin, administered at the onset of reperfusion, and independent of lipid lowering, protects the myocardium by up-regulating a pro-survival pathway J Am Coll Cardiol 41 508 15 12575984 10.1016/S0735-1097(02)02816-4 1:CAS:528:DC%2BD3sXhvFCitbg%3D (Pubitemid 36164511)
20. Singh V, Jain M, Prakash P, Misra A, Khanna V, Tiwari RL, et al. A time course study on prothrombotic parameters and their modulation by anti-platelet drugs in hyperlipidemic hamsters. J Physiol Biochem. 2011; Feb 1.
21. IS Hwang H Ho BB Hoffman GM Reaven 1987 Fructose-induced insulin resistance and hypertension in rats Hypertension 10 512 6 3311990 1:CAS:528:DyaL1cXjs1KhtA%3D%3D (Pubitemid 18011228)
22. AW Miller PV Katakam MR Ujhelyi 1999 Impaired endothelium-mediated relaxation in coronary arteries from insulin-resistant rats J Vasc Res 36 385 92 10559679 10.1159/000025678 1:CAS:528:DyaK1MXnsVykurc%3D (Pubitemid 29513660)
23. LT Tran VG Yuen JH McNeill 2009 The fructose-fed rat: a review on the mechanisms of fructose-induced insulin resistance and hypertension Mol Cell Biochem 332 145 59 19536638 10.1007/s11010-009-0184-4 1:CAS:528: DC%2BD1MXhtlKjs7zO
24. RJ Johnson SE Perez-Pozo YY Sautin J Manitius LG Sanchez-Lozada DI Feig, et al. 2009 Hypothesis: could excessive fructose intake and uric acid cause type 2 diabetes? Endocr Rev 30 96 116 19151107 10.1210/er.2008-0033 1:CAS:528:DC%2BD1MXjt1eqsrw%3D
25. R Rodriguez-Calvo E Barroso L Serrano T Coll RM Sanchez M Merlos, et al. 2009 Atorvastatin prevents carbohydrate response element binding protein activation in the fructose-fed rat by activating protein kinase A Hepatology 49 106 15 19053045 10.1002/hep.22570 1:CAS:528:DC%2BD1MXhsFGlt7c%3D
26. AM Stranahan ED Norman K Lee RG Cutler RS Telljohann JM Egan, et al. 2008 Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats Hippocampus 18 1085 8 18651634 10.1002/hipo.20470
27. Panchal S, Poudyal H, Iyer A, Nazer R, Alam A, Diwan V, et al. High carbohydrate-high fat diet-induced metabolic syndrome and cardiovascular remodeling in rats. J Cardiovasc Pharmacol. 2010;Oct 14.
28. H Awasthi S Tota K Hanif C Nath R Shukla 2010 Protective effect of curcumin against intracerebral streptozotocin induced impairment in memory and cerebral blood flow Life Sci 86 87 94 19925811 10.1016/j.lfs.2009.11.007 1:CAS:528:DC%2BC3cXjtlOmsg%3D%3D
29. Y Nakaya A Minami N Harada S Sakamoto Y Niwa M Ohnaka 2000 Taurine improves insulin sensitivity in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous type 2 diabetes Am J Clin Nutr 71 54 8 10617946 1:CAS:528:DC%2BD3cXlsFGmtQ%3D%3D (Pubitemid 30033584)
30. MI Colado E O'Shea R Granados A Misra TK Murray AR Green 1997 A study of the neurotoxic effect of MDMA ('ecstasy') on 5-HT neurones in the brains of mothers and neonates following administration of the drug during pregnancy Br J Pharmacol 121 827 33 9208155 10.1038/sj.bjp.0701201 1:CAS:528:DyaK2sXktF2ltrk%3D (Pubitemid 27260791)
31. D Giustarini R Rossi A Milzani I Dalle-Donne 2008 Nitrite and nitrate measurement by Griess reagent in human plasma: evaluation of interferences and standardization Methods Enzymol 440 361 80 18423230 10.1016/S0076-6879(07)00823- 3 1:CAS:528:DC%2BD1cXntF2hsLc%3D
32. Y Ye Y Lin S Atar MH Huang JR Perez-Polo BF Uretsky, et al. 2006 Myocardial protection by pioglitazone, atorvastatin, and their combination: mechanisms and possible interactions Am J Physiol Heart Circ Physiol 291 H1158 69 16603698 10.1152/ajpheart.00096.2006 1:CAS:528:DC%2BD28XhtVSksrjO (Pubitemid 44343659)
33. G Graff DA Gamache MT Brady JM Spellman JM Yanni 1998 Improved myeloperoxidase assay for quantitation of neutrophil influx in a rat model of endotoxin-induced uveitis J Pharmacol Toxicol Methods 39 169 78 9741392 10.1016/S1056-8719(98)00023-9 1:CAS:528:DyaK1cXns1SgsL8%3D (Pubitemid 28448798)
