Effects of artificial gravity during bed rest on bone metabolism in humans

Journal of Applied Physiology

Volumn 107, Issue 1, 2009, Pages 47-53

  Smith, S M ^a   Zwart, S R ^b   Heer, M A ^c   Baecker, N ^c   Evans, H J ^d   Feiveson, A H ^a   Shackelford, L C ^a   LeBlanc, A D ^b  

^a NASA JOHNSON SPACE CENTER   (United States)

^b UNIVERSITIES SPACE RESEARCH ASSOCIATION   (United States)

^c GERMAN AEROSPACE CENTER DLR   (Germany)

^d WYLE LABORATORIES   (United States)

Author keywords

Bone formation; Bone resorption; Countermeasure; Microgravity

Indexed keywords

ALKALINE PHOSPHATASE; CALCIUM; CARBOXY TERMINAL TELOPEPTIDE; VITAMIN D;

ADULT; ARTICLE; BED REST; BONE DENSITY; BONE METABOLISM; BONE MINERAL; CENTRIFUGATION; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIETARY INTAKE; DUAL ENERGY X RAY ABSORPTIOMETRY; GRAVITY; HEAD TILTING; HUMAN; HUMAN EXPERIMENT; MALE; MICROGRAVITY; NORMAL HUMAN; OSTEOLYSIS; PRIORITY JOURNAL; SIMULATION; SPACE FLIGHT; URINARY EXCRETION;

ADULT; BED REST; BIOLOGICAL MARKERS; BONE AND BONES; BONE DENSITY; BONE RESORPTION; CALCIUM; GRAVITY, ALTERED; HEAD-DOWN TILT; HUMANS; MALE; VITAMIN D; WEIGHT-BEARING; WEIGHTLESSNESS; WEIGHTLESSNESS COUNTERMEASURES;

EID: 67650089648     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.91134.2008     Document Type: Article

References (57)

