Generating somatic mosaicism with a Cre recombinase-microsatellite sequence transgene

Nature Methods

Volumn 5, Issue 3, 2008, Pages 231-233

  Akyol, Aytekin ^a,b   Hinoi, Takao ^a,b,c   Feng, Ying ^a   Bommer, Guido T ^a   Glaser, Thomas M ^a   Fearon, Eric R ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b HACETTEPE UNIVERSITY   (Turkey)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA GALACTOSIDASE; CRE RECOMBINASE; NUCLEOTIDE;

ALLELE; ARTICLE; CARCINOGENESIS; CELL LINEAGE; CELL PROLIFERATION; CELL SURVIVAL; CODON; COLON ADENOMA; COLON POLYPOSIS; DISEASE MODEL; GENE EXPRESSION; GENOTYPE; HOMOLOGOUS RECOMBINATION; HUMAN; IMMUNOHISTOCHEMISTRY; MOSAICISM; NONHUMAN; ONCOGENE; OPEN READING FRAME; PHENOTYPE; PRIORITY JOURNAL; SOMATIC CELL; SOMATIC MUTATION; TRANSGENE; WILD TYPE;

ADENOMA; ANIMALS; BETA-GALACTOSIDASE; COLONIC NEOPLASMS; COLONIC POLYPS; FEMALE; INTEGRASES; INTESTINES; MALE; MICE; MICE, TRANSGENIC; MICROSATELLITE REPEATS; MOSAICISM; TRANSGENES;

MUS;

EID: 40149084977     PISSN: 15487091     EISSN: 15491676     Source Type: Journal    
DOI: 10.1038/nmeth.1182     Document Type: Article

References (14)

1. Van Dyke, T. & Jacks, T. Cell 108, 135-144 (2002).
2. Jonkers, J. & Berns, A. Nat. Rev. Cancer 2, 251-265 (2002).
3. Shibata, H. et al. Science 278, 120-123 (1997).
4. Jackson, E.L. et al. Genes Dev. 15, 3243-3248 (2001).
5. Flesken-Nikitin, A., Choi, K.C., Eng, J.P., Shmidt, E.N. & Nikitin, A.Y. Cancer Res. 63, 3459-3463 (2003).
6. Zong, H., Espinosa, J.S., Su, H.H., Muzumdar, M.D. & Luo, L. Cell 121, 479-492 (2005).
7. Wang, W., Warren, M. & Bradley, A. Proc. Natl. Acad. Sci. USA 104, 4501-4505 (2007).
8. Hinoi, T. et al. Cancer Res. 67, 9721-9730 (2007).
9. Pearson, C.E. et al. Nat Rev. Genet. 6, 729-742 (2005).
10. Garcia-Diaz, M. & Kunkel, T.A. Trends Biochem. Sci. 31, 206-214 (2006).
11. Soriano, P. Nat. Genet. 21, 70-71 (1999).
12. Kinzler, K.W. & Vogelstein, B. Cell 87, 159-170 (1996).
13. DePrimo, S.E., Cao, J., Hersh, M.N. & Stringer, J.R. Methods 16 49-61 (1998).
14. Hersh, M.N., Stambrook, P.J. & Stringer, J.R. Mutat. Res. 505 51-62 (2002).