34. P Prakash A Misra WR Surin M Jain RS Bhatta R Pal, et al. 2011 Anti-platelet effects of Curcuma oil in experimental models of myocardial ischemia-reperfusion and thrombosis Thromb Res 127 111 8 21144557 10.1016/j.thromres.2010.11.007 1:CAS:528:DC%2BC3MXhtVartrY%3D
35. SA Raghavan M Dikshit 2001 L-citrulline mediated relaxation in the control and lipopolysaccharide-treated rat aortic rings Eur J Pharmacol 431 61 9 11716844 10.1016/S0014-2999(01)01407-8 1:CAS:528:DC%2BD3MXosFOjt7w%3D (Pubitemid 33082153)
36. S Rosanio Y Ye S Atar AM Rahman SY Freeberg MH Huang, et al. 2006 Enhanced cardioprotection against ischemia-reperfusion injury with combining sildenafil with low-dose atorvastatin Cardiovasc Drugs Ther 20 27 36 16435070 10.1007/s10557-005-5203-4 1:CAS:528:DC%2BD28XktVSgtrs%3D
37. P Di Napoli AA Taccardi A Grilli MA De Lutiis A Barsotti M Felaco, et al. 2005 Chronic treatment with rosuvastatin modulates nitric oxide synthase expression and reduces ischemia-reperfusion injury in rat hearts Cardiovasc Res 66 462 71 15914111 10.1016/j.cardiores.2005.02.008 (Pubitemid 40725758)
38. SV Penumathsa M Thirunavukkarasu S Koneru B Juhasz L Zhan R Pant, et al. 2007 Statin and resveratrol in combination induces cardioprotection against myocardial infarction in hypercholesterolemic rat J Mol Cell Cardiol 42 508 16 17188708 10.1016/j.yjmcc.2006.10.018 1:CAS:528:DC%2BD2sXislKhu7k%3D (Pubitemid 46349117)
39. U Laufs V La Fata J Plutzky JK Liao 1998 Upregulation of endothelial nitric oxide synthase by HMG CoA reductase inhibitors Circulation 97 1129 35 9537338 1:CAS:528:DyaK1cXisVWmsrY%3D (Pubitemid 28152885)
40. AY Kolyada A Fedtsov NE Madias 2001 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors upregulate inducible NO synthase expression and activity in vascular smooth muscle cells Hypertension 38 1024 9 11711492 10.1161/hy1101.093103 1:CAS:528:DC%2BD3MXovVOrsL0%3D (Pubitemid 34252800)
41. R Bolli 2001 Cardioprotective function of inducible nitric oxide synthase and role of nitric oxide in myocardial ischemia and preconditioning: an overview of a decade of research J Mol Cell Cardiol 33 1897 918 11708836 10.1006/jmcc.2001.1462 1:CAS:528:DC%2BD3MXot12gs7k%3D (Pubitemid 33097270)
42. JA Kim M Montagnani KK Koh MJ Quon 2006 Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms Circulation 113 1888 904 16618833 10.1161/CIRCULATIONAHA.105.563213 (Pubitemid 43739401)
43. E Cersosimo RA DeFronzo 2006 Insulin resistance and endothelial dysfunction: the road map to cardiovascular diseases Diabetes Metab Res Rev 22 423 36 16506274 10.1002/dmrr.634 1:CAS:528:DC%2BD28Xhtlemu7%2FN (Pubitemid 44774046)
44. RM Bell DM Yellon 2001 The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: the lowering of the preconditioning threshold. An investigation in eNOS knockout mice Cardiovasc Res 52 274 80 11684075 10.1016/S0008-6363(01)00394-7 1:CAS:528:DC%2BD3MXnvFCqsb4%3D (Pubitemid 33000404)
45. S Dimmeler I Fleming B Fisslthaler C Hermann R Busse AM Zeiher 1999 Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation Nature 399 601 5 10376603 10.1038/21224 1:CAS:528: DyaK1MXjvFegu7s%3D (Pubitemid 29279182)
46. Y Higashi K Noma M Yoshizumi Y Kihara 2009 Endothelial function and oxidative stress in cardiovascular diseases Circ J 73 411 8 19194043 10.1253/circj.CJ-08-1102 1:CAS:528:DC%2BD1MXjvFOru7k%3D
47. A Ceriello L Quagliaro M D'Amico C Di Filippo R Marfella F Nappo, et al. 2002 Acute hyperglycemia induces nitrotyrosine formation and apoptosis in perfused heart from rat Diabetes 51 1076 82 11916928 10.2337/diabetes.51.4.1076 1:CAS:528:DC%2BD38Xis1Oju70%3D (Pubitemid 34438352)
48. CK Roberts ND Vaziri RK Sindhu RJ Barnard 2003 A high-fat, refined-carbohydrate diet affects renal NO synthase protein expression and salt sensitivity J Appl Physiol 94 941 6 12433862 1:CAS:528:DC%2BD3sXitVyltbo%3D (Pubitemid 36232007)
49. CK Roberts ND Vaziri Z Ni RJ Barnard 2002 Correction of long-term diet-induced hypertension and nitrotyrosine accumulation by diet modification Atherosclerosis 163 321 7 12052479 10.1016/S0021-9150(02)00010-2 1:CAS:528:DC%2BD38XktFOnsbY%3D (Pubitemid 34615823)
