-
1
-
-
34447574784
-
Incretins and their role in the management of diabetes
-
DOI 10.1097/MED.0b013e32825ea2ba, PII 0126602920070800000003
-
Frias JP, Edelman SV. Incretins and their role in the management of diabetes. Curr Opin Endocrinol Diabetes Obes 2007;14:269-76. (Pubitemid 47067110)
-
(2007)
Current Opinion in Endocrinology, Diabetes and Obesity
, vol.14
, Issue.4
, pp. 269-276
-
-
Frias, J.P.1
Edelman, S.V.2
-
2
-
-
34548803017
-
Incretin-based treatment of type 2 diabetes: Glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors
-
DOI 10.1111/j.1463-1326.2007.00765.x
-
Deacon CF. Incretin-based treatment of type 2 diabetes: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors. Diabetes Obes Metab 2007;9(suppl 1):23-31. (Pubitemid 47433966)
-
(2007)
Diabetes, Obesity and Metabolism
, vol.9
, Issue.SUPPL.1
, pp. 23-31
-
-
Deacon, C.F.1
-
3
-
-
3242730474
-
Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans
-
Holst JJ, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004;287:E199-206.
-
(2004)
Am J Physiol Endocrinol Metab
, vol.287
-
-
Holst, J.J.1
Gromada, J.2
-
4
-
-
0026659679
-
Glucagon-like peptide-1, a new hormone of the entero-insular axis
-
Orskov C. Glucagon-like peptide-1, a new hormone of the entero-insular axis. Diabetologia 1992;35:701-11.
-
(1992)
Diabetologia
, vol.35
, pp. 701-711
-
-
Orskov, C.1
-
5
-
-
67049155251
-
Unraveling the science of incretin biology
-
Nauck MA. Unraveling the science of incretin biology. Am J Med 2009;122:S3-10.
-
(2009)
Am J Med
, vol.122
-
-
Nauck, M.A.1
-
6
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type- 2 diabetes mellitus
-
Nauck MA, Heimesaat MM, Orskov C, Holst JJ, Ebert R, Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 1993;91:301-7. (Pubitemid 23037285)
-
(1993)
Journal of Clinical Investigation
, vol.91
, Issue.1
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
7
-
-
57649234120
-
The incretin system and its role in type 2 diabetes mellitus
-
Holst JJ, Vilsboll T, Deacon CF. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 2008;297:127-36.
-
(2008)
Mol Cell Endocrinol
, vol.297
, pp. 127-136
-
-
Holst, J.J.1
Vilsboll, T.2
Deacon, C.F.3
-
8
-
-
0037844361
-
Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative
-
DOI 10.1016/S0928-0987(03)00073-3
-
Agerso H, Vicini P. Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative. Eur J Pharm Sci 2003;19:141-50. (Pubitemid 36668041)
-
(2003)
European Journal of Pharmaceutical Sciences
, vol.19
, Issue.2-3
, pp. 141-150
-
-
Agerso, H.1
Vicini, P.2
-
9
-
-
0037241085
-
Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects
-
DOI 10.1210/jc.2002-021053
-
Vilsboll T, Agerso H, Krarup T, Holst JJ. Similar elimination rates of glucagon-like peptide-1 in obese type 2 diabetic patients and healthy subjects. J Clin Endocrinol Metab 2003;88:220-4. (Pubitemid 36115169)
-
(2003)
Journal of Clinical Endocrinology and Metabolism
, vol.88
, Issue.1
, pp. 220-224
-
-
Vilsboll, T.1
Agerso, H.2
Krarup, T.3
Holst, J.J.4
-
10
-
-
4344675057
-
Therapeutic strategies based on glucagon-like peptide 1
-
DOI 10.2337/diabetes.53.9.2181
-
Deacon CF. Therapeutic strategies based on glucagon-like peptide 1. Diabetes 2004;53:2181-9. (Pubitemid 39145569)
-
(2004)
Diabetes
, vol.53
, Issue.9
, pp. 2181-2189
-
-
Deacon, C.F.1
-
11
-
-
35348834158
-
Application of incretin mimetics and dipeptidyl peptidase IV inhibitors in managing type 2 diabetes mellitus
-
Boyle PJ, Freeman JS. Application of incretin mimetics and dipeptidyl peptidase IV inhibitors in managing type 2 diabetes mellitus. J Am Osteopath Assoc 2007;107(suppl):S10-16.
-
(2007)
J Am Osteopath Assoc
, vol.107
, Issue.SUPPL.
