More folic acid, the five questions: Why, who, when, how much, and how

BioFactors

Volumn 37, Issue 4, 2011, Pages 272-279

  Mastroiacovo, Pierpaolo ^a   Leoncini, Emanuele ^a  

^a Alessandra Lisi International Centre on Birth Defects and Prematurity   (Italy)

Author keywords

Folate status; Folic acid; Neural tube defects; Prevention

Indexed keywords

CARBAMAZEPINE; FOLIC ACID; VALPROIC ACID;

ANENCEPHALUS; CLEFT LIP; CONGENITAL HEART MALFORMATION; DIABETES MELLITUS; DIET SUPPLEMENTATION; DIETARY INTAKE; ENCEPHALOCELE; FEVER; GENETIC RISK; HEART VENTRICLE SEPTUM DEFECT; HUMAN; LIFESTYLE; LIMB MALFORMATION; MALNUTRITION; NEURAL TUBE; NEURAL TUBE DEFECT; NUTRITION; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; SPINA BIFIDA;

DIETARY SUPPLEMENTS; FEMALE; FOLIC ACID; FOOD, FORTIFIED; HUMANS; NEURAL TUBE DEFECTS; NUTRITIONAL STATUS; PREGNANCY;

EID: 80052035706     PISSN: 09516433     EISSN: 18728081     Source Type: Journal    
DOI: 10.1002/biof.172     Document Type: Review

References (78)

