Myocardium-derived conditioned medium improves left ventricular function in rodent acute myocardial infarction

Journal of Translational Medicine

Volumn 9, Issue , 2011, Pages

  Leu, Steve ^a   Kao, Ying Hsien ^b   Sun, Cheuk Kwan ^a   Lin, Yu Chun ^a   Tsai, Tzu Hsien ^a   Chang, Li Teh ^c   Chua, Sarah ^a   Yeh, Kuo Ho ^a   Wu, Chiung Jen ^a   Fu, Morgan ^a   Yip, Hon Kan ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^b I SHOU UNIVERSITY   (Taiwan)

^c MEIHO UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BASIC FIBROBLAST GROWTH FACTOR; CASPASE 3; CHEMOKINE RECEPTOR CXCR4; COLLAGEN TYPE 1; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GAP JUNCTION PROTEIN; GELATINASE A; GELATINASE B; INTERLEUKIN 10; MESSENGER RNA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN CX43; STROMAL CELL DERIVED FACTOR 1ALPHA; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG; VASCULOTROPIN; VON WILLEBRAND FACTOR; ACTIN; MATRIX METALLOPROTEINASE; SMOOTH MUSCLE ACTIN, RAT;

ACUTE HEART INFARCTION; ANGIOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CELL THERAPY; CONTROLLED STUDY; CULTURE MEDIUM; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CELL; IN VITRO STUDY; IN VIVO STUDY; MALE; MYOFIBROBLAST; NEWBORN; NONHUMAN; OXIDATIVE STRESS; PROTEIN EXPRESSION; RAT; SPRAGUE DAWLEY RAT; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; DRUG EFFECT; EVALUATION; FIBROBLAST; GENE EXPRESSION REGULATION; GENETICS; HEART INFARCTION; HEART MUSCLE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

ACTINS; ANIMALS; ANIMALS, NEWBORN; CELLS, CULTURED; COLLAGEN TYPE I; CULTURE MEDIA, CONDITIONED; FIBROBLASTS; GENE EXPRESSION REGULATION; MALE; MATRIX METALLOPROTEINASES; MODELS, BIOLOGICAL; MYOCARDIAL INFARCTION; MYOCARDIUM; RATS; RATS, SPRAGUE-DAWLEY; VENTRICULAR FUNCTION, LEFT;

EID: 78651452300     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-9-11     Document Type: Article

References (36)

