Enteric coated magnetic HPMC capsules evaluated in human gastrointestinal tract by AC biosusceptometry

Pharmaceutical Research

Volumn 23, Issue 8, 2006, Pages 1809-1816

  Corá, Luciana A ^a   Romeiro, Fernando G ^b   Paixão, Fabiano C ^a   Américo, Madileine F ^c   Oliveira, Ricardo B ^c   Baffa, Oswaldo ^c   Miranda, José Ricardo A ^a,d  

^a IBB   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d CXP 510 ^*  (Brazil)

Author keywords

Biosusceptometry; Colonic drug delivery; Gastrointestinal motility; HPMC capsules; Magnetic images

Indexed keywords

EUDRAGIT; FERRITE; FERROMAGNETIC MATERIAL; HYDROXYPROPYLMETHYLCELLULOSE; STARCH GLYCOLATE SODIUM; VCAPS;

ADULT; ALTERNATING CURRENT BIOSUSCEPTOMETRY; ARTICLE; CECUM; CONTROLLED STUDY; DRUG CAPSULE; DRUG DOSAGE FORM; DRUG SCREENING; ENTERIC COATED TABLET; FEMALE; GASTRIC RESIDENCE TIME; GASTROINTESTINAL MOTILITY; HUMAN; HUMAN EXPERIMENT; IMAGE ANALYSIS; IN VITRO STUDY; IN VIVO STUDY; INTESTINE TRANSIT TIME; MAGNETISM; MALE; NON INVASIVE MEASUREMENT; NORMAL HUMAN; OROCECAL TRANSIT TIME; PRIORITY JOURNAL; SENSOR; SMALL INTESTINE; TABLET DISINTEGRATION TIME; TECHNIQUE;

ADULT; CAPSULES; CECUM; EXCIPIENTS; FEMALE; FERRIC COMPOUNDS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; GASTROINTESTINAL TRANSIT; HUMANS; HYDROGEN-ION CONCENTRATION; ILEOCECAL VALVE; INTESTINE, SMALL; MAGNETICS; MALE; METHYLCELLULOSE; POLYMETHACRYLIC ACIDS; SOLUBILITY; TABLETS, ENTERIC-COATED;

EID: 33746920384     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-006-9035-0     Document Type: Article

References (40)