-
-
Boyle, P.J.1
Freeman, J.S.2
-
13
-
-
7444228521
-
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
-
DOI 10.2337/diacare.27.11.2628
-
Buse JB, Henry RR, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 2004;27:2628-35. (Pubitemid 39441462)
-
(2004)
Diabetes Care
, vol.27
, Issue.11
, pp. 2628-2635
-
-
Buse, J.B.1
Henry, R.R.2
Han, J.3
Kim, D.D.4
Fineman, M.S.5
Baron, A.D.6
-
14
-
-
18144401971
-
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2
-
DOI 10.2337/diacare.28.5.1092
-
DeFronzo RA, Ratner RE, Han J, Kim DD, Fineman MS, Baron AD. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 2005;28:1092-100. (Pubitemid 40616618)
-
(2005)
Diabetes Care
, vol.28
, Issue.5
, pp. 1092-1100
-
-
DeFronzo, R.A.1
Ratner, R.E.2
Han, J.3
Kim, D.D.4
Fineman, M.S.5
Baron, A.D.6
-
15
-
-
17144371646
-
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
-
DOI 10.2337/diacare.28.5.1083
-
Kendall DM, Riddle MC, Rosenstock J, et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 2005;28:1083-91. (Pubitemid 40616617)
-
(2005)
Diabetes Care
, vol.28
, Issue.5
, pp. 1083-1091
-
-
Kendall, D.M.1
Riddle, M.C.2
Rosenstock, J.3
Zhuang, D.4
Kim, D.D.5
Fineman, M.S.6
Baron, A.D.7
-
16
-
-
33746800119
-
Investigational treatments for Type 2 diabetes mellitus: Exenatide and liraglutide
-
DOI 10.1517/13543784.15.8.887
-
Gonzalez C, Beruto V, Keller G, Santoro S, Di GG. Investigational treatments for type 2 diabetes mellitus: exenatide and liraglutide. Expert Opin Invest Drugs 2006;15:887-95. (Pubitemid 44177842)
-
(2006)
Expert Opinion on Investigational Drugs
, vol.15
, Issue.8
, pp. 887-895
-
-
Gonzalez, C.1
Beruto, V.2
Keller, G.3
Santoro, S.4
Di, G.G.5
-
17
-
-
77951100878
-
Albiglutide: A new GLP-1 analog for the treatment of type 2 diabetes
-
St Onge EL, Miller SA. Albiglutide: a new GLP-1 analog for the treatment of type 2 diabetes. Expert Opin Biol Ther 2010;10:801-6.
-
(2010)
Expert Opin Biol Ther
, vol.10
, pp. 801-806
-
-
St Onge, E.L.1
Miller, S.A.2
-
18
-
-
79953040963
-
An overview of once-weekly GLP-1 receptor agonists: Available efficacy and safety data and perspectives for the future
-
Madsbad S, Kielgast U, Asmar M, Deacon C, Torekov SS, Holst JJ. An overview of once-weekly GLP-1 receptor agonists: available efficacy and safety data and perspectives for the future. Diabetes Obes Metab 2011;13:394-407.
-
(2011)
Diabetes Obes Metab
, vol.13
, pp. 394-407
-
-
Madsbad, S.1
Kielgast, U.2
Asmar, M.3
Deacon, C.4
Torekov, S.S.5
Holst, J.J.6
-
19
-
-
77955887980
-
Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled trial
-
Ratner RE, Rosenstock J, Boka G. Dose-dependent effects of the once-daily GLP-1 receptor agonist lixisenatide in patients with type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled trial. Diabet Med 2010;27:1024-32.
-
(2010)
Diabet Med
, vol.27
, pp. 1024-1032
-
-
Ratner, R.E.1
Rosenstock, J.2
Boka, G.3
-
20
-
-
79952291919
-
GLP-1 for type 2 diabetes
-
Ahren B. GLP-1 for type 2 diabetes. Exp Cell Res 2011;317: 1239-45.
-
(2011)
Exp Cell Res
, vol.317
, pp. 1239-1245
-
-
Ahren, B.1
-
21
-
-
77953613604
-
Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide?
-
Christensen M, Knop FK. Once-weekly GLP-1 agonists: How do they differ from exenatide and liraglutide? Curr Diab Rep 2010;10:124-32.
-
(2010)
Curr Diab Rep
, vol.10
, pp. 124-132
-
-
Christensen, M.1
Knop, F.K.2
-
22
-
-
79955661908
-
DURATION-5: Exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes
-
Blevins T, Pullman J, Malloy J, et al. DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes. J Clin Endocrinol Metab 2011;96:1301-10.
-
(2011)
J Clin Endocrinol Metab
, vol.96
, pp. 1301-1310
-
-
Blevins, T.1
Pullman, J.2
Malloy, J.3
-
23
-
-
33644840976
-
Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus
-
DOI 10.1016/j.biocel.2005.07.011, PII S1357272505002566, Diabetes: New Research and Novel Therapies
-
De Leon DD, Crutchlow MF, Ham JY, Stoffers DA. Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus. Int J Biochem Cell Biol 2006;38:845-59. (Pubitemid 43363416)
-
(2006)
International Journal of Biochemistry and Cell Biology
, vol.38
, Issue.5-6
, pp. 845-859
-
-
Leon, D.D.D.1
Crutchlow, M.F.2
Ham, J.-Y.N.3
Stoffers, D.A.4
-
24
-
-
35348924943
-
Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in Type 2 diabetes management
-
Crepaldi G, Carruba M, Comaschi M, Del PS, Frajese G, Paolisso G. Dipeptidyl peptidase 4 (DPP-4) inhibitors and their role in type 2 diabetes management. J Endocrinol Invest 2007;30:610-14. (Pubitemid 47577816)
-
(2007)
Journal of Endocrinological Investigation
, vol.30
, Issue.7
, pp. 610-614
-
-
Crepaldi, G.1
Carruba, M.2
Comaschi, M.3
Del, P.S.4
Frajese, G.5
Paolisso, G.6
-
25
-
-
41949103059
-
Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes
-
Deacon CF. Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes. Curr Opin Invest Drugs 2008;9:402-13. (Pubitemid 351507666)
-
(2008)
Current Opinion in Investigational Drugs
, vol.9
, Issue.4
, pp. 402-413
-
-
Deacon, C.F.1
-
26
-
-
77952309372
-
Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: A 26-week, randomised, parallel-group, open-label trial
-
Erratum in Lancet 2010;376:234
-
Pratley RE, Nauck M, Bailey T, et al. Liraglutide versus sitagliptin for patients with type 2 diabetes who did not have adequate glycaemic control with metformin: a 26-week, randomised, parallel-group, open-label trial. Lancet 2010;375:1447-56. (Erratum in Lancet 2010;376:234.)