1. Strauer BE, Brehm M, Zeus T, Kostering M, Hernandez A, Sorg RV, Kogler G, Wernet P. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 2002, 106:1913-1918. 10.1161/01.CIR.0000034046.87607.1C, 12370212.
2. Wang JS, Shum-Tim D, Chedrawy E, Chiu RC. The coronary delivery of marrow stromal cells for myocardial regeneration: pathophysiologic and therapeutic implications. J Thorac Cardiovasc Surg 2001, 122:699-705. 10.1067/mtc.2001.116317, 11581601.
3. Dai W, Hale SL, Martin BJ, Kuang JQ, Dow JS, Wold LE, Kloner RA. Allogeneic mesenchymal stem cell transplantation in postinfarcted rat myocardium: short- and long-term effects. Circulation 2005, 112:214-223. 10.1161/CIRCULATIONAHA.104.527937, 15998673.
4. Yip HK, Chang LT, Wu CJ, Sheu JJ, Youssef AA, Pei SN, Lee FY, Sun CK. Autologous bone marrow-derived mononuclear cell therapy prevents the damage of viable myocardium and improves rat heart function following acute anterior myocardial infarction. Circ J 2008, 72:1336-1345. 10.1253/circj.72.1336, 18654023.
5. Sun CK, Chang LT, Sheu JJ, Chiang CH, Lee FY, Wu CJ, Chua S, Fu M, Yip HK. Bone marrow-derived mononuclear cell therapy alleviates left ventricular remodeling and improves heart function in rat-dilated cardiomyopathy. Crit Care Med 2009, 37:1197-1205. 10.1097/CCM.0b013e31819c0667, 19242323.
6. Makino S, Fukuda K, Miyoshi S, Konishi F, Kodama H, Pan J, Sano M, Takahashi T, Hori S, Abe H, et al. Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest 1999, 103:697-705. 10.1172/JCI5298, 408125, 10074487.
7. Toma C, Pittenger MF, Cahill KS, Byrne BJ, Kessler PD. Human mesenchymal stem cells differentiate to a cardiomyocyte phenotype in the adult murine heart. Circulation 2002, 105:93-98. 10.1161/hc0102.101442, 11772882.
8. Tse HF, Kwong YL, Chan JK, Lo G, Ho CL, Lau CP. Angiogenesis in ischaemic myocardium by intramyocardial autologous bone marrow mononuclear cell implantation. Lancet 2003, 361:47-49. 10.1016/S0140-6736(03)12111-3, 12517468.
9. Davani S, Marandin A, Mersin N, Royer B, Kantelip B, Herve P, Etievent JP, Kantelip JP. Mesenchymal progenitor cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a rat cellular cardiomyoplasty model. Circulation 2003, 108(Suppl 1):II253-258.
10. Mangi AA, Noiseux N, Kong D, He H, Rezvani M, Ingwall JS, Dzau VJ. Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts. Nat Med 2003, 9:1195-1201. 10.1038/nm912, 12910262.
11. Zhang M, Mal N, Kiedrowski M, Chacko M, Askari AT, Popovic ZB, Koc ON, Penn MS. SDF-1 expression by mesenchymal stem cells results in trophic support of cardiac myocytes after myocardial infarction. Faseb J 2007, 21:3197-3207. 10.1096/fj.06-6558com, 17496162.
12. Porter KE, Turner NA. Cardiac fibroblasts: at the heart of myocardial remodeling. Pharmacol Ther 2009, 123:255-278. 10.1016/j.pharmthera.2009.05.002, 19460403.
13. Mias C, Lairez O, Trouche E, Roncalli J, Calise D, Seguelas MH, Ordener C, Piercecchi-Marti MD, Auge N, Salvayre AN, et al. Mesenchymal stem cells promote matrix metalloproteinase secretion by cardiac fibroblasts and reduce cardiac ventricular fibrosis after myocardial infarction. Stem Cells 2009, 27:2734-2743. 10.1002/stem.169, 19591227.
14. Ottani F, Galvani M, Ferrini D, Sorbello F, Limonetti P, Pantoli D, Rusticali F. Prodromal angina limits infarct size. A role for ischemic preconditioning. Circulation 1995, 91:291-297.
15. Noda T, Minatoguchi S, Fujii K, Hori M, Ito T, Kanmatsuse K, Matsuzaki M, Miura T, Nonogi H, Tada M, et al. Evidence for the delayed effect in human ischemic preconditioning: prospective multicenter study for preconditioning in acute myocardial infarction. J Am Coll Cardiol 1999, 34:1966-1974. 10.1016/S0735-1097(99)00462-3, 10588211.
16. Divald A, Kivity S, Wang P, Hochhauser E, Roberts B, Teichberg S, Gomes AV, Powell SR. Myocardial ischemic preconditioning preserves postischemic function of the 26S proteasome through diminished oxidative damage to 19S regulatory particle subunits. Circ Res 2010, 106:1829-1838. 10.1161/CIRCRESAHA.110.219485, 20431057.
17. Cheng Y, Zhu P, Yang J, Liu X, Dong S, Wang X, Chun B, Zhuang J, Zhang C. Ischaemic preconditioning-regulated miR-21 protects heart against ischaemia/reperfusion injury via anti-apoptosis through its target PDCD4. Cardiovasc Res 2010, 87:431-439. 10.1093/cvr/cvq082, 20219857.
18. Cribier A, Korsatz L, Koning R, Rath P, Gamra H, Stix G, Merchant S, Chan C, Letac B. Improved myocardial ischemic response and enhanced collateral circulation with long repetitive coronary occlusion during angioplasty: a prospective study. J Am Coll Cardiol 1992, 20:578-586. 10.1016/0735-1097(92)90011-B, 1512336.
