A Promoter polymorphism (rs17222919, -1316T/G) of ALOX5AP is associated with intracerebral hemorrhage in Korean population

Prostaglandins Leukotrienes and Essential Fatty Acids

Volumn 85, Issue 3-4, 2011, Pages 115-120

  Kim, Dong Hwan ^a   Ahn, Woo Yong ^b   Kim, Dong Kwan ^a   Choe, Bong Keun ^a   Kim, Su Kang ^a   Jo, Dae Jean ^a   Kim, Jae Young ^a   Chung, Joo Ho ^a   Jeong, Yong Seol ^a   Yun, Dong Hwan ^a   Yoo, Seung Don ^a   Kim, Hee Sang ^a   Baik, Hyung Hwan ^b  

^a Kyung Hee University   (South Korea)

^b Kyung Hee University Hospital   (South Korea)

Author keywords

ALOX5AP; Intracerebral hemorrhage; Ischemic stroke; Leukotriene; Polymorphism; Prostaglandin

Indexed keywords

ADULT; AGED; ARACHIDONATE 12 LIPOXYGENASE GENE; ARACHIDONATE 5 LIPOXYGENASE ACTIVATING PROTEIN GENE; ARACHIDONATE 5 LIPOXYGENASE GENE; ARTICLE; BRAIN HEMORRHAGE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENOTYPE; HUMAN; KOREA; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROMOTER REGION; PTGES GENE; PTGIS GENE; PTGS1 GENE; PTGS2 GENE; REGULATOR GENE; SEQUENCE ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM;

5-LIPOXYGENASE-ACTIVATING PROTEINS; ADULT; AGED; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 5-LIPOXYGENASE; CASE-CONTROL STUDIES; CEREBRAL HEMORRHAGE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; HAPLOTYPES; HUMANS; INTRAMOLECULAR OXIDOREDUCTASES; LOGISTIC MODELS; MALE; MIDDLE AGED; ODDS RATIO; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; REPUBLIC OF KOREA;

EID: 80052271965     PISSN: 09523278     EISSN: 15322823     Source Type: Journal    
DOI: 10.1016/j.plefa.2011.07.004     Document Type: Article

References (25)

1. Phillis J.W., O'Regan M.H. The role of phospholipases, cyclooxygenases, and lipoxygenases in cerebral ischemic/traumatic injuries. Crit. Rev. Neurobiol. 2003, 15:61-90.
2. Lucas S.M., Rothwell N.J., Gibson R.M. The role of inflammation in CNS injury and disease. Br. J. Pharmacol. 2006, 147(Suppl. 1):S232-S240.
3. Wang J., Dore S. Inflammation after intracerebral hemorrhage. J. Cereb. Blood Flow Metab. 2007, 27:894-908.
4. Funk C.D. Prostaglandins and leukotrienes: advances in eicosanoid biology. Science 2001, 294:1871-1875.
5. Samuelsson B., Morgenstern R., Jakobsson P.J. Membrane prostaglandin E synthase-1: a novel therapeutic target. Pharmacol. Rev. 2007, 59:207-224.
6. Ryan A., Godson C. Lipoxins: regulators of resolution. Curr. Opin. Pharmacol. 2010, 10:166-172.
7. Cipollone F., Toniato E., Martinotti S., et al. A polymorphism in the cyclooxygenase 2 gene as an inherited protective factor against myocardial infarction and stroke. J. Am. Med. Assoc. 2004, 291:2221-2228.
8. Maguire J., Thakkinstian A., Levi C., et al. Impact of COX-2 rs5275 and rs20417 and GPIIIa rs5918 polymorphisms on 90-day ischemic stroke functional outcome: a novel finding. J. Stroke Cerebrovasc. Dis. 2010, Epub ahead of print.
9. Park S.A., Park B.L., Park J.H., et al. Association of polymorphisms in thromboxane A2 receptor and thromboxane A synthase 1 with cerebral infarction in a Korean population. BMB Rep. 2009, 42:200-205.
10. Zhang W.L., Yang X.M., Shi J., Sun K., Hui R.T. Polymorphism of SG13S114T/A in the ALOX5AP gene and the risk for stroke in a large Chinese cohort. Yi Chuan Xue Bao 2006, 33:678-684.
11. Fu Z., Nakayama T., Sato N., et al. A haplotype of the CYP4F2 gene is associated with cerebral infarction in Japanese men. Am. J. Hypertens. 2008, 21:1216-1223.
12. Hallstrand T.S., Henderson W.R. An update on the role of leukotrienes in asthma. Curr. Opin. Allergy Clin. Immunol. 2010, 10:60-66.
13. Evans J.F., Ferguson A.D., Mosley R.T., Hutchinson J.H. What's all the FLAP about?: 5-lipoxygenase-activating protein inhibitors for inflammatory diseases. Trends Pharmacol. Sci. 2008, 29:72-78.
14. Via M., De Giacomo A., Corvol H., et al. The role of LTA4H and ALOX5AP genes in the risk for asthma in Latinos. Clin. Exp. Allergy 2010, 40:582-589.
15. Al-Shemari H., Bosse Y., Hudson T.J., et al. Influence of leukotriene gene polymorphisms on chronic rhinosinusitis. BMC Med. Genet. 2008, 9:21.
16. Crosslin D.R., Shah S.H., Nelson S.C., et al. Genetic effects in the leukotriene biosynthesis pathway and association with atherosclerosis. Hum. Genet. 2009, 125:217-229.
17. Burdon K.P., Rudock M.E., Lehtinen A.B., et al. Human lipoxygenase pathway gene variation and association with markers of subclinical atherosclerosis in the diabetes heart study. Mediators Inflamm. 2010, 2010:170153.
18. Linsel-Nitschke P., Gotz A., Medack A., et al. Genetic variation in the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) is associated with myocardial infarction in the German population. Clin. Sci. (Lond) 2008, 115:309-315.
19. Helgadottir A., Manolescu A., Thorleifsson G., et al. The gene encoding 5-lipoxygenase activating protein confers risk of myocardial infarction and stroke. Nat. Genet. 2004, 36:233-239.
20. Helgadottir A., Gretarsdottir S., Clair D., et al. Association between the gene encoding 5-lipoxygenase-activating protein and stroke replicated in a Scottish population. Am. J. Hum. Genet. 2005, 76:505-509.
21. Lohmussaar E., Gschwendtner A., Mueller J.C., et al. ALOX5AP gene and the PDE4D gene in a central European population of stroke patients. Stroke 2005, 36:731-736.
22. Domingues-Montanari S., Fernandez-Cadenas I., del Rio-Espinola A., et al. Association of a genetic variant in the ALOX5AP with higher risk of ischemic stroke: a case-control, meta-analysis and functional study. Cerebrovasc. Dis. 2010, 29:528-537.
23. Kaushal R., Pal P., Alwell K., et al. Association of ALOX5AP with ischemic stroke: a population-based case-control study. Hum. Genet. 2007, 121:601-607.
24. Zee R.Y., Cheng S., Hegener H.H., Erlich H.A., Ridker P.M. Genetic variants of arachidonate 5-lipoxygenase-activating protein, and risk of incident myocardial infarction and ischemic stroke: a nested case-control approach. Stroke 2006, 37:2007-2011.
25. Zintzaras E., Rodopoulou P., Sakellaridis N. Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene and risk of stroke: a HuGE gene-disease association review and meta-analysis. Am. J. Epidemiol. 2009, 169:523-532.