-
(2010)
Lancet
, vol.375
, pp. 1447-1456
-
-
Pratley, R.E.1
Nauck, M.2
Bailey, T.3
-
27
-
-
77955573674
-
Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): A randomised trial
-
Bergenstal RM, Wysham C, Macconell L, et al. Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial. Lancet 2010;376:431-9.
-
(2010)
Lancet
, vol.376
, pp. 431-439
-
-
Bergenstal, R.M.1
Wysham, C.2
Macconell, L.3
-
28
-
-
33847072735
-
Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not
-
Raun K, von VP, Gotfredsen CF, Golozoubova V, Rolin B, Knudsen LB. Liraglutide, a long-acting glucagon-like peptide-1 analog, reduces body weight and food intake in obese candy-fed rats, whereas a dipeptidyl peptidase-IV inhibitor, vildagliptin, does not. Diabetes 2007;56:8-15.
-
(2007)
Diabetes
, vol.56
, pp. 8-15
-
-
Raun, K.1
Von, V.P.2
Gotfredsen, C.F.3
Golozoubova, V.4
Rolin, B.5
Knudsen, L.B.6
-
29
-
-
77952315531
-
Addition of incretin therapy to metformin in type 2 diabetes
-
Scheen AJ, Radermecker RP. Addition of incretin therapy to metformin in type 2 diabetes. Lancet 2010;375:1410-12.
-
(2010)
Lancet
, vol.375
, pp. 1410-1412
-
-
Scheen, A.J.1
Radermecker, R.P.2
-
30
-
-
0034108646
-
Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration
-
DOI 10.1021/jm9909645
-
Knudsen LB, Nielsen PF, Huusfeldt PO, et al. Potent derivatives of glucagon-like peptide-1 with pharmacokinetic properties suitable for once daily administration. J Med Chem 2000;43:1664-9. (Pubitemid 30304999)
-
(2000)
Journal of Medicinal Chemistry
, vol.43
, Issue.9
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
Johansen, N.L.4
Madsen, K.5
Pedersen, F.Z.6
Thogersen, H.7
Wilken, M.8
Agerso, H.9
-
32
-
-
37849026464
-
Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: Importance of fatty acid length, polarity, and bulkiness
-
Madsen K, Knudsen LB, Agersoe H, et al. Structure-activity and protraction relationship of long-acting glucagon-like peptide-1 derivatives: importance of fatty acid length, polarity, and bulkiness. J Med Chem 2007;50:6126-32.
-
(2007)
J Med Chem
, vol.50
, pp. 6126-6132
-
-
Madsen, K.1
Knudsen, L.B.2
Agersoe, H.3
-
33
-
-
33745276226
-
An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide
-
Damholt B, Golor G, Wierich W, Pedersen P, Ekblom M, Zdravkovic M. An open-label, parallel group study investigating the effects of age and gender on the pharmacokinetics of the once-daily glucagon-like peptide-1 analogue liraglutide. J Clin Pharmacol 2006;46:635-41.
-
(2006)
J Clin Pharmacol
, vol.46
, pp. 635-641
-
-
Damholt, B.1
Golor, G.2
Wierich, W.3
Pedersen, P.4
Ekblom, M.5
Zdravkovic, M.6
-
34
-
-
15744381238
-
The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro
-
DOI 10.1016/j.bbrc.2005.03.013
-
Bregenholt S, Moldrup A, Blume N, et al. The long-acting glucagon-like peptide-1 analogue, liraglutide, inhibits β-cell apoptosis in vitro. Biochem Biophys Res Commun 2005;330: 577-84. (Pubitemid 40417684)
-
(2005)
Biochemical and Biophysical Research Communications
, vol.330
, Issue.2
, pp. 577-584
-
-
Bregenholt, S.1
Moldrup, A.2
Blume, N.3
Karlsen, A.E.4
Friedrichsen, B.N.5
Tornhave, D.6
Knudsen, L.B.7
Petersen, J.S.8
-
35
-
-
62449129181
-
Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
-
Marre M, Shaw J, Brandle M, et al. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 2009;26:268-78.