19. Kosuge M, Kimura K, Kojima S, Sakamoto T, Ishihara M, Asada Y, Tei C, Miyazaki S, Sonoda M, Tsuchihashi K, et al. Effects of preinfarction angina pectoris on infarct size and in-hospital mortality after coronary intervention for acute myocardial infarction. Am J Cardiol 2003, 92:840-843. 10.1016/S0002-9149(03)00896-8, 14516889.
20. Anzai T, Yoshikawa T, Asakura Y, Abe S, Akaishi M, Mitamura H, Handa S, Ogawa S. Preinfarction angina as a major predictor of left ventricular function and long-term prognosis after a first Q wave myocardial infarction. J Am Coll Cardiol 1995, 26:319-327. 10.1016/0735-1097(95)80002-X, 7608430.
21. Cao CM, Yan WY, Liu J, Kam KW, Zhan SZ, Sham JS, Wong TM. Attenuation of mitochondrial, but not cytosolic, Ca2+ overload reduces myocardial injury induced by ischemia and reperfusion. Acta Pharmacol Sin 2006, 27:911-918. 10.1111/j.1745-7254.2006.00391.x, 16787576.
22. Caplan AI, Dennis JE. Mesenchymal stem cells as trophic mediators. J Cell Biochem 2006, 98:1076-1084. 10.1002/jcb.20886, 16619257.
23. Togel F, Weiss K, Yang Y, Hu Z, Zhang P, Westenfelder C. Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol 2007, 292:F1626-1635. 10.1152/ajprenal.00339.2006, 17213465.
24. Sadat S, Gehmert S, Song YH, Yen Y, Bai X, Gaiser S, Klein H, Alt E. The cardioprotective effect of mesenchymal stem cells is mediated by IGF-I and VEGF. Biochem Biophys Res Commun 2007, 363:674-679. 10.1016/j.bbrc.2007.09.058, 17904522.
25. Takahashi T, Kalka C, Masuda H, Chen D, Silver M, Kearney M, Magner M, Isner JM, Asahara T. Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med 1999, 5:434-438. 10.1038/8462, 10202935.
26. Schober A, Karshovska E, Zernecke A, Weber C. SDF-1alpha-mediated tissue repair by stem cells: a promising tool in cardiovascular medicine?. Trends Cardiovasc Med 2006, 16:103-108. 10.1016/j.tcm.2006.01.006, 16713531.
27. Kocher AA, Schuster MD, Bonaros N, Lietz K, Xiang G, Martens TP, Kurlansky PA, Sondermeijer H, Witkowski P, Boyle A, et al. Myocardial homing and neovascularization by human bone marrow angioblasts is regulated by IL-8/Gro CXC chemokines. J Mol Cell Cardiol 2006, 40:455-464. 10.1016/j.yjmcc.2005.11.013, 16438981.
28. Huang PH, Chen YH, Wang CH, Chen JS, Tsai HY, Lin FY, Lo WY, Wu TC, Sata M, Chen JW, Lin SJ. Matrix metalloproteinase-9 is essential for ischemia-induced neovascularization by modulating bone marrow-derived endothelial progenitor cells. Arterioscler Thromb Vasc Biol 2009, 29:1179-1184. 10.1161/ATVBAHA.109.189175, 19461050.
29. Elmadbouh I, Haider H, Jiang S, Idris NM, Lu G, Ashraf M. Ex vivo delivered stromal cell-derived factor-1alpha promotes stem cell homing and induces angiomyogenesis in the infarcted myocardium. J Mol Cell Cardiol 2007, 42:792-803. 10.1016/j.yjmcc.2007.02.001, 2753220, 17350033.
30. Das H, George JC, Joseph M, Das M, Abdulhameed N, Blitz A, Khan M, Sakthivel R, Mao HQ, Hoit BD, et al. Stem cell therapy with overexpressed VEGF and PDGF genes improves cardiac function in a rat infarct model. PLoS One 2009, 4:e7325. 10.1371/journal.pone.0007325, 2752797, 19809493.
31. Garrido AM, Griendling KK. NADPH oxidases and angiotensin II receptor signaling. Mol Cell Endocrinol 2009, 302:148-158. 10.1016/j.mce.2008.11.003, 2835147, 19059306.
32. Jalife J, Morley GE, Vaidya D. Connexins and impulse propagation in the mouse heart. J Cardiovasc Electrophysiol 1999, 10:1649-1663. 10.1111/j.1540-8167.1999.tb00230.x, 10636196.
33. Vozzi C, Dupont E, Coppen SR, Yeh HI, Severs NJ. Chamber-related differences in connexin expression in the human heart. J Mol Cell Cardiol 1999, 31:991-1003. 10.1006/jmcc.1999.0937, 10336839.
34. LaFramboise WA, Scalise D, Stoodley P, Graner SR, Guthrie RD, Magovern JA, Becich MJ. Cardiac fibroblasts influence cardiomyocyte phenotype in vitro. Am J Physiol Cell Physiol 2007, 292:C1799-1808. 10.1152/ajpcell.00166.2006, 17229813.
35. Mazhari R, Hare JM. Mechanisms of action of mesenchymal stem cells in cardiac repair: potential influences on the cardiac stem cell niche. Nat Clin Pract Cardiovasc Med 2007, 4(Suppl 1):S21-26. 10.1038/ncpcardio0770, 17230212.
36. Xie XJ, Wang JA, Cao J, Zhang X. Differentiation of bone marrow mesenchymal stem cells induced by myocardial medium under hypoxic conditions. Acta Pharmacol Sin 2006, 27:1153-1158. 10.1111/j.1745-7254.2006.00436.x, 16923335.