Pharmacological evaluation of insulin mimetic novel suppressors of PEPCK gene transcription from Paeoniae Rubra Radix

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 592-600

  Juan, Yi Chen ^a,b   Chang, Chia Chuan ^a   Tsai, Wei Jern ^a   Lin, Yun Lian ^a   Hsu, Yi Shin ^a   Liu, Hui Kang ^a  

^a NATIONAL RESEARCH INSTITUTE OF CHINESE MEDICINE   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

1,2,3,4,6 Penta O galloyl beta d glucose (PGG); cAMP responsive element binding protein (CREB) inhibitor; Glucocorticoids antagonist; Non PGG fraction (NPF); Paeoniae Rubra Radix; Phosphoenolpyruvate carboxykinase (PEPCK)

Indexed keywords

1,2,3,4,6 PENTA O GALLOYL BETA DEXTRO GLUCOSE; 8 BROMO CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXAMETHASONE; DNA BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; GREEN FLUORESCENT PROTEIN; HNMP AM3; INSULIN; INSULIN DERIVATIVE; INSULIN RECEPTOR; MESSENGER RNA; PAEONIA RADIX; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PREGNANE X RECEPTOR; SERINE; TANNIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STIMULATION; CHEMICAL ANALYSIS; CHEMICAL COMPOSITION; COLORIMETRY; CONTROLLED STUDY; DNA BINDING; DRUG EFFICACY; DRUG MECHANISM; FRACTIONATION; GENE EXPRESSION; GENE REPRESSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEDICINAL PLANT; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PAEONIA; PHARMACOLOGICAL PARAMETERS; PROMOTER REGION; PROTEIN PHOSPHORYLATION; REPORTER GENE; SIGNAL TRANSDUCTION; TRANSACTIVATION; TRANSCRIPTION INITIATION;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ANIMALS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLORIMETRY; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DEXAMETHASONE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; DRUGS, CHINESE HERBAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENES, REPORTER; GLUCOCORTICOIDS; GREEN FLUORESCENT PROTEINS; HYDROLYZABLE TANNINS; HYPOGLYCEMIC AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; NAPHTHALENES; PAEONIA; PHOSPHONIC ACIDS; PHOSPHORYLATION; PLANT ROOTS; PROTEIN-SERINE-THREONINE KINASES; RATS; RECEPTOR, INSULIN; RECEPTORS, GLUCOCORTICOID; RECEPTORS, STEROID; RNA, MESSENGER; SIGNAL TRANSDUCTION; TANNINS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION;

PAEONIA LACTIFLORA;

EID: 80052038092     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.007     Document Type: Article

References (29)