1. Arnaud SB, Powell MR, Vernikos-Danellis J, Buchanan P. Bone mineral and body composition after 30 day head down tilt bed rest. J Bone Miner Res 3: S119, 1988.
2. Arnaud SB, Wolinsky I, Fung P, Vernikos J. Dietary salt and urinary calcium excretion in a human bed rest spaceflight model. Aviat Space Environ Med 71: 1115-1119, 2000.
3. Baecker N, Tomic A, Mika C, Gotzmann A, Platen P, Gerzer R, Heer M. Bone resorption is induced on the second day of bed rest: results of a controlled crossover trial. J Appl Physiol 95: 977-982, 2003.
4. Batra NN, Li YJ, Yellowley CE, You L, Malone AM, Kim CH, Jacobs CR. Effects of short-term recovery periods on fluid-induced signaling in osteoblastic cells. J Biomech 38: 1909-1917, 2005.
5. Bloomfield SA, Allen MR, Hogan HA, Delp MD. Site- and compartment-specific changes in bone with hindlimb unloading in mature adult rats. Bone 31: 149-157, 2002.
6. Caillot-Augusseau A, Lafage-Proust MH, Soler C, Pernod J, Dubois F, Alexandre C. Bone formation and resorption biological markers in cosmonauts during and after a 180-day space flight (Euromir 95). Clin Chem 44: 578-585, 1998.
7. Caillot-Augusseau A, Vico L, Heer M, Voroviev D, Souberbielle JC, Zitterman A, Alexandre C, Lafage-Proust M-H. Space flight is associated with rapid decreases of undercarboxylated osteocalcin and increases of markers of bone resorption without changes in their circadian variation: observations in two cosmonauts. Clin Chem 46: 1136-1143, 2000.
8. Colleran PN, Wilkerson MK, Bloomfield SA, Suva LJ, Turner RT, Delp MD. Alterations in skeletal perfusion with simulated microgravity: a possible mechanism for bone remodeling. J Appl Physiol 89: 1046-1054, 2000.
9. Duncan RL, Turner CH. Mechanotransduction and the functional response of bone to mechanical strain. Calcif Tissue Int 57: 344-358, 1995.
10. Fenton TR, Eliasziw M, Lyon AW, Tough SC, Hanley DA. Meta-analysis of the quantity of calcium excretion associated with the net acid excretion of the modern diet under the acid-ash diet hypothesis. Am J Clin Nutr 88: 1159-1166, 2008.
11. Forwood MR, Turner CH. Skeletal adaptations to mechanical usage: results from tibial loading studies in rats. Bone 17: 197S-205S, 1995.
12. Fosse G, Gat H, Holmbakken N, Kvinnsland S. Bone atrophy and hypergravity in mice. Growth 38: 329-342, 1974.
13. Gross TS, Poliachik SL, Ausk BJ, Sanford DA, Becker BA, Srinivasan S. Why rest stimulates bone formation: a hypothesis based on complex adaptive phenomenon. Exerc Sport Sci Rev 32: 9-13, 2004.
14. Heer M, Baecker N, Mika C, Boese A, Gerzer R. Immobilization induces a very rapid increase in osteoclast activity. Acta Astronaut 57: 31-36, 2005.
15. Iwase S, Takada H, Watanabe Y, Ishida K, Akima H, Katayama K, Iwase M, Hirayanagi K, Shiozawa T, Hamaoka T, Masuo Y, Custaud MA. Effect of centrifuge-induced artificial gravity and ergometric exercise on cardiovascular deconditioning, myatrophy, and osteoporosis induced by a -6 degrees head-down bedrest. J Gravit Physiol 11: P243-P244, 2004.
16. Jaekel E, Amtmann E, Oyama J. Effect of chronic centrifugation on bone density of the rat. Anat Embryol (Berl) 151: 223-232, 1977.
17. LaMothe JM, Hamilton NH, Zernicke RF. Strain rate influences periosteal adaptation in mature bone. Med Eng Phys 27: 277-284, 2005.
18. Lang T, LeBlanc A, Evans H, Lu Y, Genant H, Yu A. Cortical and trabecular bone mineral loss from the spine and hip in long-duration spaceflight. J Bone Miner Res 19: 1006-1012, 2004.
19. LeBlanc A, Schneider V, Shackelford L, West S, Oganov V, Bakulin A, Voronin L. Bone mineral and lean tissue loss after long duration space flight. J Musculoskelet Neuronal Interact 1: 157-160, 2000.
20. LeBlanc AD, Driscol TB, Shackelford LC, Evans HJ, Rianon NJ, Smith SM, Feeback DL, Lai D. Alendronate as an effective countermeasure to disuse induced bone loss. J Musculoskelet Neuronal Interact 2: 335-343, 2002.
