Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days

Toxicology Letters

Volumn 206, Issue 2, 2011, Pages 166-171

  Camacho, Luísa ^a   Kelly, Kevin P ^a   Beland, Frederick A ^a   Costa, Gonçalo Gamboa da ^a  

^a NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH   (United States)

Author keywords

Biomarkers; Cyanuric acid; Gene expression; Kidney; Melamine

Indexed keywords

BIOLOGICAL MARKER; CLUSTERIN; CYANURIC ACID; KIDNEY INJURY MOLECULE 1; MELAMINE; METALLOPEPTIDASE INHIBITOR 1; METALLOPROTEINASE INHIBITOR; NEUTROPHIL GELATINASE ASSOCIATED LIPOCALIN; OSTEOPONTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; KIDNEY PARENCHYMA; MALE; NEPHROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; SEX DIFFERENCE; UPREGULATION;

ACUTE-PHASE PROTEINS; ANIMALS; BIOLOGICAL MARKERS; CELL ADHESION MOLECULES; CLUSTERIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENVIRONMENTAL POLLUTANTS; FEMALE; GENE EXPRESSION REGULATION; KIDNEY; LIPOCALINS; MALE; NO-OBSERVED-ADVERSE-EFFECT LEVEL; OSTEOPONTIN; PROTO-ONCOGENE PROTEINS; RATS; RATS, INBRED F344; RENAL INSUFFICIENCY; RNA, MESSENGER; SEX CHARACTERISTICS; TISSUE INHIBITOR OF METALLOPROTEINASE-1; TRIAZINES;

ANIMALIA; RATTUS;

EID: 80052095659     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.07.009     Document Type: Article

References (18)

1. Balakumar P., Rohilla A., Thangathirupathi A. Gentamicin-induced nephrotoxicity: do we have a promising therapeutic approach to blunt it?. Pharmacol. Res. 2010, 62:179-186.
2. Chiusolo A., Defazio R., Zanetti E., Mongillo M., Mori N., Cristofori P., Trevisan A. Kidney injury molecule-1 expression in rat proximal tubule after treatment with segment-specific nephrotoxicants: a tool for early screening of potential kidney toxicity. Toxicol. Pathol. 2010, 38:338-345.
3. Davis J.W., Kramer J.A. Genomic-based biomarkers of drug-induced nephrotoxicity. Expert Opin. Drug Metab. Toxicol. 2006, 2:95-101.
4. Dieterle F., Sistare F., Goodsaid F., Papaluca M., Ozer J.S., Webb C.P., Baer W., Senagore A., Schipper M.J., Vonderscher J., Sultana S., Gerhold D.L., Phillips J.A., Maurer G., Carl K., Laurie D., Harpur E., Sonee M., Ennulat D., Holder D., Andrews-Cleavenger D., Gu Y-Z., Thompson K.L., Goering P.L., Vidal J-M., Abadie E., Maciulaitis R., Jacobson-Kram D., Defelice A.F., Hausner E.A., Blank M., Thompson A., Harlow P., Throckmorton D., Xiao S., Xu N., Taylor W., Vamvakas S., Flamion B., Lima B.S., Kasper P., Pasanen M., Prasad K., Troth S., Bounous D., Robinson-Gravatt D., Betton G., Davis M.A., Akunda J., McDuffie J.E., Suter L., Obert L., Guffroy M., Pinches M., Jayadev S., Blomme E.A., Beushausen S.A., Barlow V.G., Collins N., Waring J., Honor D., Snook S., Lee J., Rossi P., Walker E., Mattes W. Renal biomarker qualification submission: a dialog between the FDA-EMEA and Predictive Safety Testing consortium. Nat. Biotechnol. 2010, 28:455-462.
5. Dirheimer G., Creppy E.E. Mechanism of action of ochratoxin A. IARC Sci. Publ. 1991, 115:171-186.
6. Dobson R.L.M., Motlagh S., Quijano M., Cambron R.T., Baker T.R., Pullen A.M., Regg B.T., Bigalow-Kern A.S., Vennard T., Fix A., Reimschuessel R., Overmann G., Shan Y., Daston G.P. Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs. Toxicol. Sci. 2008, 106:251-262.
7. Ichimura T., Hung C.C., Yang S.A., Stevens J.L., Bonventre J.V. Kidney injury molecule-1: a tissue and urinary biomarker for nephrotoxicant-induced renal injury. Am. J. Physiol. Renal Physiol. 2004, 286:F552-F563.
8. Ichimura T., Bonventre J.V., Bailly V., Wei H., Hession C.A., Cate R.L., Sanicola M. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury. J. Biol. Chem. 1998, 273:4135-4142.
9. Jacob C.C., Reimschuessel R., Von Tungeln L.S., Olson G.R., Warbritton A.R., Hattan D.G., Beland F.A., Gamboa da Costa G. Dose-response assessment of nephrotoxicity from a 7-day combined-exposure to melamine and cyanuric acid in F344 rats. Toxicol. Sci. 2011, 119:391-397.
10. Kondo C., Minowa Y., Uehara T., Okuno Y., Nakatsu N., Ono A., Maruyama T., Kato I., Yamate J., Yamada H., Ohno Y., Urushidani T. Identification of genomic biomarkers for concurrent diagnosis of drug-induced renal tubular injury using a large-scale toxicogenomics database. Toxicology 2009, 265:15-26.
11. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method. Methods 2001, 25:402-408.
12. Ozer J.S., Dieterle F., Troth S., Perentes E., Cordier A., Verdes P., Staedtler F., Mahl A., Grenet O., Roth D.R., Wahl D., Legay F., Holder D., Erdos Z., Vlasakova K., Jin H., Yu Y., Muniappa N., Forest T., Clouse H.K., Reynolds S., Bailey W.J., Thudium D.T., Topper M.J., Skopek T.R., Sina J.F., Glaab W.E., Vonderscher J., Maurer G., Chibout S-D., Sistare F.D., Gerhold D.L. A panel of urinary biomarkers to monitor reversibility of renal injury and a serum marker with improved potential to assess renal function. Nat. Biotechnol. 2010, 28:486-494.
13. Pabla N., Dong Z. Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int. 2008, 73:994-1007.
14. Puschner B., Poppenga R.H., Lowenstine L.J., Filigenzi M.S., Pesavento P.A. Assessment of melamine and cyanuric acid toxicity in cats. J. Vet. Diagn. Invest. 2007, 19:616-624.
15. Rached E., Hoffmann D., Blumbach K., Weber K., Dekant W., Mally A. Evaluation of putative biomarkers of nephrotoxicity after exposure to ochratoxin A in vivo and in vitro. Toxicol. Sci. 2008, 103:371-381.
16. Vaidya V.S., Ozer J.S., Dieterle F., Collings F.B., Ramirez V., Troth S., Muniappa N., Thudium D., Gerhold D., Holder D.J., Bobadilla N.A., Marrer E., Perentes E., Cordier A., Vonderscher J., Maurer G., Goering P.L., Sistare F.D., Bonventre J.V. Kidney injury molecule-1 outperforms traditional biomarkers of kidney injury in preclinical biomarker qualification studies. Nat. Biotechnol. 2010, 28:478-485.
17. Wang E-J., Snyder R.D., Fielden M.R., Smith R.J., Gu Y-Z. Validation of putative genomic biomarkers of nephrotoxicity in rats. Toxicology 2008, 246:91-100.
18. Zhou Y., Vaidya V.S., Brown R.P., Zhang J., Rosenzweig B.A., Thompson K.L., Miller T.J., Bonventre J.V., Goering P.L. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium. Toxicol. Sci. 2008, 101:159-170.