Intra-articular administration of tachykinin NK 1 receptor antagonists reduces hyperalgesia and cartilage destruction in the inflammatory joint in rats with adjuvant-induced arthritis

European Journal of Pharmacology

Volumn 668, Issue 1-2, 2011, Pages 163-168

  Uematsu, Takuya ^a   Sakai, Atsushi ^a   Ito, Hiromoto ^a   Suzuki, Hidenori ^a  

^a NIPPON MEDICAL SCHOOL   (Japan)

Author keywords

Arthritis; Cartilage; Hyperalgesia; Intra articular treatment; NK 1 antagonist; Substance P

Indexed keywords

17ALPHA ETHYNYL 17BETA HYDROXY 5ALPHA ANDROSTANO[3,2 B]PYRIMIDO[1,2 A]BENZIMIDAZOLE; FREUND ADJUVANT; INDOMETACIN; PHYSALAEMIN[9 DEXTRO PROLINE SPIRO GAMMA LACTAM 10 LEUCINE 11 TRYPTOPHAN];

ADJUVANT ARTHRITIS; ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; CARTILAGE DEGENERATION; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; HISTOPATHOLOGY; HYPERALGESIA; MALE; MONARTHRITIS; NONHUMAN; PRIORITY JOURNAL; RAT; TREATMENT RESPONSE;

ANALGESICS; ANDROSTANES; ANIMALS; ANKLE JOINT; ARTHRITIS, EXPERIMENTAL; BENZIMIDAZOLES; CARTILAGE; FREUND'S ADJUVANT; HYPERALGESIA; INDOMETHACIN; INFLAMMATION; INJECTIONS, SUBCUTANEOUS; MALE; PHYSALAEMIN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TACHYKININ;

EID: 80052052663     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.06.037     Document Type: Article

References (41)

