WISE-2005: Bed-rest induced changes in bone mineral density in women during 60days simulated microgravity

Bone

Volumn 49, Issue 4, 2011, Pages 858-866

  Beller, Gisela ^a   Belavỳ, Daniel L ^a   Sun, Lianwen ^a,b   Armbrecht, Gabriele ^a   Alexandre, Christian ^c   Felsenberg, Dieter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b BEIHANG UNIVERSITY   (China)

^c UNIVERSITY HOSPITAL OF SAINT ETIENNE   (France)

Author keywords

Bone mineral density; DXA; Microgravity; PQCT; Spaceflight

Indexed keywords

ADULT; ARTICLE; BED REST; BODY COMPOSITION; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAPHYSIS; DUAL ENERGY X RAY ABSORPTIOMETRY; ENDURANCE TRAINING; EXERCISE; FEMALE; HUMAN; HUMAN EXPERIMENT; MICROGRAVITY; NORMAL HUMAN; NUTRITIONAL ASSESSMENT; QUANTITATIVE ANALYSIS; RESISTANCE TRAINING; TRABECULAR BONE; WOMEN'S HEALTH;

ABSORPTIOMETRY, PHOTON; ADULT; BED REST; BONE DENSITY; FEMALE; HIP; HUMANS; MUSCLES; SPACE FLIGHT; TIBIA; TOMOGRAPHY, X-RAY COMPUTED; WEIGHTLESSNESS COUNTERMEASURES; WEIGHTLESSNESS SIMULATION;

EID: 80052278378     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.06.021     Document Type: Article

References (62)

