GC × GC-MS hyphenated techniques for the analysis of volatile organic compounds in air

Journal of Liquid Chromatography and Related Technologies

Volumn 34, Issue 13, 2011, Pages 1077-1111

  Arsene, Cecilia ^a   Vione, Davide ^b   Grinberg, Nelu ^c   Olariu, Romeo Iulian ^a  

^a ALEXANDRU IOAN CUZA UNIVERSITY OF IASI   (Romania)

^b UNIVERSITY OF TURIN   (Italy)

^c BOEHRINGER INGELHEIM PHARMACEUTICALS INC   (United States)

Author keywords

air; comprehensive GC GC; gas; particles; volatile semivolatile organic compounds

Indexed keywords

COMPLEX MIXTURE; COMPREHENSIVE TWO-DIMENSIONAL GAS CHROMATOGRAPHY; DETECTION TECHNIQUE; HYPHENATED TECHNIQUES; QUANTITATIVE INFORMATION; SEMIVOLATILE COMPOUNDS; SEMIVOLATILE ORGANIC COMPOUNDS; TWO DIMENSIONAL GAS CHROMATOGRAPHY; VOLATILE/SEMIVOLATILE ORGANIC COMPOUNDS;

TWO DIMENSIONAL; VOLATILE ORGANIC COMPOUNDS;

GAS CHROMATOGRAPHY;

VOLATILE ORGANIC COMPOUND;

AIR QUALITY CONTROL; AIRBORNE PARTICLE; ARTICLE; GAS; GAS CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; SEPARATION TECHNIQUE;

EID: 80052012995     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.587749     Document Type: Article

References (140)

