메뉴 건너뛰기




Volumn 103, Issue 2, 2007, Pages 456-466

Cyclic AMP-dependent protein kinase (PKA) phosphorylates Ser362 and 467 and protein kinase C phosphorylates Ser550 within the M3/M4 cytoplasmic domain of human nicotinic receptor α4 subunits

Author keywords

Neuronal nicotinic receptor; Phosphorylation; Protein kinase A; Protein kinase C

Indexed keywords

AMINO ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYTOPLASM PROTEIN; FORSKOLIN; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR ALPHA4; PHORBOL DIBUTYRATE; PHOSPHOAMINO ACID; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; SERINE; UNCLASSIFIED DRUG;

EID: 34848915528     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2007.04853.x     Document Type: Article
Times cited : (26)

References (35)
  • 1
    • 0033579464 scopus 로고    scopus 로고
    • Sequence and structure-based prediction of eukaryotic protein phosphorylation sites
    • Blom N., Gammeltoft S. Brunak S. (1999) Sequence and structure-based prediction of eukaryotic protein phosphorylation sites. J. Mol. Biol. 294, 1351 1362.
    • (1999) J. Mol. Biol. , vol.294 , pp. 1351-1362
    • Blom, N.1    Gammeltoft, S.2    Brunak, S.3
  • 2
    • 2942564430 scopus 로고    scopus 로고
    • Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence
    • Blom N., Sicheritz-Ponten T., Gupta R., Gammeltoft S. Brunak S. (2004) Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence. Proteomics 4, 1633 1649.
    • (2004) Proteomics , vol.4 , pp. 1633-1649
    • Blom, N.1    Sicheritz-Ponten, T.2    Gupta, R.3    Gammeltoft, S.4    Brunak, S.5
  • 3
    • 0025998840 scopus 로고
    • Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates
    • Boyle W. J., van der Geer P. Hunter T. (1991) Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates. Methods Enzymol. 201, 110 149.
    • (1991) Methods Enzymol. , vol.201 , pp. 110-149
    • Boyle, W.J.1    Van Der Geer, P.2    Hunter, T.3
  • 4
    • 0035869342 scopus 로고    scopus 로고
    • Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function
    • Buisson B. Bertrand D. (2001) Chronic exposure to nicotine upregulates the human α4β2 nicotinic acetylcholine receptor function. J. Neurosci. 21, 1819 1829.
    • (2001) J. Neurosci. , vol.21 , pp. 1819-1829
    • Buisson, B.1    Bertrand, D.2
  • 5
    • 0031466434 scopus 로고    scopus 로고
    • Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism
    • Eilers H., Schaeffer E., Bickler P. E. Forsayeth J. R. (1997) Functional deactivation of the major neuronal nicotinic receptor caused by nicotine and a protein kinase C-dependent mechanism. Mol. Pharmacol. 52, 1105 1112.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 1105-1112
    • Eilers, H.1    Schaeffer, E.2    Bickler, P.E.3    Forsayeth, J.R.4
  • 6
    • 33745911142 scopus 로고    scopus 로고
    • Chaperone protein 14-3-3 and protein kinase a increase the relative abundance of low agonist sensitivity human α4β2 nicotinic acetylcholine receptors in Xenopus oocytes
    • Exley R., Moroni M., Sasdelli F., Houlihan L. M., Lukas R. J., Sher E., Zwart R. Bermudez I. (2006) Chaperone protein 14-3-3 and protein kinase A increase the relative abundance of low agonist sensitivity human α4β2 nicotinic acetylcholine receptors in Xenopus oocytes. J. Neurochem. 98, 876 885.
    • (2006) J. Neurochem. , vol.98 , pp. 876-885
    • Exley, R.1    Moroni, M.2    Sasdelli, F.3    Houlihan, L.M.4    Lukas, R.J.5    Sher, E.6    Zwart, R.7    Bermudez, I.8
  • 8
    • 0026593533 scopus 로고