1. Homocysteine Lowering Trialists' Collaboration. (1998) Lowering blood homocysteine with folic acid based supplements: meta-analysis of randomised trials. BMJ 316, 894-898.
2. Miller, R. E., III, Juraschek, S. Pastor-Barriuse, R., Bazzano, L. A., Appel, L. J., and Guallar, E. (2010) Meta-analysis of folic acid supplementation trials on risk of cardiovascular disease and risk interaction with baseline homocysteine levels. Am. J. Cardiol. 106, 517-527.
3. Lee, M., Hong K-S., Chang, S-C., and Saver, J. L. (2010) Efficacy of homocysteine-lowering therapy with folic acid in stroke prevention. Stroke 41, 1205-1212.
4. Clarke, R., Halsey, H., Lewington, S., Lonn, E., Armitage, J., Manson, J. E., Bonaa, K. H., Spende, J. D., Nygard, O., Jamison, R., Gaziano, J. M., Guarino, P., Bennet, D., Mir, F., Peto, R., and Collins, R., for the B-Vitamin Treatment Trialists' Collaboration (2010) Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality. Arch. Intern. Med. 170, 1622-1631.
5. Marti-Carvajal, A. J., Solà, I. Lathyris, and D. Salanti, G. (2009) Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst. Rev. 4, CD006612.
6. Carroll, C., Cooper, K., Papaioannou, D., Hind, D., Tappenden, P., Pilgrim, H., Booth, A. (2010) Meta-analysis: folic acid in the chemoprevention of colorectal adenomas and colorectal cancer. Aliment. Pharmacol. Ther. 31, 708-718.
7. Ibrahim, E. M. and Zekri, J. M. (2010) Folic acid supplementation for the prevention of recurrence of colorectal adenomas: metaanalysis of interventional trials. Med. Oncol. 27, 915-918.
8. Wald, D. S., Kasturiratne, A., and Simmonds, M. (2010) Effect of folic acid, with or without other B vitamins, on cognitive decline: meta-analysis of randomized trials. Am. J. Med. 123, 522-527.
9. Yakoob, M. Y., Menezes, V. E., Soomro, T., Haws, R. A., Darmstadt, G. L., and Bhutta, Z. A. (2009) Reducing stillbirths: behavioural and nutritional interventions before and during pregnancy. BMC Pregnancy Childbirth 9(Suppl 1), S3.
10. Pena-Rosas, J. P., and Viteri, F. E. (2009) Effects and safety of preventive oral iron or iron+folic acid supplementation for women during pregnancy. Cochrane Database Syst. Rev. 4, CDC004736.
11. March of Dimes (2006) Global Report on Birth Defects. March of Dimes Birth Defects Foundation, White Plains, NY.
12. International Clearinghouse for Birth Defects Surveillance and Research (2010) Annual Report 2009 (with data for 2007). ICBD, Rome.
13. Cherian, A., Seena, S., Bullock, R. K., and Antony, A. C. (2005) Incidence of neural tube defects in the least-developed area of India: a population-based study. Lancet 366, 930-931.
14. Smithells, R. W., Sheppard, S., and Schorah, C. J. (1976) Vitamin deficiencies and neural tube defects. Arch. Dis. Child. 51, 944-950.
15. Smithells, R. W., Sheppard, S., Schorah, C. J., Seller, M. J., Nevin, N. C., Harris, R., and Read, A. P. (1980) Fielding D. W. Possible prevention of neural-tube defects by periconceptional vitamin supplementation. Lancet 1, 339-340.
16. Czeizel, A. E. (2009) Periconceptional folic acid and multivitamin supplementation for the prevention of neural tube defects and other congenital abnormalities. Birth Defects Res. A Clin. Mol. Teratol. 85, 260-268.
17. Berry, R. J., Li, Z., Erickson, J. D., Li, S., Moore, C. A., Wang, H., Mulinare, J., Zhao, P., Wong, L. Y., Gindler, J., Hong, S. X., and Correa, A. (1999) Prevention of neural-tube defects with folic acid in China. China-U. S. Collaborative Project for Neural Tube Defect Prevention. N. Engl. J. Med. 341, 1485-1490. Erratum in: N. Engl. J. Med. 1999, 341, 1864.
18. De Wals, P., Tairou, F., Van Allen, M. I., Uh, S. H., Lowry, R. B., Sibbald, B., Evans, J. A., Van den Hof, M. C., Zimmer, P., Crowley, M., Fernandez, B., Lee, N. S., and Niyonsenga, T. (2007) Reduction in neural-tube defects after folic acid fortification in Canada. N. Engl. J. Med. 357, 135-142.
19. Milunsky, A., Jick, H., Jick, S. S., Bruell, C. L., MacLaughlin, D. S., Rothman, K. J., and Willett, W. (1989) Multivitamin/folic acid supplementation in early pregnancy reduces the prevalence of neural tube defects. JAMA 262, 2847-2852.
20. Alasfoor, D., Elsayed, M. K., and Mohammed, A. J. (2010) Spina bifida and birth outcome before and after fortification of flour with iron and folic acid in Oman. East Mediterr. Health. J. 16, 533-538.