1. Panic, O.; Gorecki, T. Comprehensive Two-dimensional Gas Chromatography (GC×GC) in Environmental Analysis and Monitoring. Anal. Bioanal. Chem. 2006, 386, 1013-1023.
2. Jimenez, J. L.; Canagaratna, M. R.; Donahue, N. M. Evolution of Organic Aerosols in the Atmosphere. Science 2009, 326, 1525-1529.
3. Goldstein, A. H.; Galbally, I. E. Known and Unexplored Organic Constituents in the Earth's Atmosphere. Environ. Sci. Technol. 2007, 41, 1515-1521.
4. Robinson, A. L.; Donahue, N. M.; Shrivastava, M. K. Rethinking Organic Aerosols: Semivolatile Emissions and Photochemical Aging. Science 2007, 315, 1259-1262.
5. Farmer, D. K.; Jimenez, J. L. Real-time Atmospheric Chemistry Field Instrumentation. Anal. Chem. 2010, 82, 7879-7884.
6. Dimandja, J. M. D. Comprehensive 2-D GC Provides High-Performance Separations in Terms of Selectivity, Sensitivity, Speed and Structure. Anal. Chem. 2004, 1, 167A-174A.
7. Helmig, D.; Klinger, L. F.; Guenther, A.; Vierling, L.; Geron, C. Zimmerman, P. Biogenic Volatile Organic Compound Emissions (BVOCs) I. Identifications from Three Continental Sites in the US. Chemosphere 1999, 38, 2163-2187.
8. Phillips, M.; Herrera, J.; Krishan, S.; Zain, M.; Greenberg, J.; Cataneo, R. N. Variation in Volatile Organic Compounds in the Breath of Normal Humans. J. Chromatogr. B 1999, 729, 75-88.
9. Huybrechts, T.; Dewulf, J.; Van Langenhove, H. State-of-the-art of Gas Chromatography-based Methods for Analysis of Anthropogenic Volatile Organic Compounds in Estuarine Waters, Illustrated with the River Scheldt as an Example. J. Chromatogr. A 2003, 1000, 283-297.
10. Dewulf, J.; Huybrechts, T.; Van Langenhove, H. Developments in the Analysis of Volatile Halogenated Compounds. Trends Anal. Chem. 2006, 25, 300-309.
11. Hirschfeld, T. Hy-phen-ated Methods. Anal. Chem. 1980, 52, 297A-312A.
12. Apel, E. C.; Hills, A. J.; Lueb, R.; Zindel, S.; Eisele, S.; Riemer, D. D. A Fast-GC/MS System to Measure C2 to C4 Carbonyls and Methanol Aboard Aircraft. J. Geophys. Res. 2003, 108, 8794-8809.
13. Shimmo, M.; Hyotylainen, T.; Kallio, M.; Anttila, P.; Riekkola, M. L. Multidimensional and Hyphenated Techniques in Aerosols Analysis. LC. GC Europe 2004, 17, 640-645.
14. Shimmo, M.; Jantti, J.; Aalto, P.; Hartonen, K.; Hyotylainen, T.; Kulmala, M.; Riekkola, M. L. Characterization of Organic Compounds in Aerosol Particles from a Finnish Forest by On-line Coupled Supercritical Fluid Extraction-Liquid Chromatography-Gas Chromatography-Mass Spectrometry. Anal. Bioanal. Chem. 2004, 378, 1982-1990.
15. Shimmo, M.; Anttila, P.; Hartonen, K.; Hyotylainen, T.; Paatero, J.; Kulmala, M.; Riekkola, M. L. Identification of Organic Compounds in Atmospheric Aerosol Particles by On-line Supercritical Fluid Extraction-Liquid Chromatography-Gas Chromatography-Mass Spectrometry. J. Chromatogr. A 2004, 1022, 151-159.
16. Odabasi, M.; Ongan, O.; Cetin, E. Quantitative Analysis of Volatile Organic Compounds (VOCs) in Atmospheric Particles. Atmos. Environ. 2005, 39, 3763-3770.
17. Alves, C. A.; Vicente, A.; Evtyugina, M.; Pio, C. A.; Hoffer, A.; Kiss, G.; Decesari, S.; Hillamo, R.; Swietlicki, E. Characterization of Hydrocarbons in Atmospheric Aerosols from Different European Sites. World Academy Sci. Engin. Technol. 2009, 57, 236-242.
18. Fu, P.; Kawamura, K.; Kanaya, Y.; Wang, Z. Contributors of biogenic volatile organic Compounds to the Formation of Secondary Organic Aerosols Over Mt. Tai, Central East China. Atmos. Environ. 2010, 44, 4817-4826.
19. Parshintsev, J.; Kivilompolo, M.; Ruiz-Jimenez, J.; Hartonen, K.; Kulmala, M.; Riekkola, M. L. Particle-into-liquid Sampler On-line Coupled with Solid-Phase Extraction-Liquid Chromatography- Mass Spectrometry for the Determination of Organic Acids in Atmospheric Aerosols. J. Chromatogr. A 2010, 1217, 5427-5433.
20. Ciccioli, P.; Brancaleoni, E.; Frattoni, M.; Cecinato, A.; Pinciarelli, L. Determination of Volatile Organic Compounds (VOC) Emitted from Biomass Burning of Mediterranean Vegetation Species by GC-MS. Anal. Lett. 2001, 34, 937-955.
21. Wiedinmyer, C.; Friedfeld, S.; Baugh, W.; Greenberg, J.; Guenther, A.; Fraser, M.; Allen, D. Measurement and Analysis of Atmospheric Concentrations of Isoprene and Its Reaction Products in Central Texas. Atmos. Environ. 2001, 35, 1001-1013.
