Baclofen-loaded solid lipid nanoparticles: Preparation, electrophysiological assessment of efficacy, pharmacokinetic and tissue distribution in rats after intraperitoneal administration

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 79, Issue 1, 2011, Pages 135-141

  Priano, Lorenzo ^a,b   Zara, Gian Paolo ^b   El Assawy, Nadia ^a   Cattaldo, Stefania ^a   Muntoni, Elisabetta ^b   Milano, Eva ^a   Serpe, Loredana ^b   Musicanti, Claudia ^c   Pérot, Chantal ^d   Gasco, Maria Rosa ^c   Miscio, Giacinta ^a   Mauro, Alessandro ^a,b  

^a ISTITUTO AUXOLOGICO ITALIANO   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c NANOVECTOR S R L   (Italy)

^d UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

Author keywords

Baclofen; H reflex; Intraperitoneal; Rats; Solid lipid nanoparticles; Spasticity

Indexed keywords

BACLOFEN; SOLID LIPID NANOPARTICLE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG FORMULATION; ELECTROPHYSIOLOGY; MALE; NONHUMAN; RAT; TISSUE DISTRIBUTION;

ANIMALS; BACLOFEN; BEHAVIOR, ANIMAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG DELIVERY SYSTEMS; DRUG EVALUATION, PRECLINICAL; H-REFLEX; INJECTIONS, INTRAPERITONEAL; LIPIDS; MALE; MUSCLE RELAXANTS, CENTRAL; MUSCLE SPASTICITY; NANOPARTICLES; RATS; RATS, WISTAR; TISSUE DISTRIBUTION;

EID: 80052261944     PISSN: 09396411     EISSN: 18733441     Source Type: Journal    
DOI: 10.1016/j.ejpb.2011.02.009     Document Type: Article

References (42)

