I.c.v administration of an endothelin ETB receptor agonist stimulates vascular endothelial growth factor-A production and activates vascular endothelial growth factor receptors in rat brain

Neuroscience

Volumn 192, Issue , 2011, Pages 689-698

  Koyama, Y ^a   Nagae, R ^b   Tokuyama, S ^b   Tanaka, K ^a  

^a OSAKA OHTANI UNIVERSITY   (Japan)

^b KOBE GAKUIN UNIVERSITY   (Japan)

Author keywords

Astrocyte; Brain injury; Endothelin 1; Gene expression; VEGF

Indexed keywords

ALANINE; ANGIOPOIETIN 1; ANGIOPOIETIN 2; ENDOTHELIN; ENDOTHELIN 1; ENDOTHELIN B RECEPTOR AGONIST; GLIAL FIBRILLARY ACIDIC PROTEIN; MESSENGER RNA; N (2,6 DIMETHYLPIPERIDINOCARBONYL) 4 METHYLLEUCYL DEXTRO (1 METHOXYCARBONYLTRYPTOPHANYL) DEXTRO NORLEUCINE; PLACENTAL GROWTH FACTOR; TYROSINE; VASCULOTROPIN A; VASCULOTROPIN B; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BRAIN; BRAIN CAPILLARY; CONTROLLED STUDY; ENDOTHELIUM CELL; IMMUNOREACTIVITY; MALE; MICROGLIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIUM;

ANIMALS; BRAIN; ENDOTHELIN-1; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION REGULATION; INJECTIONS, INTRAVENTRICULAR; MALE; RATS; RATS, WISTAR; RECEPTOR, ENDOTHELIN B; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 80052265900     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2011.05.058     Document Type: Article

References (43)