22. Singh, H. B.; Salas, L. J.; Chatfield, R. B.; Czech, E.; Fried, A.; Walega, J.; Evans, M. J.; Field, B. D.; Jacob, D. J.; Blake, D.; Heikes, B.; Talbot, R.; Sachse, G.; Crawford, J. H.; Avery, M. A.; Sandholm, S.; Fuelberg, H. Analysis of the Atmospheric Distribution, Sources, and Sinks of Oxygenated Volatile Organic Chemicals Based on Measurements Over The Pacific During TRACE-P. J. Geophys. Res. 2004, 109, D15S07.
23. Tang, J.; Chan, C. Y.; Wang, X.; Chan, L. Y.; Sheng, G. Volatile Organic Compounds in a Multi-story Shopping Mall in Guangzhou, South China. Atmos. Environ. 2005, 39, 7374-7383.
24. Tanner, D.; Helming, J.; Hueber, J.; Goldan, P. Gas Chromatography System for the Automated, Unattended, and Cryogen-Free Monitoring of C2 to C6 Non-Methane Hydrocarbons in the Remote Troposphere. J. Chromatogr. A 2006, 1111, 76-88.
25. Mansilha, C.; Melo, A.; Rebelo, H.; Ferreira, I. M. P. L. V. O.; Pinho, O.; Domingues, V.; Pinho, C.; Gameiro, P. Quantification of Endocrine Disruptors and Pesticides in Water by Gas Chromatography- Tandem Mass Spectrometry. Method Validation Using Weighted Linear Regression Schemes. J. Chromatogr. A 2010, 1217, 6681-6691.
26. Hobbs, P. J.; Webb, J.; Mottram, T. T.; Grant, B.; Misselbrook, T. M. Emissions of Volatile Organic Compounds Originating from UK livestock agriculture. J. Sci. Food Agric. 2004, 84, 1414-1420.
27. Bermejo, A. M.; Lopez, P.; Alvarez, I.; Tabernero, M. J.; Fernandez, P. Solid-phase Microextraction for the Determination of Cocaine and Cocaethylene in Human Hair by Gas Chromatography- Mass Spectrometry. Forensic. Sci. Int. 2006, 156, 2-8.
28. Wang, S.; Chen, Q.; He, L. Development and Validation of a Gas Chromatography-Mass Spectrometry Method for the Determination of Isoimperatorin in Rat Plasma and Tissue: Application to the Pharmacokinetic and Tissue Distribution Study. J. Chromatogr. B 2007, 852, 473-478.
29. Akyuz, M.; Ata, S. Determination of Aromatic Amines in Hair Dye and Henna Samples by Ion-pair Extraction and Gas Chromatography-Mass Spectrometry. J. Pharm. Biomed. Anal. 2008, 47, 68-80.
30. Bichon, E.; Richard, C. A.; Le Bizec, B. Development and Validation of a Method for Fipronil Residue Determination in Ovine Plasma Using 96-well Plate Solid-Phase Extraction and Gas Chromatography-Tandem Mass Spectrometry. J. Chromatogr. A 2008, 1201, 91-99.
31. Chung, L. W.; Liu, G. J.; Li, Z. G.; Chang, Y. Z.; Leea, M. R. Solvent-ENHANCED Microwave-Assisted Derivatization Following Solid-Phase Extraction Combined with Gas Chromatography-Mass Spectrometry for Determination of Amphetamines in Urine. J. Chromatogr. B 2008, 874, 115-118.
32. Hamelin, E.; Swaim, L.; Thomas, J.; Kobelski, R.; Johnson, R. C. Quantitation of Tetramethylene Disulfotetramine in Human Urine Using Isotope Dilution Gas Chromatography Massspectrometry (GC/MS and GC/MS/MS). J. Chromatogr. B 2010, 878, 2541-2547.
33. Hercegova, A.; Domotorova, M.; Matisova, E.; Kirchner, M.; Otrekal, R.; Stefuca, V. Fast Gas Chromatography with Solid Phase Extraction Clean-up for Ultratrace Analysis of Pesticide Residues in Baby Food. J. Chromatogr. A 2005, 1084, 46-53.
34. Guardia-Rubio, M.; Marchal-Lopez, R. M.; Ayora-Canada, M. J.; Ruiz-Medina, A. Determination of Pesticides in Olives by Gas Chromatography Using Different Detection Systems. J. Chromatogr. A 2007, 1145, 195-203.
35. Barboni, T.; Luro, F.; Chiaramonti, N.; Desjobert, J. M.; Muselli, A.; Costa, J. Volatile Composition of Hybrids Citrus Juices by Headspace Solid-Phase Micro Extraction/Gas Chromatography/Mass Spectrometry. Food Chem. 2009, 116, 382-390.
36. Cunha, S. C.; Fernandes, J. O.; Alves, A.; Oliveira, M. B. P. P. Fast Low-Pressure Gas Chromatography- Mass Spectrometry Method for the Determination of Multiple Pesticides in Grapes, Musts and Wines. J. Chromatogr. A 2009, 1216, 119-126.
37. Losada, S.; Santos, F. J.; Covaci, A.; Galceran, M. T. Gas Chromatography-Ion Trap Tandem Mass Spectrometry Method for the Analysis of Methoxylated Polybrominated Diphenyl Ethers in Fish. J. Chromatogr. A 2010, 1217, 5253-5260.
38. Valente-Campos, S.; Yonamine, M.; Moreau, R. L. M.; Silva, O. A. Validation of a Method to Detect Cocaine and Its Metabolites in Nails by Gas Chromatography-Mass Spectrometry. Forensic. Sci. Int. 2006, 159, 218-222.