21. Sayed, A. R., Bourne, D., Pattinson, R., Nixon, J., and Henderson, B. (2008) Decline in the prevalence of neural tube defects following folic acid fortification and its cost-benefit in South Africa. Birth Defects Res. A Clin. Mol. Teratol. 82, 211-216.
22. De Wals, P., Rusen, I. D., Lee, N. S., Morin, P., and Niyonsenga, T. (2003) Trend in prevalence of neural tube defects in Quebec. Birth Defects Res. A Clin. Mol. Teratol. 67, 919-923.
23. Amarin, Z. O. and Obeidat, A. Z. (2010) Effect of folic acid fortification on the incidence of neural tube defects. Paediatr. Perinat. Epidemiol. 23, 349-351.
24. López-Camelo, J. S., Orioli, I. M., da Graça Dutra, M., Nazer-Herrera, J., Rivera, N., Ojeda, M. E., Canessa, A., Wettig, E., Fontannaz, A. M., Mellado, C., and Castilla, E. E. (2005) Reduction of birth prevalence rates of neural tube defects after folic acid fortification in Chile. Am. J. Med. Genet. A. 135, 120-125.
25. Palomaki, G. E., Williams, J., and Haddow, J. E. (2003) Comparing the observed and predicted effectiveness of folic acid fortification in preventing neural tube defects. J. Med. Screen, 10, 52-53 (Letter).
26. Botto, L. D., Lisi, A., Bower, C., Canfield, M. A., Dattani, N., De Vigan, C., De Walle, H., Erickson, D. J., Halliday, J., Irgens, L. M., Lowry, R. B., McDonnell, R., Metneki, J., Poetzsch, S., Ritvanen,A, Robert-Gnansia, E., Siffel, C., Stoll, C., and Mastroiacovo, P. (2006) Trends of selected malformations in relation to folic acid recommendations and fortification: an international assessment. Birth Defects Res. A Clin. Mol. Teratol. 76, 693-705.
27. Ray, J. G., Meier, C., Vermeulen, M. J., Boss, S., Wyatt, P. R., and Cole, D. E. (2002) Association of neural tube defects and folic acid food fortification in Canada. Lancet 360, 2047-2048.
28. Simmons, C. J., Mosley, B. S., Fulton-Bond, C. A., and Hobbs, C. A. (2004) Birth defects in Arkansas: is folic acid fortification making a difference? Birth Defects Res. A Clin. Mol. Teratol. 70, 559-564.
29. Forrester, M. B. and Merz, R. D. (2005). Rates of selected birth defects in relation to folic acid fortification, Hawaii, 1986-2002. Hawaii Med. J. 64, 302-305.
30. Lambert-Messerlian, G., Halliday, J., Williams, J., Cain, R., Msall, M. E., Palomaki, G. E., and Canick, J. A. (2004) Effect of folic acid fortification on prevalence of neural tube defects in Rhode Island. J. Med. Screen 11, 106-107 (Letter).
31. Mullenix A, Stock J, Meyer R, Major J, and Morgan, L. Prevalence of Neural Tube Defects in North Carolina, 1995/1996 to 2004/2005. Poster at the NBDPN Annual Meeting, 2008.
32. Chen, L. T. and Rivera, M. A. (2004) The Costa Rican experience: reduction of neural tube defects following food fortification programs. Nutr. Rev. 62, S40-S43.
33. Chen, B. H., Carmichael, S. L., Selvin, S., Abrams, B., and Shaw, G. M. (2008) NTD prevalences in central California before and after folic acid fortification. Birth Defects Res. A Clin. Mol. Teratol. 82, 547-552.
34. Centers for Disease Control and Prevention (1992). Recommendations for the use of folic acid to reduce the number of cases of spina bifida and other neural tube defects. MMWR 41(RR-14), 1-7.
35. Commission of the European Community. Report of the Scientific Committee for Food (Thirty-first Series), Directorate-General Industry, 1993: (accessed April 18, 2011).
36. Botto, LD., Olney, R. S., and Erickson, J. D. (2004) Vitamin supplements and the risk for congenital anomalies other than neural tube defects. Am. J. Med. Genet. C Semin. Med. Genet. 125C, 12-21.
37. Czeizel, A. E. (1998) Periconceptional folic acid containing multivitamin supplementation. Eur. J. Obstet. Gynecol. Reprod. Biol. 78, 151-161.
38. Shaw, G. M., O'Malley, C. D., Wasserman, C. R., Tolarova, M. M., and Lammer, E. J. (1995) Maternal periconceptional use of multivitamins and reduced risk for conotruncal heart defects and limb deficiencies among offspring. Am. J. Med. Genet. 59, 536-545.
39. Scanlon, K. S., Ferencz, C., Loffredo, C. A., Wilson, P. D., Correa-Villasenor, A., Khoury, M. J., and Willett, W. C. (1998) Preconceptional folate intake and malformations of the cardiac outflow tract. Baltimore-Washington Infant Study Group. Epidemiology 9, 95-98.