21. LeBlanc AD, Spector ER, Evans HJ, Sibonga JD. Skeletal responses to space flight and the bed rest analog: a review. J Musculoskelet Neuronal Interact 7: 33-47, 2007.
22. Martinez DA, Orth MW, Carr KE, Vanderby R Jr, Vasques M, Grindeland RE, Vailas AC. Cortical bone responses to 2G hypergravity in growing rats. Aviat Space Environ Med 69: A17-A22, 1998.
23. Naumann FL, Bennell KL, Wark JD. The effects of +Gz force on the bone mineral density of fighter pilots. Aviat Space Environ Med 72: 177-181, 2001.
24. Naumann FL, Grant MC, Dhaliwal SS. Changes in cervical spine bone mineral density in response to flight training. Aviat Space Environ Med 75: 255-259, 2004.
25. Nomura S, Takano-Yamamoto T. Molecular events caused by mechanical stress in bone. Matrix Biol 19: 91-96, 2000.
26. Owan I, Burr DB, Turner CH, Qiu J, Tu Y, Onyia JE, Duncan RL. Mechanotransduction in bone: osteoblasts are more responsive to fluid forces than mechanical strain. Am J Physiol Cell Physiol 273: C810-C815, 1997.
27. Oyama J. Response and adaptation of beagle dogs to hypergravity. Life Sci Space Res 13: 11-17, 1975.
28. Parfitt AM. Bone effects of space flight: analysis by quantum concept of bone remodelling. Acta Astronaut 8: 1083-1090, 1981.
29. Pavy-Le Traon A, Heer M, Narici MV, Rittweger J, and Vernikos J. From space to Earth: advances in human physiology from 20 years of bed rest studies (1986 -2006). Eur J Appl Physiol 101: 143-194, 2007.
30. Roer RD, Dillaman RM. Bone growth and calcium balance during simulated weightlessness in the rat. J Appl Physiol 68: 13-20, 1990.
31. Searby ND, Steele CR, Globus RK. Influence of increased mechanical loading by hypergravity on the microtubule cytoskeleton and prostaglandin E2 release in primary osteoblasts. Am J Physiol Cell Physiol 289: C148-C158, 2005.
32. Sellmeyer DE, Schloetter M, Sebastian A. Potassium citrate prevents increased urine calcium excretion and bone resorption induced by a high sodium chloride diet. J Clin Endocrinol Metab 87: 2008-2012, 2002.
33. Shackelford LC, LeBlanc AD, Driscoll TB, Evans HJ, Rianon NJ, Smith SM, Spector E, Feeback DL, Lai D. Resistance exercise as a countermeasure to disuse-induced bone loss. J Appl Physiol 97: 119-129, 2004.
34. Smith MC Jr, Rambaut PC, Vogel JM, Whittle MW. Bone mineral measurement-experiment M078. In: Biomedical Results from Skylab (NASA SP-377), edited by Johnston RS and Dietlein LF. Washington, DC: National Aeronautics and Space Administration, 1977, p. 183-190.
35. Smith SM, Davis-Street JE, Fesperman JV, Calkins DS, Bawa M, Macias BR, Meyer RS, Hargens AR. Evaluation of treadmill exercise in a lower body negative pressure chamber as a countermeasure for weightlessness-induced bone loss: a bed rest study with identical twins. J Bone Miner Res 18: 2223-2230, 2003.
36. Smith SM, Dillon EL, DeKerlegand DE, Davis-Street JE. Variability of collagen crosslinks: impact of sample collection period. Calcif Tissue Int 74: 336-341, 2004.
37. Smith SM, Nillen JL, LeBlanc A, Lipton A, Demers LM, Lane HW, Leach CS. Collagen cross-link excretion during space flight and bed rest. J Clin Endocrinol Metab 83: 3584-3591, 1998.
38. Smith SM, Wastney ME, Morukov BV, Larina IM, Nyquist LE, Abrams SA, Taran EN, Shih CY, Nillen JL, Davis-Street JE, Rice BL, Lane HW. Calcium metabolism before, during, and after a 3-mo space-flight: kinetic and biochemical changes. Am J Physiol Regul Integr Comp Physiol 277: R1-R10, 1999.
39. Smith SM, Wastney ME, O'Brien KO, Morukov BV, Larina IM, Abrams SA, Davis-Street JE, Oganov V, Shackelford LC. Bone markers, calcium metabolism, and calcium kinetics during extended-duration space flight on the Mir space station. J Bone Miner Res 20: 208-218, 2005.