39. Liberto, E.; Cagliero, C.; Sgorbini, B.; Bicchi, C.; Sciarrone, D.; Zellner, B. D.; Mondello, L.; Rubiolo, P. Enantiomer Identification in the Flavor and Fragrance Fields by "Interactive" Combination Of Linear Retention Indices From Enantioselective Gas Chromatography and Mass Spectrometry. J. Chromatogr. A 2008, 1195, 117-126.
40. Wang, F. C. Y.; Qian, K.; Green, L. A. GC×MS of Diesel: A two-dimensional Separation Approach. Anal. Chem. 2005, 77, 2777-2785.
41. Helmig, D. Ozone Removal Techniques in the Sampling of Atmospheric Volatile Organic Trace Gases. Atmos. Environ. 1997, 31, 3635-3651.
42. Komenda, M.; Schaub, A.; Koppmann, R. Description and Characterization of an On-line System for Long-term Measurements of Isoprene, Methyl Vinyl Ketone, and Methacrolein in Ambient Air. J. Chromatogr. A 2003, 995, 185-201.
43. Phillips, J. B.; Xu, J. Z. Comprehensive Multidimensional Gas-Chromatography. J. Chromatogr. A 1995, 703, 327-334.
44. Schomburg, G. 2-Dimensional Gas Chromatography - Principles, Instrumentation, Methods. J. Chromatogr. A 1995, 703, 309-325.
45. Phillips, J. B.; Beens, J. Comprehensive Two-Dimensional Gas Chromatography: A Hyphenated Method with Strong Coupling Between the Two Dimensions. J. Chromatogr. A 1999, 856, 331-347.
46. Beens, J.; Brinkman, U. A. Th. The Role of Gas Chromatography in Compositional Analyses in the Petroleum Industry. Trends Anal. Chem. 2000, 19, 260-275.
47. Hinshaw, J. V. Comprehensive Two-Dimensional Gas Chromatography. LC GC Eur. 2004, February, 2-7.
48. Beens, J.; Brinkman, U. A. Th. Comprehensive Two-Dimensional Gas Chromatography-A Powerful and Versatile Technique. Analyst 2005, 130, 123-127.
49. Adahchour, M.; Beens, J.; Vreuls, R. J. J.; Brinkman, U.A.Th. Recent Developments in Comprehensive Two-Dimensional Gas Chromatography (GC×GC) I. Introduction and Instrumental Set-up. Trends Anal. Chem. 2006, 25, 438-454.
50. Adahchour, M.; Beens, J.; Vreuls, R. J. J.; Brinkman, U. A. Th. Recent Developments in Comprehensive Two-Dimensional Gas Chromatography (GC×GC) II. Introduction Modulation and Detection. Trends Anal. Chem. 2006, 25, 540-553.
51. Adahchour, M.; Beens, J.; Brinkman, U. A. Th. Recent Developments in the Application of Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2008, 1186, 67-108.
52. Wang, Y. W.; Chen, Q. A.; Norwood, D. L.; McCaffrey, J. Recent Development in the Applications of Comprehensive Two-Dimensional Gas Chromatograph. J. Liq. Chromatogr. Rel. Technol. 2010, 33, 1082-1115.
53. Dorman, F. L.; Whiting, J. J.; Cochran, J. W.; Gardea-Torresdey, J. Gas Chromatography. Anal. Chem. 2010, 82, 4775-4785.
54. Ledford, E. B.; Billesbach, C. A.; Zhu, Q. GC3: Comprehensive Three-Dimensional Gas Chromatography. J. High Resolut. Chromatogr. 2000, 23, 205-207.
55. Seeley, J. V.; Kramp, F. J.; Hicks, C. J. Comprehensive Two-Dimensional Gas Chromatography via Differential Flow Modulation. Anal. Chem. 2000, 72, 4346-4352.
56. Seeley, J. V.; Kramp, F. J.; Sharpe, K. S. A Dual-Secondary Column Comprehensive Two- Dimensional Gas Chromatograph for the Analysis of Volatile Organic Compounds Mixtures. J. Sep. Sci. 2001, 24, 444-450.
57. Marriott, P. J.; Haglund, P.; Ong, R. C. Y. A Review of Environmental Toxicant Analysis by Using Multidimensional Gas Chromatography and Comprehensive GCA Review of Environmental Toxicant Analysis by Using Multidimensional Gas Chromatography and Comprehensive GC. Clin. Chim. Acta 2003, 328, 1-19.
58. Bertoncini, F.; Vendeuvre, C.; Thiebaut, D. Interest and Applications of Multidimensional Gas Chromatography from Trace Analysis in the Petroleum Industry. Oil Gas Sci. Technol. 2005, 60, 937-950.
59. 60 for Analysis of Vacuum Gas Oils. J. Chromatogr. A 2009, 1216, 2905-2912.
60. Eschner, M.; Welthagen, W.; Groger, T. M.; Gonin, M.; Fuhrer, K.; Zimmermann, R. Comprehensive Multidimensional Separation Methods by Hyphenation of Single-Photon Ionization Time-Of- Flight Mass Spectrometry (SPI-TOF-MS) with GC and GC×GC. Anal. Bioanal. Chem. 2010, 398, 1435-1445.
61. Wulf, V.; Wienand, N.; Wirtz, M.; Kling, H.; Gäb, S.; Schmitz, O. J. Analysis of Special Surfactants by Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry. J. Chromatogr. A 2010, 1217, 749-754.
