Orthovanadate-induced cell death in RET/PTC1-harboring cancer cells involves the activation of caspases and altered signaling through PI3K/Akt/mTOR

Life Sciences

Volumn 89, Issue 11-12, 2011, Pages 371-377

  Gonçalves, António Pedro ^a,b   Videira, Arnaldo ^a,b   Soares, Paula ^b,c   Máximo, Valdemar ^b,c  

^a UNIVERSITY OF PORTO   (Portugal)

^b UNIVERSITY OF PORTO   (Portugal)

^c University of Porto   (Portugal)

Author keywords

Apoptosis; Orthovanadate; PI3K Akt mTOR signaling pathway; RET PTC1; Vanadium

Indexed keywords

ACTIN; CASPASE; CASPASE 3; CYCLIN D1; DNA FRAGMENT; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN P21; PROTEIN P27; PROTEIN PATCHED 1; PROTEIN RET; REACTIVE OXYGEN METABOLITE; TYROSINE; VANADATE SODIUM;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CHROMOSOME REARRANGEMENT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; NICK END LABELING; ONCOGENE; ONCOGENE PTC1; ONCOGENE RET; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; THYROID PAPILLARY CARCINOMA; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASES; CELL PROLIFERATION; ENZYME ACTIVATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; ONCOGENE PROTEIN V-AKT; ONCOGENE PROTEINS, FUSION; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; THYROID NEOPLASMS; TOR SERINE-THREONINE KINASES; TUMOR CELLS, CULTURED; VANADATES;

EID: 80052036577     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2011.07.004     Document Type: Article

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