1. M. Kita, and D.E. Goodkin Drugs used to treat spasticity Drugs 59 3 2000 487 495 (Pubitemid 30213859)
2. J.S. Rietman, and J.H. Geertzen Efficacy of intrathecal baclofen delivery in the management of severe spasticity in upper motor neuron syndrome Acta Neurochir. Suppl. 97 Pt 1 2007 205 211
3. A. Dario, and G. Tomei A benefit-risk assessment of baclofen in severe spinal spasticity Drug Saf. 27 11 2004 799 818 (Pubitemid 39243562)
4. F. Lagarce, P. Renaud, N. Faisant, G. Nicolas, A. Cailleux, J. Richard, P. Menei, and J.P. Benoit Baclofen-loaded microspheres: preparation and efficacy testing in a new rabbit model Eur. J. Pharm. Biopharm. 59 3 2005 449 459 (Pubitemid 40342519)
5. M.K. Shellenberger, L. Groves, J. Shah, and G.D. Novack A controlled pharmacokinetic evaluation of tizanidine and baclofen at steady state Drug Metab. Dispos. 27 2 1999 201 204 (Pubitemid 29072072)
6. A.J. Almeida, and E. Souto Solid lipid nanoparticles as a drug delivery system for peptides and proteins Adv. Drug Deliv. Rev. 59 6 2007 478 490 (Pubitemid 47260710)
7. M. Uner, and G. Yener Importance of solid lipid nanoparticles (SLN) in various administration routes and future perspectives Int. J. Nanomed. 2 3 2007 289 300 (Pubitemid 350047774)
8. V. Podio, G.P. Zara, M. Carazzonet, R. Cavalli, and M.R. Gasco Biodistribution of stealth and non-stealth solid lipid nanospheres after intravenous administration to rats J. Pharm. Pharmacol. 52 9 2000 1057 1063
9. A. Fundaro, R. Cavalli, A. Bargoni, D. Vighetto, G.P. Zara, and M.R. Gasco Non-stealth and stealth solid lipid nanoparticles (SLN) carrying doxorubicin: pharmacokinetics and tissue distribution after i.v. administration to rats Pharmacol. Res. 42 4 2000 337 343
10. G.P. Zara, R. Cavalli, A. Bargoni, A. Fundaro, D. Vighetto, and M.R. Gasco Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: pharmacokinetics and distribution of doxorubicin in brain and other tissues J. Drug Target. 10 4 2002 327 335 (Pubitemid 34746314)
11. A. Bargoni, R. Cavalli, O. Caputo, A. Fundaro, M.R. Gasco, and G.P. Zara Solid lipid nanoparticles in lymph and plasma after duodenal administration to rats Pharm. Res. 15 5 1998 745 750 (Pubitemid 28275652)
12. A. Bargoni, R. Cavalli, G.P. Zara, A. Fundaro, O. Caputo, and M.R. Gasco Transmucosal transport of tobramycin incorporated in solid lipid nanoparticles (SLN) after duodenal administration to rats. Part II - tissue distribution Pharmacol. Res. 43 5 2001 497 502 (Pubitemid 32578867)
13. R. Cavalli, A. Bargoni, V. Podio, E. Muntoni, G.P. Zara, and M.R. Gasco Duodenal administration of solid lipid nanoparticles loaded with different percentages of tobramycin J. Pharm. Sci. 92 5 2003 1085 1094 (Pubitemid 36523455)
14. G.P. Zara, A. Bargoni, R. Cavalli, A. Fundaro, D. Vighetto, and M.R. Gasco Pharmacokinetics and tissue distribution of idarubicin-loaded solid lipid nanoparticles after duodenal administration to rats J. Pharm. Sci. 91 5 2002 1324 1333 (Pubitemid 34651194)
15. R. Cavalli, M.R. Gasco, P. Chetoni, S. Burgalassi, and M.F. Saettone Solid lipid nanoparticles (SLN) as ocular delivery system for tobramycin Int. J. Pharm. 238 1-2 2002 241 245 (Pubitemid 34457892)
16. L. Priano, D. Esposti, R. Esposti, G. Castagna, C. De Medici, F. Fraschini, M.R. Gasco, and A. Mauro Solid lipid nanoparticles incorporating melatonin as new model for sustained oral and transdermal delivery systems J. Nanosci. Nanotechnol. 7 10 2007 3596 3601
17. X.Y. Chen, L. Chen, and J.R. Wolpaw Time course of H-reflex conditioning in the rat Neurosci. Lett. 302 2-3 2001 85 88 (Pubitemid 32274215)
18. H.M. Meinck Occurrence of the H reflex and the F wave in the rat Electroencephalogr. Clin. Neurophysiol. 41 5 1976 530 533
19. X.Y. Chen, L. Chen, J.R. Wolpaw, and L.B. Jakeman Corticospinal tract transection reduces H-reflex circadian rhythm in rats Brain Res. 942 1-2 2002 101 108 (Pubitemid 34597074)
20. C. Perot, and M.I. Almeida-Silveira The human H and T reflex methodologies applied to the rat J. Neurosci. Methods 51 1 1994 71 76 (Pubitemid 24089273)