    • A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment
    • Flores C. M., Rogers S. W., Pabreza L. A., Wolfe B. B. Kellar K. J. (1992) A subtype of nicotinic cholinergic receptor in rat brain is composed of α4 and β2 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharmacol. 41, 31 37.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 31-37
    • Flores, C.M.1    Rogers, S.W.2    Pabreza, L.A.3    Wolfe, B.B.4    Kellar, K.J.5
  • 9
    • 0030610921 scopus 로고    scopus 로고
    • Regulation of human α4β2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways
    • Gopalakrishnan M., Molinari E. J. Sullivan J. P. (1997) Regulation of human α4β2 neuronal nicotinic acetylcholine receptors by cholinergic channel ligands and second messenger pathways. Mol. Pharmacol. 52, 524 534.
    • (1997) Mol. Pharmacol. , vol.52 , pp. 524-534
    • Gopalakrishnan, M.1    Molinari, E.J.2    Sullivan, J.P.3
  • 10
    • 0036068573 scopus 로고    scopus 로고
    • Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor α4 subunits
    • Guo X. Wecker L. (2002) Identification of three cAMP-dependent protein kinase (PKA) phosphorylation sites within the major intracellular domain of neuronal nicotinic receptor α4 subunits. J. Neurochem. 82, 439 447.
    • (2002) J. Neurochem. , vol.82 , pp. 439-447
    • Guo, X.1    Wecker, L.2
  • 11
    • 0036896928 scopus 로고    scopus 로고
    • Changes in conformation and subcellular distribution of α4β2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras
    • Harkness P. C. Millar N. S. (2002) Changes in conformation and subcellular distribution of α4β2 nicotinic acetylcholine receptors revealed by chronic nicotine treatment and expression of subunit chimeras. J. Neurosci. 22, 10172 10181.
    • (2002) J. Neurosci. , vol.22 , pp. 10172-10181
    • Harkness, P.C.1    Millar, N.S.2
  • 12
    • 0030722148 scopus 로고    scopus 로고
    • Nicotine enhances the cyclic AMP-dependent protein kinase-mediated phosphorylation of α4 subunits of neuronal nicotinic receptors
    • Hsu Y. N., Edwards S. C. Wecker L. (1997) Nicotine enhances the cyclic AMP-dependent protein kinase-mediated phosphorylation of α4 subunits of neuronal nicotinic receptors. J. Neurochem. 69, 2427 2431.
    • (1997) J. Neurochem. , vol.69 , pp. 2427-2431
    • Hsu, Y.N.1    Edwards, S.C.2    Wecker, L.3
  • 13
    • 0035958852 scopus 로고    scopus 로고
    • The chaperone protein 14-3-3η interacts with the nicotinic acetylcholine receptor α4 subunit. Evidence for a dynamic role in subunit stabilization
    • Jeanclos E. M., Lin L., Treuil M. W., Rao J., DeCoster M. A. Anand R. (2001) The chaperone protein 14-3-3η interacts with the nicotinic acetylcholine receptor α4 subunit. Evidence for a dynamic role in subunit stabilization. J. Biol. Chem. 276, 28281 28290.
    • (2001) J. Biol. Chem. , vol.276 , pp. 28281-28290
    • Jeanclos, E.M.1    Lin, L.2    Treuil, M.W.3    Rao, J.4    Decoster, M.A.5    Anand, R.6
  • 14
    • 0014949207 scopus 로고
    • Cleavage of structural proteins during the assembly of the head of bacteriophage T4
    • Laemmli U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 227, 680 685.
    • (1970) Nature , vol.227 , pp. 680-685
    • Laemmli, U.K.1
  • 15
    • 0032616958 scopus 로고    scopus 로고
    • Modulation of ion channels by protein phosphorylation. How the brain works
    • Levitan I. B. (1999) Modulation of ion channels by protein phosphorylation. How the brain works. Adv. Second Messenger Phosphoprotein Res. 33, 3 22.
