A mouse model of term chorioamnionitis: Unraveling causes of adverse neurological outcomes

Reproductive Sciences

Volumn 18, Issue 9, 2011, Pages 900-907

  Burd, Irina ^a   Brown, Amy ^a   Gonzalez, Juan M ^a   Chai, Jinghua ^a   Elovitz, Michal A ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

chorioamnionitis; delayed neurotoxicity; mouse model of intrauterine inflammation; neuroinflammation; neuronal injury

Indexed keywords

GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; MESSENGER RNA; MICROTUBULE ASSOCIATED PROTEIN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; ASTROCYTOSIS; BRAIN DAMAGE; BRAIN INJURY; CELL DAMAGE; CELL VIABILITY; CHORIOAMNIONITIS; CONTROLLED STUDY; CYTOKINE RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; IMMUNOCYTOCHEMISTRY; MOUSE; NONHUMAN; OLIGODENDROGLIA; PRIORITY JOURNAL; STAINING; UTERUS HORN; WHITE MATTER;

ANIMALS; BRAIN INJURIES; CHORIOAMNIONITIS; FEMALE; MICE; NEURONS; PREGNANCY;

EID: 80052009143     PISSN: 19337191     EISSN: 19337205     Source Type: Journal    
DOI: 10.1177/1933719111398498     Document Type: Article

References (45)