1. L. Yang, J. S. Chu, and J. A. Fix. Colon-specific drug delivery: new approaches and in vitro/in vivo evaluation. Int. J. Pharm. 235:1-15 (2002).
2. M. A. Shareef, R. K. Khar, A. Ahuja, F. J. Ahmad, and S. Raghava. Colonic drug delivery: an updated review. AAPS Pharm. Sci. 5:1-26 (2003).
3. E. T. Cole, R. A. Scott, A. L. Connor, I. R. Wilding, H-U. Petereit, C. Schminke, T. Beckert, and D. Cadé. Enteric coated HPMC capsules designed to achieve intestinal targeting. Int. J. Pharm. 231:83-95 (2002).
4. O. Honkanen, J. Marvola, H. Kanerva, K. Lindevall, M. Lipponen, T. Kekki, A. Ahonen, and M. Marvola. Gamma scintigraphic evaluation of the fate of hydroxypropyl methylcellulose capsules in the human gastrointestinal tract. Eur. J. Pharm. Sci. 21:671-678 (2004).
5. C. S. Leopold. Coated dosage forms for colon-specific drug delivery. Pharm. Sci. Technol. Today 2:197-252 (1999).
6. C. D. Melia and S. S. Davis. Review article: mechanisms of drug release from tablets and capsules. I: disintegration. Aliment. Pharmacol. Ther. 3:223-232 (1989).
7. E. Lipka and G. L. Amidon. Setting bioequivalence requirements for drug development based on preclinical data: optimizing oral drug delivery systems. J. Control. Release 62:41-49 (1999).
8. M. Zahirul and I. Khan. Dissolution testing for sustained or controlled release oral dosage forms and correlation with in vivo data: challenges and opportunities. Int. J. Pharm. 140:131-143 (1996).
9. N. Rouge, P. Buri, and E. Doelker. Drug absorption sites in the gastrointestinal tract and dosage forms for site-specific delivery. Int. J. Pharm. 136:117-139 (1996).
10. M. Singh and V. Waluch. Physics and instrumentation for imaging in-vivo drug distribution. Adv. Drug Deliv. Rev. 4:7-20 (2000).
11. I. R. Wilding, A. J. Coupe, and S. S. Davis. The role of γ-scintigraphy in oral drug delivery. Adv. Drug Deliv. Rev. 46:103-124 (2001).
12. J. C. Richardson, R. W. Bowtell, K. Mäder, and C. D. Melia. Pharmaceutical applications of magnetic resonance imaging (MRI). Adv. Drug Deliv. Rev. 57:1191-1209 (2005).
13. A. Steingoetter, D. Weishaup, P. Kunz, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, and W. Schwizer. Magnetic resonance imaging for the in vivo evaluation of gastric-retentive tablets. Pharm. Res. 20:2001-2007 (2003).
14. A. Steingoetter, P. Kunz, D. Weishaupt, K. Mäder, H. Lengsfeld, M. Thumshirn, P. Boesiger, M. Fried, and W. Schwizer. Analysis of the meal-dependent intragastric performance of a gastric-retentive tablet assessed by magnetic resonance imaging. Aliment. Pharmacol. Ther. 18:713-720 (2003).
15. W. Weitschies, O. Kosch, H. Mönnikes, and L. Trahms. Magnetic Marker Monitoring: an application of biomagnetic measurement instrumentation and principles for the determination of the gastrointestinal behavior of magnetically marked solid dosage forms. Adv. Drug Deliv. Rev. 57:1210-1222 (2005).
16. J. R. A. Miranda, O. Baffa, and R. B. Oliveira. An AC biosusceptometer to study gastric emptying. Med. Phys. 19:445-448 (1992).
17. L. A. Corá, M. F. Américo, R. B. Oliveira, O. Baffa, R. Moraes, F. G. Romeiro, and J. R. A. Miranda. Disintegration of magnetic tablets in human stomach evaluated by alternate current biosusceptometry. Eur. J. Pharm. Biopharm. 56:413-420 (2003).
18. L. A. Corá, F. G. Romeiro, M. Stelzer, M. F. Américo, R. B. Oliveira, O. Baffa, and J. R. A. Miranda. AC biosusceptometry in the study of drug delivery. Adv. Drug Deliv. Rev. 57:1223-1241 (2005).
19. O. Baffa, R. B. Oliveira, J. R. A. Miranda, and L. E. A. Troncon. Analysis and development of AC biosusceptometer for orocaecal transit time measurements. Med. Biol. Eng. Comput. 33:353-357 (1995).