-
(2009)
Diabet Med
, vol.26
, pp. 268-278
-
-
Marre, M.1
Shaw, J.2
Brandle, M.3
-
36
-
-
69949117621
-
Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: A randomised controlled trial (LEAD-5 met+SU)
-
Russell-Jones D, Vaag A, Schmitz O, et al. Liraglutide vs insulin glargine and placebo in combination with metformin and sulfonylurea therapy in type 2 diabetes mellitus: a randomised controlled trial (LEAD-5 met+SU). Diabetologia 2009;52:2046-55.
-
(2009)
Diabetologia
, vol.52
, pp. 2046-2055
-
-
Russell-Jones, D.1
Vaag, A.2
Schmitz, O.3
-
37
-
-
0036676385
-
Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects
-
DOI 10.2337/diacare.25.8.1398
-
Elbrond B, Jakobsen G, Larsen S, et al. Pharmacokinetics, pharmacodynamics, safety, and tolerability of a single-dose of NN2211, a long-acting glucagon-like peptide 1 derivative, in healthy male subjects. Diabetes Care 2002;25:1398-404. (Pubitemid 41071152)
-
(2002)
Diabetes Care
, vol.25
, Issue.8
, pp. 1398-1404
-
-
Elbrond, B.1
Jakobsen, G.2
Larsen, S.3
Agerso, H.4
Jensen, L.B.5
Rolan, P.6
Sturis, J.7
Hatorp, V.8
Zdravkovic, M.9
-
38
-
-
57649231326
-
The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide
-
abstract. abstract 552-P
-
Steensgaard DB, Thomsen JK, Olsen HB, Knudsen LB. The molecular basis for the delayed absorption of the once-daily human GLP-1 analogue, liraglutide [abstract]. Diabetes 2008;57(suppl 1):abstract 552-P.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Steensgaard, D.B.1
Thomsen, J.K.2
Olsen, H.B.3
Knudsen, L.B.4
-
39
-
-
77955820667
-
Population pharmacokinetics of liraglutide, a once-daily human glucagonlike peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide
-
Watson E, Jonker DM, Jacobsen LV, Ingwersen SH. Population pharmacokinetics of liraglutide, a once-daily human glucagonlike peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide. J Clin Pharmacol 2010;50:886-94.
-
(2010)
J Clin Pharmacol
, vol.50
, pp. 886-894
-
-
Watson, E.1
Jonker, D.M.2
Jacobsen, L.V.3
Ingwersen, S.H.4
-
40
-
-
0036189831
-
The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men
-
DOI 10.1007/s00125-001-0719-z
-
Agerso H, Jensen LB, Elbrond B, Rolan P, Zdravkovic M. The pharmacokinetics, pharmacodynamics, safety and tolerability of NN2211, a new long-acting GLP-1 derivative, in healthy men. Diabetologia 2002;45:195-202. (Pubitemid 34208381)
-
(2002)
Diabetologia
, vol.45
, Issue.2
, pp. 195-202
-
-
Agerso, H.1
Jensen, L.B.2
Elbrond, B.3
Rolan, P.4
Zdravkovic, M.5
-
41
-
-
0036066641
-
Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes
-
Juhl CB, Hollingdal M, Sturis J, et al. Bedtime administration of NN2211, a long-acting GLP-1 derivative, substantially reduces fasting and postprandial glycemia in type 2 diabetes. Diabetes 2002;51:424-9. (Pubitemid 34764798)
-
(2002)
Diabetes
, vol.51
, Issue.2
, pp. 424-429
-
-
Juhl, C.B.1
Hollingdal, M.2
Sturis, J.3
Jakobsen, G.4
Agerso, H.5
Veldhuis, J.6
Porksen, N.7
Schmitz, O.8
-
42
-
-
79955845067
-
Effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide
-
Kapitza C, Zdravkovic M, Zijlstra E, Segel S, Heise T, Flint A. Effect of three different injection sites on the pharmacokinetics of the once-daily human GLP-1 analogue liraglutide. J Clin Pharmacol 2011;51:951-5.
-
(2011)
J Clin Pharmacol
, vol.51
, pp. 951-955
-
-
Kapitza, C.1
Zdravkovic, M.2
Zijlstra, E.3
Segel, S.4
Heise, T.5
Flint, A.6
-
43
-
-
78049365082
-
Metabolism and excretion of the once-daily human GLP-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase
-
Malm-Erjefalt M, Bjornsdottir I, Vanggaard J, et al. Metabolism and excretion of the once-daily human GLP-1 analog liraglutide in healthy male subjects and its in vitro degradation by dipeptidyl peptidase IV and neutral endopeptidase. Drug Metab Disposition 2010;38:1944-53.
-
(2010)
Drug Metab Disposition
, vol.38
, pp. 1944-1953
-
-
Malm-Erjefalt, M.1
Bjornsdottir, I.2
Vanggaard, J.3
-
44
-
-
78049354214
-
Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide
-
Flint A, Nazzal K, Jagielski P, Hindsberger C, Zdravkovic M. Influence of hepatic impairment on pharmacokinetics of the human GLP-1 analogue, liraglutide. Br J Clin Pharmacol 2010;70:807-14.