    • (1999) Adv. Second Messenger Phosphoprotein Res. , vol.33 , pp. 3-22
    • Levitan, I.B.1
  • 17
    • 0011631320 scopus 로고
    • Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP
    • Miles K., Anthony D. T., Rubin L. L., Greengard P. Huganir R. L. (1987) Regulation of nicotinic acetylcholine receptor phosphorylation in rat myotubes by forskolin and cAMP. Proc. Natl Acad. Sci. USA 84, 6591 6595.
    • (1987) Proc. Natl Acad. Sci. USA , vol.84 , pp. 6591-6595
    • Miles, K.1    Anthony, D.T.2    Rubin, L.L.3    Greengard, P.4    Huganir, R.L.5
  • 18
    • 0027304248 scopus 로고
    • Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro
    • Nakayama H., Okuda H. Nakashima T. (1993) Phosphorylation of rat brain nicotinic acetylcholine receptor by cAMP-dependent protein kinase in vitro. Brain Res. Mol. Brain Res. 20, 171 177.
    • (1993) Brain Res. Mol. Brain Res. , vol.20 , pp. 171-177
    • Nakayama, H.1    Okuda, H.2    Nakashima, T.3
  • 19
    • 0347064158 scopus 로고    scopus 로고
    • Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: Effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons
    • Nashmi R., Dickinson M. E., McKinney S., Jareb M., Labarca C., Fraser S. E. Lester H. A. (2003) Assembly of α4β2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. J. Neurosci. 23, 11554 11567.
    • (2003) J. Neurosci. , vol.23 , pp. 11554-11567
    • Nashmi, R.1    Dickinson, M.E.2    McKinney, S.3    Jareb, M.4    Labarca, C.5    Fraser, S.E.6    Lester, H.A.7
  • 20
    • 0038356890 scopus 로고    scopus 로고
    • Phosphorylation of the α4 subunit of human α4β2 nicotinic receptors: Role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    • Pacheco M. A., Pastoor T. E. Wecker L. (2003) Phosphorylation of the α4 subunit of human α4β2 nicotinic receptors: role of cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Brain Res. Mol. Brain Res. 114, 65 72.
    • (2003) Brain Res. Mol. Brain Res. , vol.114 , pp. 65-72
    • Pacheco, M.A.1    Pastoor, T.E.2    Wecker, L.3
  • 21
    • 0031573415 scopus 로고    scopus 로고
    • Comparison of DNA sequences with protein sequences
    • Pearson W. R., Wood T., Zhang Z. Miller W. (1997) Comparison of DNA sequences with protein sequences. Genomics 46, 24 36.
    • (1997) Genomics , vol.46 , pp. 24-36
    • Pearson, W.R.1    Wood, T.2    Zhang, Z.3    Miller, W.4
  • 22
    • 0035726679 scopus 로고    scopus 로고
    • Neuronal nicotinic acetylcholine receptor subunit knockout mice: Physiological and behavioral phenotypes and possible clinical implications
    • Picciotto M. R., Caldarone B. J., Brunzell D. H., Zachariou V., Stevens T. R. King S. L. (2001) Neuronal nicotinic acetylcholine receptor subunit knockout mice: physiological and behavioral phenotypes and possible clinical implications. Pharmacol. Ther. 92, 89 108.
    • (2001) Pharmacol. Ther. , vol.92 , pp. 89-108
    • Picciotto, M.R.1    Caldarone, B.J.2    Brunzell, D.H.3    Zachariou, V.4    Stevens, T.R.5    King, S.L.6
  • 24
    • 0030034224 scopus 로고    scopus 로고
    • Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line
    • Rothhut B., Romano S. J., Vijayaraghavan S. Berg D. K. (1996) Post-translational regulation of neuronal acetylcholine receptors stably expressed in a mouse fibroblast cell line. J. Neurobiol. 29, 115 125.
    • (1996) J. Neurobiol. , vol.29 , pp. 115-125
    • Rothhut, B.1    Romano, S.J.2    Vijayaraghavan, S.3    Berg, D.K.4
  • 26
    • 0035341508 scopus 로고    scopus 로고
    • An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing
    • Scott D. B., Blanpied T. A., Swanson G. T., Zhang C. Ehlers M. D. (2001) An NMDA receptor ER retention signal regulated by phosphorylation and alternative splicing. J. Neurosci. 21, 3063 3072.
    • (2001) J. Neurosci. , vol.21 , pp. 3063-3072
    • Scott, D.B.1    Blanpied, T.A.2    Swanson, G.T.3    Zhang, C.4    Ehlers, M.D.5
  • 29
    • 20444368757 scopus 로고    scopus 로고
    • Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism
    • Vallejo Y. F., Buisson B., Bertrand D. Green W. N. (2005) Chronic nicotine exposure upregulates nicotinic receptors by a novel mechanism. J. Neurosci. 25, 5563 5572.
    • (2005) J. Neurosci. , vol.25 , pp. 5563-5572
    • Vallejo, Y.F.1    Buisson, B.2    Bertrand, D.3    Green, W.N.4
  • 30
    • 0025499657 scopus 로고
    • Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor α-type subunit
    • Vijayaraghavan S., Schmid H. A., Halvorsen S. W. Berg D. K. (1990) Cyclic AMP-dependent phosphorylation of a neuronal acetylcholine receptor α-type subunit. J. Neurosci. 10, 3255 3262.
    • (1990) J. Neurosci. , vol.10 , pp. 3255-3262
    • Vijayaraghavan, S.1    Schmid, H.A.2    Halvorsen, S.W.3    Berg, D.K.4
  • 31
    • 0032528973 scopus 로고    scopus 로고
    • The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo
    • Viseshakul N., Figl A., Lytle C. Cohen B. N. (1998) The α4 subunit of rat α4β2 nicotinic receptors is phosphorylated in vivo. Brain Res. Mol. Brain Res. 59, 100 104.
    • (1998) Brain Res. Mol. Brain Res. , vol.59 , pp. 100-104
    • Viseshakul, N.1    Figl, A.2    Lytle, C.3    Cohen, B.N.4
  • 32
    • 0037375682 scopus 로고    scopus 로고
    • Phosphorylation sites within α4 subunits of α4β2 neuronal nicotinic receptors: A comparison of substrate specificities for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC)
    • Wecker L. Rogers C. Q. (2003) Phosphorylation sites within α4 subunits of α4β2 neuronal nicotinic receptors: a comparison of substrate specificities for cAMP-dependent protein kinase (PKA) and protein kinase C (PKC). Neurochem. Res. 28, 431 436.
    • (2003) Neurochem. Res. , vol.28 , pp. 431-436
    • Wecker, L.1    Rogers, C.Q.2
  • 33
    • 0035150853 scopus 로고    scopus 로고
    • Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of α4 neuronal nicotinic receptor subunits
    • Wecker L., Guo X., Rycerz A. M. Edwards S. C. (2001) Cyclic AMP-dependent protein kinase (PKA) and protein kinase C phosphorylate sites in the amino acid sequence corresponding to the M3/M4 cytoplasmic domain of α4 neuronal nicotinic receptor subunits. J. Neurochem. 76, 711 720.
    • (2001) J. Neurochem. , vol.76 , pp. 711-720
    • Wecker, L.1    Guo, X.2    Rycerz, A.M.3    Edwards, S.C.4
  • 34
    • 0022919287 scopus 로고
    • Pharmacological properties of immuno-isolated neuronal nicotinic receptors
    • Whiting P. Lindstrom J. (1986) Pharmacological properties of immuno-isolated neuronal nicotinic receptors. J. Neurosci. 6, 3061 3069.
    • (1986) J. Neurosci. , vol.6 , pp. 3061-3069
    • Whiting, P.1    Lindstrom, J.2
  • 35
    • 0028949913 scopus 로고
    • Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems
    • Zoli M., Le Novere N., Hill J. A. Jr. Changeux J. P. (1995) Developmental regulation of nicotinic ACh receptor subunit mRNAs in the rat central and peripheral nervous systems. J. Neurosci. 15, 1912 1939.
    • (1995) J. Neurosci. , vol.15 , pp. 1912-1939
    • Zoli, M.1    Le Novere, N.2    Hill Jr., J.A.3    Changeux, J.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.