20. R. B. Oliveira, O. Baffa, L. E. A. Troncon, J. R. A. Miranda, and C. R. Cambrea. Evaluation of a biomagnetic technique for measurement of orocaecal transit time. Eur. J. Gastroenterol. Hepatol. 8:491-495 (1996).
21. J. R. A. Miranda, R. B. Oliveira, P. L. Sousa, F. J. H. Braga, and O. Baffa. A novel biomagnetic method to study gastric antral contractions. Phys. Med. Biol. 42:1791-1799 (1997).
22. R. Moraes, L. A. Corá, M. F. Américo, R. B. Oliveira, O. Baffa, and J. R. A. Miranda. Measurement of gastric contraction activity in dogs by means of AC biosusceptometry. Physiol. Meas. 24:337-345 (2003).
23. M. Moreira, L. Murta, and O. Baffa. Imaging ferromagnetic tracers with an AC biosusceptometer. Rev. Sci.Instrum. 71:2532-2538 (2000).
24. L. A. Corá, U. Andreis, F. G. Romeiro, M. F. Américo, R. B. Oliveira, O. Baffa, and J. R. A. Miranda. Magnetic images of the disintegration process of tablets in the human stomach by ac biosusceptometry. Phys. Med. Biol. 50:5523-5534 (2005).
25. L. A. Corá, F. G. Romeiro, M. F. Américo, R. B. Oliveira, O. Baffa, M. Stelzer, and J. R. A. Miranda. Gastrointestinal transit and disintegration of enteric coated magnetic tablets assessed by ac biosusceptometry. Eur. J. Pharm. Sci. 27:1-8 (2006).
26. E. H. Frei, E. Gunders, M. Pajewsky, W. J. Alkan, and J. Eshcher. Ferrites as contrast material for medical X-ray diagnosis. J. Appl. Phys. 39:99-1001 (1968).
27. V. G. Belikov and A. G. Kuregyan. Generation and medicobiological application of magnetic fields and carriers (review). Pharm. Chem. J. 35:88-95 (2001).
28. A. David, B. Yagen, A. Sintov, and A. Rubinstein. Acrylic polymers for colon-specific drug delivery. STP Pharma Sci. 7:546-554 (1997).
29. K. Lehman. Practical Course in Film Coating of Pharmaceutical Dosage Forms with Eudragit® Pharma Polymers, Darmstadt, 2001.
30. D. F. Evans, G. Pye, R. Bramley, A. G. Clark, T. J. Dyson, and J. D. Hardcastle Measurement of gastrointestinal pH profiles in normal ambulant human subjects. Gut 29:1035-1041 (1988).
31. M. K. Chourasia and S. K. Jain. Pharmaceutical approaches to colon target drug delivery systems. J. Pharm. Pharmaceut. Sci. 6:33-66 (2003).
32. E. M. M. Quigley. Gastric and small motility in health and disease. Gastroenterol. Clin. North Am. 25:113-145 (1996).
33. A. J. Coupe, S. S. Davis, and I. R. Wilding. Variation in gastrointestinal transit of pharmaceutical dosage forms in healthy subjects. Pharm. Res. 8:360-364 (1991).
34. F. Kedzierewicz, P. Thouvenot, J. Lemut, A. Etienne, M. Hoffman, and P. Maincent. Evaluation of peroral silicone dosage forms in humans by gamma-scintigraphy. J. Control. Release 58:195-205 (1999).
35. S. S. Davis, J. G. Hardy, and J. W. Fara. Transit of pharmaceutical dosage forms through the small intestine. Gut 27:886-892 (1986).
36. D. Harris, J. T. Fell, H. L. Sharma, and D. C. Taylor. GI transit of potential bioadhesive formulations in man: a scintigraphy study. J. Control. Release 12:45-53 (1990).
37. C. J. Kenyon, R. V. Nardi, D. Wong, G. Hooper, I. R. Wilding, and D. R. Friend. Colonic delivery of dexamethasone: a pharmacoscintigraphic evaluation. Aliment. Pharmacol. Ther. 11:205-213 (1997).
38. C. Tuleu, A. W. Basit, W. A. Waddington, P. J. Ell, and J. M. Newton. Colonic delivery of 4-aminosalicylic acid using amylase-ethylcellulose-coated hydroxypropylmethylcellulose capsules. Aliment. Pharmacol.Ther. 16:1771-1779 (2002).
39. K.-H. Lin, S.-Y. Lin, and M.-J. Li. Compression forces and amount of outer coating layer affecting the time-controlled disintegration of the compression-coated tablets prepared by direct compression with micronized ethylcellulose. J. Pharm. Sci. 90:2005-2009 (2001).
40. H. Zhou. Pharmacokinetic strategies in deciphering atypical drug absorption profiles. J. Clin. Pharmacol. 43:211-227 (2003).