1. A. Abramovici, I. Daizade, Z. Yosipovitch, S.J. Gibson, and J.M. Polak The distribution of peptide-containing nerves in the synovia of the cat knee joint Histol. Histopathol. 6 1991 469 476
2. M.J. Alcaraz, J. Megías, I. García-Arnandis, V. Clérigues, and M.I. Guillén New molecular targets for the treatment of osteoarthritis Biochem. Pharmacol. 80 2010 13 21
3. R.D. Altman New guidelines for topical NSAIDs in the osteoarthritis treatment paradigm Curr. Med. Res. Opin. 26 2010 2871 2876
4. M. Anichini, S. Cesaretti, M. Lepori, S. Maddali Bongi, M. Maresca, and M. Zoppi Substance P in the serum of patients with rheumatoid arthritis Rev. Rhum. Engl. Ed. 64 1997 18 21 (Pubitemid 27099682)
5. J. Arrich, F. Piribauer, P. Mad, D. Schmid, K. Klaushofer, and M. Müllner Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis CMAJ. 172 2005 1039 1043 (Pubitemid 40546601)
6. H.R. Barthel, and R.A. Axford-Gatley Topical nonsteroidal anti-inflammatory drugs for osteoarthritis Postgrad. Med. 122 2010 98 106
7. A. Bjurholm, A. Kreicbergs, E. Brodin, and M. Schultzberg Substance P- and CGRP-immunoreactive nerves in bone Peptides 9 1988 165 171 (Pubitemid 18070144)
8. H. Breivik, B. Collett, V. Ventafridda, R. Cohen, and D. Gallacher Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment Eur. J. Pain 10 2006 287 333
9. P.G. Bullough Orthopaedic Pathology fifth ed. 2010 Mosby Maryland Heights, MO
10. T. Cao, E. Pintér, S. Al-Rashed, N. Gerard, J.R. Hoult, and S.D. Brain Neurokinin-1 receptor agonists are involved in mediating neutrophil accumulation in the inflamed, but not normal, cutaneous microvasculature: an in vivo study using neurokinin-1 receptor knockout mice J. Immunol. 164 2000 5424 5429 (Pubitemid 30305225)
11. Y. Chen, H.H. Willcockson, and J.G. Valtschanoff Vanilloid receptor TRPV1-mediated phosphorylation of ERK in murine adjuvant arthritis Osteoarthr. Cartil. 17 2009 244 251
12. P. Danielson, H. Alfredson, and S. Forsgren Distribution of general (PGP 9.5) and sensory (substance P/CGRP) innervations in the human patellar tendon Knee Surg. Sports Traumatol. Arthrosc. 14 2006 125 132 (Pubitemid 43195807)
13. P. Devillier, B. Weill, M. Renoux, C. Menkès, and P. Pradelles Elevated levels of tachykinin-like immunoreactivity in joint fluids from patients with rheumatic inflammatory diseases N. Engl. J. Med. 314 1986 1323 (Pubitemid 16101405)
14. W.R. Ferrell, J.C. Lockhart, and S.M. Karimian Tachykinin regulation of basal synovial blood flow Br. J. Pharmacol. 121 1997 29 34 (Pubitemid 27192785)
15. T. Goto, T. Yamaza, M.A. Kido, and T. Tanaka Light- and electron-microscopic study of the distribution of axons containing substance P and the localization of neurokinin-1 receptor in bone Cell Tissue Res. 293 1998 87 93 (Pubitemid 28331977)
16. O. Grimsholm, Y.Z. Guo, T. Ny, S. Rantapää-Dahlqvist, and S. Forsgren Are neuropeptides important in arthritis? Studies on the importance of bombesin/GRP and substance P in a murine arthritis model Ann. N. Y. Acad. Sci. 1110 2007 525 538 (Pubitemid 350043042)
17. O. Gureje, M. Von Korff, G.E. Simon, and R. Gater Persistent pain and well-being: a World Health Organization study in primary care JAMA 280 1998 147 151 (Pubitemid 28498386)
18. G.S. Habib Systemic effects of intra-articular corticosteroids Clin. Rheumatol. 28 2009 749 756
19. 1 (substance P) receptor antagonists - why are they not analgesic in humans? Trends Pharmacol. Sci. 21 2000 244 246 (Pubitemid 30445249)
20. S.K. Hong, J.S. Han, S.S. Min, J.M. Hwang, Y.I. Kim, H.S. Na, Y.W. Yoon, and H.C. Han Local neurokinin-1 receptor in the knee joint contributes to the induction, but not maintenance, of arthritic pain in the rat Neurosci. Lett. 322 2002 21 24 (Pubitemid 34215021)
21. A. Iwasaki, K. Inoue, and S. Hukuda Distribution of neuropeptide- containing nerve fibers in the synovium and adjacent bone of the rat knee joint Clin. Exp. Rheumatol. 13 1995 173 178
22. J.E. Keeble, and S.D. Brain A role for substance P in arthritis? Neurosci. Lett. 361 2004 176 179 (Pubitemid 38609245)
23. F.F.Y. Lam, and E.S.K. Ng Substance P and glutamate receptor antagonists improve the anti-arthritic actions of dexamethasone in rats Br. J. Pharmacol. 159 2010 958 969
24. J.D. Levine, S.J. Dardick, M.F. Roizen, C. Helms, and A.I. Basbaum Contribution of sensory afferents and sympathetic efferents to joint injury in experimental arthritis J. Neurosci. 6 1986 3423 3429 (Pubitemid 17208527)
25. D. Liu, L.S. Jiang, and L.Y. Dai Substance P and its receptors in bone metabolism Neuropeptides 41 2007 271 283 (Pubitemid 47247867)
26. M. Lotz, D.A. Carson, and J.H. Vaughan Substance P activation of rheumatoid synoviocytes: neural pathway in pathogenesis of arthritis Science 235 1987 893 895 (Pubitemid 17019128)
27. C.A. Lunam, and M.J. Gentle Substance P immunoreactive nerve fibres in the domestic chick ankle joint before and after acute urate arthritis Neurosci. Lett. 354 2004 87 90 (Pubitemid 38032840)
28. M. Matucci-Cerinic, A. Lombardi, G. Leoncini, A. Pignone, L. Sacerdoti, M.G. Spillantini, and G. Partsch Neutral endopeptidase (3.4.24.11) in plasma and synovial fluid of patients with rheumatoid arthritis. A marker of disease activity or a regulator of pain and inflammation? Rheumatol. Int. 13 1993 1 4 (Pubitemid 23188940)
29. J.J. McDougall Arthritis and pain: neurogenic origin of joint pain Arthritis Res. Ther. 8 2006 220
30. 1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity Exp. Brain Res. 137 2001 249 253 (Pubitemid 32250038)
31. D.A. Nelson, and K.L. Bost Non-neuronal mammalian tachykinin expression Front. Biosci. 9 2004 2166 2176
32. M. Pawlak, R.F. Schmidt, B. Heppelmann, and U. Hanesch The neurokinin-1 receptor antagonist RP 67580 reduces the sensitization of primary afferents by substance P in the rat Eur. J. Pain 5 2001 69 79 (Pubitemid 32661929)
33. 1 receptor. Part II: distribution and pathophysiological roles Neuropeptides 32 1998 1 49 (Pubitemid 28167857)
34. H.G. Schaible, F. Richter, A. Ebersberger, M.K. Boettger, H. Vanegas, G. Natura, E. Vazquez, and G. Segond von Banchet Joint pain Exp. Brain Res. 196 2009 153 162
35. K.A. Sluka, M.A. Milton, W.D. Willis, and K.N. Westlund Differential roles of neurokinin 1 and neurokinin 2 receptors in the development and maintenance of heat hyperalgesia induced by acute inflammation Br. J. Pharmacol. 120 1997 1263 1273 (Pubitemid 27149676)
36. M.A. Thacker, A.K. Clark, F. Marchand, and S.B. McMahon Pathophysiology of peripheral neuropathic pain: immune cells and molecules Anesth. Analg. 105 2007 838 847 (Pubitemid 47300869)
37. 1 receptor antagonists - are they really without effect in the pain clinic? Trends Pharmacol. Sci. 21 2000 462 464
38. C.T. Wang, J. Lin, C.J. Chang, Y.T. Lin, and S.M. Hou Therapeutic effects of hyaluronic acid on osteoarthritis of the knee. A meta-analysis of randomized controlled trials J. Bone Joint Surg. Am. 86-A 2004 538 545 (Pubitemid 38269025)
39. J.V. Weinstock The role of substance P, hemokinin and their receptor in governing mucosal inflammation and granulomatous responses Front. Biosci. 9 2004 1936 1943 (Pubitemid 38918643)
40. H. Zhang, C.L. Cang, Y. Kawasaki, L.L. Liang, Y.Q. Zhang, R.R. Ji, and Z.Q. Zhao Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCε: A novel pathway for heat hyperalgesia J. Neurosci. 27 2007 12067 12077 (Pubitemid 350072102)
41. M. Zimmermann Ethical guidelines for investigations of experimental pain in conscious animals Pain 16 1983 109 110 (Pubitemid 13058546)