-
(2010)
Br J Clin Pharmacol
, vol.70
, pp. 807-814
-
-
Flint, A.1
Nazzal, K.2
Jagielski, P.3
Hindsberger, C.4
Zdravkovic, M.5
-
45
-
-
70849096647
-
Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide
-
Jacobsen LV, Hindsberger C, Robson R, Zdravkovic M. Effect of renal impairment on the pharmacokinetics of the GLP-1 analogue liraglutide. Br J Clin Pharmacol 2009;68:898-905.
-
(2009)
Br J Clin Pharmacol
, vol.68
, pp. 898-905
-
-
Jacobsen, L.V.1
Hindsberger, C.2
Robson, R.3
Zdravkovic, M.4
-
46
-
-
79959692519
-
Mild renal impairment has no effect on the efficacy and safety of liraglutide
-
[published online ahead of print December 6, 2010]. Available from
-
Davidson JA, Brett J, Falahati A, Scott D. Mild renal impairment has no effect on the efficacy and safety of liraglutide [published online ahead of print December 6, 2010]. Endocr Pract. Available from http://dx.doi.org/10.4158/ EP10215.OR.
-
Endocr Pract
-
-
Davidson, J.A.1
Brett, J.2
Falahati, A.3
Scott, D.4
-
47
-
-
39749143348
-
Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with Type 2 diabetes mellitus
-
DOI 10.1111/j.1464-5491.2007.02333.x
-
Vilsboll T, Brock B, Perrild H, et al. Liraglutide, a once-daily human GLP-1 analogue, improves pancreatic B-cell function and arginine-stimulated insulin secretion during hyperglycaemia in patients with type 2 diabetes mellitus. Diabet Med 2008;25:152-6. (Pubitemid 351293400)
-
(2008)
Diabetic Medicine
, vol.25
, Issue.2
, pp. 152-156
-
-
Vilsboll, T.1
Brock, B.2
Perrild, H.3
Levin, K.4
Lervang, H.-H.5
Kolendorf, K.6
Krarup, T.7
Schmitz, O.8
Zdravkovic, M.9
Le-Thi, T.10
Madsbad, S.11
-
48
-
-
2342599057
-
One Week's Treatment with the Long-Acting Glucagon-Like Peptide 1 Derivative Liraglutide (NN2211) Markedly Improves 24-h Glycemia and α- and β-Cell Function and Reduces Endogenous Glucose Release in Patients with Type 2 Diabetes
-
DOI 10.2337/diabetes.53.5.1187
-
Degn KB, Juhl CB, Sturis J, et al. One week's treatment with the long-acting glucagon-like peptide 1 derivative liraglutide (NN2211) markedly improves 24-h glycemia and α- and β-cell function and reduces endogenous glucose release in patients with type 2 diabetes. Diabetes 2004;53:1187-94. (Pubitemid 38569002)
-
(2004)
Diabetes
, vol.53
, Issue.5
, pp. 1187-1194
-
-
Degn, K.B.1
Juhl, C.B.2
Sturis, J.3
Jakobsen, G.4
Brock, B.5
Chandramouli, V.6
Rungby, J.7
Landau, B.R.8
Schmitz, O.9
-
49
-
-
0021813187
-
Homeostasis model assessment: Insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man
-
DOI 10.1007/BF00280883
-
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-19. (Pubitemid 15018832)
-
(1985)
Diabetologia
, vol.28
, Issue.7
, pp. 412-419
-
-
Matthews, D.R.1
Hosker, J.P.2
Rudenski, A.S.3
-
50
-
-
0031737373
-
Correct homeostasis model assessment (HOMA) evaluation uses the computer program [3]
-
Levy JC, Matthews DR, Hermans MP. Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 1998;21:2191-2. (Pubitemid 28549174)
-
(1998)
Diabetes Care
, vol.21
, Issue.12
, pp. 2191-2192
-
-
Levy, J.C.1
Matthews, D.R.2
Hermans, M.P.3
-
51
-
-
2542451393
-
Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the long-acting glucagon-like peptide 1 analog liraglutide (NN2211): A 12-week, double-blind, randomized, controlled trial
-
DOI 10.2337/diacare.27.6.1335
-
Madsbad S, Schmitz O, Ranstam J, Jakobsen G, Matthews DR. Improved glycemic control with no weight increase in patients with type 2 diabetes after once-daily treatment with the longacting glucagon-like peptide 1 analog liraglutide (NN2211): a 12-week, double-blind, randomized, controlled trial. Diabetes Care 2004;27:1335-42. (Pubitemid 38679980)
-
(2004)
Diabetes Care
, vol.27
, Issue.6
, pp. 1335-1342
-
-
Madsbad, S.1
Schmitz, O.2
Ranstam, J.3
Jakobsen, G.4
Matthews, D.R.5
-
52
-
-
34249869806
-
Liraglutide, a long-acting human glucagon-like peptide-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes
-
DOI 10.2337/dc06-2593
-
Vilsboll T, Zdravkovic M, Le-Thi T, et al. Liraglutide, a longacting human GLP-1 analog, given as monotherapy significantly improves glycemic control and lowers body weight without risk of hypoglycemia in patients with type 2 diabetes mellitus. Diabetes Care 2007;30:1608-10. (Pubitemid 46871185)
-
(2007)
Diabetes Care
, vol.30
, Issue.6
, pp. 1608-1610
-
-
Vilsboll, T.1
Zdravkovic, M.2
Le-Thi, T.3
Krarup, T.4
Schmitz, O.5
Courreges, J.-P.6
Verhoeven, R.7
Buganova, I.8
Madsbad, S.9
-
53
-
-
0031791047
-
Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus
-
DOI 10.1210/jc.83.2.604
-
Roder M, Porte D Jr, Schwartz RS, Kahn SE. Disproportionately elevated proinsulin levels reflect the degree of impaired B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 1998;83:604-8. (Pubitemid 28496546)
-
(1998)
Journal of Clinical Endocrinology and Metabolism
, vol.83
, Issue.2
, pp. 604-608
-
-
Roder, M.E.1
Porte Jr., D.2
Schwartz, R.S.3
Kahn, S.E.4
-
54
-
-
59449101432
-
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): A randomised, 52-week, phase III, double-blind, parallel-treatment trial
-
Garber A, Henry R, Ratner R, et al. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 2009;373:473-81.