62. Mondello, L.; Casilli, A.; Tranchida, P. Q.; Dugo, G.; Dugo, P. Comprehensive Two-Dimensional Gas Chromatography in Combination with Rapid Scanning Quadrupole Mass Spectrometry in Perfume Analysis. J. Chromatogr. A 2005, 1067, 235-243.
63. Dunn, M. S.; Vulic, N.; Shellie, R. A.; Whitehead, S.; Morrison, P.; Marriott, P. J. Targeted Multidimensional Gas Chromatography for the Quantitative Analysis of Suspected Allergens in Fragrance Products. J. Chromatogr. A 2006, 1130, 122-129.
64. Eyres, G.; Marriott, P. J.; Dufour, J. P. The Combination of Gas Chromatography-Olfactometry and Multidimensional Gas Chromatography for the Characterization of Essential Oils. J. Chromatogr. A 2007, 1150, 70-77.
65. Amorim, L. C. A.; Dimandja, J. M.; Cardeal, Z. L. Analysis of Hydroxylated Polycyclic Aromatic Hydrocarbons in Urine Using Comprehensive Two-Dimensional Gas Chromatography with a Flame Ionization Detector. J. Chromatogr. A 2009, 1216, 2900-2904.
66. Windt, M.; Meier, D.; Marsman, J. H.; Heeres, H. J.; de Koning, S. Micro-pyrolysis of Technical Lignins in a New Modular Rig and Product Analysis by GC-MS/FID and GC×GC-TOFMS/FID. J. Anal. Appl. Pyrolysis 2009, 85, 38-46.
67. van Mispelaar, V. G.; Smilde, A. K.; de Noord, O. E.; Blomberg, J.; Schoenmakers, P. J. Classification of Highly Similar Crude Oils Using Data Sets from Comprehensive Two-Dimensional Gas Chromatography and Multivariate Techniques. J. Chromatogr. A 2005a, 1096, 156-164.
68. Schmarr, H. G.; Bernhardt, J. Profiling Analysis of Volatile Compounds from Fruits Using Comprehensive Two-Dimensional Gas Chromatography and Image Processing Techniques. J. Chromatogr. A 2010, 1217, 565-574.
69. Zhu, S.; Lu, X.; Xin, J. Zhang, S.; Kong, H.; Xu, G.; Wu, C. Comparison of Comprehensive Two-Dimensional Gas Chromatography/Time-Of-Flight Mass Spectrometry and Gas Chromatography- Mass Spectrometry for the Analysis of Tobacco Essential Oils. Anal. Chim. Acta 2005, 545, 224-231.
70. Morales-Munoz, S.; Vreuls, R. J. J.; Luque de Castro, M. D. Dynamic Ultrasound-Assisted Extraction of Environmental Pollutants from Marine Sediments for Comprehensive Two-Dimensional Gas Chromatography with Time-Of-Flight Mass Spectrometric Detection. J. Chromatogr. A 2005, 1086, 122-127.
71. Goldstein, A. H.; Worton, D. R.; Williams, B. J. Thermal Desorption Comprehensive Two- Dimensional Gas Chromatography for In-situ Measurements of Organic Aerosols. J. Chromatogr. A 2008, 1186, 340-347.
72. Hamilton, J. F. Using Comprehensive Two-Dimensional Gas Chromatography to Study the Atmosphere. J. Chromatogr. Sci. 2010, 48, 274-282.
73. Marriott, P. J.; Massil, T.; Hugel, H. Molecular Structure Retention Relationships in Comprehensive Two-Dimensional Gas Chromatography. J. Sep. Sci. 2004, 27, 1273-1284.
74. van Mispelaar, V. G.; Janssen, H. G.; Tas, A. C.; Schoenmakers, P. J. Novel System for Classifying Chromatographic Applications, Exemplified by Comprehensive Two-Dimensional Gas Chromatography and Multivariate Analysis. J. Chromatogr. A 2005, 1071, 229-237.
75. Laj, P.; Klausen, J.; Bilde, M. Plass-Duelmer, C.; Pappalardo, G.; Clerbaux, C.; Baltensperger, U.et al Measuring Atmospheric Composition Change. Atmos. Environ. 2009, 43, 5351-5414.
76. Truong, T. T.; Marriott, P. J.; Porter, N. A. Analytical Study of Comprehensive and Targeted Multidimensional Gas Chromatography Incorporating Modulated Cryogenic Trapping. J. AOC Internat. 2001, 84, 323-335.
77. Ryan, D.; Morrison, P.; Marriott, P. Orthogonality Considerations in Comprehensive Two- Dimensional Gas Chromatography. J. Chromatogr. A 2005, 1071, 47-53.
78. Dorman, F. L.; Schettler, P. D.; Vogt, L. A.; Cochran, J. Using Computer Modeling to Predict and Optimize Separations for Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2008, 1186, 196-201.
79. Harynuk, J.; Marriott, P. J. Fast GC×GC with Short Primary Column. Anal. Chem. 2006, 78, 2028-2034.
80. Junge, M.; Bieri, S.; Huegel, H.; Marriott, P. J. Fast Comprehensive Two-Dimensional Gas Chromatography with Cryogenic Modulation. Anal. Chem. 2007, 79, 4448-4454.
81. Seeley, J. V. Theoretical Study of Incomplete Sampling of the First Dimension in Comprehensive Two-Dimensional Chromatography. J. Chromatogr. A 2002, 962, 21-27.
