Participation of NK1 receptors in nociceptin-induced modulation of rat knee joint mechanosensitivity

Experimental Brain Research

Volumn 137, Issue 2, 2001, Pages 249-253

  McDougall, J J ^a   Hanesch, U ^a   Pawlak, M ^a   Schmidt, R F ^a  

^a UNIVERSITY OF CALGARY   (Canada)

Author keywords

Knee joint; Mechanoreceptors; Neuropeptides; Pain; Sensory nerves

Indexed keywords

2 [1 IMINO 2 (2 METHOXYPHENYL)ETHYL] 7,7 DIPHENYLPERHYDROISOINDOL 4 ONE; NEUROKININ 1 RECEPTOR; NEUROKININ 1 RECEPTOR ANTAGONIST; NOCICEPTIN; SUBSTANCE P; ANALGESIC AGENT; INDOLE DERIVATIVE; OPIATE PEPTIDE;

ARTICLE; CONTROLLED STUDY; JOINT MOBILITY; KNEE; MALE; MECHANORECEPTOR; NEUROMODULATION; NOCICEPTION; NONHUMAN; PAIN; PHYSICAL SENSITIVITY; PRIORITY JOURNAL; RAT; RECEPTOR UPREGULATION; SENSORY NERVE; ACTION POTENTIAL; ANIMAL; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; INNERVATION; JOINT CHARACTERISTICS AND FUNCTIONS; METABOLISM; NERVE CONDUCTION; PHYSIOLOGY; PROPRIOCEPTION; SENSORY NERVE CELL; STIMULATION; WISTAR RAT;

ACTION POTENTIALS; AFFERENT PATHWAYS; ANALGESICS; ANIMALS; INDOLES; KNEE JOINT; MALE; MECHANORECEPTORS; NEURAL CONDUCTION; NEURONS, AFFERENT; OPIOID PEPTIDES; PHYSICAL STIMULATION; PROPRIOCEPTION; RANGE OF MOTION, ARTICULAR; RATS; RATS, WISTAR; RECEPTORS, NEUROKININ-1; SUBSTANCE P;

EID: 0034745277     PISSN: 00144819     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002210000650     Document Type: Article

References (18)

1. Reverse physiology: Discovery of the novel neuropeptide, orphanin FQ/nociceptin
2. The orphanin FQ system: An emerging target for the management of pain?
3. Orphanin FQ/nociceptin: A role in pain and analgesia, but so much more
4. Articular proprioception and nociception
5. Pharmacological properties of a potent and selective nonpeptide substance P antagonist
6. The role of PGE2 in the sensitization of mechanoreceptors in normal and inflamed ankle joints of the rat
7. Sensitisation of articular afferents in normal and inflamed knee joints by substance P in the rat
8. Nociceptin/orphanin FQ-induced nociceptive responses through substance P release from peripheral nerve endings in mice
9. Tachykinin-mediated effect of nociceptin in the rat urinary bladder in vivo
10. Peripheral modulation of rat knee joint afferent mechanosensitivity by nociceptin/orphanin FQ
11. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat
12. Sensitization of articular afferents to mechanical stimuli by SP is mediated by NK1 receptors
13. Orphanin FQ/nociceptin-immunoreactive nerve fibers parallel those containing endogenous opioids in rat spinal cord
14. Antinociceptive activity of NK1 receptor antagonists: Non-specific effects of racemic RP67580
15. Effects of an experimental arthritis on the sensory properties of fine articular afferent units
16. Time course of mechanosensi-tivity changes in articular afferents during a developing experimental arthritis
17. The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels
18. Determination of nociceptin-like immunoreactivity in the rat dorsal spinal cord