1. S. Adisakwattana, P. Jiphimai, P. Prutanopajai, B. Chanathong, S. Sapwarobol, and T. Ariyapitipan Evaluation of alpha-glucosidase, alpha-amylase and protein glycation inhibitory activities of edible plants International Journal of Food Sciences and Nutrition 61 2010 295 305
2. A. Barthel, and D. Schmoll Novel concepts in insulin regulation of hepatic gluconeogenesis American Journal of Physiology-Endocrinology and Metabolism 285 2003 E685 692
3. J.D. Cameron, and J.K. Cruickshank Glucose, insulin, diabetes and mechanisms of arterial dysfunction Clinical and Experimental Pharmacology and Physiology 34 2007 677 682 (Pubitemid 46953118)
4. C.C. Chen, C.Y. Hsu, C.Y. Chen, and H.K. Liu Fructus Corni suppresses hepatic gluconeogenesis related gene transcription, enhances glucose responsiveness of pancreatic beta-cells, and prevents toxin induced beta-cell death Journal of Ethnopharmacology 117 2008 483 490
5. D.M Erion, I.D. Ignatova, S. Yonemitsu, Y. Nagai, P. Chatterjee, D. Weismann, J.J. Hsiao, D. Zhang, T. Iwasaki, R. Stark, C. Flannery, M. Kahn, C.M. Carmean, X.X. Yu, S.F. Murray, S. Bhanot, B.P. Monia, G.W. Cline, V.T. Samuel, and G.I. Shulman Prevention of hepatic steatosis and hepatic insulin resistance by knockdown of cAMP response element-binding protein Cell Metabolism 10 2009 499 506
6. R.K. Hall, X.L. Wang, L. George, S.R. Koch, and D.K. Granner Insulin represses phosphoenolpyruvate carboxykinase gene transcription by causing the rapid disruption of an active transcription complex: a potential epigenetic effect Molecular Endocrinology 21 2007 550 563 (Pubitemid 46188283)
7. L. He, A. Sabet, S. Djedjos, R. Miller, X. Sun, M.A. Hussain, S. Radovick, and F.E. Wondisford Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein Cell 137 2009 635 646
8. Y.C. Juan, W.J. Tsai, Y.L. Lin, G.J. Wang, J.J. Cheng, H.Y. Yang, C.Y. Hsu, and H.K. Liu The novel anti-hyperglycemic effect of Paeoniae radix via the transcriptional suppression of phosphoenopyruvate carboxykinase (PEPCK) Phytomedicine 17 2010 626 634
9. S.A. Kliewer, B. Goodwin, and T.M. Willson The nuclear pregnane X receptor: a key regulator of xenobiotic metabolism Endocrine Review 23 2002 687 702 (Pubitemid 35191629)
10. Y. Li, J. Kim, J. Li, F. Liu, X. Liu, K. Himmeldirk, Y. Ren, T.E. Wagner, and X. Chen Natural anti-diabetic compound 1,2,3,4,6-penta-O-galloyl-d- glucopyranose binds to insulin receptor and activates insulin-mediated glucose transport signaling pathway Biochemical and Biophysical Research Communications 336 2005 430 437 (Pubitemid 41267248)
11. C. Lipina, X. Huang, D. Finlay, E.J. McManus, D.R. Alessi, and C. Sutherland Analysis of hepatic gene transcription in mice expressing insulin-insensitive GSK3 Biochemical Journal 392 2005 633 639 (Pubitemid 43024281)
12. P.A. Lochhead, I.P. Salt, K.S. Walker, D.G. Hardie, and C. Sutherland 5-aminoimidazole-4-carboxamide riboside mimics the effects of insulin on the expression of the 2 key gluconeogenic genes PEPCK and glucose-6-phosphatase Diabetes 49 2000 896 903 (Pubitemid 30349410)
13. L. Logie, A.J. Ruiz-Alcaraz, M. Keane, Y.L. Woods, J. Bain, R. Marquez, D.R. Alessi, and C. Sutherland Characterization of a protein kinase B inhibitor in vitro and in insulin-treated liver cells Diabetes 56 2007 2218 2227 (Pubitemid 47358228)
14. M.A. Magnuson, P.G. Quinn, and D.K. Granner Multihormonal regulation of phosphoenolpyruvate carboxykinase-chloramphenicol acetyltransferase fusion genes. Insulin's effects oppose those of cAMP and dexamethasone The Journal of Biological Chemistry 262 1987 14917 14920 (Pubitemid 17160168)
15. H.P.S. Makkar, and K. Becker Vanillin-HCl method for condensed tannins: effect of organic solvents used for extraction of tannins Journal of Chemical Ecology 19 1993 613 621
16. M. Nichols, F. Weih, W. Schmid, C. DeVack, E. Kowenz-Leutz, B. Luckow, M. Boshart, and G. Schutz Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription EMBO Journal 11 1992 3337 3346
17. J.M. Pascussi, L. Drocourt, J.M. Fabre, P. Maurel, and M.J. Vilarem Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators Molecular Pharmacology 58 2000 361 372 (Pubitemid 30497480)
18. S. Patel, C. Lipina, and C. Sutherland Different mechanisms are used by insulin to repress three genes that contain a homologous thymine-rich insulin response element FEBS Letters 549 2003 72 76 (Pubitemid 36959847)
19. R.M. Perrin, S.J. Harper, and D.O. Bates A role for the endothelial glycocalyx in regulating microvascular permeability in diabetes mellitus Cell Biochemistry and Biophysics 49 2007 65 72 (Pubitemid 47574998)
20. J. Serrano, R. Puupponen-Pimia, A. Dauer, A.M. Aura, and F. Saura-Calixto Tannins: current knowledge of food sources, intake, bioavailability and biological effects Molecular Nutrition & Food Research 53 Suppl. 2 2009 S310 329
21. P. Suryanarayana, P.A. Kumar, M. Saraswat, J.M. Petrash, and G.B. Reddy Inhibition of aldose reductase by tannoid principles of Emblica officinalis: implications for the prevention of sugar cataract Molecular Vision 10 2004 148 154 (Pubitemid 38658950)
22. C. Sutherland, R.M. O'Brien, and D.K. Granner New connections in the regulation of PEPCK gene expression by insulin Philosophical Transactions of the Royal Society of London 351 1996 191 199 (Pubitemid 126745329)
23. C. Sutherland, R.M. O'Brien, and D.K. Granner Genetic regulation of glucose metabolism L.S. Jefferson, A.D. Cherrington, Handbook of Physiology 2003 Oxford University Press UK, Oxford 707 734
24. A.I. Taylor, N. Frizzell, A.M. McKillop, P.R. Flatt, and V.A. Gault Effect of RU486 on hepatic and adipocyte gene expression improves diabetes control in obesity-type 2 diabetes Hormone and Metabolic Research 41 2009 899 904
25. L.U. Thompson, J.H. Yoon, D.J. Jenkins, T.M. Wolever, and A.L. Jenkins Relationship between polyphenol intake and blood glucose response of normal and diabetic individuals The American Journal of Clinical Nutrition 39 1984 745 751 (Pubitemid 14101230)
26. M. Vallejo, M.E. Gosse, W. Beckman, and J.F. Habener Impaired cyclic AMP-dependent phosphorylation renders CREB a repressor of C/EBP-induced transcription of the somatostatin gene in an insulinoma cell line Molecular and Cellular Biology 15 1995 415 424 (Pubitemid 24379940)
27. L. Xing, and P.G. Quinn Involvement of 3',5'-cyclic adenosine monophosphate regulatory element binding protein (CREB) in both basal and hormone-mediated expression of the phosphoenolpyruvate carboxykinase (PEPCK) gene Molecular Endocrinology 7 1993 1484 1494 (Pubitemid 23345024)
28. N. Yabaluri, and M.D. Bashyam Hormonal regulation of gluconeogenic gene transcription in the liver Journal of Biosciences 35 2010 473 484
29. K. Yamada, D.T. Duong, D.K. Scott, J.C. Wang, and D.K. Granner CCAAT/enhancer-binding protein beta is an accessory factor for the glucocorticoid response from the cAMP response element in the rat phosphoenolpyruvate carboxykinase gene promoter The Journal of Biological Chemistry 274 1999 5880 5887 (Pubitemid 29109245)