-
(2009)
Lancet
, vol.373
, pp. 473-481
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
-
55
-
-
62449169287
-
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: The LEAD (liraglutide effect and action in diabetes)-2 study
-
Nauck M, Frid A, Hermansen K, et al. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin, in type 2 diabetes: the LEAD (liraglutide effect and action in diabetes)-2 study. Diabetes Care 2009;32:84-90.
-
(2009)
Diabetes Care
, vol.32
, pp. 84-90
-
-
Nauck, M.1
Frid, A.2
Hermansen, K.3
-
56
-
-
67650066860
-
Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD)
-
Zinman B, Gerich J, Buse JB, et al. Efficacy and safety of the human GLP-1 analog liraglutide in combination with metformin and TZD in patients with type 2 diabetes mellitus (LEAD-4 Met+TZD). Diabetes Care 2009;32:1224-30.
-
(2009)
Diabetes Care
, vol.32
, pp. 1224-1230
-
-
Zinman, B.1
Gerich, J.2
Buse, J.B.3
-
57
-
-
67649666737
-
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: A 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
-
Buse JB, Rosenstock J, Sesti G, et al. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 2009;374:39-47.
-
(2009)
Lancet
, vol.374
, pp. 39-47
-
-
Buse, J.B.1
Rosenstock, J.2
Sesti, G.3
-
58
-
-
33846799072
-
Liraglutide: A once-daily GLP-1 analogue for the treatment of Type 2 diabetes mellitus
-
DOI 10.1517/13543784.16.2.231
-
Vilsboll T. Liraglutide: a once-daily GLP-1 analogue for the treatment of type 2 diabetes mellitus. Expert Opin Invest Drugs 2007;16:231-7. (Pubitemid 46206637)
-
(2007)
Expert Opinion on Investigational Drugs
, vol.16
, Issue.2
, pp. 231-237
-
-
Vilsboll, T.1
-
59
-
-
34547684649
-
Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions
-
DOI 10.2337/dc07-0310
-
Mari A, Degn K, Brock B, Rungby J, Ferrannini E, Schmitz O. Effects of the long-acting human glucagon-like peptide-1 analog liraglutide on beta-cell function in normal living conditions. Diabetes Care 2007;30:2032-3. (Pubitemid 47219415)
-
(2007)
Diabetes Care
, vol.30
, Issue.8
, pp. 2032-2033
-
-
Mari, A.1
Degn, K.2
Brock, B.3
Rungby, J.4
Ferrannini, E.L.E.5
Schmitz, O.6
-
60
-
-
3342984674
-
The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes
-
DOI 10.2337/diacare.27.8.1915
-
Harder H, Nielsen L, Thi TD, Astrup A. The effect of liraglutide, a long-acting glucagon-like peptide 1 derivative, on glycemic control, body composition, and 24-h energy expenditure in patients with type 2 diabetes. Diabetes Care 2004;27:1915-21. (Pubitemid 38989232)
-
(2004)
Diabetes Care
, vol.27
, Issue.8
, pp. 1915-1921
-
-
Harder, H.1
Nielsen, L.2
Thi, T.D.T.3
Astrup, A.4
-
61
-
-
22644444292
-
Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with Type 2 diabetes
-
DOI 10.1111/j.1464-5491.2005.01567.x
-
Feinglos MN, Saad MF, Pi-Sunyer FX, An B, Santiago O. Effects of liraglutide (NN2211), a long-acting GLP-1 analogue, on glycaemic control and bodyweight in subjects with type 2 diabetes. Diabet Med 2005;22:1016-23. (Pubitemid 41025998)
-
(2005)
Diabetic Medicine
, vol.22
, Issue.8
, pp. 1016-1023
-
-
Feinglos, M.N.1
Saad, M.F.2
Pi-Sunyer, F.X.3
An, B.4
Santiago, O.5
-
62
-
-
33750288460
-
Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes
-
DOI 10.1055/s-2006-924230
-
Nauck MA, Hompesch M, Filipczak R, Le TD, Zdravkovic M, Gumprecht J. Five weeks of treatment with the GLP-1 analogue liraglutide improves glycaemic control and lowers body weight in subjects with type 2 diabetes. Exp Clin Endocrinol Diabetes 2006;114:417-23. (Pubitemid 44620484)
-
(2006)
Experimental and Clinical Endocrinology and Diabetes
, vol.114
, Issue.8
, pp. 417-423
-
-
Nauck, M.A.1
Hompesch, M.2
Filipczak, R.3
Le, T.D.T.4
Zdravkovic, M.5
Gumprecht, J.6
-
63
-
-
77956076972
-
Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents
-
Buse JB, Sesti G, Schmidt WE, et al. Switching to once-daily liraglutide from twice-daily exenatide further improves glycemic control in patients with type 2 diabetes using oral agents. Diabetes Care 2010;33:1300-3.