1. Soper DE, Mayhall CG, Froggatt JW. Characterization and control of intraamniotic infection in an urban teaching hospital. Am J Obstet Gynecol. 1996 ; 175 (2). 304 309-309 310
2. Soper DE, Mayhall CG, Dalton HP. Risk factors for intraamniotic infection: a prospective epidemiologic study. Am J Obstet Gynecol. 1989 ; 161 (3). 562 566-566 568
3. Shatrov JG, Birch SC, Lam LT, Quinlivan JA, McIntyre S, Mendz GL. Chorioamnionitis and cerebral palsy: a meta-analysis. Obstet Gynecol. 2010 ; 116 (2 Pt 1). 387-392
4. Becroft DM, Thompson JM, Mitchell EA. Placental chorioamnionitis at term: epidemiology and follow-up in childhood. Pediatr Dev Pathol. 2010; 13(4): 282-90. 2009 ;:
5. Impey LW, Greenwood CE, Black RS, Yeh PS, Sheil O, Doyle P. The relationship between intrapartum maternal fever and neonatal acidosis as risk factors for neonatal encephalopathy. Am J Obstet Gynecol. 2008 ; 198 (1). 49.e41 - e46
6. Nelson KB, Ellenberg JH. Antecedents of cerebral palsy. I. Univariate analysis of risks. Am J Dis Child. 1985 ; 139 (10). 1031-1038 (Pubitemid 16236502)
7. Nelson KB, Ellenberg JH. Antecedents of cerebral palsy. Multivariate analysis of risk. N Engl J Med. 1986 ; 315 (2). 81-86 (Pubitemid 16093209)
8. Grether JK, Nelson KB. Maternal infection and cerebral palsy in infants of normal birth weight. JAMA. 1997 ; 278 (3). 207-211 (Pubitemid 27339585)
9. Wu YW, Colford JM. Chorioamnionitis as a risk factor for cerebral palsy: a meta-analysis. JAMA. 2000 ; 284 (11). 1417-1424
10. Wu YW, Croen LA, Shah SJ, Newman TB, Najjar DV. Cerebral palsy in a term population: risk factors and neuroimaging findings. Pediatrics. 2006 ; 118 (2). 690-697 (Pubitemid 46085426)
11. Wu YW, Escobar GJ, Grether JK, Croen LA, Greene JD, Newman TB. Chorioamnionitis and cerebral palsy in term and near-term infants. JAMA. 2003 ; 290 (20). 2677-2684 (Pubitemid 37475595)
12. Neufeld MD, Frigon C, Graham AS, Mueller BA. Maternal infection and risk of cerebral palsy in term and preterm infants. J Perinatol. 2005 ; 25 (2). 108-113 (Pubitemid 40277382)
13. Nelson KB, Dambrosia JM, Grether JK, Phillips TM. Neonatal cytokines and coagulation factors in children with cerebral palsy. Ann Neurol. 1998 ; 44 (4). 665-675 (Pubitemid 28477855)
14. Nitsos I, Rees SM, Duncan J, et al. Chronic exposure to intra-amniotic lipopolysaccharide affects the ovine fetal brain. J Soc Gynecol Investig. 2006 ; 13 (4). 239-247 (Pubitemid 43668396)
15. Burd I, Bentz AI, Chai J, et al. Inflammation-induced preterm brith alters neuronal morphology in the mouse fetal brain. J Neurosci Res. 2010 ; 88 (9). 1872-81
16. Burd I, Bentz A, Gonzalez J, et al. Inflammation-induced preterm birth alters neuronal morphology in the mouse fetal brain. J Neurosci Res. 2010 ;:
17. Elovitz MA, Mrinalini C, Sammel MD. Elucidating the early signal transduction pathways leading to fetal brain injury in preterm birth. Pediatr Res. 2006 ; 59 (1). 50-55
18. Debillon T, Gras-Leguen C, Leroy S, Caillon J, Roze JC, Gressens P. Patterns of cerebral inflammatory response in a rabbit model of intrauterine infection-mediated brain lesion. Brain Res Dev Brain Res. 2003 ; 145 (1). 39-48 (Pubitemid 38368640)
19. Bell MJ, Hallenbeck JM. Effects of intrauterine inflammation on developing rat brain. J Neurosci Res. 2002 ; 70 (4). 570-579 (Pubitemid 35253527)
20. Leviton A, Gressens P. Neuronal damage accompanies perinatal white-matter damage. Trends Neurosci. 2007 ; 30 (9). 473-478 (Pubitemid 47374834)
21. Gonzalez JM, Ofori E, Burd I, Chai J, Scholler N, Elovitz MA. Maternal mortality from systemic illness: unraveling the contribution of the immune response. Am J Obstet Gynecol. 2009 ; 200 (4). 430.e431 - e438
22. Elovitz MA, Mrinalini C. Can medroxyprogesterone acetate alter Toll-like receptor expression in a mouse model of intrauterine inflammation?. Am J Obstet Gynecol. 2005 ; 193 (3 Pt 2). 1149-1155 (Pubitemid 41285510)
23. Elovitz MA, Wang Z, Chien EK, Rychlik DF, Phillippe M. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. Am J Pathol. 2003 ; 163 (5). 2103-2111 (Pubitemid 37310039)