82. Dalluge, J.; Vreuls, R. J. J.; Beens, J.; Brinkman, U. A. Th. Optimization and Characterization of Comprehensive Two-Dimensional Gas Chromatography with Time-of-Flight Mass Spectrometric Detection (GC×GC-TOF MS). J. Sep. Sci. 2002, 25, 201-214.
83. Harynuk, J. Comprehensive Two-Dimensional Gas Chromatography (GC×GC). 2009. http:// www.scitopics.com/Comprehensive-Two-dimensional- Gas-Chromatography-GCxGC.html (accessed Nov 22, 2010).
84. Blumberg, L. M.; David, F.; Klee, M. S.; Sandra, P. Comparison of One-Dimensional and Comprehensive Two-Dimensional Separations by Gas Chromatography. J. Chromatogr. A 2008, 1188, 2-16.
85. Beens, J.; Tijssen, R.; Blomberg, J. Prediction of Comprehensive Two-Dimensional Gas Chromatographic Separations: A Theoretical and Practical Exercise. J. Chromatogr. A 1998, 822, 233-251.
86. Korytar, P.; Danielsson, C.; Leonards, P. E. G.; Haglund, P.; de Boer, J.; Brinkman, U. A. Th. Separation of Seventeen 2,3,7,8-substituted Polychlorinated Dibenzo-p-dioxins and Dibenzofurans and 12 Dioxin-like Polychlorinated Biphenyls by Comprehensive Two-Dimensional Gas Chromatography with Electron-Capture Detection. J. Chromatogr. A 2004, 1038, 189-199.
87. Korytar, P.; Leonards, P. E. G.; de Boer, J.; Brinkman, U. A. Th. Group Separation of Organohalogenated Compounds by Means of Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2005, 1086, 29-44.
88. Adahchour, M.; Tasoz, A.; Beens, J.; Batenburg, A. M.; Brinkman, U. A. Th. Fast Comprehensive Two-Dimensional Gas Chromatography (GC×GC) Using 50-mm ID Second-Dimension Columns. J. Sep. Sci. 2003, 26, 753-760.
89. Beens, J.; Janssen, H. G.; Adahchour, M.; Brinkman, U. A. Th. Flow Regime at Ambient Outlet Pressure and Its Influence in Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2005, 1086, 141-150.
90. Shellie, R. A.; Marriott, P. J.; Morrison, P.; Mondello, L. Effects of Pressure Drop on Absolute Retention Matching in Comprehensive Two-Dimensional Gas Chromatography. J. Sep. Sci. 2004, 27, 504-512.
91. Harynuk, J.; Gorecki, T.; de Zeeuw, J. Overloading of the Second-Dimension Column in Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2005, 1071, 21-27.
92. Lee, A. L.; Bartle, K. D.; Lewis, A. C. A Model of Peak Amplitude Enhancement in Orthogonal Two-Dimensional Gas Chromatography. Anal. Chem. 2001, 73, 1330-1335.
93. Adahchour, M.; Beens, J.; Vreuls, R. J. J.; Batenburg, A. M.; Brinkman, U. A. Th. Comprehensive Two-Dimensional Gas Chromatography of Complex Samples by Using a "Reversed-type" Column Combination: Application to Food Analysis. J. Chromatogr. A 2004, 1054, 47-55.
94. Mondello, L.; Casilli, A.; Tranchida, P. Q.; Dugo, P.; Costa, R.; Festa, S.; Dugo, G. Comprehensive Multidimensional GC for the Characterization of Roasted Coffee Beans. J. Sep. Sci. 2004, 27, 442-450.
95. Shellie, R. A.; Marriott, P. J. Comprehensive Two-Dimensional Gas Chromatography with Fast Enantioseparation. Anal. Chem. 2002, 74, 5426-5430.
96. Ledford, E. B.; Billesbach, C. Jet-cooled Thermal Modulator for Comprehensive Multidimensional Gas Chromatography. J. High Resol. Chromatogr. 2000, 23, 202-204.
97. Khummueng, W.; Harynuk, J.; Marriott, P. J. Modulation Ratio in Comprehensive Two-Dimensional Gas Chromatography. Anal. Chem. 2006, 78, 4578-4587.
98. Dalluge, J.; Beens, J.; Brinkman, U. A. Th. Comprehensive Two-Dimensional Gas Chromatography: A Powerful and Versatile Analytical Tool. J. Chromatogr. A 2003, 1000, 69-108.
99. Lewis, A. C.; Carslaw, N.; Marriott, P. J.; Kinghorn, R. M.; Morrison, P. D.; Lee, A. L.; Bartle, K. D.; Pilling, M. J. A Larger Pool of Ozone-forming Carbon Compounds in Urban Atmospheres. Nature 2000, 405, 778-781.
100. Marriott, P. J.; Kinghorn, R. M.; Ong, R.; Morrison, P.; Haglund, P., Harju, M. Comparison of Thermal Sweeper and Cryogenic Modulator Technology for Comprehensive Gas Chromatography. J. High Resol. Chromatogr. 2000, 23, 253-258.
101. Kristenson, E. M.; Korytar, P.; Danielsson, C.; Kallio, M.; Brandt, M.; Makela, J.; Vreuls, R. J.; Beens, J.; Brinkman, U. A. Evaluation of Modulators and Electron-capture Detectors for Comprehensive Two-Dimensional GC of Halogenated Organic Compounds. J. Chromatogr. A 2003, 1019, 65-77.