-
(2010)
Diabetes Care
, vol.33
, pp. 1300-1303
-
-
Buse, J.B.1
Sesti, G.2
Schmidt, W.E.3
-
64
-
-
70450190143
-
Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue
-
Jendle J, Nauck MA, Matthews DR, et al. Weight loss with liraglutide, a once-daily human glucagon-like peptide-1 analogue for type 2 diabetes treatment as monotherapy or added to metformin, is primarily as a result of a reduction in fat tissue. Diabetes Obes Metab 2009;11:1163-72.
-
(2009)
Diabetes Obes Metab
, vol.11
, pp. 1163-1172
-
-
Jendle, J.1
Nauck, M.A.2
Matthews, D.R.3
-
65
-
-
67049122423
-
Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline
-
abstract. abstract 888
-
Schmitz O, Russell-Jones D, Shaw J, et al. Liraglutide, a human GLP-1 analogue, reduces bodyweight in subjects with type 2 diabetes, irrespective of body mass index at baseline [abstract]. Diabetologia 2008;51(suppl 1):abstract 888.
-
(2008)
Diabetologia
, vol.51
, Issue.SUPPL. 1
-
-
Schmitz, O.1
Russell-Jones, D.2
Shaw, J.3
-
67
-
-
53849095733
-
Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: A review of clinical trials
-
Madsbad S, Krarup T, Deacon CF, Holst JJ. Glucagon-like peptide receptor agonists and dipeptidyl peptidase-4 inhibitors in the treatment of diabetes: a review of clinical trials. Curr Opin Clin Nutr Metab Care 2008;11:491-9.
-
(2008)
Curr Opin Clin Nutr Metab Care
, vol.11
, pp. 491-499
-
-
Madsbad, S.1
Krarup, T.2
Deacon, C.F.3
Holst, J.J.4
-
68
-
-
64649102619
-
GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice
-
Noyan-Ashraf MH, Momen MA, Ban K, et al. GLP-1R agonist liraglutide activates cytoprotective pathways and improves outcomes after experimental myocardial infarction in mice. Diabetes 2009;58:975-83.
-
(2009)
Diabetes
, vol.58
, pp. 975-983
-
-
Noyan-Ashraf, M.H.1
Momen, M.A.2
Ban, K.3
-
69
-
-
84914113891
-
The GLP-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes: A meta-analysis of six randomized clinical trials
-
in press
-
Fonseca V, DeVries H, Henry R, Jensen K, Falahati A, Plutzky J. The GLP-1 analog liraglutide reduces systolic blood pressure in patients with type 2 diabetes: a meta-analysis of six randomized clinical trials. Circulation, in press.
-
Circulation
-
-
Fonseca, V.1
DeVries, H.2
Henry, R.3
Jensen, K.4
Falahati, A.5
Plutzky, J.6
-
70
-
-
72749125264
-
A randomised, double-blind, cross-over trial investigating the effect of liraglutide on the absorption pharmacokinetics of concomitantly administered oral drugs in healthy subjects
-
abstract. abstract 434-P
-
Malm-Erjefalt M, Ekblom M, Brondsted L, Vouis J, Lennernas H, Zdravkovic M. A randomised, double-blind, cross-over trial investigating the effect of liraglutide on the absorption pharmacokinetics of concomitantly administered oral drugs in healthy subjects [abstract]. Diabetes 2008;57(suppl 1):abstract 434-P.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Malm-Erjefalt, M.1
Ekblom, M.2
Brondsted, L.3
Vouis, J.4
Lennernas, H.5
Zdravkovic, M.6
-
71
-
-
70349093453
-
The effect of the once-daily human GLP-1 analogue liraglutide on the pharmacokinetics of paracetamol
-
abstract. abstract 2145-PO
-
Kapitza C, Flint A, Hindsberger C, Zdravkovic M. The effect of the once-daily human GLP-1 analogue liraglutide on the pharmacokinetics of paracetamol [abstract]. Diabetes 2008;57(suppl 1):abstract 2145-PO.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Kapitza, C.1
Flint, A.2
Hindsberger, C.3
Zdravkovic, M.4
-
72
-
-
82955241439
-
Treatment with liraglutide - A once-daily GLP-1 analog - does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug
-
[published online ahead of print January 12, 2001]. Available from
-
Jacobsen LV, Vouis J, Hindsberger C, Zdravkovic M. Treatment with liraglutide - a once-daily GLP-1 analog - does not reduce the bioavailability of ethinyl estradiol/levonorgestrel taken as an oral combination contraceptive drug [published online ahead of print January 12, 2001]. J Clin Pharmacol. Available from http://dx.doi.org/10.1177/0091270010389471.
