Effects of tanshinone IIA, a major component of Salvia miltiorrhiza, on platelet aggregation in healthy newborn piglets

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 44-49

  Liu, Jiang Qin ^a   Lee, Tze Fun ^a   Miedzyblocki, Margaret ^a   Chan, Godfrey C F ^b   Bigam, David L ^a   Cheung, Po Yin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Danshen (Salvia miltiorrhiza); Endothelial microparticles; Newborn piglet; Platelet aggregation; Tanshinone IIA

Indexed keywords

COLLAGEN; GELATINASE A; GELATINASE B; NITRATE; NITRITE; TANSHINONE IIA; THROMBOXANE B2;

ARTICLE; CONTROLLED STUDY; ENDOTHELIAL MICROPARTICLE; ENZYME ACTIVITY; EX VIVO STUDY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MORPHOLOGY; NONHUMAN; PIGLET; SALVIA MILTIORRHIZA; SCANNING ELECTRON MICROSCOPY; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANGINA; SALVIA MILTIORRHIZA;

EID: 80052031837     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.03.047     Document Type: Article

References (21)

1. A. Agouni, A.H. Lagrue-Lak-Hal, P.H. Ducluzeau, H.A. Mostefai, C. Draunet-Busson, G. Leftheriotis, C. Heymes, M.C. Martinez, and R. Andriantsitohaina Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome American Journal of Pathology 173 2008 1210 1219
2. H.C. Bi, Z. Zuo, X. Chen, C.S. Xu, Y.Y. Wen, H.Y. Sun, L.Z. Zhao, Y. Pan, Y. Deng, P.Q. Liu, L.Q. Gu, Z.Y. Huang, S.F. Zhou, and M. Huang Preclinical factors affecting the pharmacokinetic behaviour of tanshinone IIA, an investigational new drug isolated from Salvia miltiorrhiza for the treatment of ischaemic heart diseases Xenobiotica 38 2008 185 222
3. J. Cao, Y.J. Wei, L.W. Qi, P. Li, Z.M. Qian, H.W. Luo, J. Chen, and J. Zhao Determination of fifteen bioactive components in Radix et Rhizoma Salviae Miltiorrhizae by high-performance liquid chromatography with ultraviolet and mass spectrometric detection Biomedical Chromatography 22 2008 164 172 (Pubitemid 351260194)
4. T.O. Cheng Cardiovascular effect of Danshen International Journal of Cardiology 121 2007 9 22
5. W.S. Choi, O.H. Jeon, H.H. Kim, and D.S. Kim MMP-2 regulates human platelet activation by interacting with integrin alphaIIbbeta3 Journal of Thrombosis and Haemostasis 6 2008 517 523
6. G. Davi, and C. Patrono Platelet activation and atherothrombosis New England Journal of Medicine 357 2007 2482 2494
7. E. Falcinelli, G. Guglielmini, M. Torti, and P. Gresele Intraplatelet signaling mechanisms of the priming effect of matrix metal loproteinase-2 on platelet aggregation Journal of Thrombosis and Haemostasis 3 2005 2526 2535 (Pubitemid 41727170)
8. Z.Y. Fang, R. Lin, B.X. Yuan, Y. Liu, and H. Zhang Tanshinone IIA inhibits atherosclerotic plaque formation by down-regulating MMP-2 and MMP-9 expression in rabbits fed a high-fat diet Life Sciences 81 2007 1339 1345 (Pubitemid 47599531)
9. P.L. Giesen, U. Rauch, B. Bohrmann, D. Kling, M. Roqué, J.T. Fallon, J.J. Badimon, J. Himber, M.A. Riederer, and Y. Nemerson Blood-borne tissue factor: another view of thrombosis Proceedings of the National Academy of Sciences of the United States of America 96 1999 2311 2315 (Pubitemid 29117911)
10. J.-Y. Han, J.-Y. Fan, Y. Horie, S. Miura, D.H. Cui, H. Ishii, T. Hibi, H. Tsuneki, and I. Kimura Ameliorating effects of compounds derived from Salvia miltiorrhiza root extract on microcirculatory disturbance and target organ injury by ischemia and reperfusion Pharmacology and Therapeutics 117 2008 280 295
11. L.K. Jennings Mechanisms of platelet activation: need for new strategies to protect against platelet-mediated atherothrombosis Thrombosis and Haemostasis 102 2009 248 257
12. H.S. Ji, F. Yu, and J. Yang Comparative research on pharmacodynamics of Danshen co-microemulsion on hemorheology in rats with hyperlipidemia Zhong Yao Cai 31 2008 566 569
13. K.Y. Jiang, C.G. Ruan, Z.L. Gu, W.Y. Zhou, and C.Y. Guo Effects of tanshinone II-A sulfonate on adhesion molecule expression of endothelial cells and platelets in vitro Zhongguo Yao Li Xue Bao 19 1998 47 50
14. Y.M. Lee, J.J. Lee, M.Y. Shen, G. Hsiao, and J.R. Sheu Inhibitory mechanisms of activated matrix metalloproteinase-9 on platelet activation European Journal of Pharmacology 537 2006 52 58
15. C.Z. Li, S.C. Yang, and F.D. Zhao Effects of tanshinone II-A sulfonate on thrombus formation, platelet and blood coagulation in rats and mice Zhongguo Yao Li Xue Bao 5 1984 39 42 (Pubitemid 14135111)
16. X.J. Li, M. Zhou, X.H. Li, Y.H. Xu, H. Liu, and M. Yang Effects of tanshinone IIa on cytokines and platelets in immune vasculitis and its mechanism Zhongguo Shi Yan Xue Ye Xue Za Zhi 17 2009 188 192
17. J. Liu, J. Morton, M. Miedzyblocki, T.F. Lee, D.L. Bigam, T.F. Fok, C. Chen, S.K. Lee, S.T. Davidge, and P.Y. Cheung Sodium tanshinone IIA sulfonate increased intestinal hemodynamics without systemic circulatory changes in healthy newborn piglets American Journal of Physiology: Heart and Circulatory Physiology 297 2009 H1217 H1224
18. S. Nomura, N.N. Tandon, T. Nakamura, J. Cone, S. Fukuhara, and J. Kambayashi High-shear-stress-induced activation of platelets and microparticles enhances expression of cell adhesion molecules in THP-1 and endothelial cells Atherosclerosis 158 2001 277 287 (Pubitemid 32913636)
19. S.L. Pfister Role of platelet microparticles in the production of thromboxane by rabbit pulmonary artery Hypertension 43 2004 428 433 (Pubitemid 38174150)
20. W.L. Smith Prostanoid biosynthesis and mechanisms of action American Journal of Physiology 263 1992 F181 191
21. L. Zhou, Z. Zao, and M.S.S. Chow Danshen: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use Journal of Clinical Pharmacology 45 2005 1345 1359 (Pubitemid 41643896)