1. Price T.B., Kamen G., Damon B.M., Knight C.A., Applegate B., Gore J.C., et al. Comparison of MRI with EMG to study muscle activity associated with dynamic plantar flexion. Magn Reson Imaging 2003, 21:853-861.
2. Jørgensen L., Crabtree N.J., Reeve J., Jacobsen B.K. Ambulatory level and asymmetrical weight bearing after stroke affects bone loss in the upper and lower part of the femoral neck differently: bone adaptation after decreased mechanical loading. Bone 2000, 27:701-707.
3. Biering-Sørensen F., Bohr H.H., Schaadt O.P. Longitudinal study of bone mineral content in the lumbar spine, the forearm and the lower extremities after spinal cord injury. Eur J Clin Invest 1990, 20:330-335.
4. Frey-Rindova P., de Bruin E.D., Stüssi E., Dambacher M.A., Dietz V. Bone mineral density in upper and lower extremities during 12months after spinal cord injury measured by peripheral quantitative computed tomography. Spinal Cord 2000, 38:26-32.
5. Shackelford L.C., LeBlanc A.D., Driscoll T.B., Evans H.J., Rianon N.J., Smith S.M., et al. Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 2004, 97:119-129.
6. Oganov V.S., Grigoriev A.I., Voronin L.I., Rakmanov A.S., Bakulin A.V., Schneider V., et al. Bone mineral density in cosmonauts after 4.5-6month long flights aboard orbital station MIR, Aerospace. Environ Med 1992, 26:20-24.
7. Le Blanc A., Lin C., Shackelford L., Sinitsyn V., Evans H., Belichenko O., et al. Muscle volume, MRI relaxation times (T2), and body composition after spaceflight. J Appl Physiol 2000, 89:2158-2164.
8. Le Blanc A., Schneider V., Shackelford L., West S., Oganov V., Bakulin A., et al. Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 2000, 1:157-160.
9. Nicogossian A.E., Dietlein L.F. Microgravity simulation and analogues. Space physiology and medicine 1982, 240-248. Lea & Febiger, Philadelphia. A.E. Nicogossian (Ed.).
10. Smith S.M., Nillen J.L., Leblanc A., Lipton A., Demers L.M., Lane H.W., et al. Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 1998, 83:3584-3591.
11. Armbrecht G., Belavỳ D.L., Gast G., Bongrazio M., Touby F., Beller G., et al. Resistive vibration exercise attenuates bone and muscle atrophy in 56days of bed rest: biochemical markers of bone metabolism. Osteoporosis Int. 2010, 21:597-607.
12. Zerwekh J.E., Ruml L.A., Gottschalk F., Pak C.Y.C. The effects of twelve weeks of bed rest on bone histology, biochemical markers of bone turnover, and calcium homeostasis in eleven normal subjects. J Bone Miner Res 1998, 13:1594-1601.
13. Baecker N., Tomic A., Mika C., Gotzmann A., Platen P., Gerzer R., et al. Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial. J Appl Physiol 2003, 95:977-982.
14. Le Blanc A.D., Driscol T.B., Shackelford L.C., Evans H.J., Rianon N.J., Smith S.M., et al. Alendronate as an effective countermeasure to disuse induced bone loss. J Muskuloskel Neuron Interact 2002, 2:335-343.
15. Smith S.M., Wastney M.E., Morukov B.V., Larina I.M., Nyquist L.E., Abrams S.A., et al. Calcium metabolism before, during, and after a 3-mo spaceflight: kinetic and biochemical changes. Am J Physiol Regulatory Integrative Comp Physiol 1999, 277:1-10.
16. Holick M.F. Perspective on the impact of weightlessness on calcium and bone metabolism. Bone 1998, 22:105S-111S.
17. Arnaud S.B., Sherrard D.J., Maloney N., Whalen R.T., Fung P. Effects of 1-week head-down tilt bed rest on bone formation and the calcium endocrine system. Aviat Space Environ Med 1992, 63:14-20.
18. Donaldson C.L., Hulley S.B., Vogel J.M., Hattner R.S., Bayers J.H., McMillan D.E. Effect of prolonged bed rest on bone mineral. Metabolism 1970, 19:1071-1084.
19. Le Blanc A.D., Schneider V.S., Evans H.J., Engelbretson D.A., Krebs J.M. Bone mineral loss and recovery after 17weeks of bed rest. J Bone Miner Res 1990, 5:843-850.
20. Le Blanc A., Schneider V., Spector E., Evans H., Rowe R., Lane H., et al. Calcium absorption, endogenous secretion and endocrine changes during and after long-term bed rest. Bone 1995, 16:301S-304S.
21. Lueken S.A., Arnaud S.B., Taylor A.K., Baylink D.J. Changes in markers of bone formation and resorption in a bed rest model of weightlessness. J Bone Miner Res 1993, 8:1433-1438.
22. Lang T., LeBlanc A., Evans H., Lu Y., Genant H., Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 2004, 19:1006-1012.
23. Trappe T.A., Burd N.A., Louis E.S., Lee G.A., Trappe S.W. Influence of concurrent exercise or nutrition countermeasures on thigh and calf muscle size and function during 60days of bed rest in women. Acta Physiol (Oxf) 2007, 191:147-159.
24. Alkner B.A., Tesch P.A. Knee extensor and plantar flexor muscle size and function following 90days of bed rest with or without resistance exercise. Eur J Appl Physiol 2004, 93:294-305.
25. Alkner B.A., Tesch P.A. Efficacy of a gravity-independent resistance exercise device as a countermeasure to muscle atrophy during 29-day bed rest. Acta Physiol Scand 2004, 181:345-357.
26. Berg H.E., Tesch A. A gravity-independent ergometer to be used for resistance training in space. Aviat Space Environ Med 1994, 65:752-756.
27. Trappe S., Trappe T., Gallagher P., Harber M., Alkner B., Tesch P. Human single muscle fibre function with 84day bed-rest and resistance exercise. J Physiol 2004, 557:501-513.
28. Lee S.M., Bennett B.S., Hargens A.R., Watenpaugh D.E., Ballard R.E., Murthy G., et al. Upright exercise or supine lower body negative pressure exercise maintains exercise responses after bed rest. Med Sci Sports Exerc 1997, 29:892-900.
29. Watenpaugh D.E., Ballard R.E., Schneider S.M., Lee S.M., Ertl A.C., William J.M., et al. Supine lower body negative pressure exercise during bed rest maintains upright exercise capacity. J Appl Physiol 2000, 89:218-227.
30. Cao P., Kimura S., Macias B.R., Ueno T., Watenpaugh D.E., Hargens A.R. Exercise within lower body negative pressure partially counteracts lumbar spine deconditioning associated with 28-day bed rest. J Appl Physiol 2005, 99:39-44.
