Mounting evidence that increased consumption of α-linolenic acid, the vegetable n-3 fatty acid, may benefit cardiovascular health

Clinical Lipidology

Volumn 6, Issue 4, 2011, Pages 365-369

  Sala Vila, Aleix ^a   Ros, Emilio ^b  

^a INSTITUTO DE SALUD CARLOS III   (Spain)

^b HOSPITAL CLÍNIC   (Spain)

Author keywords

linolenic acid; cardiovascular outcomes; coronary heart disease; diet; prospective studies; stroke

Indexed keywords

DOCOSAHEXAENOIC ACID; FISH OIL; ICOSAPENTAENOIC ACID; LINOLENIC ACID; OMEGA 3 FATTY ACID;

ARTICLE; BRAIN ISCHEMIA; CARDIOVASCULAR EFFECT; CLINICAL EFFECTIVENESS; EATING HABIT; EVIDENCE BASED MEDICINE; FAT INTAKE; FATTY ACID SYNTHESIS; HEALTH STATUS; HEART PROTECTION; HUMAN; ISCHEMIC HEART DISEASE; LEAFY VEGETABLE; NONHUMAN; NUTRIENT MANAGEMENT; NUTRITIONAL ASSESSMENT; NUTRITIONAL HEALTH; NUTRITIONAL VALUE; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RISK REDUCTION;

EID: 80051979453     PISSN: 17460875     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.11.36     Document Type: Article

References (20)

1. de Goede J, Verschuren WM, Boer JM, Kromhout D, Geleijnse JM. α-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in The Netherlands. PLoS ONE 6(3), e17967 (2011)
2. Connor WE. α-linolenic acid in health and disease. Am. J. Clin. Nutr. 69(5), 827-828 (1999)
3. Lavie CJ, Milani RV, Mehra MR, Ventura HO. ω-3 polyunsaturated fatty acids and cardiovascular diseases. J. Am. Coll. Cardiol. 54(7), 585-594 (2009)
4. Geleijnse JM, de Goede J, Brouwer IA. α-linolenic acid: is it essential to cardiovascular health? Curr. Atheroscler. Rep. 12(6), 359-367 (2010)
5. Mente A, de Koning L, Shannon HS, Anand SS. A systematic review of the evidence supporting a causal link between dietary factors and coronary heart disease. Arch. Intern. Med. 169(7), 659-669 (2009)
6. Burdge GC. Metabolism of α-linolenic acid in humans. Prostaglandins Leukot. Essent. Fatty Acids 75(3), 161-168 (2006)
7. Kris-Etherton PM, Hu FB, Ros E, Sabaté J. The role of tree nuts and peanuts in the prevention of coronary heart disease: multiple potential mechanisms. J. Nutr. 138(9), S1746-S1751 (2008)
8. López-Miranda J, Pérez-Jiménez F, Ros E, et al. Olive oil and health: summary of the II International Conference on Olive Oil and Health consensus report, Jaén and Córdoba (Spain) 2008. Nutr. Metab. Cardiovasc. Dis. 20(4), 284-294 (2010)
9. Kang J, Badger TM, Ronis MJ, Wu X. Non-isoflavone phytochemicals in soy and their health effects. J. Agric. Food Chem. 58(14), 8119-8133 (2010)
10. Welch AA, Lund E, Amiano P, et al. Variability of fish consumption within the 10 European countries participating in the European Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr. 5(6B), 1273-1285 (2002) (Pubitemid 36313618)
11. Baylin A, Campos H. The use of fatty acid biomarkers to reflect dietary intake. Curr. Opin. Lipidol. 17(1), 22-27 (2006) (Pubitemid 43100299)
12. Simon JA, Fong J, Bernert JT Jr, Browner WS. Serum fatty acids and the risk of stroke. Stroke 26(5), 778-782 (1995)
13. Park Y, Park S, Yi H, et al. Low level of n-3 polyunsaturated fatty acids in erythrocytes is a risk factor for both acute ischemic and hemorrhagic stroke in Koreans. Nutr. Res. 29(12), 825-830 (2009)
14. Blondeau N, Nguemeni C, Debruyne DN, et al. Subchronic α-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: a versatile potential therapy for stroke. Neuropsychopharmacology 34(12), 2548-2559 (2009)
15. Blondeau N, Pétrault O, Manta S, et al. Polyunsaturated fatty acids are cerebral vasodilators via the TREK-1 potassium channel. Circ. Res. 101(2), 176-184 (2007) (Pubitemid 47196585)
16. Winnik S, Lohmann C, Richter EK, et al. Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. Eur. Heart. J. DOI: 10.1093/eurheartj/ehq501 (2011) (Epub ahead of print)
17. Djoussé L, Folsom AR, Province MA, Hunt SC, Ellison RC. Dietary linolenic acid and carotid atherosclerosis: the National Heart, Lung, and Blood Institute Family Heart Study. Am. J. Clin. Nutr. 77(4), 819-825 (2003)
18. Sala-Vila A, Cofán M, Pérez-Heras A, et al. Fatty acids in serum phospholipids and carotid intima-media thickness in Spanish subjects with primary dyslipidemia. Am. J. Clin. Nutr. 92(1), 186-193 (2010)
19. Sala-Vila A, Cofán M, Núñez I, Gilabert R, Junyent M, Ros E. Carotid and femoral plaque burden is inversely associated with the α-linolenic acid proportion of serum phospholipids in Spanish subjects with primary dyslipidemia. Atherosclerosis 214(1), 209-214 (2011)
20. Kromhout D, Giltay EJ, Geleijnse JM; Alpha Omega Trial Group. n-3 fatty acids and cardiovascular events after myocardial infarction. N. Engl. J. Med. 363(21), 2015-2026 (2010)