40. Botto, L. D., Mulinare, J., and Erickson, J. D. (2000) Occurrence of congenital heart defects in relation to maternal multivitamin use. Am. J. Epidemiol. 151, 878-884.
41. Werler, M. M., Hayes, C., Louik, C., Shapiro, S., and Mitchell, A. A. (1999) Multivitamin supplementation and risk of birth defects. Am. J. Epidemiol. 150, 675-682.
42. van Beynum, I. M., Kapusta, L., Bakker, M. K., den Heijer, M., Blom, H. J., and de Walle, H. E. (2010) Protective effect of periconceptional folic acid supplements on the risk of congenital heart defects: a registry-based case-control study in the northern Netherlands. Eur. Heart J. 31, 464-471.
43. Johnson, C. Y. and Little, J. (2008) Folate intake, markers of folate status and oral clefts: is the evidence converging? Int. J. Epidemiol. 37, 1041-1058.
44. Wehby, G. and Murray, J. C. (2010) Folic acid and orofacial clefts: a review of the evidence. Oral Dis. 16, 11-19.
45. Goh, Y. I., Bollano, E., Einarson, T. R., and Koren, G. (2006) Prenatal multivitamin supplementation and rates of congenital anomalies: a meta-analysis. J. Obstet. Gynaecol. Can. 28, 680-689.
46. Botto, L. D., Correa, A., and Erickson, J. D. (2001) Racial and temporal variations in the prevalence of heart defects. Pediatrics, 107, E32.
47. Dolk, H., Loane, M., and Garne, E., European Surveillance of Congenital Anomalies (EUROCAT) Working Group (2011) Congenital heart defects in Europe: prevalence and perinatal mortality, 2000 to 2005. Circulation 123, 841-849.
48. Daly, L. E., Peadar, N. K., Molloy, A., Weir, D. G., and Scott, J. M. (1995) Folate levels and neural tube defects. JAMA 274, 1698-1702.
49. Kirke, P. N., Molloy, A. M., Daly, L. E., Burke, H., Weir, D. G., and Scott, J. M. (1993) Maternal plasma folate and vitamin B12 are independent risk factors for neural tube defects. QJM 86, 703-708.
50. Pietrzik, K., Lamers, Y., Bramswig, S., and Prinz-Langerohl, R. (2007) Calculation of red blood cell folate steady state conditions and elimination kinetics after daily supplementation with various folate forms and doses in women of childbearing age. Am. J. Clin. Nutr. 86, 1414-1419.
51. Hoey, L., McNulty, H., Askin, N., Dunne, A., Ward, M., Pentieva, K., Strain, J. J., Molloy, A. M., Flynn, A. C., and Scott, J. M. (2007) Effect of a voluntary food fortification policy on folate, related B vitamin status, and homocysteine in healthy adults. Am. J. Clin. Nutr. 86, 1405-1413.
52. Houghton, L. A., Sherwood, K. L., and O'Connor, D. L. (2007) How well do blood folate concentrations predict dietary folate intakes in a sample of Canadian lactating women exposed to high levels of folate? An observational study. BMC Pregnancy Childbirth 25, 7-25.
53. Lamers, Y., Prinz-Langenohl, R., Brämswig, S., and Pietrzik, K. (2006) Red blood cell folate concentrations increase more after supplementation with [6S]-5-methyltetrahydrofolate than with folic acid in women of childbearing age. Am. J. Clin. Nutr. 84, 156-161.
54. Lamers, Y., Prinz-Langenohl, R., Moser, R., and Pietrzik, K. (2004) Supplementation with [6S]-5-methyltetrahydrofolate or folic acid equally reduces plasma total homocysteine concentrations in healthy women. Am. J. Clin. Nutr. 79, 473-478.
55. Hao, L., Yang, Q-H., Li, Z., Bailey, L. B., Zhu, J-H., Hu, D. J., Zhang, B-L., and Erickson, D. (2008) Folate status and homocysteine response to folic acid doses and withdrawal among young Chinese women in a large-scale randomized double-blind trial. Am. J. Clin. Nutr. 88, 448-457.
56. Bramswig, S., Prinz-Langenohl, R., Lamers, Y., Tobolski, O., Wintergerst, E., Berthold, H. K., and Pietrzik, K. (2009) Supplementation with a multivitaminic containing 800 μg of folic acid shortens the time to reach the preventive red blood cell folate concentration in healthy women. Int. J. Vitam. Nutr. Res. 79, 61-70.
57. DailyMed, Current Medication Information: (accessed April 18, 2011).
58. McLean, E., de Benoist, B., and Allen, L. H. (2008) Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr. Bull. 29 (2 Suppl), 38-51.
59. Tam, C., McKenna, K., Goh, Y. I., Klieger-Grossman, C., O'Connor, D. L., Einarson, A., and Koren, G. (2009) Periconceptional folic acid supplementation: a new indication for therapeutic drug monitoring. Ther. Drug Monit. 31, 319-326.