21. I. Tsunoda, L.Q. Kuang, N.D. Tolley, J.L. Whitton, and R.S. Fujinami Enhancement of experimental allergic encephalomyelitis (EAE) by DNA immunization with myelin proteolipid protein (PLP) plasmid DNA J. Neuropathol. Exp. Neurol. 57 8 1998 758 767 (Pubitemid 28378153)
22. M. Nemethy, L. Paroli, P.G. Williams-Russo, and T.J. Blanck Assessing sedation with regional anesthesia: inter-rater agreement on a modified Wilson sedation scale Anesth. Analg. 94 3 2002 723 728 table of contents (Pubitemid 34177579)
23. T.L. Chuck, P.J. McLaughlin, M.N. Arizzi-LaFrance, J.D. Salamone, and M. Correa Comparison between multiple behavioral effects of peripheral ethanol administration in rats: sedation, ataxia, and bradykinesia Life Sci. 79 2 2006 154 161 (Pubitemid 43737067)
24. A.M. Rustum Simple and rapid reversed-phase high-performance liquid chromatographic determination of baclofen in human plasma with ultraviolet detection. Application to a pharmacokinetic study J. Chromatogr. 487 1 1989 107 115 (Pubitemid 19122054)
25. D. Dykstra, M. Stuckey, L. DesLauriers, D. Chappuis, and L. Krach Intrathecal baclofen in the treatment of spasticity Acta Neurochir. Suppl. 97 Pt 1 2007 163 171
26. D.S. Stokic, and S.A. Yablon Neurophysiological basis and clinical applications of the H-reflex as an adjunct for evaluating response to intrathecal baclofen for spasticity Acta Neurochir. Suppl. 97 Pt 1 2007 231 241
27. D.S. Stokic, S.A. Yablon, A. Hayes, V. Vesovic-Potic, and J. Olivier Dose-response relationship between the H-reflex and continuous intrathecal baclofen administration for management of spasticity Clin. Neurophysiol. 117 6 2006 1283 1289 (Pubitemid 43825777)
28. M. Pohl, G. Rockstroh, S. Ruckriem, J. Mehrholz, M. Pause, R. Koch, and H. Strik Time course of the effect of a bolus dose of intrathecal baclofen on severe cerebral spasticity J. Neurol. 250 10 2003 1195 1200 (Pubitemid 37289651)
29. C. Detrembleur, and L. Plaghki Quantitative assessment of intrathecally administered baclofen in spasticity Arch. Phys. Med. Rehabil. 81 3 2000 279 284 (Pubitemid 30149274)
30. M.L. Latash, R.D. Penn, D.M. Corcos, and G.L. Gottlieb Short-term effects of intrathecal baclofen in spasticity Exp. Neurol. 103 2 1989 165 172 (Pubitemid 19047245)
31. Y. Lazorthes, B. Sallerin-Caute, J.C. Verdie, R. Bastide, and J.P. Carillo Chronic intrathecal baclofen administration for control of severe spasticity J. Neurosurg. 72 3 1990 393 402 (Pubitemid 20072962)
32. B. Dachy, and B. Dan Electrophysiological assessment of the effect of intrathecal baclofen in spastic children Clin. Neurophysiol. 113 3 2002 336 340 (Pubitemid 34233854)
33. G. Orsnes, C. Crone, C. Krarup, N. Petersen, and J. Nielsen The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients Clin. Neurophysiol. 111 8 2000 1372 1379 (Pubitemid 30445169)
34. D.S. Stokic, S.A. Yablon, and A. Hayes Comparison of clinical and neurophysiologic responses to intrathecal baclofen bolus administration in moderate-to-severe spasticity after acquired brain injury Arch. Phys. Med. Rehabil. 86 9 2005 1801 1806 (Pubitemid 41354194)
35. X.Y. Chen, and J.R. Wolpaw Circadian rhythm in rat H-reflex Brain Res. 648 1 1994 167 170 (Pubitemid 24171587)
36. H. Mohler, D. Benke, and J.M. Fritschy GABA(B)-receptor isoforms molecular architecture and distribution Life Sci. 68 19-20 2001 2297 2300 (Pubitemid 32452385)
37. R.A. Nicoll My close encounter with GABA(B) receptors Biochem. Pharmacol. 68 8 2004 1667 1674
38. M. Chebib, and G.A. Johnston The 'ABC' of GABA receptors: a brief review Clin. Exp. Pharmacol. Physiol. 26 11 1999 937 940 (Pubitemid 29513638)
39. J. Ong, and D.I. Kerr Recent advances in GABAB receptors: from pharmacology to molecular biology Acta Pharmacol. Sin. 21 2 2000 111 123 (Pubitemid 30094209)
40. A. Dario, R. Pisani, S. Sangiorgi, F. Pessina, and G. Tomei Relationship between intrathecal baclofen and the central nervous system Acta Neurochir. Suppl. 97 Pt 1 2007 461 464
41. U. Misgeld, M. Bijak, and W. Jarolimek A physiological role for GABAB receptors and the effects of baclofen in the mammalian central nervous system Prog. Neurobiol. 46 4 1995 423 462
42. N.G. Bowery GABAB receptor: a site of therapeutic benefit Curr. Opin. Pharmacol. 6 1 2006 37 43 (Pubitemid 43103818)