The mechanism of vasorelaxation induced by ethanol extract of Sophora flavescens in rat aorta

Journal of Ethnopharmacology

Volumn 137, Issue 1, 2011, Pages 547-552

  Jin, Song Nan ^a   Wen, Jin Fu ^a   Li, Xiang ^b   Kang, Dae Gill ^b   Lee, Ho Sub ^b   Cho, Kyung Woo ^a  

^a TAISHAN MEDICAL UNIVERSITY   (China)

^b Wonkwang University   (South Korea)

Author keywords

Guanosine 3 ,5 cyclic monophosphate; Nitric oxide; Sophora flavescens; Vasorelaxation

Indexed keywords

1H 1,2,4 OXADIAZOLO[4,3 A]QUINOXALIN 1 ONE; ALCOHOL; ATROPINE; BETA ADRENERGIC RECEPTOR; CYCLIC GMP; GLIBENCLAMIDE; GUANYLATE CYCLASE; INDOMETACIN; MUSCARINIC RECEPTOR; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE SYNTHASE; PHENYLEPHRINE; POTASSIUM CHANNEL; PROPRANOLOL; PROSTAGLANDIN SYNTHASE; SOPHORA FLAVESCENS EXTRACT; TETRYLAMMONIUM;

ANIMAL TISSUE; ARTERY ENDOTHELIUM; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; MALE; MEDICINAL PLANT; NONHUMAN; PLANT ROOT; RAT; SOPHORA; SOPHORA FLAVESCENS; THORACIC AORTA; TISSUE LEVEL; VASCULAR RING; VASODILATATION;

ADRENERGIC BETA-ANTAGONISTS; ANIMALS; AORTA, THORACIC; CYCLIC GMP; CYCLOOXYGENASE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUGS, CHINESE HERBAL; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ETHANOL; GUANYLATE CYCLASE; MALE; MUSCARINIC ANTAGONISTS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PLANT ROOTS; PLANTS, MEDICINAL; POTASSIUM CHANNEL BLOCKERS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SOLVENTS; SOPHORA; VASODILATION; VASODILATOR AGENTS;

RATTUS; SOPHORA FLAVESCENS;

EID: 80052029293     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2011.06.013     Document Type: Article

References (30)