102. Tobias, H. J., Sacks, G. L., Zhang, Y., Brenna, J. T. Comprehensive Two-Dimensional Gas Chromatography Combustion Isotope Ratio Mass Spectrometry. Anal. Chem. 2008, 80, 8613-8621.
103. Kochman, M.; Gordin, A.; Alon, T.; Amirav, A. Flow Modulation Comprehensive Two-Dimensional Gas Chromatography-Mass Spectrometry with a Supersonic Molecular Beam. J. Chromatogr. A 2006, 1129, 95-104.
104. Poliak, M.; Fialkov, A. B.; Amirav, A. Pulsed Flow Modulation Two-Dimensional Comprehensive Gas Chromatography-Tandem Mass Spectrometry with Supersonic Molecular Beams. J. Chromatogr. A 2008, 1210, 108-114.
105. Blumberg, L. M. Comprehensive Two-Dimensional Gas Chromatography: Metrics, Potentials, Limits. J. Chromatogr. A 2003, 985, 29-38.
106. Seeley, J. V.; Micyus, N. J.; Bandurski, S. V.; Seeley, S. K.; McCurry, J. D. Microfluidic Deans Switch for Comprehensive Two-Dimensional Gas Chromatography. Anal. Chem. 2007, 79, 1840-1847.
107. Kallio, M.; Hyotylainen, T. Simple Calibration Procedure for Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2008, 1200, 264-267.
108. Harynuk, J.; Gorecki, T. Comparison of Comprehensive Two-Dimensional Gas Chromatography in Conventional and Stop-flow Modes. J. Chromatogr. A 2006, 1105, 159-167.
109. Chin, S. T.; Wu, Z. Y.; Morrison, P. D.; Marriott, P. Observations on Comprehensive Two-Dimensional Gas Chromatography Coupled with Flame Photometric Detection for Sulfurand Phosphorus-Containing Compounds. Anal. Methods 2010, 2, 243-253.
110. Handley, A. Advances in Gas Chromatography. Chromatogr. Today 2010, February/March, 40-43.
111. Tranchida, P. Q.; Purcaro, G.; Sciarrone, D.; Dugo, P.; Dugo, G.; Mondello, L. Accurate Quadrupole MS Peak Reconstruction in Optimized Gas-Flow Comprehensive Two-Dimensional Gas Chromatography. J. Sep. Sci. 2010, 33, 2791-2795.
112. Skoczynska, E.; Korytar, P.; De Boer, J. Maximizing Chromatographic Information from Environmental Extracts by GC×GC-ToF-MS. Environ. Sci. Technol. 2008, 42, 6611-6618.
113. Tran, T. C.; Marriott, P. J. Comprehensive Two-Dimensional Gas Chromatography - Time-of-Flight Mass Spectrometry and Simultaneous Electron Capture Detection/Nitrogen Phosphorous Detection for Incense Analysis. Atmos. Environ. 2008, 42, 7360-7372.
114. Adahchour, M.; Brandt, M.; Baier, H. U.; Vreuls, R. J. J.; Batenburg, A. M.; Brinkman, U. A. Th. Comprehensive Two-Dimensional Gas Chromatography Coupled to a Rapid-Scanning Quadrupole Mass Spectrometer: Principles and Applications. J. Chromatogr. A 2005, 1067, 245-254.
115. Korytar, P.; Parera, J.; Leonards, P. E. G.; de Boer J.; Brinkman, U. A. Th. Quadrupole Mass Spectrometer Operating in the Electron-Capture Negative Ion Mode as Detector for Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2005, 1067, 255-264.
116. Zimmermann, R.; Welthagen, W.; Groger, T. Photo-Ionization Mass Spectrometry as Detection Method for Gas Chromatography. Optical Selectivity and Multidimensional Comprehensive Separations. J. Chromatogr. A 2008, 1184, 296-308.
117. Demeestere, K.; Dewulf, J.; De Roo, K.; De Wispelaere, P.; Van Langenhove, H. Quality Control in Quantification of Volatile Organic Compounds Analyzed by Thermal Desorption-Gas Chormatography- Mass Spectrometry. J. Chromatogr. A 2008, 1186, 348-357.
118. Mitschke, S.; Welthagen, W.; Zimmermann, R. Comprehensive Gas Chromatography-Time-of- Flight Mass Spectrometry Using Soft and Selective Photoionization Techniques. Anal. Chem. 2006, 78, 6364-6375.
119. Zimmermann, R.; Welthagen, W. Multidimensional Chemical Analysis of Complex Systems with GC and MS. Nachr. Chem. 2006, 54, 1115-1119.
120. Welthagen, W.; Schnelle-Kreis, J.; Zimmermann, R. Search Criteria and Rules for Comprehensive Two-Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry Analysis of Airborne Particulate Matter. J. Chromatogr. A 2003, 1019, 233-249.
121. Ong, R. C. Y.; Marriott, P. J. A Review of Basic Concepts in Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. Sci. 2002, 40, 276-291.
122. Johnson, K., Prazen, B. J., Young, D. C.; Synovec, R. E. Quantification of Naphthalenes in Jet Fuel with GC×GC/Tri-PLS and Windowed Rank Minimization Retention Time Alignment. J. Sep. Sci. 2004, 27, 410-416.