24. Monnerie H, Le Roux PD. Glutamate receptor agonist kainate enhances primary dendrite number and length from immature mouse cortical neurons in vitro. J Neurosci Res. 2006 ; 83 (6). 944-956
25. Monnerie H, Le Roux PD. Reduced dendrite growth and altered glutamic acid decarboxylase (GAD) 65- and 67-kDa isoform protein expression from mouse cortical GABAergic neurons following excitotoxic injury in vitro. Exp Neurol. 2007 ; 205 (2). 367-382 (Pubitemid 46755759)
26. Monnerie H, Shashidhara S, Le Roux PD. Effect of excess extracellular glutamate on dendrite growth from cerebral cortical neurons at 3 days in vitro: involvement of NMDA receptors. J Neurosci Res. 2003 ; 74 (5). 688-700 (Pubitemid 37475449)
27. Coronas V, Arnault P, Roger M. Cortical diffusible factors increase MAP-2 immunoreactive neuronal population in thalamic cultures. Neurosci Res. 2002 ; 43 (1). 57-67 (Pubitemid 34628583)
28. Benitez-King G, Ramirez-Rodriguez G, Ortiz L, Meza I. The neuronal cytoskeleton as a potential therapeutic target in neurodegenerative diseases and schizophrenia. Curr Drug Targets CNS Neurol Disord. 2004 ; 3 (6). 515-533 (Pubitemid 40081279)
29. Whitford KL, Dijkhuizen P, Polleux F, Ghosh A. Molecular control of cortical dendrite development. Annu Rev Neurosci. 2002 ; 25: 127-149 (Pubitemid 34748014)
30. Whitford KL, Marillat V, Stein E, et al. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron. 2002 ; 33 (1). 47-61 (Pubitemid 34088178)
31. Holgado A, Ferreira A. Synapse formation proceeds independently of dendritic elongation in cultured hippocampal neurons. J Neurobiol. 2000 ; 43 (2). 121-131 (Pubitemid 30241210)
32. Martone ME, Hu BR, Ellisman MH. Alterations of hippocampal postsynaptic densities following transient ischemia. Hippocampus. 2000 ; 10 (5). 610-616
33. Kishi N, Macklis JD. MeCP2 functions largely cell-autonomously, but also non-cell-autonomously, in neuronal maturation and dendritic arborization of cortical pyramidal neurons. Exp Neurol. 2010 ; 222 (1). 51-58
34. Fatemi SH. The role of Reelin in pathology of autism. Mol Psychiatry. 2002 ; 7 (9). 919-920 (Pubitemid 35333041)
35. Abuhatzira L, Shemer R, Razin A. MeCP2 involvement in the regulation of neuronal alpha-tubulin production. Hum Mol Genet. 2009 ; 18 (8). 1415-1423
36. Rousset CI, Chalon S, Cantagrel S, et al. Maternal exposure to LPS induces hypomyelination in the internal capsule and programmed cell death in the deep gray matter in newborn rats. Pediatr Res. 2006 ; 59 (3). 428-433 (Pubitemid 43740083)
37. Wang X, Hagberg H, Zhu C, Jacobsson B, Mallard C. Effects of intrauterine inflammation on the developing mouse brain. Brain Res. 2007 ; 1144: 180-185 (Pubitemid 46440844)
38. Cai Z, Pan ZL, Pang Y, Evans OB, Rhodes PG. Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration. Pediatr Res. 2000 ; 47 (1). 64-72 (Pubitemid 30038893)
39. Saadani-Makki F, Kannan S, Lu X, et al. Intrauterine administration of endotoxin leads to motor deficits in a rabbit model: a link between prenatal infection and cerebral palsy. Am J Obstet Gynecol. 2008 ; 199 (6). 651.e651 - e657
40. Wang X, Rousset CI, Hagberg H, Mallard C. Lipopolysaccharide-induced inflammation and perinatal brain injury. Semin Fetal Neonatal Med. 2006 ; 11 (5). 343-353 (Pubitemid 44038704)
41. Marlow N, Wolke D, Bracewell MA, Samara M. Neurologic and developmental disability at six years of age after extremely preterm birth. N Engl J Med. 2005 ; 352 (1). 9-19 (Pubitemid 40075676)
42. Anderson P, Doyle LW. Neurobehavioral outcomes of school-age children born extremely low birth weight or very preterm in the 1990s. JAMA. 2003 ; 289 (24). 3264-3272 (Pubitemid 37430079)
43. Anderson PJ, Doyle LW. Cognitive and educational deficits in children born extremely preterm. Semin Perinatol. 2008 ; 32 (1). 51-58 (Pubitemid 351181451)
44. Rademaker KJ, Uiterwaal CS, Beek FJ, et al. Neonatal cranial ultrasound versus MRI and neurodevelopmental outcome at school age in children born preterm. Arch Dis Child Fetal Neonatal Ed. 2005 ; 90 (6). F489 - F493
45. Kuban KC, Allred EN, O'Shea TM, et al. Cranial ultrasound lesions in the NICU predict cerebral palsy at age 2 years in children born at extremely low gestational age. J Child Neurol. 2009 ; 24 (1). 63-72