31. Rittweger J., Beller G., Ehrig J., Jung C., Koch U., Ramolla J., et al. Bone-muscle strength indices for the human lower leg. Bone 2000, 27:319-326.
32. Rittweger J., Frost H.M., Schiessl H., Ohshima H., Alkner B., Tesch P., et al. Muscle atrophy and bone loss after 90days bed rest and the effects of flywheel resistive exercise and pamidronate: results from the LTBR study. Bone 2005, 36:1019-1029.
33. Glüer C.C., Blake G., Lu Y., Blunt B.A., Jergas M., Genant H.K. Accurate assessment of precision errors: how to measure the reproducibility of bone densitometry techniques. Osteoporos Int 1995, 5:262-270.
34. Pinheiro J.C., Bates D.M. Mixed-effects models in S and S-PLUS 2000, Springer, Berlin. 1st ed.
35. Smith S.M., Zwart S.R., Heer M., Lee S.M., Baecker N., Meuche S., et al. WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity. Bone 2008, 42:572-581.
36. Zwart S.R., Hargens A.R., Lee S.M., Macias B.R., Watenpaugh D.E., Tse K., et al. Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins. Bone 2007, 40:529-537.
37. Greenspan S.L., Maitland L.A., Myers E.R., Krasnow M.B., Kido T.H. Femoral bone loss progresses with age: a longitudinal study in women over age 65. J Bone Miner Res 1994, 9:1959-1965.
38. Reid I.R., Ames R.W., Evans M.C., Gamble G.D., Sharpe S.J. Effect of calcium SUPPLementation on bone loss in postmenopausal women. N Engl J Med 1993, 328:460-464.
39. Ito M., Nakamura T., Tsurusaki K., Uetani M., Hayashi K. Effects of menopause on age-dependent bone loss in the axial and appendicular skeletons in healthy Japanese women. Osteoporos Int 1999, 10:377-383.
40. Rittweger J., Beller G., Armbrecht G., Mulder E., Buehring B., Gast U., et al. Prevention of bone loss during 56days of strict bed rest by side-alternating resistive vibration exercise. Bone 2010, 46:137-147.
41. Belavỳ D.L., Beller G., Armbrecht G., Perschel F.H., Fitzner R., Bock O., et al. Evidence for an additional effect of whole-body vibration above resistive exercise alone in preventing bone loss during prolonged bed-rest. Osteoporosis Int 2011, 22:1581-1591.
42. O'Neill T.W., Cooper C., Finn J.D., Lunt M., Purdie D., Reid D.M., et al. Incidence of distal forearm fracture in British men and women. Osteoporos Int 2001, 12:555-558.
43. Belavỳ D.L., Miokovic T., Armbrecht G., Rittweger J., Felsenberg D. Resistive vibration exercise reduces lower limb muscle atrophy during 56-day bed-rest. J Musculoskelet Neuronal Interact 2009, 9:225-235.
44. Smith S.M., Zwart S.R., Heer M.A., Baecker N., Evans H.J., Feiveson A.H., et al. Effects of artificial gravity during bed rest on bone metabolism in humans. J Appl Physiol 2009, 107:47-53.
45. Turner C.H., Forwood M.R., Rho J.Y., Yoshikawa T. Mechanical loading thresholds for lamellar and woven bone formation. J Bone Miner Res 1994, 9:87-97.
46. Hsieh Y.F., Robling A.G., Ambrosius W.T., Burr D.B., Turner C.H. Mechanical loading of diaphyseal bone in vivo: the strain threshold for an osteogenic response varies with location. J Bone Miner Res 2001, 16:2291-2297.
47. Hsieh Y.F., Turner C.H. Effects of loading frequency on mechanically induced bone formation. J Bone Miner Res 2001, 16:918-924.
48. De Souza R.L., Matsuura M., Eckstein F., Rawlinson S.C., Lanyon L.E., Pitsillides A.A. Non-invasive axial loading of mouse tibiae increases cortical bone formation and modifies trabecular organization: a new model to study cortical and cancellous compartments in a single loaded element. Bone 2005, 37:810-818.
49. Robling A.G., Duijvelaar K.M., Geevers J.V., Ohashi N., Turner C.H. Modulation of appositional and longitudinal bone growth in the rat ulna by applied static and dynamic force. Bone 2001, 29:105-113.
50. Sugiyama T., Price J.S., Lanyon L.E. Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones. Bone 2010, 46:314-321.
51. Zhang P., Tanaka S.M., Jiang H., Su M., Yokota H. Diaphyseal bone formation in murine tibiae in response to knee loading. J Appl Physiol 2006, 100:1452-1459.
52. Forwood M.R., Li L., Kelly W.L., Bennett M.B. Growth hormone is permissive for skeletal adaptation to mechanical loading. J Bone Miner Res 2001, 16:2284-2290.
53. Turner C.H., Forwood M.R., Otter M.W. Mechanotransduction in bone: do bone cells act as sensors of fluid flow?. FASEB J 1994, 8:875-878.
54. Turner C.H., Owan I., Takano Y. Mechanotransduction in bone: role of strain rate. Am J Physiol 1995, 269:E438-E442.
55. Mosley J.R., Lanyon L.E. Strain rate as a controlling influence on adaptive modeling in response to dynamic loading of the ulna in growing male rats. Bone 1998, 23:313-318.
56. Rubin C.T., Lanyon L.E. Regulation of bone formation by applied dynamic loads. J. Bone Joint Surg. Am. 1984, 66:397-402.
57. Srinivasan S., Ausk B.J., Poliachik S.L., Warner S.E., Richardson T.S., Gross T.S. Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles. J Appl Physiol 2007, 102:1945-1952.
58. Cullen D.M., Smith R.T., Akhter M.P. Bone-loading response varies with strain magnitude and cycle number. J Appl Physiol 2001, 91:1971-1976.
59. Umemura Y., Ishiko T., Yamauchi T., Kurono M., Mashiko S. Five jumps per day increase bone mass and breaking force in rats. J Bone Miner Res 1997, 12:1480-1485.
60. Conley M.S., Foley J.M., Ploutz-Snyder L.L., Meyer R.A., Dudley G.A. Effect of acute head-down tilt on skeletal muscle cross-sectional area and proton transverse relaxation time. J Appl Physiol 1996, 81:1572-1577.
61. Wade C., Baer L. WISE 2005-2006: 60-days of head-down bed rest increases the incidence of menstrual cycle disruption [abstract]. FASEB J 2007, 21:771.11.
62. Cobb K.L., Bachrach L.K., Greendale G., Marcus R., Neer R.M., Nieves J., et al. Disordered eating, menstrual irregularity, and bone mineral density in female runners. Med Sci Sports Exerc 2003, 35:711-719.