The dependence receptor Ret induces apoptosis in somatotrophs through a Pit-1/p53 pathway, preventing tumor growth

EMBO Journal

Volumn 26, Issue 8, 2007, Pages 2015-2028

  Cañibano, Carmen ^a   Rodriguez, Noela L ^a   Saez, Carmen ^b   Tovar, Sulay ^a   Garcia Lavandeira, Montse ^a   Borrello, Maria Grazia ^c   Vidal, Anxo ^a   Costantini, Frank ^d   Japon, Miguel ^b   Dieguez, Carlos ^a   Alvarez, Clara V ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b HOSPITAL UNIVERSITARIO VIRGEN DEL ROCÍO   (Spain)

^c NATIONAL CANCER INSTITUTE   (Italy)

^d NewYork Presbyterian Hospital   (United States)

Author keywords

c EBPa; Caspase 3; GDNF; Pituitary; PKCd

Indexed keywords

BINDING PROTEIN; CASPASE 3; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; ENHANCER BINDING PROTEIN ALPHA; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; GROWTH HORMONE; PROTEIN KINASE B; PROTEIN KINASE C DELTA; PROTEIN P53; PROTEIN RET; SMALL INTERFERING RNA; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR PIT 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL COUNT; CELL CULTURE; CELL HYPERPLASIA; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; GROWTH HORMONE SECRETING CELL; HORMONE SYNTHESIS; HYPOPHYSIS ADENOMA; HYPOPHYSIS CELL; IN VIVO STUDY; KNOCKOUT MOUSE; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RETROVIRUS;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DNA PRIMERS; GENE EXPRESSION REGULATION; GLIAL CELL LINE-DERIVED NEUROTROPHIC FACTOR; HUMANS; IMMUNOHISTOCHEMISTRY; MAP KINASE KINASE 4; MICE; MICE, KNOCKOUT; NEOPLASMS; PROTEIN KINASE C-DELTA; PROTO-ONCOGENE PROTEINS C-RET; RATS; RNA INTERFERENCE; SIGNAL TRANSDUCTION; SOMATOTROPHS; TRANSCRIPTION FACTOR PIT-1; TUMOR SUPPRESSOR PROTEIN P53;

ANIMALIA; MUS;

EID: 34247192417     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/sj.emboj.7601636     Document Type: Article

References (48)