1. W.K. Alderton, C.E. Cooper, and R.G. Knowles Nitric oxide synthases: structure, function and inhibition The Biochemical Journal 357 2001 593 615 (Pubitemid 32735142)
2. J.A. Beavo Cyclic nucleotide phosphodiesterase: functional implications of multiple isoforms Physiological Reviews 75 1995 725 748
3. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Analytical Biochemistry 72 1976 248 254
4. P.A. Bush, W.J. Aronson, M.B. Georgette, J. Rajfer, and L.J. Ignarro Nitric oxide is a potent relaxant of human and rabbit corpus cavernosum The Journal of Urology 147 1992 1650 1655
5. S. Dai, M.Y. Chan, S.S. Lee, and C.W. Ogle The antiarrhythmic effects of Sophora flavescens AIT in rats and mice The American Journal of Chinese Medicine 14 1986 119 123
6. I. Fleming, and R. Busse Signal transduction of eNOS activation Cardiovascular Research 43 1999 532 541 (Pubitemid 29369252)
7. R.F. Furchgott, and J.V. Zawadzki The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine Nature 288 1980 373 376 (Pubitemid 11169009)
8. 2+ channels in arterial smooth muscle cells Kidney & Blood Pressure Research 20 1997 355 371 (Pubitemid 28021637)
9. C.A. Gruetter, B.K. Barry, D.B. McNamara, D.Y. Gruetter, P.J. Kadowitz, and L. Ignarro Relaxation of bovine coronary artery and activation of coronary arterial guanylate cyclase by nitric oxide, nitroprusside and a carcinogenic nitrosoamine Journal of Cyclic Nucleotide Research 5 1979 211 224 (Pubitemid 9246716)
10. E.A. Jaffe Physiologic functions of normal endothelial cells Annals of New York Academy of Science 454 1985 279 291 (Pubitemid 16198861)
11. C.H. Jung, S. Zhou, G.X. Ding, J.H. Kim, M.H. Hong, Y.C. Shin, G.J. Kim, and S.G. Ko Antihyperglycemic activity of herb extracts on streptozotocin- induced diabetic rats Bioscience, Biotechnology, and Biochemistry 70 2006 2556 2559 (Pubitemid 44656429)
12. H.J. Jung, S.S. Kang, J.J. Woo, and J.S. Choi A new lavandulylated flavonoid with free radical and ONOO-scavenging activities from Sophora flavescens Archives of Pharmacal Research 28 2005 1333 1336
13. D.W. Kim, Y.S. Chi, K.H. Son, H.W. Chang, J.S. Kim, S.S. Kang, and H.P. Kim Effects of sophora flavanone G, a prenylated flavonoid from Sophora flavescens, on cyclooxygenase-2 and in vivo inflammatory response Archives of Pharmacal Research 25 2002 329 335 (Pubitemid 43093314)
14. T. Kitazono, F.M. Faraci, H. Taguchi, and D.D. Heistad Role of potassium channels in cerebral blood vessels Stroke 26 1995 1713 1723
15. T.M. Lincoln, N. Dey, and H. Sellak Invited review: cGMP-dependent protein kinase signaling mechanisms in smooth muscle: from the regulation of tone to gene expression Journal of Applied Physiology 91 2001 1421 1430 (Pubitemid 32803941)
16. F. Liu, J. Liu, Q.J. Wang, W.P. Cui, X. Chen, and Q.S. Li Effects of oxymatrine on blood pressure in rats Journal of Jilin University (Medicine Edition) 31 2005 417 419 (in Chinese) (Pubitemid 40883624)
17. J.R. McNeill, and T.M. Jurgens A systematic review of mechanisms by which natural products of plant origin evoke vasodilatation Canadian Journal of Physiology and Pharmacology 84 2006 803 821 (Pubitemid 46132206)
18. S. Moncada, and A. Higgs The l-arginine-nitric oxide pathway The New England Journal of Medicine 329 1993 2002 2012 (Pubitemid 24015045)
19. B. Nilius, and G. Droogmans Ion channels and their functional role in vascular endothelium Physiological Reviews 81 2001 1415 1459 (Pubitemid 32947776)
20. R.M. Rapoport, and F. Murad Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP Circulation Research 52 1983 352 357 (Pubitemid 13158751)
21. N. Satake, S. Kiyoto, S. Shibata, V. Gandhi, D.J. Jones, and M. Morikawa Possible mechanisms of inhibition with atropine against noradrenaline-induced contraction in the rabbit aorta British Journal of Pharmacology 107 1992 553 558
22. J. Schlossmann, A. Ammendola, K. Ashman, X. Zong, A. Huber, G. Neubauer, G.X. Wang, H.D. Allescher, M. Korth, M. Wilm, F. Hofmann, and P. Ruth Regulation of intracellular calcium by a signaling complex of IRAG, IP3 receptor and cGMP kinase Ibeta Nature 404 2000 197 201 (Pubitemid 30154489)
23. H.J. Shin, H.J. Kim, J.H. Kwak, H.O. Chun, J.H. Kim, H.K. Park, D.H. Kim, and Y.S. Lee A prenylated flavonol, sophoflavescenol: a potent and selective inhibitor of cGMP phosphodiesterase 5 Bioorganic & Medicinal Chemistry Letters 12 2002 2313 2316 (Pubitemid 34879856)
24. + channels in arterial smooth muscle Science 245 1989 177 180 (Pubitemid 19193933)
25. W. Tang, and G. Eisenbrand Chinese Drugs of Plant Origin: Chemistry, Pharmacology, and Use in Traditional and Modern Medicine 1992 Springer-Verlag Berlin pp. 931-943
26. Q.K. Tran, K. Ohashi, and H. Watanabe Calcium signaling in endothelial cells Cardiovascular Research 48 2000 13 22
27. J.C. Tsai, S. Tsai, and W.C. Chang Effect of ethanol extracts of three Chinese medicinal plants with anti-diarrheal properties on ion transport of the rat intestinal epithelia Journal of Pharmacological Sciences 94 2004 60 66 (Pubitemid 38197186)
28. J.F. Wen, X. Cui, J.Y. Jin, S.M. Kim, S.Z. Kim, S.H. Kim, H.S. Lee, and K.W. Cho High and low gain switches for regulation of cAMP efflux concentration. Distinct roles for particulate GC- and soluble GC-cGMP-PDE3 signaling in rabbit atria Circulation Research 94 2004 936 943 (Pubitemid 38490071)
29. J. Yamahara, G. Kobayashi, M. Iwamoto, T. Chisaka, H. Fujimura, Y. Takaishi, M. Yoshida, T. Tomimatsu, and Y. Tamai Vasodilatory active principles of Sophora flavescens root Journal of Ethnopharmacology 29 1990 79 85 (Pubitemid 20115466)
30. Y. Zhou, H. Shan, G. Qiao, X. Sui, Y. Lu, and B. Yang Inotropic effects and mechanisms of matrine, a main alkaloid from Sophora flavescens AIT Biological & Pharmaceutical Bulletin 31 2008 2057 2062