40. Smith SM, Zwart SR, Block G, Rice BL, Davis-Street JE. Nutritional status assessment of International Space Station crew members. J Nutr 135: 437-443, 2005.
41. Smith SM, Zwart SR, Heer M, Lee SMC, Baecker N, Meuche S, Macias BR, Shackelford LC, Schneider S, Hargens AR. WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity. Bone 42: 572-581, 2008.
42. Srinivasan S, Ausk BJ, Poliachik SL, Warner SE, Richardson TS, Gross TS. Rest-inserted loading rapidly amplifies the response of bone to small increases in strain and load cycles. J Appl Physiol 102: 1945-1952, 2007.
43. Szczesniak AM, Gilbert RW, Mukhida M, Anderson GI. Mechanical loading modulates glutamate receptor subunit expression in bone. Bone 37: 63-73, 2005.
44. Vernikos J, Ludwig DA, Ertl AC, Wade CE, Keil L, O'Hara D. Effect of standing or walking on physiological changes induced by head down bed rest: implications for spaceflight. Aviat Space Environ Med 67: 1069-1079, 1996.
45. Watanabe Y, Ohshima H, Mizuno K, Sekiguchi C, Fukunaga M, Kohri K, Rittweger J, Felsenberg D, Matsumoto T, Nakamura T. Intravenous pamidronate prevents femoral bone loss and renal stone formation during 90-day bed rest. J Bone Miner Res 19: 1771-1778, 2004.
46. Weaver CM, LeBlanc A, Smith SM. Calcium and related nutrients in bone metabolism. In: Nutrition in Spaceflight and Weightlessness Models, edited by Lane HW and Schoeller DA. Boca Raton, FL: CRC, 2000, p. 179-201.
47. Westfall PH, Young SS. Resampling-Based Multiple Testing. New York: John Wiley & Sons, 1993.
48. Whedon G, Lutwak L, Rambaut P, Whittle M, Leach C, Reid J, Smith M. Effect of weightlessness on mineral metabolism; metabolic studies on Skylab orbital flights. Calcif Tissue Res 21, Suppl: 423-430, 1976.
49. Whedon GD, Lutwak L, Rambaut PC, Whittle MW, Smith MC, Reid J, Leach C, Stadler CR, Sanford DD. Mineral and nitrogen metabolic studies, experiment M071. In: Biomedical Results from Skylab (NASA SP-377), edited by Johnston RS and Dietlein LF. Washington, DC: National Aeronautics and Space Administration, 1977, p. 164-174.
50. Xing W, Baylink D, Kesavan C, Hu Y, Kapoor S, Chadwick RB, Mohan S. Global gene expression analysis in the bones reveals involvement of several novel genes and pathways in mediating an anabolic response of mechanical loading in mice. J Cell Biochem 96: 1049-1060, 2005.
51. x gravitation in preventing deconditioning due to simulated microgravity. J Appl Physiol 95: 207-218, 2003.
52. Zittermann A, Heer M, Caillot-Augusso A, Rettberg P, Scheld K, Drummer C, Alexandre C, Horneck G, Vorobiev D. Microgravity inhibits intestinal calcium absorption as shown by a stable strontium test. Eur J Clin Invest 30: 1036-1043, 2000.
53. Zwart SR, Crawford GE, Gillman PL, Kala G, Rodgers AS, Rogers A, Inniss AM, Rice BL, Ericson K, Coburn SP, Bourbeau Y, Hudson E, Booth SL, DeKerlegand DE, Sams CF, Heer MA, Smith SM. Effects of 21 days of bed rest, with or without artificial gravity, on nutritional status of humans. J Appl Physiol (December 12, 2008). doi:10.1152/japplphysiol.91136.2008.
54. Zwart SR, Davis-Street JE, Paddon-Jones D, Ferrando AA, Wolfe RR, Smith SM. Amino acid supplementation alters bone metabolism during simulated weightlessness. J Appl Physiol 99: 134-140, 2005.
55. Zwart SR, Hargens AR, Lee SM, Macias BR, Watenpaugh DE, Tse K, Smith SM. Lower body negative pressure treadmill exercise as a countermeasure for bed rest-induced bone loss in female identical twins. Bone 40: 529-537, 2007.
56. Zwart SR, Hargens AR, Smith SM. The ratio of animal protein intake to potassium intake is a predictor of bone resorption in space flight analogues and in ambulatory subjects. Am J Clin Nutr 80: 1058-1065, 2004.
57. Zwart SR, Oliver SM, Fesperman JV, Kala G, Krauhs J, Ericson K, Smith SM. Nutritional status assessment before, during, and after long-duration head-down bed rest. Aviat Space Environ Med 80: A15-A22, 2009.