1. Arighi E, Borrello MG, Sariola H (2005) RET tyrosine kinase signaling in development and cancer. Cytokine Growth Factor Rev 16: 441-467
2. Besset V, Scott RP, Ibanez CF (2000) Signaling complexes and protein-protein interactions involved in the activation of the Ras and phosphatidylinositol 3-kinase pathways by the c-Ret receptor tyrosine kinase. J Biol Chem 275: 39159-39166
3. Blois JT, Mataraza JM, Mecklenbrauker I, Tarakhovsky A, Chiles TC (2004) B cell receptor-induced cAMP-response element-binding protein activation in B lymphocytes requires novel protein kinase Cdelta. J Biol Chem 279: 30123-30132
4. Bordeaux MC, Forcet C, Granger L, Corset V, Bidaud C, Billaud M, Bredesen DE, Edery P, Mehlen P (2000) The RET proto-oncogene induces apoptosis: a novel mechanism for Hirschsprung disease. EMBO J 19: 4056-4063
5. Bravo SB, Pampin S, Cameselle-Teijeiro J, Carneiro C, Dominguez F, Barreiro F, Alvarez CV (2003) TGF-beta-induced apoptosis in human thyrocytes is mediated by p27kip1 reduction and is overridden in neoplastic thyrocytes by NF-kappaB activation. Oncogene 22: 7819-7830
6. Bredesen DE, Mehlen P, Rabizadeh S (2004) Apoptosis and dependence receptors: a molecular basis for cellular addiction. Physiol Rev 84: 411-430
7. Brenner S, Prosch S, Schenke-Layland K, Riese U, Gausmann U, Platzer C (2003) cAMP-induced Interleukin-10 promoter activation depends on CCAAT/enhancer-binding protein expression and monocytic differentiation. J Biol Chem 278: 5597-5604
8. Carneiro C, Alvarez CV, Zalvide J, Vidal A, Dominguez F (1998) TGF-beta1 actions on FRTL-5 cells provide a model for the physiological regulation of thyroid growth. Oncogene 16: 1455-1465
9. Castrillo JL, Theill LE, Karin M (1991) Function of the homeo-domain protein GHF1 in pituitary cell proliferation. Science 253: 197-199
10. Chiariello M, Visconti R, Carlomagno F, Melillo RM, Bucci C, de Franciscis V, Fox GM, Jing S, Coso OA, Gutkind JS, Fusco A, Santoro M (1998) Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKS): evidence for a divergence of the ERKs and JNKs pathways induced by Ret. Oncogene 16: 2435-2445
11. Coya R, Alvarez CV, Perez F, Gianzo C, Dieguez C (1999) Effects of TGF-beta1 on prolactin synthesis and secretion: an in-vitro study. J Neuroendocrinol 11: 351-360
12. De Vita G, Melillo RM, Carlomagno F, Visconti R, Castellone MD, Bellacosa A, Billaud M, Fusco A, Tsichlis PN, Santoro M (2000) Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival. Cancer Res 60: 3727-3731
13. Delhase M, Vergani P, Malur A, Velkeniers B, Teugels E, Trouillas J, Hooghe-Peters EL (1993) Pit-1/GHF-1 expression in pituitary adenomas: further analogy between human adenomas and rat SMtTW tumours. J Mol Endocrinol 11: 129-139
14. DeVries TA, Neville MC, Reyland ME (2002) Nuclear import of PKCdelta is required for apoptosis: identification of a novel nuclear import sequence. EMBO J 21: 6050-6060
15. Feng L, Wang CY, Jiang H, Oho C, Dugich-Djordjevic M, Mei L, Lu B (1999) Differential signaling of glial cell line-derived neurothrophic factor and brain-derived neurotrophic factor in cultured ventral mesencephalic neurons. Neuroscience 93: 265-273
16. Garcia A, Alvarez CV, Smith RG, Dieguez C (2001) Regulation of Pit-1 expression by ghrelin and GHRP-6 through the GH secretagogue receptor. Mol Endocrinol 15: 1484-1495
17. Hayashi H, Ichihara M, Iwashita T, Murakami H, Shimono Y, Kawai K, Kurokawa K, Murakumo Y, Imai T, Funahashi H, Nakao A, Takahashi M (2000) Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene 19: 4469-4475
18. Hoggard N, Callaghan K, Levy A, Davis JR (1993) Expression of Pit-1 and related proteins in diverse human pituitary adenomas. J Mol Endocrinol 11: 283-290
19. Holdaway IM, Rajasoorya C (1999) Epidemiology of acromegaly. Pituitary 2: 29-41
20. Humphries MJ, Limesand KH, Schneider JC, Nakayama KI, Anderson SM, Reyland ME (2006) Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo. J Biol Chem 281: 9728-9737
21. Japon MA, Urbano AG, Saez C, Segura DI, Cerro AL, Dieguez C, Alvarez CV (2002) Glial-derived neurotropic factor and RET gene expression in normal human anterior pituitary cell types and in pituitary tumors. J Clin Endocrinol Metab 87: 1879-1884
22. Kaltsas GA, Nomikos P, Kontogeorgos G, Buchfelder M, Grossman AB (2005) Clinical review: diagnosis and management of pituitary carcinomas. J Clin Endocrinol Metab 90: 3089-3099
23. Liu J, Yang D, Minemoto Y, Leitges M, Rosner MR, Lin A (2006) NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta. Mol Cell 21: 467-480