1. Argaw A.T., Zhang Y., Snyder B.J., Zhao M.L., Kopp N., Lee S.C., Raine C.S., Brosnan C.F., John G.R. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol 2006, 177:5574-5584.
2. Beck H., Acker T., Püschel A.W., Fujisawa H., Carmeliet P., Plate K.H. Cell type-specific expression of neuropilins in an MCA-occlusion model in mice suggests a potential role in post-ischemic brain remodeling. J Neuropathol Exp Neurol 2002, 61:339-350.
3. Choi J.S., Kim H.Y., Cha J.H., Choi J.Y., Park S.I., Jeong C.H., Jeun S.S., Lee M.Y. Upregulation of vascular endothelial growth factor receptors Flt-1 and Flk-1 following acute spinal cord contusion in rats. J Histochem Cytochem 2007, 55:821-830.
4. Cobbs C.S., Chen J., Greenberg D.A., Graham S.H. Vascular endothelial growth factor expression in transient focal cerebral ischemia in the rat. Neurosci Lett 1998, 249:79-82.
5. Fischer S., Wobben M., Kleinstück J., Renz D., Schaper W. Effect of astroglial cells on hypoxia-induced permeability in PBMEC cells. Am J Physiol Cell Physiol 2000, 279:C935-C944.
6. Hayashi T., Abe K., Suzuki H., Itoyama Y. Rapid induction of vascular endothelial growth factor gene expression after transient middle cerebral artery occlusion in rats. Stroke 1997, 28:2039-2044.
7. Ishikawa N., Takemura M., Koyama Y., Shigenaga Y., Okada T., Baba A. Endothelins promote the activation of astrocytes in rat neostriatum through ETB receptors. Eur J Neurosci 1997, 9:895-901.
8. Jin K.L., Mao X.O., Greenberg D.A. Vascular endothelial growth factor: direct neuroprotective effect in in vitro ischemia. Proc Natl Acad Sci U S A 2000, 97:10242-10247.
9. Kimura R., Nakase H., Tamaki R., Sakaki T. Vascular endothelial growth factor antagonist reduces brain edema formation and venous infarction. Stroke 2005, 36:1259-1263.
10. Koyama Y., Baba A., Matsuda T. Production of monocyte chemoattractant protein-1 and cytokine-induced neutrophil chemoattractant-1 in rat brain is stimulated by intracerebroventricular administration of an endothelin ETB receptor agonist. Neuroreport 2007, 18:1275-1279.
11. Koyama Y., Takemura M., Fujiki K., Ishikawa N., Shigenaga Y., Baba A. BQ788, an endothelin ETB receptor antagonist, attenuates stab wound injury-induced reactive astrocytes in rat brain. Glia 1999, 26:268-271.
12. Koyama Y., Tanaka K. Endothelins stimulate the production of stromelysin-1 in cultured rat astrocytes. Biochem Biophys Res Commun 2008, 371:659-663.
13. Koyama Y., Tanaka K. Intracerebroventricular administration of an endothelin ETB-receptor agonist increases expression of matrix metalloproteinase-2 and -9 in rat brain. J Pharmacol Sci 2010, 114:433-443.
14. Koyama Y., Tsujikawa K., Matsuda T., Baba A. Intracerebroventricular administration of an endothelin ETB receptor agonist increases expressions of GDNF and BDNF in rat brain. Eur J Neurosci 2003, 18:887-894.
15. Krum J.M., Mani N., Rosenstein J.M. Roles of the endogenous VEGF receptors flt-1 and flk-1 in astroglial and vascular remodeling after brain injury. Exp Neurol 2008, 212:108-117.
16. Krum J.M., Rosenstein J.M. VEGF mRNA and its receptor flt-1 are expressed in reactive astrocytes following neural grafting and tumor cell implantation in the adult CNS. Exp Neurol 1998, 154:57-65.
17. Lin T.N., Wang C.K., Cheung W.M., Hsu C.Y. Induction of angiopoietin and Tie receptor mRNA expression after cerebral ischemia-reperfusion. J Cereb Blood Flow Metab 2000, 20:387-395.
18. Loeffler S., Fayard B., Weis J., Weissenberger J. Interleukin-6 induces transcriptional activation of vascular endothelial growth factor (VEGF) in astrocytes in vivo and regulates VEGF promoter activity in glioblastoma cells via direct interaction between STAT3 and Sp1. Int J Cancer 2005, 115:202-213.
19. Macrae I.M., Robinson M.J., Graham D.I., Reid J.L., McCulloch J. Endothelin-1-induced reductions in cerebral blood flow: dose dependency, time course, and neuropathological consequences. J Cereb Blood Flow Metab 1993, 13:276-284.
20. Matsuzaki H., Tamatani M., Yamaguchi A., Namikawa K., Kiyama H., Vitek M.P., Mitsuda N., Tohyama M. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J 2001, 15:1218-1220.
21. Nag S., Eskandarian M.R., Davis J., Eubanks J.H. Differential expression of vascular endothelial growth factor-A (VEGF-A) and VEGF-B after brain injury. J Neuropathol Exp Neurol 2002, 61(9):778-788.