123. Amador-Munoz, O.; Marriott, P. J. Quantification in Comprehensive Two-Dimensional Gas Chromatography and a Model of Quantification Based on Selected Summed Modulated Peaks. J. Chromatogr. A 2008, 1184, 323-340.
124. Hollingsworth, B. V.; Reichenbach, S. E.; Tao, Q.; Visvanathan, A. Comparative Visualization for Comprehensive Two-Dimensional Gas-Chromatography. J. Chromatogr. A. 2006, 1105, 51-58.
125. Dorman, F. L.; Schettler, P. D.; English, C.M.; Patwardhan, D. V. Predicting Gas Chromatographic Separation and Stationary-Phase Selectivity Using Computer Modeling. Anal. Chem. 2002, 74, 2133-2138.
126. Vogt, L.; Groger, T.; Zimmermann, R. Automated Compound Classification for Ambient Aerosol Sample Separations Using Comprehensive Two-Dimensional Gas Chromatography-Time-of-Flight Mass Spectrometry. J. Chromatogr. A 2007, 1150, 2-12.
127. Semard, G.; Peulon-Agasse, V.; Bruchet, A.; Bouillon, J. P.; Cardinael, P. Convex Hull: A New Method to Determine the Separation Space Used and to Optimize Operating Conditions for Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2010, 1217, 5449-5454.
128. Kallio, M.; Hyotylainen, T. Quantitative Aspects in Comprehensive Two-Dimensional Gas Chromatography. J. Chromatogr. A 2007, 1148, 228-235.
129. Xu, X.; van Stee, L. L. P.; Williams, J.; Beens, J.; Adahchour, M.; Vreuls, R. J. J.; Brinkman, U. A. Th.; Lelieveld, J. Comprehensive Two Dimensional Gas Chromatography(GC×GC) Measurements of Volatile Organic Compounds in the Atmosphere. Atmos. Chem. Phys. 2003, 3, 665-682.
130. Xu, X.; Williams, J.; Dulmer, C. P.; Berresheim, H.; Salisbury, G.; Lange, L.; Lelieveld, J. GC×GC Measurements of C7-C11 Aromatic and n-Alkane Hydrocarbons on Crete, in Air from Eastern Europe During the MINOS Campaign. Atmos. Chem. Phys. 2003, 3, 1461-1475.
131. Hamilton, J. F.; Webb, P. J.; Lewis, A. C.; Hopkins, J. R.; Smith, S.; Davy, P. Partially Oxidized Organic Components in Urban Aerosol Using GC×GC-TOF/MS. Atmos. Chem. Phys. 2004, 4, 1279-1290.
132. Anttila, P.; Rissanen, T.; Shimmo, M.; Kallio, M.; Hyotylainen, T.; Kulmala, M.; Riekola, M. L. Organic Compounds in Atmospheric Aerosols from a Finnish Coniferous Forest. Boreal Environ. Res. 2005, 10, 371-384.
133. Kallio, M.; Jussila, M.; Rissanen, T.; Anttila, P.; Hartonen, K.; Reissell, A.; Vreuls, R.; Adahchour, M.; Hyotylainen, T. Comprehensive Two-Dimensional Gas Chromatography Coupled to Time-of-Flight Mass Spectrometry in the Identification of Organic Compounds in Atmospheric Aerosols from Coniferous Forest. J. Chromatogr. A 2006, 1125, 234-243.
134. Ochiai, N.; Ieda, T.; Sasamato, K.; Fushimi, A.; Hasegawa, S.; Tanabe, K.; Kobayashi, S. Characterization of Organic Compounds in Atmospheric Nanoparticles by Thermal Extraction- Comprehensive Two-Dimensional Gas Chromatography (GC×GC) in Combination with Selective Detection, Mass Spectrometry and Accurate Mass Detection. App. Note 2007, 7, 1-14.
135. Saxton, J. E.; Lewis, A. C.; Kettwell, J. H.; Ozel, M. Z.; Gogus, F.; Boni, Y.; Korogone, S. O. U.; Serca, D. Isoprene and Monoterpene Measurements in a Secondary Forest in Northern Benin. Atmos. Chem. Phys. 2007, 7, 4095-4106.
136. Welthagen, W.; Mitschke, S.; Muhlberger, F.; Zimmermann, R. One-Dimensional and Comprehensive Two-Dimensional Gas Chromatography Coupled to Soft Photo Ionization Time-of-Flight Mass Spectrometry: A Two- and Three-Dimensional Separation Approach. J. Chromatogr. A 2007, 1150, 54-61.
137. Laitinen, T.; Martin, S. H.; Parshintsev, J.; Hyotylainen, T.; Hartonen, K.; Riekkola, M. L.; Kulmala, M.; Pavon, J. L. P. Determination of Organic Compounds from Wood Combustion Aerosol Nanoparticles by Different Gas Chromatographic Systems and by Aerosol Mass Spectrometry. J. Chromatogr. A 2010, 1217, 151-159.
138. Hamilton, J. F.; Lewis, A. C. Monoaromatic Complexity in Urban Air and Gasoline Assessed Using Comprehensive GC and Fast GC-TOF/MS. Atmos. Environ. 2003, 37, 589-602.
139. 3. Atmos. Chem. Phys. 2007, 7, 1-14.
140. Ochiai, N.; Ieda, T.; Sasamoto, K.; Fushimi, A.; Hasegawa, S.; Tanabe, K.; Kobayashi, S. Comprehensive Two-Dimensional Gas Chromatography Coupled to High-Resolution Time-of-Flight Mass Spectrometry and Simultaneous Nitrogen Phosphorous and Mass Spectrometric Detection for Characterization of Nanoparticles in Roadside Atmosphere. J. Chromatogr. A 2007, 1150, 13-20.