50. H Li A Samouilov X Liu JL Zweier 2001 Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrite reduction. Evaluation of its role in nitric oxide generation in anoxic tissues J Biol Chem 276 24482 9 11312267 10.1074/jbc.M011648200 1:CAS:528:DC%2BD3MXlt1agsrk%3D
51. H Li A Samouilov X Liu JL Zweier 2003 Characterization of the magnitude and kinetics of xanthine oxidase-catalyzed nitrate reduction: evaluation of its role in nitrite and nitric oxide generation in anoxic tissues Biochemistry 42 1150 9 12549937 10.1021/bi026385a 1:CAS:528:DC%2BD3sXlsFOk (Pubitemid 36159550)
52. JW Calvert DJ Lefer 2009 Myocardial protection by nitrite Cardiovasc Res 83 195 203 19251721 10.1093/cvr/cvp079 1:CAS:528:DC%2BD1MXnvVOktr8%3D
53. S Shiva MN Sack JJ Greer M Duranski LA Ringwood L Burwell, et al. 2007 Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer J Exp Med 204 2089 102 17682069 10.1084/jem.20070198 1:CAS:528:DC%2BD2sXhtVWnurjL (Pubitemid 47360871)
54. SJ Cleland N Sattar JR Petrie NG Forouhi HL Elliott JM Connell 2000 Endothelial dysfunction as a possible link between C-reactive protein levels and cardiovascular disease Clin Sci (Lond) 98 531 5 10.1042/CS20000013 1:CAS:528:DC%2BD3cXktVOkt74%3D (Pubitemid 30261001)
55. SK Venugopal S Devaraj I Yuhanna P Shaul I Jialal 2002 Demonstration that C-reactive protein decreases eNOS expression and bioactivity in human aortic endothelial cells Circulation 106 1439 41 12234944 10.1161/01.CIR.0000033116. 22237.F9 1:CAS:528:DC%2BD38XntVKksLg%3D
56. FC McGillicuddy EH Chiquoine CC Hinkle RJ Kim R Shah HM Roche, et al. 2009 Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway J Biol Chem 284 31936 44 19776010 10.1074/jbc.M109.061655 1:CAS:528: DC%2BD1MXhtlyjsLbK
57. V Rotter I Nagaev U Smith 2003 Interleukin-6 (IL-6) induces insulin resistance in 3T3-L1 adipocytes and is, like IL-8 and tumor necrosis factor-alpha, overexpressed in human fat cells from insulin-resistant subjects J Biol Chem 278 45777 84 12952969 10.1074/jbc.M301977200 1:CAS:528: DC%2BD3sXosl2itrs%3D (Pubitemid 37432722)
58. F Kim B Gallis MA Corson 2001 TNF-alpha inhibits flow and insulin signaling leading to NO production in aortic endothelial cells Am J Physiol Cell Physiol 280 C1057 65 11287317 1:CAS:528:DC%2BD3MXjsVaitbg%3D
59. DM Yellon DJ Hausenloy 2007 Myocardial reperfusion injury N Engl J Med 357 1121 35 17855673 10.1056/NEJMra071667 1:CAS:528:DC%2BD2sXhtVKgtLzF (Pubitemid 47443217)
60. AW Thorburn LH Storlien AB Jenkins S Khouri EW Kraegen 1989 Fructose-induced in vivo insulin resistance and elevated plasma triglyceride levels in rats Am J Clin Nutr 49 1155 63 2658534 1:CAS:528:DyaL1MXksFKhurs%3D (Pubitemid 19169675)
61. I Zavaroni S Sander S Scott GM Reaven 1980 Effect of fructose feeding on insulin secretion and insulin action in the rat Metabolism 29 970 3 6999292 10.1016/0026-0495(80)90041-4 1:CAS:528:DyaL3cXltlWisb8%3D (Pubitemid 10014402)
62. S Morel C Berthonneche S Tanguy MC Toufektsian T Foulon M de Lorgeril, et al. 2003 Insulin resistance modifies plasma fatty acid distribution and decreases cardiac tolerance to in vivo ischaemia/reperfusion in rats Clin Exp Pharmacol Physiol 30 446 51 12823257 10.1046/j.1440-1681.2003.03858.x 1:CAS:528:DC%2BD3sXls1KrtLg%3D (Pubitemid 36836559)
63. Bouchard-Thomassin AA, Lachance D, Drolet MC, Couet J, Arsenault MC. A high fructose diet worsens eccentric left ventricular hypertrophy in experimental volume overload. Am J Physiol Heart Circ Physiol. 2010:Oct 22.
64. AW Miller CD Tulbert DW Busija 2004 Rosuvastatin treatment reverses impaired coronary artery vasodilation in fructose-fed, insulin-resistant rats Am J Physiol Regul Integr Comp Physiol 287 R157 60 15044186 10.1152/ajpregu.00647. 2003 1:CAS:528:DC%2BD2cXmtVeksLg%3D (Pubitemid 38856322)