60. Fazili, Z., Pfeiffer, C. M., Zhang, M., Jain, R. B., and Koontz, D. (2008) Influence of 5, 10-methylenetetrahydrofolate reductase polymorphism on whole-blood folate concentrations measured by LC-MS/MS, microbiologic assay, and bio-rad radioassay. Clin. Chem. 54, 197-201.
61. Fazili, Z., Pfeiffer, C. M., and Zhang, M. (2007) Comparison of serum folate species analyzed by LC-MS/MS with total folate measured by microbiologic assay and Bio-Rad radioassay. Clin. Chem. 53, 781-784.
62. Kuskelly, G. J., McNulty, H., and Scott, J. M. (1996). Effect of increasing dietary folate on red-cell folate: implications for prevention of neural tube defects. Lancet 347, 657-658.
63. Ashfield-Watt, P. A., Whiting, J. M., Clark, Z. E., Moat, S. J., Newcombe, R. G., Burr, M. L., and McDowell, I. F. (2003) A comparison of the effect of advice to eat either '5-a-day' fruit and vegetables or folic acid-fortified foods on plasma folate and homocysteine. Eur. J. Clin. Nutr. 57, 316-23.
64. Bogers, R. P., Dagnelie, P. C., Bast, A., van Leeuwen, M., van Klaveren, J. D., and van den Brandt, P. A. (2007) Effect of increased vegetable and fruit consumption on plasma folate and homocysteine concentrations. Nutrition 23, 97-102.
65. Holst-Schumacher, I., Monge-Rojas, R., Cambronero-Gutiérrez, P., and Brenes, G. (2005) Genetic, dietary, and other lifestyle determinants of serum homocysteine levels in young adults in Costa Rica. Rev. Panam. Salud Publica 17, 263-270.
66. Hertrampf, E., Cortés, F., Erickson, J. D., Cayazzo, M., Freire, W., Bailey, L. B., Howson, C., Kauwell, G. P., and Pfeiffer, C. (2003) Consumption of folic acid-fortified bread improves folate status in women of reproductive age in Chile. J. Nutr. 133, 3166-3169.
67. McDowell, M. A., Lacher, D. A., Pfeiffer, C. M., Mulinare, J, Picciano, M. F., Rader, J. I., Yetley, E. A., Kennedy-Stephenson, J., and Johnson, C. L. (2008) Blood folate levels: the latest NHANES results. NCHS Data Brief 6, 1-8.
68. Ray, J. G., Goodman, J., O'Mahoney, P. R., Mamdani, M. M., and Jiang, D. (2008) High rate of maternal vitamin B12 deficiency nearly a decade after Canadian folic acid flour fortification. QJM 101, 475-477.
69. Colapinto, C. K., O'Connor, D. L., and Tremblay, M. S. (2011) Folate status of the population in the Canadian Health Measures Survey. CMAJ 183, E100-E106.
70. Johansson, M., Witthoft, C. M., Bruce, A., and Jargerstad, M. (2002) Study of wheat breakfast rolls fortified with folic acid. Eur. J. Nutr. 41, 279-286.
71. Venn, B. J., Mann, J. I., Williams, S. M., Riddell, L. J., Chisholm, A., Harper, M. J., Aitken, W., and Rossaak, J. I. (2002) Assessment of three levels of folic acid on serum folate and plasma homocysteine: a randomised placebo-controlled double-blind dietary intervention trial. Eur. J. Clin. Nutr. 56, 748-754.
72. Tucker, K. L., Olson, B., Bakun, P., Dallal, G. E., Selhub, J., and Rosenberg, I. H. (2004) Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am. J. Clin. Nutr. 79, 805-811.
73. Molloy, A. M., Kirke, P. N., Troendle, J. F., Burke, H., Sutton, M., Brody, L. C., Scott, J. M., and Mills, J. L. (2009) Maternal vitamin B12 status and risk of neural tube defects in a population with high neural tube defect prevalence and no folic Acid fortification. Pediatrics, 123, 917-923.
74. NICE, National Institute for Health and Clinical Excellence. Clinical guideline 62. Antenatal care: routine care for the healthy pregnant woman. (accessed April 18, 2011).
75. Rothman, K. J., Moore, L. L., Singer, M. R., Nguyen, U. S., Mannino, S., and Milunsky, A. (1995) Teratogenicity of high vitamin A intake. N. Engl. J. Med. 333, 1369-1373.
76. Ye, R., Ren, A., Zhang, L., Li, Z., Liu, J., Pei, L., and Zheng, X. (2011) Tea Drinking as a Risk Factor for Neural Tube Defects in Northern China. Epidemiology, in press.
77. Shiraishi, M., Haruna, M., Matsuzaki, M., Ota, E., Murayama, R., and Murashima, S. (2010) Association between the serum folate levels and tea consumption during pregnancy. Biosci. Trends, 4, 225-230.
78. Messika, A. H., Kaluski, D. N., Lev, E., Iakobishvili, Z., Shohat, M., Hasdai, D., and Mager, A. (2010) Nutrigenetic impact of daily folate intake on plasma homocysteine and folate levels in patients with different methylenetetrahydrofolate reductase genotypes. Eur. J. Cardiovasc. Prev. Rehabil. 17, 701-705.