Administration of naked plasmid encoding hepatic stimulator substance by hydrodynamic tail vein injection protects mice from hepatic failure by suppressing the mitochondrial permeability transition

Journal of Pharmacology and Experimental Therapeutics

Volumn 338, Issue 3, 2011, Pages 750-757

  Li, Shenglan ^a   Tang, Zuoqing ^a   Yu, Hao ^a   Li, Wen ^a   Jiang, Ying ^a   Wang, Yutong ^a   An, Wei ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLOSPORIN A [4 N METHYLISOLEUCINE]; CYTOCHROME C; ENHANCED GREEN FLUORESCENT PROTEIN; GALACTOSAMINE; HEPATIC STIMULATOR SUBSTANCE; LIPOPOLYSACCHARIDE; SCATTER FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL LEVEL; CELL STRUCTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ADMINISTRATION ROUTE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG MECHANISM; FULMINANT HEPATIC FAILURE; GENE; GENE DELIVERY SYSTEM; GENE EXPRESSION SYSTEM; HEPATIC STIMULATOR SUBSTANCE GENE; HYDRODYNAMICS BASED TRANSFECTION; LIVER FUNCTION; LIVER PROTECTION; LIVER STRUCTURE; MALE; MEMBRANE DAMAGE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRION SWELLING; MOUSE; NONHUMAN; PLASMID; PRIORITY JOURNAL; REPORTER GENE; SURVIVAL RATE;

ADENOSINE TRIPHOSPHATE; ANIMALS; BLOTTING, WESTERN; CYCLOSPORINE; CYTOCHROMES C; CYTOSOL; ENERGY METABOLISM; GENE THERAPY; GREEN FLUORESCENT PROTEINS; HUMANS; INJECTIONS, INTRAVENOUS; LIVER; LIVER FAILURE, ACUTE; MALE; MEMBRANE POTENTIALS; MICE; MICE, INBRED BALB C; MITOCHONDRIA, LIVER; MITOCHONDRIAL SWELLING; PEPTIDES; PERMEABILITY; PLASMIDS; REGIONAL BLOOD FLOW; TAIL; VEINS;

EID: 80052169195     PISSN: 00223565     EISSN: 15210103     Source Type: Journal    
DOI: 10.1124/jpet.111.181305     Document Type: Article

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