Keratin 7 expression in colorectal cancer - freak of nature or significant finding?

Histopathology

Volumn 59, Issue 2, 2011, Pages 225-234

  Harbaum, Lars ^a   Pollheimer, Marion J ^a   Kornprat, Peter ^a   Lindtner, Richard A ^a   Schlemmer, Andrea ^a   Rehak, Peter ^a   Langner, Cord ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

Colorectal cancer; Epithelial mesenchymal transition; Keratin 7; Prognosis; Tumour budding

Indexed keywords

CYTOKERATIN 7; KI 67 ANTIGEN; MUCIN 2; UVOMORULIN;

ADULT; AGED; ARTICLE; COLORECTAL CANCER; DISEASE COURSE; FEMALE; FOLLOW UP; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TISSUE MICROARRAY; TUMOR DIFFERENTIATION;

ADENOCARCINOMA; ADULT; AGED; AGED, 80 AND OVER; CELL TRANSDIFFERENTIATION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; HUMANS; KERATIN-20; KERATIN-7; MALE; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM INVASIVENESS; NEOPLASM STAGING; TISSUE ARRAY ANALYSIS; TUMOR MARKERS, BIOLOGICAL;

EID: 80052191351     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2011.03694.x     Document Type: Article

References (37)

1. Boyle P, Levin B. World Health Organization world cancer report. Lyon: IARC Press, 2008.
2. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistics, 2009. CA Cancer J. Clin. 2009; 59; 225-249.
3. Hampton T. New therapies for GI cancers fall short. JAMA 2009; 302; 373-374.
4. Owens DW, Lane EB. The quest for the function of simple epithelial keratins. Bioessays 2003; 25; 748-758.
5. Magin TM, Vijayaraj P, Leube RE. Structural and regulatory functions of keratins. Exp. Cell Res. 2007; 313; 2021-2032.
6. Helfand BT, Chang L, Goldman RD. Intermediate filaments are dynamic and motile elements of cellular architecture. J. Cell Sci. 2004; 117; 133-141.
7. Varadhachary GR, Raber MN, Matamoros A, Abbruzzese JL. Carcinoma of unknown primary with a colon-cancer profile-changing paradigm and emerging definitions. Lancet Oncol. 2008; 9; 596-599.
8. Hernandez BY, Frierson HF, Moskaluk CA et al. CK20 and CK7 protein expression in colorectal cancer: demonstration of the utility of a population-based tissue microarray. Hum. Pathol. 2005; 36; 275-281.
9. Lugli A, Tzankov A, Zlobec I, Terracciano LM. Differential diagnostic and functional role of the multi-marker phenotype CDX2/CK20/CK7 in colorectal cancer stratified by mismatch repair status. Mod. Pathol. 2008; 21; 1403-1412.
10. Kummar S, Fogarasi M, Canova A, Mota A, Ciesielski T. Cytokeratin 7 and 20 staining for the diagnosis of lung and colorectal adenocarcinoma. Br. J. Cancer 2002; 86; 1884-1887.
11. Park SY, Kim HS, Hong EK, Kim WH. Expression of cytokeratins 7 and 20 in primary carcinomas of the stomach and colorectum and their value in the differential diagnosis of metastatic carcinomas to the ovary. Hum. Pathol. 2002; 33; 1078-1085.
12. Tatsumi N, Mukaisho K, Mitsufuji S et al. Expression of cytokeratins 7 and 20 in serrated adenoma and related diseases. Dig. Dis. Sci. 2005; 50; 1741-1746.
13. Chu P, Wu E, Weiss LM. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod. Pathol. 2000; 13; 962-972.
14. Kende AJ, Carr NJ, Sobin LH. Expression of cytokeratins 7 and 20 in carcinomas of the gastrointestinal tract. Histopathology 2003; 42; 137-140.
15. Tatsumi N, Kushima R, Vieth M et al. Cytokeratin 7/20 and mucin core protein expression in ulcerative colitis-associated colorectal neoplasms. Virchows Arch. 2006; 448; 756-762.
16. Stenling R, Lindberg J, Rutegård J, Palmqvist R. Altered expression of CK7 and CK20 in preneoplastic and neoplastic lesions in ulcerative colitis. APMIS 2007; 115; 1219-1226.
