Synthesis and evaluation of 3-aryl piperidine analogs as potent and efficacious dopamine D4 receptor agonists

Bioorganic and Medicinal Chemistry

Volumn 13, Issue 15, 2005, Pages 4667-4678

  Wang, Xueqing ^a   Bhatia, Pramila A ^a   Daanen, Jerome F ^a   Latsaw, Steve P ^a   Rohde, Jeffrey ^a   Kolasa, Teodozyi ^a   Hakeem, Ahmed A ^a   Matulenko, Mark A ^a   Nakane, Masaki ^a   Uchic, Marie E ^a   Miller, Loan N ^a   Chang, Renjie ^a   Moreland, Robert B ^a   Brioni, Jorge D ^a   Stewart, Andrew O ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

3 Aryl piperidines; Agonist efficacy; Agonist potency; Dopamine D4 receptor

Indexed keywords

DOPAMINE 4 RECEPTOR AGONIST; DOPAMINE RECEPTOR STIMULATING AGENT; PIPERIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AGONIST; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION;

CELL LINE; DOPAMINE AGONISTS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PIPERIDINES; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 20744455249     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.04.060     Document Type: Article

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