24. Llambi F, Lourenco FC, Gozuacik D, Guix C, Pays L, Del Rio G, Kimchi A, Mehlen P (2005) The dependence receptor UNC5H2 mediates apoptosis through DAP-kinase. EMBO J 24: 1192-1201
25. Mazelin L, Bernet A, Bonod-Bidaud C, Pays L, Arnaud S, Gespach C, Bredesen DE, Scoazec JY, Mehlen P (2004) Netrin-1 controls colorectal tumorigenesis by regulating apoptosis. Nature 431: 80-84
26. Mecklenbrauker I, Kalled SL, Leitges M, Mackay F, Tarakhovsky A (2004) Regulation of B-cell survival by BAFF-dependent PKCdelta-mediated nuclear signalling. Nature 431: 456-461
27. Mecklenbrauker I, Saijo K, Zheng NY, Leitges M, Tarakhovsky A (2002) Protein kinase Cdelta controls self-antigen-induced B-cell tolerance. Nature 416: 860-865
28. Melmed S (2003) Mechanisms for pituitary tumorigenesis: the plastic pituitary. J Clin Invest 112: 1603-1618
29. Miyamoto A, Nakayama K, Imaki H, Hirose S, Jiang Y, Abe M, Tsukiyama T, Nagahama H, Ohno S, Hatakeyama S, Nakayama KI (2002) Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature 416: 865-869
30. Morohashi KI, Omura T (1996) Ad4BP/SF-1, a transcription factor essential for the transcription of steroidogenic cytochrome P450 genes and for the establishment of the reproductive function. FASEB J 10: 1569-1577
31. Musat M, Korbonits M, Kola B, Borboli N, Hanson MR, Nanzer AM, Grigson J, Jordan S, Morris DG, Gueorguiev M, Coculescu M, Basu S, Grossman AB (2005) Enhanced protein kinase B/Akt signalling in pituitary tumours. Endocr Relat Cancer 12: 423-433
32. Pellegrini I, Barlier A, Gunz G, Figarella-Branger D, Enjalbert A, Grisoli F, Jaquet P (1994) Pit-1 gene expression in the human pituitary and pituitary adenomas. J Clin Endocrinol Metab 79: 189-196
33. Pezeshki G, Franke B, Engele J (2001) Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret. J Neurosci Res 66: 390-395
34. Pfaffle RW, DiMattia GE, Parks JS, Brown MR, Wit JM, Jansen M, Van der Nat H, Van den Brande JL, Rosenfeld MG, Ingraham HA (1992) Mutation of the POU-specific domain of Pit-1 and hypopituitarism without pituitary hypoplasia. Science 257: 1118-1121
35. Pombo CM, Zalvide J, Gaylinn BD, Dieguez C (2000) Growth hormone-releasing hormone stimulates mitogen-activated protein kinase. Endocrinology 141: 2113-2119
36. Porter AG, Dhakshinamoorthy S (2004) Apoptosis initiated by dependence receptors: a new paradigm for cell death? Bioessays 26: 656-664
37. Poteryaev D, Titievsky A, Sun YF, Thomas-Crusells J, Lindahl M, Billaud M, Arumae U, Saarma M (1999) GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1. FEBS Lett 463: 63-66
38. Santoro M, Melillo RM, Carlomagno F, Vecchio G, Fusco A (2004) Minireview: RET: normal and abnormal functions. Endocrinology 145: 5448-5451
39. Schaufele F (1996) CCAAT/enhancer-binding protein alpha activation of the rat growth hormone promoter in pituitary progenitor GHFT1-5 cells. J Biol Chem 271: 21484-21489
40. Schuchardt A, D'Agati V, Larsson-Blomberg L, Costantini F, Pachnis V (1994) Defects in the kidney and enteric nervous system of mice lacking the tyrosine kinase receptor Ret. Nature 367: 319-320
41. Soto JL, Castrillo JL, Dominguez F, Dieguez C (1995) Regulation of the pituitary-specific transcription factor GHF-1/Pit-1 messenger ribonucleic acid levels by growth hormone-secretagogues in rat anterior pituitary cells in monolayer culture. Endocrinology 136: 3863-3870
42. Tahira T, Ishizaka Y, Itoh F, Sugimura T, Nagao M (1990) Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line. Oncogene 5: 97-102
43. Tanikawa C, Matsuda K, Fukuda S, Nakamura Y, Arakawa H (2003) p53RDL1 regulates p53-dependent apoptosis. Nat Cell Biol 5: 216-223
44. Trupp M, Scott R, Whittemore SR, Ibanez CF (1999) Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J Biol Chem 274: 20885-20894
45. Tsukahara S, Kambe F, Suganuma N, Tomoda Y, Seo H (1994) Increase in Pit-1 mRNA is not required for the estrogen-induced expression of prolactin gene and lactotroph proliferation. Endocr J 41: 579-584
46. Urbano AG, Suarez-Penaranda JM, Dieguez C, Alvarez CV (2000) GDNF and RET-gene expression in anterior pituitary-cell types. Endocrinology 141: 1893-1896
47. Voss OH, Kim S, Wewers MD, Doseff AI (2005) Regulation of monocyte apoptosis by the protein kinase Cdelta-dependent phosphorylation of caspase-3. J Biol Chem 280: 17371-17379
48. Wang GL, Iakova P, Wilde M, Awad S, Timchenko NA (2004) Liver tumors escape negative control of proliferation via PI3K/Akt-mediated block of C/EBP alpha growth inhibitory activity. Genes Dev 18: 912-925