The contribution of endothelial nitric oxide synthase to early ischaemic preconditioning: The lowering of the preconditioning threshold. An investigation in eNOS knockout mice

Cardiovascular Research

Volumn 52, Issue 2, 2001, Pages 274-280

  Bell, Robert M ^a   Yellon, Derek M ^a,b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY COLLEGE HOSPITAL   (United Kingdom)

Author keywords

Infarction; Ischemia; Nitric oxide; Preconditioning; Reperfusion

Indexed keywords

N ACETYL S NITROSOPENICILLAMINE; NITRIC OXIDE; NITRIC OXIDE DONOR; NITRIC OXIDE SYNTHASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME SYNTHESIS; HEART INFARCTION PREVENTION; HEART INFARCTION SIZE; HEART MUSCLE ISCHEMIA; HEART MUSCLE REPERFUSION; HEART PROTECTION; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; STIMULUS RESPONSE;

ANALYSIS OF VARIANCE; ANIMALS; FEMALE; ISCHEMIC PRECONDITIONING, MYOCARDIAL; LINEAR MODELS; MALE; MICE; MICE, KNOCKOUT; MODELS, ANIMAL; MYOCARDIAL CONTRACTION; MYOCARDIAL INFARCTION; MYOCARDIUM; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; NITRIC OXIDE SYNTHASE TYPE III; PERFUSION;

EID: 0034777430     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(01)00394-7     Document Type: Article

References (40)

1. Four brief periods of ischaemia cause no cumulative ATP loss or necrosis
2. Time course of delayed myocardial protection after transient adenosine A1 receptor activation in the rabbit
3. Nitric oxide donors induce late preconditioning against myocardial stunning and infarction in conscious rabbits via an antioxidant-sensitive mechanism
4. Pharmacological evidence that inducible nitric oxide synthase is a mediator of delayed preconditioning
5. Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbits
6. Exogenous nitric oxide can trigger a preconditioned state through a free radical mechanism, but endogenous nitric oxide is not a trigger of classical ischemic preconditioning
7. No involvement of endogenous nitric oxide in classical ischemic preconditioning in swine
8. Inhibition of nitric oxide synthesis reduces infarct size by an adenosine-dependent mechanism
9. Inhibition of nitric oxide synthesis does not affect ischemic preconditioning in isolated perfused rat hearts
10. Does the antiarrhythmic effect of ischemic preconditioning in rats involve the l-arginine nitric oxide pathway?
11. Loss of pacing-induced preconditioning in rat hearts: Role of nitric oxide and cholesterol-enriched diet
12. Enzymatic function of nitric oxide synthases
13. Electron transfer, oxygen binding, and nitric oxide feedback inhibition in endothelial nitric-oxide synthase
14. The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase gene
15. Role of bradykinin in protection of ischemic preconditioning in rabbit hearts
16. 2 receptor activation in human heart
17. Receptor-regulated translocation of endothelial nitric-oxide synthase
18. Endothelial nitric oxide synthase interactions with G-protein-coupled receptors
19. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
20. Acute modulation of endothelial Akt/PKB activity alters nitric oxide-dependent vasomotor activity in vivo
21. Endothelial nitric-oxide synthase (type III) is activated and becomes calcium independent upon phosphorylation by cyclic nucleotide-dependent protein kinases
22. AMP-activated protein kinase phosphorylation of endothelial NO synthase
23. Ischemic preconditioning activates phosphatidylinositol-3-kinase upstream of protein kinase C
24. Activation of adenylate cyclase system in the preconditioned rat heart
25. Heterogeneous basal expression of nitric oxide synthase and superoxide dismutase isoforms in mammalian heart: Implications for mechanisms governing indirect and direct nitric oxide-related effects
26. Hypertension in mice lacking the gene for endothelial nitric oxide synthase
27. Overexpression of the rat inducible 70-kD heat stress protein in a transgenic mouse increases the resistance of the heart to ischemic injury
28. Characterisation and validation of a murine model of global ischaemia-reperfusion injury
29. Attenuation of reperfusion injury by renal ischaemic preconditioning: The role of nitric oxide
30. Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning
31. Oxygen radicals released during ischemic preconditioning contribute to cardioprotection in the rabbit myocardium
32. 2+/calmodulin-dependent and tetrahydrobiopterin regulatory process
33. Superoxide anion production is increased in a model of genetic hypertension: Role of the endothelium
34. Attenuation of myocardial ischemia/reperfusion injury by superinduction of inducible nitric oxide synthase
35. A common variant of the endothelial nitric oxide synthase (Glu298→Asp) is a major risk factor for coronary artery disease in the UK
36. Chronic 17beta-estradiol replacement increases nitric oxide-mediated vasodilation of guinea pig coronary microcirculation
37. 17 beta-Estradiol prevents dysfunction of canine coronary endothelium and myocardium and reperfusion arrhythmias after brief ischemia/reperfusion
38. Myocardial ischemia-reperfusion injury in estrogen receptor-alpha knockout and wild-type mice
39. Is there a gender difference in infarct size and arrhythmias following experimental coronary occlusion and reperfusion?
40. Gender does not influence acute myocardial infarction in adult dogs