22. Nie X.J., Olsson Y. Endothelin peptides in brain diseases. Rev Neurosci 1996, 7:177-186.
23. Olsson A.K., Dimberg A., Kreuger J., Claesson-Welsh L. VEGF receptor signalling-in control of vascular function. Nat Rev Mol Cell Biol 2006, 7:359-371.
24. Ostrow L.W., Sachs F. Mechanosensation and endothelin in astrocytes-hypothetical roles in CNS pathophysiology. Brain Res Brain Res Rev 2005, 48:488-508.
25. Papavassiliou E., Gogate N., Proescholdt M., Heiss J.D., Walbridge S., Edwards N.A., Oldfield E.H., Merrill M.J. Vascular endothelial growth factor (vascular permeability factor) expression in injured rat brain. J Neurosci Res 1997, 49:451-460.
26. Pekny M., Nilsson M. Astrocyte activation and reactive gliosis. Glia 2005, 50:427-434.
27. Petreaca M.L., Yao M., Liu Y., Defea K., Martins-Green M. Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. Mol Biol Cell 2007, 18:5014-5023.
28. Plate K.H., Beck H., Danner S., Allegrini P.R., Wiessner C. Cell type specific upregulation of vascular endothelial growth factor in an MCA-occlusion model of cerebral infarct. J Neuropathol Exp Neurol 1999, 58:654-666.
29. Poesen K., Lambrechts D., Van Damme P., Dhondt J., Bender F., Frank N., Bogaert E., Claes B., Heylen L., Verheyen A., Raes K., Tjwa M., Eriksson U., Shibuya M., Nuydens R., Van Den Bosch L., Meert T., D'Hooge R., Sendtner M., Robberecht W., Carmeliet P. Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration. J Neurosci 2008, 28:10451-10459.
30. Rogers S.D., Peters C.M., Pomonis J.D., Hagiwara H., Ghilardi J.R., Mantyh P.W. Endothelin B receptors are expressed by astrocytes and regulate astrocyte hypertrophy in the normal and injured CNS. Glia 2003, 41:180-190.
31. Roskoski R. VEGF receptor protein-tyrosine kinases: structure and regulation. Biochem Biophys Res Commun 2008, 375:287-291.
32. Roy H., Bhardwaj S., Ylä-Herttuala S. Biology of vascular endothelial growth factors. FEBS Lett 2006, 580:2879-2887.
33. Sharkey J., Ritchie I.M., Kelly P.A. Perivascular microapplication of endothelin-1: a new model of focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 1993, 13:865-871.
34. Shibuya M. Brain angiogenesis in developmental and pathological processes: therapeutic aspects of vascular endothelial growth factor. FEBS J 2009, 276:4636-4643.
35. Shim W.S., Ho I.A., Wong P.E. Angiopoietin: a TIE(d) balance in tumor angiogenesis. Mol Cancer Res 2007, 5:655-665.
36. Sköld M.K., von Gertten C., Sandberg-Nordqvist A.C., Mathiesen T., Holmin S. VEGF and VEGF receptor expression after experimental brain contusion in rat. J Neurotrauma 2005, 22:353-367.
37. Sofroniew M.V. Reactive astrocytes in neural repair and protection. Neuroscientist 2005, 11:400-407.
38. Storkebaum E., Lambrechts D., Dewerchin M., Moreno-Murciano M.P., Appelmans S., Oh H., Van Damme P., Rutten B., Man W.Y., De Mol M., Wyns S., Manka D., Vermeulen K., Van Den Bosch L., Mertens N., Schmitz C., Robberecht W., Conway E.M., Collen D., Moons L., Carmeliet P. Treatment of motoneuron degeneration by intracerebroventricular delivery of VEGF in a rat model of ALS. Nat Neurosci 2005, 8:85-92.
39. Stratmann A., Risau W., Plate K.H. Cell type-specific expression of angiopoietin-1 and angiopoietin-2 suggests a role in glioblastoma angiogenesis. Am J Pathol 1998, 153:1459-1466.
40. Sun Y., Jin K., Xie L., Childs J., Mao X.O., Logvinova A., Greenberg D.A. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J Clin Invest 2003, 111:1843-1851.
41. van Bruggen N., Thibodeaux H., Palmer J.T., Lee W.P., Fu L., Cairns B., Tumas D., Gerlai R., Williams S.P., van Lookeren Campagne M., Ferrara N. VEGF antagonism reduces edema formation and tissue damage after ischemia/reperfusion injury in the mouse brain. J Clin Invest 1999, 104:1613-1620.
42. Yoshida H., Imaizumi T., Tanji K., Matsumiya T., Sakaki H., Kimura D., Cui X.F., Kumagai M., Tamo W., Shibata T., Hatakeyama M., Sato Y., Satoh K. Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. Brain Res 2002, 944:65-72.
43. zZhang Z.G., Zhang L., Jiang Q., Zhang R., Davies K., Powers C., Bruggen N., Chopp M. VEGF enhances angiogenesis and promotes blood-brain barrier leakage in the ischemic brain. J Clin Invest 2000, 106:829-838.