-
J Clin Pharmacol
-
-
Jacobsen, L.V.1
Vouis, J.2
Hindsberger, C.3
Zdravkovic, M.4
-
73
-
-
84914125552
-
The effect of liraglutide on intragastric pH in healthy human subjects
-
abstract. abstract 2144-PO
-
Malm-Erjefalt M, Brondsted L, Zdravkovic M. The effect of liraglutide on intragastric pH in healthy human subjects [abstract]. Diabetes 2008;57(suppl 1):abstract 2144-PO.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Malm-Erjefalt, M.1
Brondsted, L.2
Zdravkovic, M.3
-
74
-
-
44949255097
-
Impact of therapeutic advances on hypoglycaemia in type 2 diabetes
-
DOI 10.1002/dmrr.795
-
Boyle PJ, Zrebiec J. Impact of therapeutic advances on hypoglycaemia in type 2 diabetes. Diabetes Metab Res Rev 2008;24:257-85. (Pubitemid 351802792)
-
(2008)
Diabetes/Metabolism Research and Reviews
, vol.24
, Issue.4
, pp. 257-285
-
-
Boyle, P.J.1
Zrebiec, J.2
-
75
-
-
65949111736
-
Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: A retrospective cohort study
-
Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care 2009;32:834-8.
-
(2009)
Diabetes Care
, vol.32
, pp. 834-838
-
-
Noel, R.A.1
Braun, D.K.2
Patterson, R.E.3
Bloomgren, G.L.4
-
76
-
-
84877598164
-
-
Center for Drug Evaluation and Research. Available from Accessed August 31, 2008
-
U.S. Food and Drug Administration, Center for Drug Evaluation and Research. Information for healthcare professionals: exenatide (marketed as Byetta)-8/2008 update. Available from http://www.fda.gov/Drugs/DrugSafety/ PostmarketDrugSafetyInformationforPatientsandProviders/ucm 124713.htm. Accessed August 31, 2008.
-
Information for Healthcare Professionals: Exenatide (Marketed As Byetta)-8/2008 Update
-
-
-
77
-
-
77950228684
-
Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation
-
Knudsen LB, Madsen LW, Andersen S, et al. Glucagon-like peptide-1 receptor agonists activate rodent thyroid C-cells causing calcitonin release and C-cell proliferation. Endocrinology 2010;151:1473-86.
-
(2010)
Endocrinology
, vol.151
, pp. 1473-1486
-
-
Knudsen, L.B.1
Madsen, L.W.2
Andersen, S.3
-
78
-
-
77649294607
-
Weighing risks and benefits of liraglutide - The FDA's review of a new antidiabetic therapy
-
Parks M, Rosebraugh C. Weighing risks and benefits of liraglutide - the FDA's review of a new antidiabetic therapy. N Engl J Med 2010;362:774-7.
-
(2010)
N Engl J Med
, vol.362
, pp. 774-777
-
-
Parks, M.1
Rosebraugh, C.2
-
79
-
-
33846964878
-
Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules
-
Costante G, Meringolo D, Durante C, et al. Predictive value of serum calcitonin levels for preoperative diagnosis of medullary thyroid carcinoma in a cohort of 5817 consecutive patients with thyroid nodules. J Clin Endocrinol Metab 2007;92:450-5.
-
(2007)
J Clin Endocrinol Metab
, vol.92
, pp. 450-455
-
-
Costante, G.1
Meringolo, D.2
Durante, C.3
-
80
-
-
84914148195
-
Secretagogue modulation of islet electrical activity through calcium channel phosphorylation
-
abstract. abstract 1638-P
-
Jacobson DA, Westenbroek R, Catterall WA, Philipson LH. Secretagogue modulation of islet electrical activity through calcium channel phosphorylation [abstract]. Diabetes 2008;57(suppl 1):abstract 1638-P.
-
(2008)
Diabetes
, vol.57
, Issue.SUPPL. 1
-
-
Jacobson, D.A.1
Westenbroek, R.2
Catterall, W.A.3
Philipson, L.H.4
-
81
-
-
70350430650
-
Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP- 1 analog for treatment of type 2 diabetes
-
Chatterjee DJ, Khutoryansky N, Zdravkovic M, Sprenger CR, Litwin JS. Absence of QTc prolongation in a thorough QT study with subcutaneous liraglutide, a once-daily human GLP- 1 analog for treatment of type 2 diabetes. J Clin Pharmacol 2009;49:1353-62.
-
(2009)
J Clin Pharmacol
, vol.49
, pp. 1353-1362
-
-
Chatterjee, D.J.1
Khutoryansky, N.2
Zdravkovic, M.3
Sprenger, C.R.4
Litwin, J.S.5
|