17. Moertel CG, Fleming TR, MacDonald JS et al. Levamisole and fluorouracil for adjuvant therapy of resected colon carcinoma. N. Engl. J. Med. 1990; 322; 352-358.
18. Sobin LH, Wittekind C. TNM classification of malignant tumours. New York: Wiley-Liss Inc., 2002.
19. Hamilton SR, Vogelstein B, Kudo S et al. Carcinoma of the colon and rectum. In Hamilton SR, Aaltonen LA eds. World Health Organization classification of tumour and genetics. Tumours of the digestive system. Lyon: IARC Press, 2000; 105-119.
20. Ueno H, Murphy J, Jass JR, Mochizuki H, Talbot IC. Tumour 'budding' as an index to estimate the potential of aggressiveness in rectal cancer. Histopathology 2002; 40; 127-132.
21. Kononen J, Bubendorf L, Kallioniemi A et al. Tissue microarrays for high-throughput molecular profiling of tumour specimens. Nat. Med. 1998; 4; 844-847.
22. Hintze J. Variant 2 in CANCER. NCSS, LLC, Kaysville, UT, USA. [last accessed 26 March 2010].
23. Hase K, Shatney C, Johnson D, Trollope M, Vierra M. Prognostic value of tumor 'budding' in patients with colorectal cancer. Dis. Colon Rectum 1993; 36; 627-635.
24. Prall F, Nizze H, Barten M. Tumour budding as prognostic factor in stage I/II colorectal carcinoma. Histopathology 2005; 47; 17-24.
25. Nakamura T, Mitomi H, Kanazawa H, Ohkura Y, Watanabe M. Tumor budding as an index to identify high-risk patients with stage II colon cancer. Dis. Colon Rectum 2008; 51; 568-572.
26. Wang LM, Kevans D, Mulcahy H et al. Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am. J. Surg. Pathol. 2009; 33; 134-141.
27. Prall F. Tumour budding in colorectal carcinoma. Histopathology 2007; 50; 151-162.
28. Brabletz T, Jung A, Spaderna S, Hlubek F, Kirchner T. Opinion: migrating cancer stem cells-an integrated concept of malignant tumour progression. Nat. Rev. Cancer 2005; 5; 744-749.
29. Bates RC, Pursell BM, Mercurio AM. Epithelial-mesenchymal transition and colorectal cancer: gaining insights into tumor progression using LIM 1863 cells. Cells Tissues Organs 2007; 185; 29-39.
30. Rubio CA. Arrest of cell proliferation in budding tumor cells ahead of the invading edge of colonic carcinomas. A preliminary report. Anticancer Res. 2008; 28; 2417-2420.
31. Brabletz T, Hlubek F, Spaderna S et al. Invasion and metastasis in colorectal cancer: epithelial-mesenchymal transition, mesenchymal-epithelial transition, stem cells and beta-catenin. Cells Tissues Organs 2005; 179; 56-65.
32. Yano S, Komine M, Fujimoto M, Okochi H, Tamaki K. Mechanical stretching in vitro regulates signal transduction pathways and cellular proliferation in human epidermal keratinocytes. J. Invest. Dermatol. 2004; 122; 783-790.
33. Berkowitz P, Hu P, Liu Z et al. Desmosome signaling. Inhibition of p38MAPK prevents pemphigus vulgaris IgG-induced cytoskeleton reorganization. J. Biol. Chem. 2005; 280; 23778-23784.
34. Omary MB, Ku NO, Strnad P, Hanada S. Toward unraveling the complexity of simple epithelial keratins in human disease. J. Clin. Invest.. 2009; 119; 1794-1805.
35. Langner C, Wegscheider BJ, Rehak P, Ratschek M, Zigeuner R. Prognostic value of keratin subtyping in transitional cell carcinoma of the upper urinary tract. Virchows Arch. 2004; 445; 442-448.
36. Izawa I, Inagaki M. Regulatory mechanisms and functions of intermediate filaments: a study using site- and phosphorylation state-specific antibodies. Cancer Sci. 2006; 97; 167-174.
37. Makino T, Yamasaki M, Takeno A et al. Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus. Br. J. Cancer 2009; 101; 1298-1306.