Gut-brain axis

Current Opinion in Clinical Nutrition and Metabolic Care

Volumn 11, Issue 4, 2008, Pages 518-521

  Romijn, Johannes A ^a   Corssmit, Eleonora P ^a   Havekes, Louis M ^a   Pijl, Hanno ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bone; Functional MRI; Gut peptides; Hypothalamus; Insulin sensitivity; Neuropeptide Y; Peptide YY; Sympathetic nerves; Type 2 diabetes mellitus; Vagal nerve

Indexed keywords

CHOLECYSTOKININ; FAT; FATTY ACID; GASTROINTESTINAL HORMONE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; GLUCOSE; INSULIN; OXYNTOMODULIN; PEPTIDE YY; PEPTIDE YY [3-36]; RECEPTOR PROTEIN; PEPTIDE HORMONE;

ADRENERGIC SYSTEM; ARCUATE NUCLEUS; AUTONOMIC NERVOUS SYSTEM; BLOOD BRAIN BARRIER; BONE METABOLISM; BRAIN FUNCTION; CHOLINERGIC SYSTEM; EFFERENT NERVE; ENDOCRINE SYSTEM; FOOD INTAKE; GLUCOSE METABOLISM; HORMONE ACTION; HORMONE RELEASE; HORMONE SENSITIVITY; HUMAN; HYPOTHALAMUS; HYPOTHALAMUS FUNCTION; INSULIN RELEASE; INSULIN SENSITIVITY; INTESTINE FUNCTION; INTESTINE INNERVATION; LIPID METABOLISM; NONHUMAN; PANCREAS SECRETION; PATHOPHYSIOLOGY; PROTEIN DEGRADATION; REGULATORY MECHANISM; REVIEW; SATIETY; SENSORY NERVE; STOMACH EMPTYING; VAGUS NERVE; WEIGHT CONTROL; ENERGY METABOLISM; GASTROINTESTINAL TRACT; METABOLISM; NEUROSECRETION; PHYSIOLOGY;

APPETITE REGULATION; ENERGY METABOLISM; ENTERIC NERVOUS SYSTEM; GASTROINTESTINAL HORMONES; GASTROINTESTINAL TRACT; GLUCOSE; HUMANS; HYPOTHALAMUS; NEUROSECRETORY SYSTEMS; PEPTIDE HORMONES;

EID: 54049084216     PISSN: 13631950     EISSN: 15353885     Source Type: Journal    
DOI: 10.1097/MCO.0b013e328302c9b0     Document Type: Review

References (27)

1. Cornier MA, von Kaenel SS, Bessesen DH, Tregellas JR. Effects of overfeeding on the neuronal response to visual food cues. Am J Clin Nutr 2007; 86:965-971.
2. Vidarsdottir S, Smeets PA, Eichelsheim DL, et al. Glucose ingestion fails to inhibit hypothalamic neuronal activity in patients with type 2 diabetes. Diabetes 2007; 56:2547-2550.
3. Drucker DJ, Nauck MA. The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes. Lancet 2006; 368:1696-1705.
4. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev 2007; 87:1409-1439.
5. Cummings DE, Overduin J. Gastrointestinal regulation of food intake. J Clin Invest 2007; 117:13-23.
6. Abbott CR, Small CJ, Kennedy AR, et al. Blockade of the neuropeptide Y2 receptor with the specific antagonist BIIE0246 attenuates the effect of endogenous and exogenous peptide YY(3-36) on food intake. Brain Res 2007; 1043:139-144.
7. Abbott CR, Monteiro M, Small CJ, et al. The inhibitory effects of peripheral administration of peptide YY(3-36) and glucagon-like peptide-1 on food intake are attenuated by ablation of the vagal-brainstem-hypothalamic pathway. Brain Res 2005; 1044:127-131.
8. Koda S, Date Y, Murakami N, et al. The role of the vagal nerve in peripheral PYY3-36-induced feeding reduction in rats. Endocrinology 2005; 146:2369-2375.
9. Boey D, Lin S, Enriquez RF, et al. PYY transgenic mice are protected against diet-induced and genetic obesity. Neuropeptides 2007; 42:19-30.
10. Batterham RL, Heffron A, Kapoor S, et al. Critical role for peptide YY in protein-mediated satiation and body weight regulation. Cell Metab 2006; 4:223-233.
11. Wortley KE, Garcia K, Okamoto H, et al. Peptide YY regulates bone turnover in rodents. Gastroenterology 2007; 133:1534-1543.
12. Batterham R, Cohen MA, Eliis SM, et al. Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 2003; 349:941-948.
13. Sloth B, Davidsen L, Holst JJ, et al. Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males. Am J Physiol Endocrinol Metab 2007; 293:E604-E609.
14. Tschop MH, Ravussin E. Peptide YY: obesity's cause and cure? Am J Physiol Endocrinol Metab 2007; 293:E1131-E1133.
15. Lumb KJ, DeCarr LB, Milardo LF, et al. Novel selective neuropeptide Y2 receptor PEGylated peptide agonists reduce food intake and body weight in mice. J Med Chem 2007; 50:2264-2268.
16. Batterham RL, FfytcheDH, Rosenthal JM, et al. PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 2007; 450:106-109.
17. le Roux CW, Welbourn R, Werling M, et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Ann Surg 2007; 246:780-785.
18. Pfluger PJ, Kampe J, Castaneda TR, et al. Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36. J Clin Endocrinol Metab 2007; 92:583-588.
19. van den Hoek AM, Heijboer AC, Voshol PJ, et al. Chronic PYY3-36 treatment promotes fat oxidation and ameliorates insulin resistance in C57BL6 mice. Am J Physiol Endocrinol Metab 2007; 292:E238-E245.
20. Sloth B, Holst JJ, Flint A, et al. Effects of PYY1-36 and PYY3-36 on appetite, energy intake, energy expenditure, glucose and fat metabolism in obese and lean subjects. Am J Physiol Endocrinol Metab 2007; 292:E1062-E1068.
21. Baldock PA, Sainsbury A, Couzens M, et al. Hypothalamic Y2 receptors regulate bone formation. J Clin Invest 2002; 109:915-921.
22. Li Y. Sensory signal transduction in the vagal primary afferent neurons. Curr Med Chem 2007; 14:2554-2563.
23. Beyak M, Bulmer DCE, Jiang W, et al. Extrinsic sensory afferent nerves innervating the gastrointestinal tract. In: Johnson LR, editor. Physiology of the gastrointestinal tract, vol. 1. Elsevier Academic Press; 2006. pp. 685-726.
24. Prechtl JC, Powley TL. The fiber composition of the abdominal vagus of the rat. Anat Embryol 1990; 181:101-103.
25. Li Y, Wu XY, Owyang C. Serotonin and cholecystokinin synergistically stimulate rat vagal primary afferent neurones. J Physiol 2004; 559:651-662.
26. Peters JH, Simasko SM, Ritter RC. Modulation of vagal afferent excitation and reduction of food intake by leptin and cholecystokinin. Physiol Behav 2006; 89:477-485.
27. Sobocki J, Krolczyk G, Herman RM, et al. Influence of vagal nerve stimulation on food intake and body weight: results of experimental studies. J Physiol Pharmacol 2005; 56:27-33.