Synthesis and preliminary evaluation of 2-substituted-1,3-benzoxazole and 3-[(3-substituted)propyl]-1,3-benzoxazol-2(3H)-one derivatives as potent anticancer agents

Medicinal Chemistry Research

Volumn 20, Issue 5, 2011, Pages 576-586

  Murty, M S R ^a   Ram, Kesur R ^a   Rao, Rayudu Venkateswara ^a   Yadav, J S ^a   Rao, Janapala Venkateswara ^a   Cheriyan, Vino T ^b   Anto, Ruby John ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY   (India)

Author keywords

Alkylation; Anticancer; Benzoxazole; Cell lines; Cyclic amine; Zinc

Indexed keywords

2 (4 BENZYLPIPERAZIN 1 YL) 1,3 BENZOXAZOLE; 2 (4 METHYLPIPERAZIN 1 YL) 1,3 BENZOXAZOLE; 2 (4 PHENYLPIPERAZIN 1 YL) 1,3 BENZOXAZOLE; 2 (PIPERIDIN 1 YL) 1,3 BENZOXAZOLE; 2 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL] 1,3 BENZOXAZOLE; 2 CYCLIC AMINE 1,3 BENZOXAZOLE DERIVATIVE; 3 [3 (CYCLIC AMINO)PROPYL] 1,3 BENZOXAZOL 2(3H) ONE DERIVATIVE; 5 CHLORO 3 (3 CHLOROPROPYL) 1,3 BENZOXAZOL 2(3H) ONE; 5 CHLORO 3 [3 (4 BENZYLPIPERAZIN 1 YL)PROPYL] 1,3 BENZOXAZOL 2(3H) ONE; 5 CHLORO 3 [3 [4 (3 CHLOROPHENYL)PIPERAZIN 1 YL]PROPYL] 1,3 BENZOXAZOL 2(3H) ONE; 5 CHLORO 3 [3 [4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]PROPYL] 1,3 BENZOXAZOL 2(3H) ONE; ANTINEOPLASTIC AGENT; BENZOXAZOLE DERIVATIVE; HETEROCYCLIC AMINE; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL PROLIFERATION; COLON CANCER; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LUNG CANCER; STRUCTURE ACTIVITY RELATION; UTERINE CERVIX CANCER;

EID: 80052025661     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9353-y     Document Type: Article

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